Efficacy of Bone Regeneration Cell Therapy Using Mesenchymal Stem Cells Originating from Embryonic Stem Cells in Animal Models; Bone Defects and Osteomyelitis

Dimitriou R, Jones E, McGonagle D, Giannoudis PV. Bone regeneration: current concepts and future directions. BMC Med. 2011;9:66.

Article  PubMed  PubMed Central  Google Scholar 

Roberts TT, Rosenbaum AJ. Bone grafts, bone substitutes and orthobiologics: the bridge between basic science and clinical advancements in fracture healing. Organogenesis. 2012;8:114–24.

Article  PubMed  PubMed Central  Google Scholar 

Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143–7.

Article  CAS  PubMed  Google Scholar 

Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem. 2006;98:1076–84.

Article  CAS  PubMed  Google Scholar 

Langer R, Vacanti JP. Tissue engineering. Science. 1993;260:920–6.

Article  CAS  PubMed  Google Scholar 

Chimutengwende-Gordon M, Khan WS. Advances in the use of stem cells and tissue engineering applications in bone repair. Curr Stem Cell Res Ther. 2012;7:122–6.

Article  CAS  PubMed  Google Scholar 

Quarto R, Giannoni P, Bonnaure G. Genetic engineering of mesenchymal progenitor cells in regenerative medicine. J Cell Mol Med. 2001;5:37–45.

Google Scholar 

Gamradt SC, Lieberman JR. Genetic modification of stem cells to enhance bone repair. Ann Biomed Eng. 2004;32:136–47.

Article  PubMed  Google Scholar 

O’Brien FJ. Biomaterials & scaffolds for tissue engineering. Mater Today. 2011;14:88–95.

Article  CAS  Google Scholar 

Bielby R, Jones E, McGonagle D. The role of mesenchymal stem cells in maintenance and repair of bone. Injury. 2007;38.

McLeod CM, Mauck RL. On the origin and impact of mesenchymal stem cell heterogeneity: new insights and emerging tools for single cell analysis. Eur Cells Mater. 2017;34:217–31.

Article  CAS  Google Scholar 

Bose S, Roy M, Bandyopadhyay A. Recent advances in bone tissue engineering scaffolds. Trends Biotechnol. 2012;30:546–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Granero-Moltó F, Weis JA, Miga MI, Landis B, Myers TJ, O’Rear L, et al. Regenerative effects of transplanted mesenchymal stem cells in fracture healing. Stem Cells. 2009;27:1887–98.

Article  PubMed  Google Scholar 

Neofytou EA, O’Brien CG, Couture LA, Wu JC. Hurdles to clinical translation of human induced pluripotent stem cells. J Clin Invest. 2015;125:2551–7.

Article  PubMed  PubMed Central  Google Scholar 

Wang C, Min S, Tian Y. Injectable and cell-laden hydrogel in the contained bone defect animal model: a systematic review. Tissue Eng Regen Med. 2023;20:829–37.

Article  PubMed  PubMed Central  Google Scholar 

Arai Y, Lee SH. MMP13-overexpressing mesenchymal stem cells enhance bone tissue formation in the presence of collagen hydrogel. Tissue Eng Regen Med. 2023;20:461–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang ZY, Teoh SH, Chong MSK. Superior osteogenic capacity for bone tissue engineering of fetal compared with perinatal and adult mesenchymal stem cells. Stem Cells. 2010;28:625–33.

Google Scholar 

Caplan AI. Why are MSCs therapeutic? New data: new insight J Pathol. 2009;217:318–24.

CAS  PubMed  Google Scholar 

Horwitz EM, Dominici M. How do mesenchymal stromal cells exert their therapeutic benefit? Cytotherapy. 2008;10:771–4.

Article  CAS  PubMed  Google Scholar 

Wang L, Stegemann JP. Thermogelling chitosan and fibrin glue hybrid scaffold for mesenchymal stem cell growth and delivery. J Biomed Mater Res A. 2010;93:761–8.

Google Scholar 

Yang Y, Zhang W, Li Y, Fang G, Zhang K. Scalded skin of rat treated by using fibrin glue combined with allogeneic bone marrow mesenchymal stem cells. Ann Dermatol. 2014;11:77–82.

CAS  Google Scholar 

Karyana M, Djaharuddin I, Rif’ati L, Arif M, Choi MK, Angginy N, et al. Safety of DW-MSC infusion in patients with low clinical risk COVID-19 infection: a randomized, double blind, placebo-controlled trial. Stem Cell Res Ther. 2022;13:134.

Park JH, Seo YJ, Oh HS, Byun JH. Effects of myeloid immune cells on the metabolic process of biomimetic bone regeneration. Life Sci. 2023;334:122251.

Article  CAS  PubMed  Google Scholar 

Park JH, Park BW, Kang YH, Byun SH, Hwang SC, Kim DR, et al. Lin28a enhances in vitro osteoblastic differentiation of human periosteum-derived cells. Cell Biochem Funct. 2017;35:497–509.

Article  CAS  PubMed  Google Scholar 

Kim HY, Park JH, Kim MJ, Lee JH, Oh SH, Byun JH. The effects of VEGF-centered biomimetic delivery of growth factors on bone regeneration. Biomater Sci. 2021;9:3675–91.

Article  CAS  PubMed  Google Scholar 

Patterson AL, Galloway RH, Baumgartner JC, Barsoum IS. Development of chronic mandibular osteomyelitis in a mini swine model. J Oral Maxillofac Surg. 1993;51:1358–62.

Article  CAS  PubMed  Google Scholar 

Chen FM, Wu LA. Concise review: clinical trials using mesenchymal stem cells to treat bone diseases and repair bone defects. Stem Cells Transl Med. 2011;1:351–7.

Google Scholar 

Wang Y, Chen X, Cao W, Shi Y. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nat Immunol. 2014;15:1009–16.

Article  CAS  PubMed  Google Scholar 

Dorozhkin SV. Bioceramics of calcium orthophosphates. Biomaterials. 2010;31:1465–85.

Article  CAS  PubMed  Google Scholar 

LeGeros RZ. Calcium phosphate-based osteoinductive materials. Chem Rev. 2008;108:4742–53.

Article  PubMed  Google Scholar 

Bohner M, Miron RJ. A proposed mechanism for material-induced heterotopic ossification. Mater. 2019;12:502.

Google Scholar 

Hing KA. Bone repair in the twenty-first century: biology, chemistry or engineering? Philos Trans R Soc Lond B Biol Sci. 2004;362:2821–50.

Article  CAS  Google Scholar 

Caplan AI. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol. 2007;213:341–7.

Article  CAS  PubMed  Google Scholar 

Parekkadan B, Milwid JM. Mesenchymal stem cells as therapeutics. Annu Rev Biomed Eng. 2010;12:87–117.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barrilleaux B, Phinney DG, Prockop DJ, O’Connor KC. Review: ex vivo engineering of living tissues with adult stem cells. Tissue Eng. 2006;12:3007–19.

Article  CAS  PubMed  Google Scholar 

Zhang R, Liu Y, Yan K, Chen L, Chen XR, Sun HY. Mesenchymal stem cells combined with platelet-rich plasma accelerate bone healing in a critical-sized segmental bone defect. Stem Cell Res Ther. 2020;11:1–11.

Google Scholar 

Chen Y, Shao JZ, Xiang LX, Dong XJ. Bone marrow-derived mesenchymal stem cells undergo multidirectional differentiation when treated with the conditioned medium of osteoblasts. Stem Cells. 2010;28:651–8.

CAS  Google Scholar 

Lew DP, Waldvogel FA. Osteomyelitis. Lancet. 2004;364:369–79.

Article  CAS  PubMed  Google Scholar 

Hadaya D, Seok JH, Lee SY. Pathological fractures of the mandible: a review of the literature and a unique case of segmental mandibulectomy with subsequent reconstruction using iliac crest bone graft. J Oral Maxillofac Surg. 2019;77:392–402.

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