Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.
Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, et al. The Eighth Edition AJCC Cancer Staging Manual: continuing to build a bridge from a population-based to a more “personalized” approach to cancer staging. CA Cancer J Clin. 2017;67(2):93–9.
De B, Rhome R, Jairam V, Özbek U, Holcombe RF, Buckstein M, et al. Gastric adenocarcinoma in young adult patients: patterns of care and survival in the United States. Gastric Cancer Off J Int Gastric Cancer Assoc Jpn Gastric Cancer Assoc. 2018;21(6):889–99.
Merchant SJ, Kim J, Choi AH, Sun V, Chao J, Nelson R. A rising trend in the incidence of advanced gastric cancer in young Hispanic men. Gastric Cance. 2017;20(2):226–34.
Li J. Gastric cancer in young adults: a different clinical entity from carcinogenesis to prognosis. Gastroenterol Res Pract. 2020;2020:9512707.
Article PubMed PubMed Central Google Scholar
Isobe T, Hashimoto K, Kikazi J, Miyagi M, Aoyagi K, Koufugy K, et al. Characteristics and prognosis of gastric cancer in young patients. Oncol Rep. 2013;30(1):43–9.
Article PubMed PubMed Central Google Scholar
An J, Ma X, Zhang C, Zhou W, Wang C, Miao W, et al. Comparison of incidence and prognosis between young and old gastric cancer patient in North-Western China: a retrospective cohort study. Medicine (Baltimore). 2022;101(42): e31255.
Article CAS PubMed Google Scholar
Anderson WF, Camargo MC, Fraumeni JF, Correa P, Rosenberg PS, Rabkin CS. Age-specific trends in incidence of noncardia gastric cancer in US adults. JAMA. 2010;303(17):1723–8.
Article CAS PubMed PubMed Central Google Scholar
Kist M, Thomaschewski M, Keck Y, Abdalla TSA, Zeissig SR, Kleihues-van Tol K, et al. Specifics of young gastric cancer patients: a population-based analysis of 46,110 patients with gastric cancer from the German Clinical Cancer Registry Group. Cancers. 2022;14(23):5927.
Article PubMed PubMed Central Google Scholar
Nakayama I, Chin K, Takahari D, Ogura M, Ichimura T, Wakatsuki T, et al. Treatment features of systemic chemotherapy in young adults with unresectable advanced or recurrent gastric cancer. Cancer Manag Res. 2018;10:5283–90.
Article CAS PubMed PubMed Central Google Scholar
Yamamoto R, Honda M, Kawamura H, Kobayashi H, Takiguchi K, Muto A, et al. Clinical features and survival of young adults with stage IV gastric cancer: a japanese population-based study. J Gastrointest Cancer. 2023;54(1):56–61.
Zhou L, Jiang Z, Gu W, Han S. STROBE-clinical characteristics and prognosis factors of gastric cancer in young patients aged ≤30 years. Medicine (Baltimore). 2021;100(26): e26336.
Article CAS PubMed Google Scholar
Cheng L, Chen S, Wu W, Kuo ZC, Wei Z, Meng S, et al. Gastric cancer in young patients: a separate entity with aggressive features and poor prognosis. J Cancer Res Clin Oncol. 2020;146(11):2937–47.
Article CAS PubMed Google Scholar
Nakamura R, Saikawa Y, Takahashi T, Takeuchi H, Asanuma H, Yamada Y, et al. Retrospective analysis of prognostic outcome of gastric cancer in young patients. Int J Clin Oncol. 2011;16(4):328–34.
Qu X, Zhao X, Liu Y, Wang N, Zhang L, Zhu X, et al. The clinicopathological characteristics of early-onset gastric cancer and its evolutionary trends: a retrospective study. Am J Cancer Res. 2022;12(6):2757–69.
CAS PubMed PubMed Central Google Scholar
Takatsu Y, Hiki N, Nunobe S, Ohashi M, Honda M, Yamaguchi T, et al. Clinicopathological features of gastric cancer in young patients. Gastric Cancer. 2016;19(2):472–8.
Article CAS PubMed Google Scholar
Zhou F, Shi J, Fang C, Zou X, Huang Q. Gastric carcinomas in young (younger than 40 years) chinese patients. Medicine (Baltimore). 2016;95(9): e2873.
Puhr HC, Karner A, Taghizadeh H, Jomrich G, Schoppmann SF, Preusser M, et al. Clinical characteristics and comparison of the outcome in young versus older patients with upper gastrointestinal carcinoma. J Cancer Res Clin Oncol. 2020;146(12):3313–22.
Article CAS PubMed PubMed Central Google Scholar
Liu S, Feng F, Xu G, Liu Z, Tian Y, Guo M, et al. Clinicopathological features and prognosis of gastric cancer in young patients. BMC Cancer. 2016;16:478.
Article PubMed PubMed Central Google Scholar
Guan WL, Yuan LP, Yan XL, Yang DJ, Qiu MZ. More attention should be paid to adult gastric cancer patients younger than 35 years old: extremely poor prognosis was found. J Cancer. 2019;10(2):472–8.
Article PubMed PubMed Central Google Scholar
Tekesin K, Emin Gunes M, Tural D, Akar E, Zirtiloglu A, Karaca M, et al. Clinicopathological characteristics, prognosis and survival outcome of gastric cancer in young patients: a large cohort retrospective study. J BUON Off J Balk Union Oncol. 2019;24(2):672–8.
Zhong N, Yu Y, Chen J, Shao Y, Peng Z, Li J. Clinicopathological characteristics, survival outcome and prognostic factors of very young gastric cancer. Clin Exp Med. 2023;23(2):437–45.
Ramos MFKP, Pereira MA, Sagae VMT, Mester M, Morrell ALG, Dias AR, et al. Gastric cancer in young adults: a worse prognosis group? Rev Col Bras Cir. 2019;46(4): e20192256.
Braga-Neto MB, Carneiro JG, de Castro Barbosa AM, Silva IS, Maia DC, Maciel FS, et al. Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil. BMC Cancer. 2018;18(1):131.
Article PubMed PubMed Central Google Scholar
Tavares A, Gandra A, Viveiros F, Cidade C, Maciel J. Analysis of clinicopathologic characteristics and prognosis of gastric cancer in young and older patients. Pathol Oncol Res POR. 2013;19(1):111–7.
Sandeep B, Huang X, Li Y, Mao L, Gao K, Xiao Z. Gastric carcinoma in young patients and its clinicopathological characteristics and prognosis. Gastroenterol Res Pract. 2020;2020:7378215.
Article PubMed PubMed Central Google Scholar
Niu P, Zhao L, Ling R, Zhao D, Chen Y. Clinicopathological characteristics and survival outcomes of younger patients with gastric cancer: a systematic review and meta-analysis. Transl Cancer Res. 2020;9(10):6026–38.
Article PubMed PubMed Central Google Scholar
Lee JG, Kim SA, Eun CS, Han DS, Kim YS, Choi BY, et al. Impact of age on stage-specific mortality in patients with gastric cancer: a long-term prospective cohort study. PLoS ONE. 2019;14(8): e0220660.
Article CAS PubMed PubMed Central Google Scholar
Cheng YX, Tao W, Liu XY, Yuan C, Zhang B, Zhang W, et al. The outcome of young vs. old gastric cancer patients following gastrectomy: a propensity score matching analysis. BMC Surg. 2021;21(1):399.
Jiang Y, Xie J, Huang W, Chen H, Xi S, Li T, et al. Chemotherapy use and survival among young and middle-aged patients with gastric cancer. Clin Transl Gastroenterol. 2020;11(10): e00253.
Article PubMed PubMed Central Google Scholar
Zhao B, Mei D, Lv W, Lu H, Bao S, Lin J, et al. Clinicopathologic features, survival outcome, and prognostic factors in gastric cancer patients 18–40 years of age. J Adolesc Young Adult Oncol. 2020;9(4):514–21.
Rona KA, Schwameis K, Zehetner J, Samakar K, Green K, Samaan J, et al. Gastric cancer in the young: an advanced disease with poor prognostic features. J Surg Oncol. 2017;115(4):371–5.
Qiu MZ, Wang ZQ, Zhang DS, Luo HY, Zhou ZW, Wang FH, et al. Clinicopathological characteristics and prognostic analysis of gastric cancer in the young adult in China. Tumour Biol. 2011;32(3):509–14.
Kong X, Wang JL, Chen HM, Fang JY. Comparison of the clinicopathological characteristics of young and elderly patients with gastric carcinoma: a meta analysis. J Surg Oncol. 2012;106(3):346–52.
Lumish MA, Walch H, Maron SB, Chatila W, Kemel Y, Maio A, et al. Clinical and molecular characteristics of early-onset versus average-onset esophagogastric cancer. J Natl Cancer Inst. 2023. https://doi.org/10.1093/jnci/djad186
Liu W, Quan H, Chen X, Ouyang Y, Xiao H. Clinicopathological features and prognosis of young gastric cancer patients following radical gastrectomy: a propensity score matching analysis. Sci Rep. 2019;9(1):5943.
Article PubMed PubMed Central Google Scholar
Song P, Wu L, Jiang B, Liu Z, Cao K, Guan W. Age-specific effects on the prognosis after surgery for gastric cancer: a SEER population-based analysis. Oncotarget. 2016;7(30):48614–24.
Article PubMed PubMed Central Google Scholar
Ter Veer E, Haj Mohammad N, van Valkenhoef G, Ngai LL, Mali RMA, Anderegg MC, et al. The efficacy and safety of first-line chemotherapy in advanced esophagogastric cancer: a network meta-analysis. J Natl Cancer Inst. 2016;108(10).
Lordick F, Carneiro F, Cascinu S, Fleitas T, Haustermans K, Piessen G, et al. Gastric cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up. Ann Oncol Off J Eur Soc Med Oncol. 2022;33(10):1005–20.
Janjigian YY, Shitara K, Moehler M, Garrido M, Salman P, Shen L, et al. First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial. Lancet. 2021;398(10294):27–40.
Article CAS PubMed PubMed Central Google Scholar
Sun JM, Shen L, Shah MA, Enzinger P, Adenis A, Doi T, et al. Pembrolizumab plus chemotherapy versus chemotherapy alone for first-line treatment of advanced oesophageal cancer (KEYNOTE-590): a randomised, placebo-controlled, phase 3 study. Lancet.
Comments (0)