Regulation of Atg8 membrane deconjugation by cysteine proteases in the malaria parasite Plasmodium berghei

Mizushima N, Komatsu M (2011) Autophagy: renovation of cells and tissues. Cell 147:728–741. https://doi.org/10.1016/j.cell.2011.10.026

Article  CAS  PubMed  Google Scholar 

Levine B, Kroemer G (2008) Autophagy in the pathogenesis of disease. Cell 132:27–42. https://doi.org/10.1016/j.cell.2007.12.018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Levine B, Mizushima N, Virgin HW (2011) Autophagy in immunity and inflammation. Nature 469:323–335. https://doi.org/10.1038/nature09782

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cecconi F, Levine B (2008) The role of autophagy in mammalian development: cell makeover rather than cell death. Dev Cell 15:344–357. https://doi.org/10.1016/j.devcel.2008.08.012

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baba M, Takeshige K, Baba N, Ohsumi Y (1994) Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization. J Cell Biol 124:903–913. https://doi.org/10.1083/jcb.124.6.903

Article  CAS  PubMed  Google Scholar 

Wen X, Klionsky DJ (2016) An overview of macroautophagy in yeast. J Mol Biol 428:1681–1699. https://doi.org/10.1016/j.jmb.2016.02.021

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsukada M, Ohsumi Y (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333:169–174. https://doi.org/10.1016/0014-5793(93)80398-e

Article  CAS  PubMed  Google Scholar 

Mizushima N, Yoshimori T, Ohsumi Y (2011) The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol 27:107–132. https://doi.org/10.1146/annurev-cellbio-092910-154005

Article  CAS  PubMed  Google Scholar 

Noda NN, Inagaki F (2015) Mechanisms of autophagy. Annu Rev Biophys 44:101–122. https://doi.org/10.1146/annurev-biophys-060414-034248

Article  CAS  PubMed  Google Scholar 

Kabeya Y, Mizushima N, Ueno T et al (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19:5720–5728. https://doi.org/10.1093/emboj/19.21.5720

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie Z, Nair U, Klionsky DJ (2008) Atg8 controls phagophore expansion during autophagosome formation. Mol Biol Cell 19:3290–3298. https://doi.org/10.1091/mbc.e07-12-1292

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nakatogawa H, Ichimura Y, Ohsumi Y (2007) Atg8, a ubiquitin-like protein required for autophagosome formation mediates membrane tethering and hemifusion. Cell. https://doi.org/10.1016/j.cell.2007.05.021

Article  PubMed  Google Scholar 

Fujita N, Hayashi-Nishino M, Fukumoto H et al (2008) An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Mol Biol Cell 19:4651–4659. https://doi.org/10.1091/mbc.e08-03-0312

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nakatogawa H, Ishii J, Asai E, Ohsumi Y (2012) Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis. Autophagy 8:177–186. https://doi.org/10.4161/auto.8.2.18373

Article  CAS  PubMed  Google Scholar 

Choy A, Dancourt J, Mugo B et al (2012) The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Science 338:1072–1076. https://doi.org/10.1126/science.1227026

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cervantes S, Bunnik EM, Saraf A et al (2014) The multifunctional autophagy pathway in the human malaria parasite Plasmodium falciparum. Autophagy. https://doi.org/10.4161/auto.26743

Article  PubMed  Google Scholar 

Brennand A, Gualdrón-lópez M, Coppens I et al (2011) Autophagy in parasitic protists: unique features and drug targets. Mol Biochem Parasitol 177:83–99. https://doi.org/10.1016/j.molbiopara.2011.02.003

Article  CAS  PubMed  Google Scholar 

Duszenko M, Ginger ML, Brennand A et al (2011) Autophagy in protists. Autophagy 7:127–158. https://doi.org/10.4161/auto.7.2.13310

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kitamura K, Kishi-itakura C, Tsuboi T et al (2012) Autophagy-related Atg8 localizes to the apicoplast of the human malaria parasite Plasmodium falciparum. PLoS ONE. https://doi.org/10.1371/journal.pone.0042977

Article  PubMed  PubMed Central  Google Scholar 

Taylor P, Jayabalasingham B, Voss C et al (2014) Characterization of the ATG8-conjugation system in 2 Plasmodium species with special focus on the liver stage possible linkage between the apicoplastic and autophagic systems ? Autophagy. https://doi.org/10.4161/auto.27166

Article  Google Scholar 

Eickel N, Kaiser G, Prado M et al (2013) Features of autophagic cell death in Plasmodium liver-stage parasites. Autophagy 9:568–580

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tomlins AM, Ben-rached F, Williams RAM et al (2013) Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation. Autophagy. https://doi.org/10.4161/auto.25832

Article  PubMed  Google Scholar 

Walczak M, Ganesan SM, Niles JC, Yeh E (2018) ATG8 is essential specifically for an autophagy-independent function in apicoplast biogenesis in blood-stage malaria parasites. mBio 9:1–13

Article  Google Scholar 

Lévêque MF, Berry L, Cipriano MJ et al (2015) Autophagy-related protein ATG8 has a noncanonical function for apicoplast inheritance in Toxoplasma gondii. mBio. https://doi.org/10.1128/mBio.01446-15.Invited

Article  PubMed  PubMed Central  Google Scholar 

Walker DM, Mahfooz N, Kemme KA et al (2013) Plasmodium falciparum erythrocytic stage parasites require the putative autophagy protein PfAtg7 for normal growth. PLoS ONE 8:2–9. https://doi.org/10.1371/journal.pone.0067047

Article  CAS  Google Scholar 

Bansal P, Tripathi A et al (2017) Autophagy-related protein ATG18 regulates apicoplast biogenesis in apicomplexan parasites. mBio 8:5–01468

Article  Google Scholar 

Kong-hap MA, Mouammine A, Daher W et al (2013) Regulation of ATG8 membrane association by ATG4 in the parasitic protist Toxoplasma gondii. Autophagy. https://doi.org/10.4161/auto.25189

Article  PubMed  Google Scholar 

Tang Y, Meister TR, Walczak M et al (2019) A mutagenesis screen for essential plastid biogenesis genes in human malaria parasites. PLoS Biol. https://doi.org/10.1371/journal.pbio.3000136

Article  PubMed  PubMed Central  Google Scholar 

Gupta R, Mishra A, Choudhary HH et al (2020) Secreted protein with altered thrombospondin repeat (SPATR) is essential for asexual blood stages but not required for hepatocyte invasion by the malaria parasite Plasmodium berghei. Mol Microbiol 113:478–491. https://doi.org/10.1111/mmi.14432

Article  CAS  PubMed  Google Scholar 

Janse CJ, Ramesar J, Waters AP (2006) High-efficiency transfection and drug selection of genetically transformed blood stages of the rodent malaria parasite Plasmodium berghei. Nat Protoc 1:346–356. https://doi.org/10.1038/nprot.2006.53

Article  CAS  PubMed  Google Scholar 

Gomes AR, Bushell E, Schwach F et al (2015) A genome-scale vector resource enables high-throughput reverse genetic screening in a malaria parasite. Cell Host Microbe 17:404–413. https://doi.org/10.1016/j.chom.2015.01.014

Article  CAS  PubMed  PubMed Central  Google Scholar 

Godiska R, Mead D, Dhodda V et al (2010) Linear plasmid vector for cloning of repetitive or unstable sequences in Escherichia coli. Nucleic Acids Res 38:e88. https://doi.org/10.1093/nar/gkp1181

Article  CAS  PubMed  Google Scholar 

Charan M, Choudhary HH, Singh N et al (2017) [Fe-S] cluster assembly in the apicoplast and its indispensability in mosquito stages of the malaria parasite. FEBS J 284:2629–2648. https://doi.org/10.1111/febs.14159

Article  CAS  PubMed  Google Scholar 

Al-Nihmi FMA, Kolli SK, Reddy SR et al (2017) A novel and conserved plasmodium sporozoite membrane protein SPELD is required for maturation of exo-erythrocytic forms. Sci Rep 7:40407. https://doi.org/10.1038/srep40407

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choudhary HH, Gupta R, Mishra S (2019) PKAc is not required for the preerythrocytic stages of Plasmodium berghei. Life 2:1–11

Comments (0)

No login
gif