Lambert JM, Chari RV (2014) Ado-trastuzumab Emtansine (T-DM1): an antibody–drug conjugate (ADC) for HER2-positive breast cancer. ACS Publications
Pondé N, Aftimos P, Piccart M (2019) Antibody-drug conjugates in breast cancer: a comprehensive review. Curr Treat Options Oncol 20(5):37
Beck A, Goetsch L, Dumontet C, Corvaïa N (2017) Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov 16(5):315–337
Article CAS PubMed Google Scholar
Donaghy H (2016) Effects of antibody, drug and linker on the preclinical and clinical toxicities of antibody-drug conjugates. MAbs 8(4):659–671
Article CAS PubMed PubMed Central Google Scholar
Jain N, Smith SW, Ghone S, Tomczuk B (2015) Current ADC linker chemistry. Pharm Res 32(11):3526–3540
Article CAS PubMed PubMed Central Google Scholar
Chari RV (2008) Targeted cancer therapy: conferring specificity to cytotoxic drugs. Acc Chem Res 41(1):98–107
Article CAS PubMed Google Scholar
Perez HL, Cardarelli PM, Deshpande S, Gangwar S, Schroeder GM, Vite GD, Borzilleri RM (2014) Antibody–drug conjugates: current status and future directions. Drug Discovery Today 19(7):869–881
Article CAS PubMed Google Scholar
Sievers EL, Linenberger M (2001) Mylotarg: antibody-targeted chemotherapy comes of age. Curr Opin Oncol 13(6):522–527
Article CAS PubMed Google Scholar
Beck A, Haeuw J-F, Wurch T, Goetsch L, Bailly C, Corvaïa N (2010) The next generation of antibody-drug conjugates comes of age. Discov Med 10(53):329–339
Chen RW, Gopal AK, Smith SE, Ansell SM, Rosenblatt JD, Savage KJ, Connors JM, Engert A, Larsen EK, Kennedy DA et al (2011) Results from a pivotal phase II study of brentuximab vedotin (SGN-35) in patients with relapsed or refractory Hodgkin lymphoma (HL). J Clin Oncol 29(15):8031–8031
Hurvitz SA, Dirix L, Kocsis J, Bianchi GV, Lu J, Vinholes J, Guardino E, Song C, Tong B, Ng V (2013) Phase II randomized study of trastuzumab emtansine versus trastuzumab plus docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer. J Clin Oncol 31(9):1157–1163
Article CAS PubMed Google Scholar
Tsuchikama K, An Z (2018) Antibody-drug conjugates: recent advances in conjugation and linker chemistries. Protein Cell 9(1):33–46
Article CAS PubMed Google Scholar
Afzal F, Aiman W, Zahoor H, Bajwa AR, Kazmi SH, Anwar A, Anwar MY, Rashid S, Zubair H, Kashif T et al (2023) Efficacy and safety of antibody-drug conjugates in triple-negative and HER-2 positive breast cancer: a systematic review and meta-analysis of clinical trials. Breast Dis 42(1):121–136
Dumontet C, Reichert JM, Senter PD, Lambert JM, Beck A (2023) Antibody-drug conjugates come of age in oncology. Nat Rev Drug Discov 2:2
Hafeez U, Parakh S, Gan HK, Scott AM (2020) Antibody-drug conjugates for cancer therapy. Molecules 25:20
Senter PD, Sievers EL (2012) The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma. Nat Biotechnol 30(7):631–637
Article CAS PubMed Google Scholar
Krop IE, Beeram M, Modi S, Jones SF, Holden SN, Yu W, Girish S, Tibbitts J, Yi JH, Sliwkowski MX et al (2010) Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer. J Clin Oncol 28(16):2698–2704
Article CAS PubMed Google Scholar
Nicolo E, Zagami P, Curigliano G (2020) Antibody-drug conjugates in breast cancer: the chemotherapy of the future? Curr Opin Oncol 32(5):494–502
Article CAS PubMed Google Scholar
Wynne J, Wright D, Stock W (2019) Inotuzumab: from preclinical development to success in B-cell acute lymphoblastic leukemia. Blood Adv 3(1):96–104
Article CAS PubMed PubMed Central Google Scholar
Bross PF, Beitz J, Chen G, Chen XH, Duffy E, Kieffer L, Roy S, Sridhara R, Rahman A, Williams G et al (2001) Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia. Clin Cancer Res 7(6):1490–1496
Starodub AN, Ocean AJ, Shah MA, Guarino MJ, Picozzi VJ Jr, Vahdat LT, Thomas SS, Govindan SV, Maliakal PP, Wegener WA et al (2015) First-in-human trial of a novel anti-trop-2 antibody-SN-38 conjugate, sacituzumab govitecan, for the treatment of diverse metastatic solid tumors. Clin Cancer Res 21(17):3870–3878
Article CAS PubMed PubMed Central Google Scholar
Trudel S, Lendvai N, Popat R, Voorhees PM, Reeves B, Libby EN, Richardson PG, Hoos A, Gupta I, Bragulat V et al (2019) Antibody-drug conjugate, GSK2857916, in relapsed/refractory multiple myeloma: an update on safety and efficacy from dose expansion phase I study. Blood Cancer J 9(4):37
Article PubMed PubMed Central Google Scholar
Sanchez E, Li M, Kitto A, Li J, Wang CS, Kirk DT, Yellin O, Nichols CM, Dreyer MP, Ahles CP et al (2012) Serum B-cell maturation antigen is elevated in multiple myeloma and correlates with disease status and survival. Br J Haematol 158(6):727–738
Article CAS PubMed Google Scholar
Bardia A, Mayer IA, Diamond JR, Moroose RL, Isakoff SJ, Starodub AN, Shah NC, O’Shaughnessy J, Kalinsky K, Guarino M et al (2017) Efficacy and safety of anti-trop-2 antibody drug conjugate Sacituzumab Govitecan (IMMU-132) in heavily pretreated patients with metastatic triple-negative breast cancer. J Clin Oncol 35(19):2141–2148
Article CAS PubMed PubMed Central Google Scholar
Weiss J, Glode A, Messersmith WA, Diamond J (2019) Sacituzumab govitecan: breakthrough targeted therapy for triple-negative breast cancer. Expert Rev Anticancer Ther 19(8):673–679
Article CAS PubMed Google Scholar
Bardia A, Mayer IA, Vahdat LT, Tolaney SM, Isakoff SJ, Diamond JR, O’Shaughnessy J, Moroose RL, Santin AD, Abramson VG et al (2019) Sacituzumab Govitecan-hziy in refractory metastatic triple-negative breast cancer. N Engl J Med 380(8):741–751
Article CAS PubMed Google Scholar
Bardia A, Hurvitz SA, Tolaney SM, Loirat D, Punie K, Oliveira M, Brufsky A, Sardesai SD, Kalinsky K, Zelnak AB et al (2021) Sacituzumab Govitecan in metastatic triple-negative breast cancer. N Engl J Med 384(16):1529–1541
Article CAS PubMed Google Scholar
Bardia A, Hurvitz SA, Rugo HS, Brufsky A, Cortes J, Loibl S, Piccart M, Cowden J, Spears P, Carey LA (2021) A plain language summary of the ASCENT study: Sacituzumab Govitecan for metastatic triple-negative breast cancer. Future Oncol 17(30):3911–3924
Article CAS PubMed Google Scholar
Rizzo A, Cusmai A, Acquafredda S, Rinaldi L, Palmiotti G (2022) Ladiratuzumab vedotin for metastatic triple negative cancer: preliminary results, key challenges, and clinical potential. Expert Opin Investig Drugs 8:1–4
Taylor KM, Hiscox S, Nicholson RI (2004) Zinc transporter LIV-1: a link between cellular development and cancer progression. Trends Endocrinol Metab 15(10):461–463
Article CAS PubMed Google Scholar
Huber MA, Kraut N, Beug H (2005) Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 17(5):548–558
Article CAS PubMed Google Scholar
Modi S, Pusztai L, Forero A, Mita M, Miller K, Weise A, Krop I, Burris H III, Kalinsky K, Tsai M et al (2018) Abstract PD3–14: Phase 1 study of the antibody-drug conjugate SGN-LIV1A in patients with heavily pretreated triple-negative metastatic breast cancer. Cancer Res 78:4
Tsai M, Han H, Montero A, Tkaczuk K, Assad H, Pusztai L, Hurvitz S, Wilks S, Specht J, Nanda R (2021) 259P Weekly ladiratuzumab vedotin monotherapy for metastatic triple-negative breast cancer. Ann Oncol 32:S474–S475
Modi S, Jacot W, Yamashita T, Sohn J, Vidal M, Tokunaga E, Tsurutani J, Ueno NT, Prat A, Chae YS et al (2022) Trastuzumab deruxtecan in previously treated HER2-low advanced breast cancer. N Engl J Med 387(1):9–20
Article CAS PubMed PubMed Central Google Scholar
Modi S, Jacot W, Yamashita T, Sohn J, Vidal M, Tokunaga E, Tsurutani J, Ueno NT, Prat A, Chae YS (2022) Trastuzumab deruxtecan in previously treated HER2-low advanced breast cancer. N Engl J Med 2:2
Khoury R, Saleh K, Khalife N, Saleh M, Chahine C, Ibrahim R, Lecesne A (2023) Mechanisms of resistance to antibody-drug conjugates. Int J Mol Sci 24:11
Yang R, Li Y, Wang H, Qin T, Yin X, Ma X (2022) Therapeutic progress and challenges for triple negative breast cancer: targeted therapy and immunotherapy. Mol Biomed 3(1):8
Article PubMed PubMed Central Google Scholar
Mittendorf EA, Philips AV, Meric-Bernstam F, Qiao N, Wu Y, Harrington S, Su X, Wang Y, Gonzalez-Angulo AM, Akcakanat A et al (2014) PD-L1 expression in triple-negative breast cancer. Cancer Immunol Res 2(4):361–370
Comments (0)