Investigating the role of inflammatory cytokines in mediating the effect of gut microbiota on gastrointestinal cancers: a mendelian randomization study

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229–63. https://doi.org/10.3322/caac.21834.

Article  PubMed  Google Scholar 

de Vos WM, Tilg H, Van Hul M, Cani PD. Gut microbiome and health: mechanistic insights. Gut. 2022;71(5):1020–32. https://doi.org/10.1136/gutjnl-2021-326789.

Article  CAS  PubMed  Google Scholar 

Yu X, Ou J, Wang L, Li Z, Ren Y, Xie L, et al. Gut microbiota modulate CD8+ T cell immunity in gastric cancer through Butyrate/GPR109A/HOPX. Gut Microbes. 2024;16(1):2307542. https://doi.org/10.1080/19490976.2024.2307542.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nabavi-Rad A, Yadegar A, Sadeghi A, Aghdaei HA, Zali MR, Klionsky DJ, et al. The interaction between autophagy, Helicobacter pylori, and gut microbiota in gastric carcinogenesis. Trends Microbiol. 2023;31(10):1024–43. https://doi.org/10.1016/j.tim.2023.04.001.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen C, Chen L, Lin L, Jin D, Du Y, Lyu J. Research progress on gut microbiota in patients with gastric cancer, esophageal cancer, and small intestine cancer. Appl Microbiol Biotechnol. 2021;105(11):4415–25. https://doi.org/10.1007/s00253-021-11358-z.

Article  CAS  PubMed  Google Scholar 

Wang M, Yang G, Tian Y, Zhang Q, Liu Z, Xin Y. The role of the gut microbiota in gastric cancer: the immunoregulation and immunotherapy. Front Immunol. 2023;14:1183331. https://doi.org/10.3389/fimmu.2023.1183331.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Zhang J, Ma H. Chronic inflammation and gallbladder cancer. Cancer Lett. 2014;345(2):242–8. https://doi.org/10.1016/j.canlet.2013.08.034.

Article  CAS  PubMed  Google Scholar 

Park JH, Ameri AH, Dempsey KE, Conrad DN, Kem M, Mino-Kenudson M, et al. Nuclear IL-33/SMAD signaling axis promotes cancer development in chronic inflammation. EMBO J. 2021;40(7):e106151. https://doi.org/10.15252/embj.2020106151.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schottenfeld D, Beebe-Dimmer J. Chronic inflammation: a common and important factor in the pathogenesis of neoplasia. CA Cancer J Clin. 2006;56(2):69–83.

Article  PubMed  Google Scholar 

Dranoff G. Cytokines in cancer pathogenesis and cancer therapy. Nat Rev Cancer. 2004;4(1):11–22.

Article  CAS  PubMed  Google Scholar 

Zitvogel L, Kepp O, Galluzzi L, Kroemer G. Inflammasomes in carcinogenesis and anticancer immune responses. Nat Immunol. 2012;13(4):343–51. https://doi.org/10.1038/ni.2224.

Article  CAS  PubMed  Google Scholar 

Karki R, Man SM, Kanneganti T-D. Inflammasomes and Cancer. Cancer Immunol Res. 2017;5(2):94–9. https://doi.org/10.1158/2326-6066.CIR-16-0269.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Greten FR, Grivennikov SI. Inflammation and Cancer: Triggers, Mechanisms, and Consequences. Immunity. 2019;51(1):27–41. https://doi.org/10.1016/j.immuni.2019.06.025.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cascinu S, Scartozzi M, Carbonari G, Pierantoni C, Verdecchia L, Mariani C, et al. COX-2 and NF-KB overexpression is common in pancreatic cancer but does not predict for COX-2 inhibitors activity in combination with gemcitabine and oxaliplatin. Am J Clin Oncol. 2007;30(5):526–30.

Article  CAS  PubMed  Google Scholar 

Guthrie GJK, Roxburgh CSD, Horgan PG, McMillan DC. Does interleukin-6 link explain the link between tumour necrosis, local and systemic inflammatory responses and outcome in patients with colorectal cancer? Cancer Treat Rev. 2013;39(1):89–96. https://doi.org/10.1016/j.ctrv.2012.07.003.

Article  CAS  PubMed  Google Scholar 

Sánchez-Zauco N, Torres J, Gómez A, Camorlinga-Ponce M, Muñoz-Pérez L, Herrera-Goepfert R, et al. Circulating blood levels of IL-6, IFN-γ, and IL-10 as potential diagnostic biomarkers in gastric cancer: a controlled study. BMC Cancer. 2017;17(1):384. https://doi.org/10.1186/s12885-017-3310-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rodriguez BAT, Bhan A, Beswick A, Elwood PC, Niiranen TJ, Salomaa V, et al. A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling. Am J Hum Genet. 2020;107(2):211–21. https://doi.org/10.1016/j.ajhg.2020.06.008.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Du M, Xin J, Zheng R, Yuan Q, Wang Z, Liu H, et al. CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility. Cancer Res. 2024;84(4):616–25. https://doi.org/10.1158/0008-5472.CAN-23-0900.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li C, Wei Q, Hou Y, Lin J, Ou R, Zhang L, et al. Genome-wide analyses identify NEAT1 as genetic modifier of age at onset of amyotrophic lateral sclerosis. Mol Neurodegener. 2023;18(1):77. https://doi.org/10.1186/s13024-023-00669-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duan Q-Q, Wang H, Su W-M, Gu X-J, Shen X-F, Jiang Z, et al. TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro. BMC Med. 2024;22(1):96. https://doi.org/10.1186/s12916-024-03314-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davies NM, Holmes MV, Davey Smith G. Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ. 2018;362: k601. https://doi.org/10.1136/bmj.k601.

Article  PubMed  PubMed Central  Google Scholar 

Lawlor DA, Harbord RM, Sterne JAC, Timpson N, Davey Smith G. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med. 2008;27(8):1133–63.

Article  PubMed  Google Scholar 

Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, et al. A cross-population atlas of genetic associations for 220 human phenotypes. Nat Genet. 2021;53(10):1415–24. https://doi.org/10.1038/s41588-021-00931-x.

Article  CAS  PubMed  Google Scholar 

Lopera-Maya EA, Kurilshikov A, van der Graaf A, Hu S, Andreu-Sánchez S, Chen L, et al. Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project. Nat Genet. 2022;54(2):143–51. https://doi.org/10.1038/s41588-021-00992-y.

Article  CAS  PubMed  Google Scholar 

Zhao JH, Stacey D, Eriksson N, Macdonald-Dunlop E, Hedman ÅK, Kalnapenkis A, et al. Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets. Nat Immunol. 2023;24(9):1540–51. https://doi.org/10.1038/s41590-023-01588-w.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sanderson E. Multivariable Mendelian Randomization and Mediation. Cold Spring Harb Perspect Med. 2021. https://doi.org/10.1101/cshperspect.a038984.

Article  PubMed  PubMed Central  Google Scholar 

Burgess S, Thompson SG. Interpreting findings from Mendelian randomization using the MR-Egger method. Eur J Epidemiol. 2017;32(5):377–89. https://doi.org/10.1007/s10654-017-0255-x.

Article 

Comments (0)

No login
gif