Azusa Komori: None to disclose. Shuichi Hironaka: Honoraria for lectures: Bristol Myers Squibb, Ono. Shigenori Kadowaki: Grants or contracts from any entity: Ono Pharmaceutical, Taiho Pharmaceutical, MSD, Nobel Pharmaceutical, Janssen Pharmaceutical, Bayer, Eli Lilly, Chugai Pharmaceutical, Daiichi Sankyo, Abbvie, AstraZeneca; Honoraria for lectures: Ono Pharmaceutical, Taiho Pharmaceutical, MSD, Daiichi Sankyo, Merck KgaA, Bristol-Myers Squibb, Eli Lilly, Chugai Pharmaceutical, Bayer, Eisai, Novartis. Seiichiro Mitani: Honoraria for lectures: Taiho Pharmaceutical Co. Ltd, ONO Pharmaceutical Co. Ltd, MSD; Payment for expert testimony: Chugai Pharmaceutical Co. Ltd. Mitsuhiro Furuta: None to disclose. Takeshi Kawakami: Honoraria for lectures: Bristol-Myers Squibb Co. Ltd, Astellas Pharma, Eli Lilly Japan K.K, Yakult Honsha, Ono Pharmaceutical Co. Ltd, Daiichi Sankyo Co. Ltd. Akitaka Makiyama: Honoraria for lectures: Eli Lilly Japan, Bristol-Myers Squibb Japan, Ono Pharmaceutical, Daiichi Sankyo, Taiho Pharmaceutical. Naoki Takegawa: None to disclose. Keiji Sugiyama: None to disclose. Hidekazu Hirano: Grants to the institution: PPD, Daiichi-Sankyo, Nippon Boehringer Ingelheim, ALX Oncology, BeiGene, Novartis, Amgen, Bristol-Myers Squibb, Taiho Pharmaceutical; Honoraria for lectures: FUJIFILM Toyama Chemical, Taiho Pharmaceutical, TEIJIN PHARMA, Novartis, Chugai Pharmaceutical, Bristol-Myers Squibb, Ono Pharmaceutical. Takayuki Ando: Honoraria for lectures: Bristol-Myers Squibb Co. Ltd, Eli Lilly Japan K.K, Daiichi Sankyo Co. Ltd, MSD K.K, Taiho Pharmaceutical Co. Ltd, Astellas Pharma Inc. Tomohiro Matsushima: None to disclose. Akihiko Chida: None to disclose. Tomomi Kashiwada: Honoraria for lectures: Bristol-Myers Squibb Co. Ltd, Takeda Pharmaceutical Co. Ltd, Eli Lilly Japan K.K, Taiho Pharmaceutical Co. Ltd, Daiichi Sankyo Co. Ltd, Astellas Pharma Inc. Masato Komoda: Honoraria for lectures: Ono Pharmaceutical Co. Ltd, MSD K.K, Bristol-Myers Squibb Co. Ltd, Chugai Pharmaceutical Co. Ltd, Eli Lilly Japan K.K, Taiho Pharmaceutical Co. Ltd, Daiichi Sankyo Co. Ltd, Astellas Pharma Inc. Toshihiko Matsumoto: Honoraria for lectures: Sanofi Co, Ltd, Ono Pharmaceutical Co, Ltd, Bayer Co, Ltd, Bristol-Myers Squibb Co, Ltd, Chugai Pharmaceutical Co, Ltd, Daiichi Sankyo Co, Ltd, Merck Bio Pharma Co, Ltd, Eli Lilly Japan Co, Ltd, MSD Co, Ltd, Taiho Pharmaceutical Co, Ltd, Takeda Co, Ltd. Hisanobu Oda: Honoraria for lectures: Bristol Myers Squibb, Astellas Pharma. Hiroshi Yabusaki: None to disclose. Hisato Kawakami: Grants or contracts from any entity: Eisai Co. Ltd, Bristol-Myers Squibb Co. Ltd, Kobayashi Pharmaceutical. Co., Ltd; Royalties: MEDICAL & BIOLOGICAL LABORATORIES CO., LTD; Consulting fees: Daiichi-Sankyo Co. Ltd, Astellas Pharma Inc, Abbvie GK; Honoraria for lectures: Bristol-Myers Squibb Co. Ltd, Bayer Yakuhin Ltd, Eli Lilly Japan K.K, MSD K.K, Ono Pharmaceutical Co. Ltd, Chugai Pharmaceutical Co. Ltd, Daiichi Sankyo Co. Ltd, Merck Biopharma Co., Ltd, Takeda Pharmaceutical Co. Ltd, Yakult Pharmaceutical Industry, Teijin Pharma Ltd, Taiho Pharmaceutical Co. Ltd, Otsuka Pharmaceutical Co., Ltd, Nippon Kayaku Co. Ltd, GlaxoSmithKline K.K, Amgen, Novartis International AG. Kentaro Yamazaki: Honoraria for lectures: Chugai, Takeda, Yakult, Taiho, Daiichi Sankyo, Merk Biopharm, Lily, MSD, Bristol. Narikazu Boku: Honoraria for lectures: Bristol Myers Squibb, Ono Pharmaceutical, Daiichi Sankyo, Eli Lilly, Taiho Pharmaceutical. Ichinosuke Hyodo: Participation on a Data Safety Monitoring Board or Advisory Board: Taiho Pharmaceutical Co.Ltd, Chugai Pharmaceutical Co.Ltd, Ono Pharmaceutical Co.Ltd, Eisai Pharmaceutical Co.Ltd, Daiichi Sankyo Pharmaceutical Co.Ltd, Asahi-Kasei Pharmaceutical Co.Ltd. Kenichi Yoshimura: None to disclose. Kei Muro: Research funding to the institution: Amgen, ONO PHARMACEUTICAL, Astellas, Sanofi, Taiho, PRA Health Sciences, PAREXEL International, Novartis, Chugai, MSD; Consulting fees: Amgen, AstraZeneca, ONO PHARMACEUTICAL, Astellas, Chugai; Honoraria for lectures: ONO PHARMACEUTICAL, Taiho, Bristol-Myers Squibb, Eli Lilly, MSD, Takeda, Daiichi Sankyo; Advisory Board: Astellas, Amgen, AstraZeneca, Takeda.

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and the Helsinki Declaration of 1964 and later versions. Informed consent was obtained from all patients for inclusion in the study.