Department of Hepatology, Osaka Metropolitan University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan

Masaru Enomoto, Naoshi Odagiri, Koji Rinka & Norifumi Kawada

Department of Gastroenterology, Osaka Metropolitan University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan

Hirotsugu Maruyama, Yoshinori Shimamoto, Yuki Ishikawa-Kakiya & Yasuhiro Fujiwara

Molecular Oncology and Therapeutics, Osaka Metropolitan University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan

Masakazu Yashiro

ME wrote the manuscript with the support from MY. The original idea was conceived by ME. All authors contributed to the article and approved the submitted version.