Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229–63. https://doi.org/10.3322/caac.21834.
de Vos WM, Tilg H, Van Hul M, Cani PD. Gut microbiome and health: mechanistic insights. Gut. 2022;71(5):1020–32. https://doi.org/10.1136/gutjnl-2021-326789.
Article CAS PubMed Google Scholar
Yu X, Ou J, Wang L, Li Z, Ren Y, Xie L, et al. Gut microbiota modulate CD8+ T cell immunity in gastric cancer through Butyrate/GPR109A/HOPX. Gut Microbes. 2024;16(1):2307542. https://doi.org/10.1080/19490976.2024.2307542.
Article CAS PubMed PubMed Central Google Scholar
Nabavi-Rad A, Yadegar A, Sadeghi A, Aghdaei HA, Zali MR, Klionsky DJ, et al. The interaction between autophagy, Helicobacter pylori, and gut microbiota in gastric carcinogenesis. Trends Microbiol. 2023;31(10):1024–43. https://doi.org/10.1016/j.tim.2023.04.001.
Article CAS PubMed PubMed Central Google Scholar
Chen C, Chen L, Lin L, Jin D, Du Y, Lyu J. Research progress on gut microbiota in patients with gastric cancer, esophageal cancer, and small intestine cancer. Appl Microbiol Biotechnol. 2021;105(11):4415–25. https://doi.org/10.1007/s00253-021-11358-z.
Article CAS PubMed Google Scholar
Wang M, Yang G, Tian Y, Zhang Q, Liu Z, Xin Y. The role of the gut microbiota in gastric cancer: the immunoregulation and immunotherapy. Front Immunol. 2023;14:1183331. https://doi.org/10.3389/fimmu.2023.1183331.
Article CAS PubMed PubMed Central Google Scholar
Li Y, Zhang J, Ma H. Chronic inflammation and gallbladder cancer. Cancer Lett. 2014;345(2):242–8. https://doi.org/10.1016/j.canlet.2013.08.034.
Article CAS PubMed Google Scholar
Park JH, Ameri AH, Dempsey KE, Conrad DN, Kem M, Mino-Kenudson M, et al. Nuclear IL-33/SMAD signaling axis promotes cancer development in chronic inflammation. EMBO J. 2021;40(7):e106151. https://doi.org/10.15252/embj.2020106151.
Article CAS PubMed PubMed Central Google Scholar
Schottenfeld D, Beebe-Dimmer J. Chronic inflammation: a common and important factor in the pathogenesis of neoplasia. CA Cancer J Clin. 2006;56(2):69–83.
Dranoff G. Cytokines in cancer pathogenesis and cancer therapy. Nat Rev Cancer. 2004;4(1):11–22.
Article CAS PubMed Google Scholar
Zitvogel L, Kepp O, Galluzzi L, Kroemer G. Inflammasomes in carcinogenesis and anticancer immune responses. Nat Immunol. 2012;13(4):343–51. https://doi.org/10.1038/ni.2224.
Article CAS PubMed Google Scholar
Karki R, Man SM, Kanneganti T-D. Inflammasomes and Cancer. Cancer Immunol Res. 2017;5(2):94–9. https://doi.org/10.1158/2326-6066.CIR-16-0269.
Article CAS PubMed PubMed Central Google Scholar
Greten FR, Grivennikov SI. Inflammation and Cancer: Triggers, Mechanisms, and Consequences. Immunity. 2019;51(1):27–41. https://doi.org/10.1016/j.immuni.2019.06.025.
Article CAS PubMed PubMed Central Google Scholar
Cascinu S, Scartozzi M, Carbonari G, Pierantoni C, Verdecchia L, Mariani C, et al. COX-2 and NF-KB overexpression is common in pancreatic cancer but does not predict for COX-2 inhibitors activity in combination with gemcitabine and oxaliplatin. Am J Clin Oncol. 2007;30(5):526–30.
Article CAS PubMed Google Scholar
Guthrie GJK, Roxburgh CSD, Horgan PG, McMillan DC. Does interleukin-6 link explain the link between tumour necrosis, local and systemic inflammatory responses and outcome in patients with colorectal cancer? Cancer Treat Rev. 2013;39(1):89–96. https://doi.org/10.1016/j.ctrv.2012.07.003.
Article CAS PubMed Google Scholar
Sánchez-Zauco N, Torres J, Gómez A, Camorlinga-Ponce M, Muñoz-Pérez L, Herrera-Goepfert R, et al. Circulating blood levels of IL-6, IFN-γ, and IL-10 as potential diagnostic biomarkers in gastric cancer: a controlled study. BMC Cancer. 2017;17(1):384. https://doi.org/10.1186/s12885-017-3310-9.
Article CAS PubMed PubMed Central Google Scholar
Rodriguez BAT, Bhan A, Beswick A, Elwood PC, Niiranen TJ, Salomaa V, et al. A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling. Am J Hum Genet. 2020;107(2):211–21. https://doi.org/10.1016/j.ajhg.2020.06.008.
Article CAS PubMed PubMed Central Google Scholar
Du M, Xin J, Zheng R, Yuan Q, Wang Z, Liu H, et al. CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility. Cancer Res. 2024;84(4):616–25. https://doi.org/10.1158/0008-5472.CAN-23-0900.
Article CAS PubMed PubMed Central Google Scholar
Li C, Wei Q, Hou Y, Lin J, Ou R, Zhang L, et al. Genome-wide analyses identify NEAT1 as genetic modifier of age at onset of amyotrophic lateral sclerosis. Mol Neurodegener. 2023;18(1):77. https://doi.org/10.1186/s13024-023-00669-6.
Article CAS PubMed PubMed Central Google Scholar
Duan Q-Q, Wang H, Su W-M, Gu X-J, Shen X-F, Jiang Z, et al. TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro. BMC Med. 2024;22(1):96. https://doi.org/10.1186/s12916-024-03314-1.
Article CAS PubMed PubMed Central Google Scholar
Davies NM, Holmes MV, Davey Smith G. Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ. 2018;362: k601. https://doi.org/10.1136/bmj.k601.
Article PubMed PubMed Central Google Scholar
Lawlor DA, Harbord RM, Sterne JAC, Timpson N, Davey Smith G. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med. 2008;27(8):1133–63.
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, et al. A cross-population atlas of genetic associations for 220 human phenotypes. Nat Genet. 2021;53(10):1415–24. https://doi.org/10.1038/s41588-021-00931-x.
Article CAS PubMed Google Scholar
Lopera-Maya EA, Kurilshikov A, van der Graaf A, Hu S, Andreu-Sánchez S, Chen L, et al. Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project. Nat Genet. 2022;54(2):143–51. https://doi.org/10.1038/s41588-021-00992-y.
Article CAS PubMed Google Scholar
Zhao JH, Stacey D, Eriksson N, Macdonald-Dunlop E, Hedman ÅK, Kalnapenkis A, et al. Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets. Nat Immunol. 2023;24(9):1540–51. https://doi.org/10.1038/s41590-023-01588-w.
Article CAS PubMed PubMed Central Google Scholar
Sanderson E. Multivariable Mendelian Randomization and Mediation. Cold Spring Harb Perspect Med. 2021. https://doi.org/10.1101/cshperspect.a038984.
Article PubMed PubMed Central Google Scholar
Burgess S, Thompson SG. Interpreting findings from Mendelian randomization using the MR-Egger method. Eur J Epidemiol. 2017;32(5):377–89. https://doi.org/10.1007/s10654-017-0255-x.
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