Metabolic dysregulation in myelodysplastic neoplasm: impact on pathogenesis and potential therapeutic targets

Khoury, J.D., et al., 2022 The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours Myeloid and Histiocytic Dendritic Neoplasms. Leukemia, 36(7): 1703–1719.

De Witte T, et al. Novel dynamic outcome indicators and clinical endpoints in myelodysplastic syndrome; the European LeukemiaNet MDS registry and MDS-RIGHT project perspective. Haematologica. 2020;105(11):2516–23.

Article  PubMed  PubMed Central  Google Scholar 

Hosono N. Genetic abnormalities and pathophysiology of MDS. Int J Clin Oncol. 2019;24(8):885–92.

Article  PubMed  CAS  Google Scholar 

Hellstrom-Lindberg E, Tobiasson M, Greenberg P. Myelodysplastic syndromes: moving towards personalized management. Haematologica. 2020;105(7):1765–79.

Article  PubMed  PubMed Central  Google Scholar 

Scalzulli E, et al. Therapeutic strategies in low and high-risk MDS: What does the future have to offer? Blood Rev. 2021;45:100689.

Article  PubMed  CAS  Google Scholar 

Bononi G, et al. Historical perspective of tumor glycolysis: a century with Otto Warburg. Semin Cancer Biol. 2022;86:325–33.

Article  PubMed  CAS  Google Scholar 

Berthon C, et al. Metabolites of tryptophan catabolism are elevated in sera of patients with myelodysplastic syndromes and inhibit hematopoietic progenitor amplification. Leuk Res. 2013;37(5):573–9.

Article  PubMed  CAS  Google Scholar 

Zhu L, Zhu X, Wu Y. Effects of glucose metabolism, lipid metabolism, and glutamine metabolism on tumor microenvironment and clinical implications. Biomolecules. 2022. https://doi.org/10.3390/biom12040580.

Article  PubMed  PubMed Central  Google Scholar 

Nakamura-Ishizu A, Ito K, Suda T. Hematopoietic stem cell metabolism during development and aging. Dev Cell. 2020;54(2):239–55.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Olson OC, Kang YA, Passegue E. Normal hematopoiesis is a balancing act of self-renewal and regeneration. Cold Spring Harb Perspect Med. 2020;10(12):a035519.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Suda T, Takubo K, Semenza GL. Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell. 2011;9(4):298–310.

Article  PubMed  CAS  Google Scholar 

Takubo K, et al. Regulation of the HIF-1α level Is essential for hematopoietic stem cells. Cell Stem Cell. 2010;7(3):391–402.

Article  PubMed  CAS  Google Scholar 

Takubo K, et al. Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell. 2013;12(1):49–61.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Stacpoole PW, McCall CE. The pyruvate dehydrogenase complex: life’s essential, vulnerable and druggable energy homeostat. Mitochondrion. 2023;70:59–102.

Article  PubMed  CAS  Google Scholar 

Stevens BM, et al. Unique metabolic vulnerabilities of myelodysplastic syndrome stem cells. Blood. 2021;138(Supplement 1):1511–1511.

Article  Google Scholar 

Jones CL, Inguva A, Jordan CT. Targeting energy metabolism in cancer stem cells: progress and challenges in leukemia and solid tumors. Cell Stem Cell. 2021;28(3):378–93.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jones CL, et al. 2018 inhibition of amino acid metabolism selectively targets human leukemia stem cells. Cancer Cell. 2018;34(5):724–40.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen YF, et al. The roles of reactive oxygen species (ROS) and autophagy in the survival and death of leukemia cells. Crit Rev Oncol Hematol. 2017;112:21–30.

Article  PubMed  Google Scholar 

Poulaki A, et al. Bioenergetic profiling of the differentiating human MDS myeloid lineage with low and high bone marrow blast counts. Cancers (Basel). 2020;12(12):3520.

Article  PubMed  CAS  Google Scholar 

Pronk E, Raaijmakers MHGP. The mesenchymal niche in MDS. Blood. 2019;133(10):1031–8.

Article  PubMed  CAS  Google Scholar 

Liu J, et al. Mesenchymal stem cells and their microenvironment. Stem Cell Res Ther. 2022;13(1):429.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Goulard M, Dosquet C, Bonnet D. Role of the microenvironment in myeloid malignancies. Cell Mol Life Sci. 2018;75(8):1377–91.

Article  PubMed  CAS  Google Scholar 

Zhou S, et al. Determinants of stem cell lineage differentiation toward chondrogenesis versus adipogenesis. Cell Mol Life Sci. 2019;76(9):1653–80.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Grayson WL, et al. Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells. Biochem Biophys Res Commun. 2007;358(3):948–53.

Article  PubMed  CAS  Google Scholar 

Liberti MV, Locasale JW. The warburg effect: how does it benefit cancer cells? Trends Biochem Sci. 2016;41(3):211–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pattappa G, et al. The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol. 2011;226(10):2562–70.

Article  PubMed  CAS  Google Scholar 

Li Q, et al. The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells. Protein Cell. 2017;8(6):439–45.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Heywood HK, Lee DA. Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes. Biochem Biophys Res Commun. 2008;373(2):224–9.

Article  PubMed  CAS  Google Scholar 

Baker N, Boyette LB, Tuan RS. Characterization of bone marrow-derived mesenchymal stem cells in aging. Bone. 2015;70:37–47.

Article  PubMed  CAS  Google Scholar 

Tabe Y, Lorenzi PL, Konopleva M. Amino acid metabolism in hematologic malignancies and the era of targeted therapy. Blood. 2019;134(13):1014–23.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gong T, et al. Glutamine metabolism in cancers: targeting the oxidative homeostasis. Front Oncol. 2022;12: 994672.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Matre P, et al. Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes. Oncotarget. 2016;7(48):79722–35.

Article  PubMed 

Comments (0)

No login
gif