Mechanisms of genotoxicity and proteotoxicity induced by the metalloids arsenic and antimony

Oremland RS, Stolz JF (2003) The ecology of arsenic. Science 300:939–944

Article  CAS  PubMed  Google Scholar 

Pierart A, Shahid M, Sejalon-Delmas N, Dumat C (2015) Antimony bioavailability: knowledge and research perspectives for sustainable agricultures. J Hazard Mater 289:219–234

Article  CAS  PubMed  Google Scholar 

Chen QY, Costa M (2021) Arsenic: a global environmental challenge. Annu Rev Pharmacol 61:47–63

Article  CAS  Google Scholar 

Shankar S, Shanker U, Shikha (2014) Arsenic contamination of groundwater: a review of sources, prevalence, health risks, and strategies for mitigation. Sci World J 2014:304524

Article  Google Scholar 

Shaji E, Santosh M, Sarath KV, Prakash P, Deepchand V, Divya BV (2021) Arsenic contamination of groundwater: a global synopsis with focus on the Indian Peninsula. Geosci Front 12:101079

Article  CAS  Google Scholar 

He MC, Wang XQ, Wu FC, Fu ZY (2012) Antimony pollution in China. Sci Tot Environ 421:41–50

Article  Google Scholar 

Herath I, Vithanage M, Bundschuh J (2017) Antimony as a global dilemma: geochemistry, mobility, fate and transport. Environ Pollut 223:545–559

Article  CAS  PubMed  Google Scholar 

Podgorski J, Berg M (2020) Global threat of arsenic in groundwater. Science 368:845–850

Article  CAS  PubMed  Google Scholar 

Fowler BA, Chou C-HSJ, Jones RL, Costa M, Chen C-J (2022) Arsenic. In: Nordberg GF, Costa M (eds) Handbook on the toxicology of metals. Academic Press, Cambridge, pp 41–89

Chapter  Google Scholar 

Khairul I, Wang QQ, Jiang YH, Wang C, Naranmandura H (2017) Metabolism, toxicity and anticancer activities of arsenic compounds. Oncotarget 8:23905–23926

Article  PubMed  PubMed Central  Google Scholar 

Naujokas MF, Anderson B, Ahsan H, Aposhian HV, Graziano JH, Thompson C, Suk WA (2013) The broad scope of health effects from chronic arsenic exposure: update on a worldwide public health problem. Environ Health Perspect 121:295–302

Article  PubMed  PubMed Central  Google Scholar 

Chin-Chan M, Navarro-Yepes J, Quintanilla-Vega B (2015) Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases. Front Cell Neurosci 9:124

Article  PubMed  PubMed Central  Google Scholar 

Rahman MA, Hannan MA, Uddin MJ, Rahman MS, Rashid MM, Kim B (2021) Exposure to environmental arsenic and emerging risk of Alzheimer’s disease: perspective mechanisms, management strategy, and future directions. Toxics 9:188

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sundar S, Chakravarty J (2010) Antimony toxicity. Int J Environ Res Public Health 7:4267–4277

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tamás MJ (2016) Cellular and molecular mechanisms of antimony transport, toxicity and resistance. Environ Chem 13:955–962

Article  Google Scholar 

Tylenda CA, Tomei Torres FA, Sullivan DWJ (2022) Antimony. In: Nordberg GF, Costa M (eds) Handbook on the toxicology of metals. Academic Press, Cambridge, pp 23–40

Chapter  Google Scholar 

Zhou X, Speer RM, Volk L, Hudson LG, Liu KJ (2021) Arsenic co-carcinogenesis: inhibition of DNA repair and interaction with zinc finger proteins. Semin Cancer Biol 76:86–98

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pi JB, Kumagai Y, Sun GF, Yamauchi H, Yoshida T, Iso H, Endo A, Yu LY, Yuki KC, Miyauchi T, Shimojo N (2000) Decreased serum concentrations of nitric oxide metabolites among Chinese in an endemic area of chronic arsenic poisoning in Inner Mongolia. Free Radical Biol Med 28:1137–1142

Article  CAS  Google Scholar 

Wu MM, Chiou HY, Wang TW, Hsueh YM, Wang IH, Chen CJ, Lee TC (2001) Association of blood arsenic levels with increased reactive oxidants and decreased antioxidant capacity in a human population of northeastern Taiwan. Environ Health Persp 109:1011–1017

Article  CAS  Google Scholar 

Takayama Y, Masuzaki Y, Mizutani F, Iwata T, Maeda E, Tsukada M, Nomura K, Ito Y, Chisaki Y, Murata K (2021) Associations between blood arsenic and urinary arsenic species concentrations as an exposure characterization tool. Sci Total Environ 750:141517

Article  CAS  PubMed  Google Scholar 

Green BB, Karagas MR, Punshon T, Jackson BP, Robbins DJ, Houseman EA, Marsit CJ (2016) Epigenome-wide assessment of DNA methylation in the placenta and arsenic exposure in the New Hampshire birth cohort study (USA). Environ Health Persp 124:1253–1260

Article  CAS  Google Scholar 

Shen ZX, Chen GQ, Ni JH, Li XS, Xiong SM, Qiu QY, Zhu J, Tang W, Sun GL, Yang KQ, Chen Y, Zhou L, Fang ZW, Wang YT, Ma J, Zhang P, Zhang TD, Chen SJ, Chen Z, Wang ZY (1997) Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood 89:3354–3360

Article  CAS  PubMed  Google Scholar 

Neves DBD, Caldas ED, Sampaio RNR (2009) Antimony in plasma and skin of patients with cutaneous leishmaniasis—relationship with side effects after treatment with meglumine antimoniate. Trop Med Int Health 14:1515–1522

Article  PubMed  Google Scholar 

Fairlamb AH, Horn D (2018) Melarsoprol resistance in African trypanosomiasis. Trends Parasitol 34:481–492

Article  CAS  PubMed  Google Scholar 

Frezard F, Demicheli C, Kato KC, Reis PG, Lizarazo-Jaimes EH (2013) Chemistry of antimony-based drugs in biological systems and studies of their mechanism of action. Rev Inorg Chem 33:1–12

Article  CAS  Google Scholar 

Paul NP, Galvan AE, Yoshinaga-Sakurai K, Rosen BP, Yoshinaga M (2023) Arsenic in medicine: past, present and future. Biometals 36:283–301

Article  CAS  PubMed  Google Scholar 

Fang Y, Zhang Z (2020) Arsenic trioxide as a novel anti-glioma drug: a review. Cell Mol Biol Lett 25:44

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang Y, Shen X, Zhi F, Wen Z, Gao Y, Xu J, Yang B, Bai Y (2023) An overview of arsenic trioxide-involved combined treatment algorithms for leukemia: basic concepts and clinical implications. Cell Death Discov 9:266

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hadjikakou SK, Ozturk II, Banti CN, Kourkoumelis N, Hadjiliadis N (2015) Recent advances on antimony(III/V) compounds with potential activity against tumor cells. J Inorg Biochem 153:293–305

Article  CAS  PubMed  Google Scholar 

Sharma P, Perez D, Cabrera A, Rosas N, Arias JL (2008) Perspectives of antimony compounds in oncology. Acta Pharmacol Sin 29:881–890

Article  CAS  PubMed  Google Scholar 

Lemire JA, Harrison JJ, Turner RJ (2013) Antimicrobial activity of metals: mechanisms, molecular targets and applications. Nat Rev Microbiol 11:371–384

Article  CAS  PubMed  Google Scholar 

Tamás MJ, Sharma KS, Ibstedt S, Jacobson T, Christen P (2014) Heavy metals and metalloids as a cause for protein misfolding and aggregation. Biomolecules 4:252–267

Article  PubMed  PubMed Central  Google Scholar 

Shen S, Li XF, Cullen WR, Weinfeld M, Le XC (2013) Arsenic binding to proteins. Chem Rev 113:7769–7792

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen QY, DesMarais T, Costa M (2019) Metals and mechanisms of carcinogenesis. Annu Rev Pharmacol Toxicol 59:537–554

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vergara-Geronimo CA, Leon Del Rio A, Rodriguez-Dorantes M, Ostrosky-Wegman P, Salazar AM (2021) Arsenic-protein interactions as a mechanism of arsenic toxicity. Toxicol Appl Pharmacol 431:115738

Article  CAS  PubMed  Google Scholar 

Kitchin KT, Wallace K (2008) The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem 102:532–539

Article  CAS  PubMed  Google Scholar 

Zhang XW, Yan XJ, Zhou ZR, Yang FF, Wu ZY, Sun HB, Liang WX, Song AX, Lallemand-Breitenbach V, Jeanne M, Zhang QY, Yang HY, Huang QH, Zhou GB, Tong JH, Zhang Y, Wu JH, Hu HY, de The H, Chen SJ, Chen Z (2010) Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML. Science 328:240–243

Article  CAS  PubMed  Google Scholar 

Lallemand-Breitenbach V, Jeanne M, Benhenda S, Nasr R, Lei M, Peres L, Zhou J, Zhu J, Raught B, de The H (2008) Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway. Nat Cell Biol 10:547–555

Article  CAS 

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