Dendrobium nobile Lindl. alkaloids protect CCl4-induced acute liver injury via upregulating LAMP1 expression and activating autophagy flux

Liu Z, Wang MM, Wang X, Bu QF, Wang Q, Su WT, Li L, Zhou HM, Lu L (2022) XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury. Redox Biol 52:15. https://doi.org/10.1016/j.redox.2022.102305

Article  CAS  Google Scholar 

Zhang X, Kuang G, Wan JY, Jiang R, Ma L, Gong X, Liu X (2020) Salidroside protects mice against CCl4-induced acute liver injury via down-regulating CYP2E1 expression and inhibiting NLRP3 inflammasome activation. Int Immunopharmacol 85:8. https://doi.org/10.1016/j.intimp.2020.106662

Article  CAS  Google Scholar 

Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, Deretic V, Dikic I, Elazar Z, Eskelinen EL, Fimia GM, Gewirtz DA, Green DR, Hansen M, Jäättelä M, Johansen T, Juhász G, Karantza V, Kraft C, Kroemer G, Ktistakis NT, Kumar S, Lopez-Otin C, Macleod KF, Madeo F, Martinez J, Meléndez A, Mizushima N, Münz C, Penninger JM, Perera RM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Sadoshima J, Santambrogio L, Scorrano L, Simon HU, Simon AK, Simonsen A, Stolz A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan JY, Yue ZY, Zhong Q, Galluzzi L, Pietrocola F (2021) Autophagy in major human diseases. Embo J 40:64. https://doi.org/10.15252/embj.2021108863

Article  CAS  Google Scholar 

Fu XL, Chen S, Xian ST, Wu Q, Shi JS, Zhou SY (2023) Dendrobium and its active ingredients: emerging role in liver protection. Biomed Pharmacother 157:13. https://doi.org/10.1016/j.biopha.2022.114043

Article  CAS  Google Scholar 

Wang K (2015) Autophagy and apoptosis in liver injury. Cell Cycle 14:1631–1642. https://doi.org/10.1080/15384101.2015.1038685

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chao X, Wang H, Jaeschke H, Ding WX (2018) Role and mechanisms of autophagy in acetaminophen-induced liver injury. Liver Int 38:1363–1374. https://doi.org/10.1111/liv.13866

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou J, Zhang Y, Li S, Zhou Q, Lu Y, Shi J, Liu J, Wu Q, Zhou S (2020) Dendrobium nobile Lindl. alkaloids-mediated protection against CCl4-induced liver mitochondrial oxidative damage is dependent on the activation of Nrf2 signaling pathway. Biomed Pharmacother 129:110351. https://doi.org/10.1016/j.biopha.2020.110351

Article  CAS  PubMed  Google Scholar 

Tai H, Wang Z, Gong H, Han X, Zhou J, Wang X, Wei X, Ding Y, Huang N, Qin J, Zhang J, Wang S, Gao F, Chrzanowska-Lightowlers ZM, Xiang R, Xiao H (2017) Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence. Autophagy 13:99–113. https://doi.org/10.1080/15548627.2016.1247143

Article  CAS  PubMed  Google Scholar 

Zhao T, Zheng TH, Yu HN, Hu BH, Hu B, Ma P, Yang Y, Yang ND, Hu J, Cao TT, Chen G, Yan B, Peshoff M, Hatzoglou M, Geng RS, Li B, Zheng QY (2021) Autophagy impairment as a key feature for acetaminophen-induced ototoxicity. Cell Death Dis 12:19. https://doi.org/10.1038/s41419-020-03328-6

Article  CAS  Google Scholar 

Ma XW, McKeen T, Zhang JH, Ding WX (2020) Role and mechanisms of mitophagy in liver diseases. Cells 9:30. https://doi.org/10.3390/cells9040837

Article  CAS  Google Scholar 

Al-Bari AA, Ito Y, Thomes PG, Menon MB, García-Macia M, Fadel R, Stadlin A, Peake N, Faris ME, Eid N, Klionsky DJ (2023) Emerging mechanistic insights of selective autophagy in hepatic diseases. Front Pharmacol 14:17. https://doi.org/10.3389/fphar.2023.1149809

Article  CAS  Google Scholar 

Lou J, Wang X, Zhang H, Yu G, Ding J, Zhu X, Li Y, Wu Y, Xu H, Xu H, Gao W, Xiao J, Zhou K (2022) Inhibition of PLA2G4E/cPLA2 promotes survival of random skin flaps by alleviating Lysosomal membrane permeabilization-Induced necroptosis. Autophagy 18:1841–1863. https://doi.org/10.1080/15548627.2021.2002109

Article  CAS  PubMed  Google Scholar 

Yan XF, Zhao P, Ma DY, Jiang YL, Luo JJ, Liu L, Wang XL (2017) Salvianolic acid B protects hepatocytes from H2O2 injury by stabilizing the lysosomal membrane. World J Gastroenterol 23:5333–5344. https://doi.org/10.3748/wjg.v23.i29.5333

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang FJ, Gomez-Sintes R, Boya P (2018) Lysosomal membrane permeabilization and cell death. Traffic 19:918–931. https://doi.org/10.1111/tra.12613

Article  CAS  PubMed  Google Scholar 

Yan X-F, Zhao P, Ma D-Y, Jiang Y-L, Luo J-J, Liu L, Wang X-L (2017) Salvianolic acid B protects hepatocytes from H2O2 injury by stabilizing the lysosomal membrane. World J Gastroenterol 23:5333–5344. https://doi.org/10.3748/wjg.v23.i29.5333

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo J, Yin J, Liu P, Zhang X, Wei J, Wang M, Xiao Y, Zhen Y, Lin Y, Li J (2023) Glycyrrhizin arginine salt protects against cisplation-induced acute liver injury by repressing BECN1-mediated ferroptosis. Front Pharmacol. https://doi.org/10.3389/fphar.2023.1219486

Article  PubMed  PubMed Central  Google Scholar 

Park NY, Jo DS, Kim YH, Bae JE, Kim JB, Park HJ, Choi JY, Lee H, Chang JH, Bunch H, Jeon HB, Jung YK, Cho DH (2021) Triamterene induces autophagic degradation of lysosome by exacerbating lysosomal integrity. Arch Pharm Res 44:621–631. https://doi.org/10.1007/s12272-021-01335-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wong YC, Kim S, Peng W, Krainc D (2019) Regulation and function of mitochondria-lysosome membrane contact sites in cellular homeostasis. Trends Cell Biol 29:500–513. https://doi.org/10.1016/j.tcb.2019.02.004

Article  CAS  PubMed  PubMed Central  Google Scholar 

Newman DJ, Cragg GM (2020) Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. J Nat Prod 83:770–803. https://doi.org/10.1021/acs.jnatprod.9b01285

Article  CAS  PubMed  Google Scholar 

Atanasov AG, Zotchev SB, Dirsch VM, Supuran CT (2021) Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov 20:200–216. https://doi.org/10.1038/s41573-020-00114-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nie X, Chen Y, Li W, Lu Y (2020) Anti-aging properties of Dendrobium nobile Lindl.: from molecular mechanisms to potential treatments. J Ethnopharmacol 257:112839. https://doi.org/10.1016/j.jep.2020.112839

Article  CAS  PubMed  Google Scholar 

Huang S, Wu Q, Liu H, Ling H, He Y, Wang C, Wang Z, Lu Y, Lu Y (2019) Alkaloids of Dendrobium nobile lindl. Altered hepatic lipid homeostasis via regulation of bile acids. J Ethnopharmacol 241:111976. https://doi.org/10.1016/j.jep.2019.111976

Article  CAS  PubMed  Google Scholar 

Huang XY, Yang S, Sun J, Li X, Zhou SY, Shi JS, Liu J, Wu Q (2022) Transcriptome analysis of protection by Dendrobium nobile alkaloids (DNLA) against chronic alcoholic liver injury in mice. Biomedicines 10:16. https://doi.org/10.3390/biomedicines10112800

Article  CAS  Google Scholar 

Li LS, Lu YL, Nie J, Xu YY, Zhang W, Yang WJ, Gong QH, Lu YF, Lu Y, Shi JS (2017) Dendrobium nobile Lindl. alkaloid, a novel autophagy inducer, protects against axonal degeneration induced by Aβ25-35 in hippocampus neurons in vitro. CNS Neurosci Ther 23:329–340. https://doi.org/10.1111/cns.12678

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li SY, Zhou JX, Xu SF, Li J, Liu J, Lu YF, Shi JS, Zhou SY, Wu Q (2019) Induction of Nrf2 pathway by Dendrobium nobile Lindl. alkaloids protects against carbon tetrachloride induced acute liver injury. Biomed Pharmacother 117:8. https://doi.org/10.1016/j.biopha.2019.109073

Article  CAS  Google Scholar 

Xian ST, Yang YG, Nan N, Fu XL, Shi JS, Wu Q, Zhou SY (2024) Inhibition of mitochondrial ROS-mediated necroptosis by Dendrobium nobile Lindl. alkaloids in carbon tetrachloride induced acute liver injury. J Ethnopharmacol 330:118253. https://doi.org/10.1016/j.jep.2024.118253

Article  CAS  PubMed  Google Scholar 

Yan XF, Ye TJ, Hu XD, Zhao P, Wang XL (2016) 58-F, a flavanone from Ophiopogon ja

Comments (0)

No login
gif