Japanese Gastric Cancer Association (2011) Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer. 14:101–12.
Arai T, Sakurai U, Sawabe M, Honma N, Aida J, Ushio Y, et al. Frequent microsatellite instability in papillary and solid–type, poorly differentiated adenocarcinomas of the stomach. Gastric Cancer. 2013;16:505–12.
Article CAS PubMed Google Scholar
Hirai H, Yoshizawa T, Morohashi S, Haga T, Wu YY, Ota R, et al. Clinicopathological significance of gastric poorly differentiated medullary carcinoma. Biomed Res-Tokyo. 2016;37:77–84.
Arai T, Matsuda Y, Aida J, Takubo K, Ishiwata T. Solid–type poorly differentiated adenocarcinoma of the stomach: clinicopathological and molecular cha. Gastric Cancer. 2019;22:314–22.
Article CAS PubMed Google Scholar
Tsuruta S, Kohashi K, Yamada Y, Fujiwara M, Koga Y, Ihara E, et al. Solid–type poorly differentiated adenocarcinoma of the stomach: deficiency of mismatch repair and SWI/SNF complex. Cancer Sci. 2020;111:1008–19.
Article CAS PubMed PubMed Central Google Scholar
Sasaki T, Kohashi K, Kawamoto S, Ihara E, Oki E, Nakamura M, et al. Tumor progression by epithelial–mesenchymal transition in ARID1A– and SMARCA4–aberrant solid–type poorly differentiated gastric adenocarcinoma. Virchows Arch. 2022;480:1063–75.
Article CAS PubMed Google Scholar
Kawatoko S, Kohashi K, Torisu T, Sasaki T, Umekita S, Oki E, et al. Solid–type poorly differentiated adenocarcinoma of the stomach: a characteristic morphology reveals a distinctive immunoregulatory tumor microenvironment. Pathol Res Pract. 2022;238:154124.
Article CAS PubMed Google Scholar
Umekita S, Kiyozawa D, Kohashi K, Kawatoko S, Sasaki T, Ihara E, et al. Clinicopathological significance of microsatellite instability and immune escape mechanism in patients with gastric solid–type poorly differentiated adenocarcinoma. Gastric Cancer. 2024;27:484–94.
Article CAS PubMed Google Scholar
Huang B, Lang X, Li X. The role of IL–6/JAK2/STAT3 signaling pathway in cancers. Front Oncol. 2022;16:1023177.
Zheng L, Chen J, Zhou Z, He Z. Knockdown of long non–coding RNA HOXD–AS1 inhibits gastric cancer cell growth via inactivating the JAK2/STAT3 pathway. Tumour Biol. 2017;39:1010428317705335.
Kanda N, Seno H, Konda Y, Marusawa H, Kanai M, Nakajima T, et al. STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. Oncogene. 2004;23:4921–9.
Article CAS PubMed Google Scholar
Judd LM, Menheniott TR, Ling H, Jackson CB, Howlett M, Kalantzis A, et al. Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo. PLoS One. 2014;9:e95993.
Article PubMed PubMed Central Google Scholar
Ayele TM, Muche ZT, Teklemariam AB, Kassie AB, Abebe EC. Role of JAK2/STAT3 signaling pathway in the tumorigenesis, chemotherapy resistance, and treatment of solid tumors: a systemic review. J Inflamm Res. 2022;15:1349–64.
Yakata Y, Nakayama T, Yoshizaki A, Kusaba T, Inoue K, Sekine I. Expression of p–STAT3 in human gastric carcinoma: significant correlation in tumour invasion and prognosis. Int J Oncol. 2007;30:437–42.
Kim DY, Cha ST, Ahn DH, Kang HY, Kwon CI, Ko KH, et al. STAT3 expression in gastric cancer indicates a poor prognosis. J Gastroenterol Hepatol. 2009;24:646–51.
Article CAS PubMed Google Scholar
Deng JY, Sun D, Liu XY, Pan Y, Liang H. STAT–3 correlates with lymph node metastasis and cell survival in gastric cancer. World J Gastroenterol. 2010;16:5380–7.
Article CAS PubMed PubMed Central Google Scholar
Wu LJ, Li HX, Luo XT, Lu RZ, Ma YF, Wang R, et al. STAT3 activation in tumor cell–free lymph nodes predicts a poor prognosis for gastric cancer. Int J Clin Exp Pathol. 2014;7:1140–6.
PubMed PubMed Central Google Scholar
Ullrich KAM, Schulze LL, Paap EM, Muller TM, Neurath MF, Zundler S. Immunology of IL–12: an update of functional activities and implications for disease. Exceli J. 2020;19:1563–89.
Yang C, Mai H, Peng J, Zhou B, Hou J, Jiang D. STAT4: an immunoregulator contributing to diverse human diseases. Int J Biol Sci. 2020;2020(16):1575–85.
Frucht DM, Aringer M, Galon J, Danning C, Brown M, Fan S, et al. STAT4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1–mediated inflammation. J Immunol. 2000;164:4659–64.
Article CAS PubMed Google Scholar
Zhou X, Xia Y, Su J, Zhang G. Down–regulation of miR–141 induced by helicobacter pylori promotes the invasion of gastric cancer by targeting STAT4. Cell Physiol Biochem. 2014;33:1003–12.
Article CAS PubMed Google Scholar
Xiong H, Du W, Wang JL, Wang YC, Tang JT, Hong J, et al. Constitutive activation of STAT3 is predictive of poor prognosis in human gastric cancer. J Mol Med (Berl). 2012;90:1037–46.
Article CAS PubMed Google Scholar
Wu X, Tao P, Zhou Q, Li J, Yu Z, Wang X. IL–6 secreted by cancer–associated fibroblasts promotes epithelial–mesenchymal transition and metastasis of gastric cancer via JAK2/STAT3 signaling pathway. Oncotarget. 2017;8:20741–50.
Article PubMed PubMed Central Google Scholar
Yang Y, Shi Z, Bai R, Hu W. Heterogeneity of MSI–H gastric cancer identifies a subtype with worse survival. J Med Genet. 2021;58:12–9.
Article CAS PubMed Google Scholar
Nishi M, Batsaikhan BE, Yoshikawa K, Higashijima J, Tokunaga T, Takasu C, et al. High STAT4 expression indicates better disease–free survival in patients with gastric cancer. Anticancer Res. 2017;37:6723–9.
Zhang Y, Yu C. Prognostic values of signal transducers activators of transcription in gastric cancer. Biosci Rep. 2019;39:BRS20181695.
Comments (0)