Alaghband Y, Marshall JF (2013) Common influences of non-competitive NMDA receptor antagonists on the consolidation and reconsolidation of cocaine-cue memory. Psychopharmacology 226(4):707–719. https://doi.org/10.1007/s00213-012-2793-y

Article  CAS  PubMed  Google Scholar 

Boulland JL, Levy LM (2005) Glutamate, glutamine and ischaemia in the central nervous system. Tidsskr nor Laegeforen 125(11):1479–1481

PubMed  Google Scholar 

Brini M, Calì T, Ottolini D, Carafoli E (2014) Neuronal calcium signaling: function and dysfunction. Cell Mol Life Sci 71(15):2787–2814. https://doi.org/10.1007/s00018-013-1550-7

Article  CAS  PubMed  Google Scholar 

Brittain MK, Brustovetsky T, Brittain JM, Khanna R, Cummins TR, Brustovetsky N (2012) Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons. Neuropharmacology 63(6):974–982. https://doi.org/10.1016/j.neuropharm.2012.07.012

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calvo-Rodriguez M, Hou SS, Snyder AC, Kharitonova EK, Russ AN, Das S, Fan Z, Muzikansky A, Garcia-Alloza M, Serrano-Pozo A, Hudry E, Bacskai BJ (2020) Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease. Nat Commun 11(1):2146. https://doi.org/10.1038/s41467-020-16074-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Charousaei A, Nasehi M, Babapour V, Vaseghi S, Zarrindast MR (2021) The effect of 5-HT(4) serotonin receptors in the CA3 hippocampal region on D-AP5-induced anxiolytic-like effects: isobolographic analyses. Behav Brain Res 397:112933. https://doi.org/10.1016/j.bbr.2020.112933

Article  CAS  PubMed  Google Scholar 

Chen YW, Actor-Engel H, Sherpa AD, Klingensmith L, Chowdhury TG, Aoki C (2017) NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise. Brain Struct Funct 222(5):2271–2294. https://doi.org/10.1007/s00429-016-1341-7

Article  CAS  PubMed  Google Scholar 

Chen G, Li T, Xiao J, Wang J, Shang Q, Qian H, Qiao C, Zhang P, Chen T, Liu X (2020) Ifenprodil attenuates methamphetamine-induced behavioral sensitization through the GluN2B-PP2A-AKT cascade in the dorsal striatum of mice. Neurochem Res 45(4):891–901. https://doi.org/10.1007/s11064-020-02966-8

Article  CAS  PubMed  Google Scholar 

Chen S, Chen L, Ye L, Jiang Y, Li Q, Zhang H, Zhang R, Li H, Yu D, Zhang R, Niu Y, Zhao Q, Liu J, Ouyang G, Aschner M, Zheng Y, Zhang L, Chen W, Li D (2022) PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury. J Hazard Mater 424(Pt C):127624. https://doi.org/10.1016/j.jhazmat.2021.127624

Article  CAS  PubMed  Google Scholar 

Cogliati S, Cabrera-Alarcón JL, Enriquez JA (2021) Regulation and functional role of the electron transport chain supercomplexes. Biochem Soc Trans 49(6):2655–2668. https://doi.org/10.1042/bst20210460

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dai HB, Xu MM, Lv J, Ji XJ, Zhu SH, Ma RM, Miao XL, Duan ML (2016) Mild hypothermia combined with hydrogen sulfide treatment during resuscitation reduces hippocampal neuron apoptosis via NR2A, NR2B, and PI3K-Akt signaling in a rat model of cerebral ischemia-reperfusion injury. Mol Neurobiol 53(7):4865–4873. https://doi.org/10.1007/s12035-015-9391-z

Article  CAS  PubMed  Google Scholar 

Decker JM, Krüger L, Sydow A, Dennissen FJ, Siskova Z, Mandelkow E, Mandelkow EM (2016) The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity. EMBO Rep 17(4):552–569. https://doi.org/10.15252/embr.201541439

Article  CAS  PubMed  PubMed Central  Google Scholar 

Di Lisa F, Canton M, Carpi A, Kaludercic N, Menabò R, Menazza S, Semenzato M (2011) Mitochondrial injury and protection in ischemic pre- and postconditioning. Antioxid Redox Signal 14(5):881–891. https://doi.org/10.1089/ars.2010.3375

Article  CAS  PubMed  Google Scholar 

Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rocktäschel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA (2019) Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of alzheimer’s disease. Nat Neurosci 22(3):401–412. https://doi.org/10.1038/s41593-018-0332-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Flores-Soto ME, Chaparro-Huerta V, Escoto-Delgadillo M, Vazquez-Valls E, González-Castañeda RE, Beas-Zarate C (2012) Structure and function of NMDA-type glutamate receptor subunits. Neurologia 27(5):301–310. https://doi.org/10.1016/j.nrl.2011.10.014

Article  CAS  PubMed  Google Scholar 

Fukumori R, Takarada T, Kambe Y, Nakazato R, Fujikawa K, Yoneda Y (2012) Possible involvement of mitochondrial uncoupling protein-2 in cytotoxicity mediated by acquired N-methyl-D-aspartate receptor channels. Neurochem Int 61(4):498–505. https://doi.org/10.1016/j.neuint.2012.03.019

Article  CAS  PubMed  Google Scholar 

Gascón S, Deogracias R, Sobrado M, Roda JM, Renart J, Rodríguez-Peña A, Díaz-Guerra M (2005) Transcription of the NR1 subunit of the N-methyl-D-aspartate receptor is down-regulated by excitotoxic stimulation and cerebral ischemia. J Biol Chem 280(41):35018–35027. https://doi.org/10.1074/jbc.M504108200

Article  CAS  PubMed  Google Scholar 

Gascón S, Sobrado M, Roda JM, Rodríguez-Peña A, Díaz-Guerra M (2008) Excitotoxicity and focal cerebral ischemia induce truncation of the NR2A and NR2B subunits of the NMDA receptor and cleavage of the scaffolding protein PSD-95. Mol Psychiatry 13(1):99–114. https://doi.org/10.1038/sj.mp.4002017

Article  CAS  PubMed  Google Scholar 

Hammond MS, Sims C, Parameshwaran K, Suppiramaniam V, Schachner M, Dityatev A (2006) Neural cell adhesion molecule-associated polysialic acid inhibits NR2B-containing N-methyl-D-aspartate receptors and prevents glutamate-induced cell death. J Biol Chem 281(46):34859–34869. https://doi.org/10.1074/jbc.M602568200

Article  CAS  PubMed  Google Scholar 

He Z, Ning N, Zhou Q, Khoshnam SE, Farzaneh M (2020) Mitochondria as a therapeutic target for ischemic stroke. Free Radic Biol Med 146:45–58. https://doi.org/10.1016/j.freeradbiomed.2019.11.005

Article  CAS  PubMed  Google Scholar 

Huo Y, Feng X, Niu M, Wang L, Xie Y, Wang L, Ha J, Cheng X, Gao Z, Sun Y (2021) Therapeutic time windows of compounds against NMDA receptors signaling pathways for ischemic stroke. J Neurosci Res 99(12):3204–3221. https://doi.org/10.1002/jnr.24937

Article  CAS  PubMed  Google Scholar 

Lee JH, Wei ZZ, Chen D, Gu X, Wei L, Yu SP (2015) A neuroprotective role of the NMDA receptor subunit GluN3A (NR3A) in ischemic stroke of the adult mouse. Am J Physiol Cell Physiol 308(7):C570-577. https://doi.org/10.1152/ajpcell.00353.2014

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liraz-Zaltsman S, Yaka R, Shabashov D, Shohami E, Biegon A (2016) Neuroinflammation-induced memory deficits are amenable to treatment with D-Cycloserine. J Mol Neurosci 60(1):46–62. https://doi.org/10.1007/s12031-016-0786-8

Article  CAS  PubMed  Google Scholar 

Lu Y, Zhang J, Ma B, Li K, Li X, Bai H, Yang Q, Zhu X, Ben J, Chen Q (2012) Glycine attenuates cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis in mice. Neurochem Int 61(5):649–658. https://doi.org/10.1016/j.neuint.2012.07.005

Article  CAS  PubMed  Google Scholar 

Ludhiadch A, Sharma R, Muriki A, Munshi A (2022) Role of calcium homeostasis in ischemic stroke: a review. CNS Neurol Disord Drug Targets 21(1):52–61. https://doi.org/10.2174/1871527320666210212141232

Article  CAS  PubMed  Google Scholar 

Luo Y, Ma H, Zhou JJ, Li L, Chen SR, Zhang J, Chen L, Pan HL (2018) Focal cerebral ischemia and reperfusion induce brain injury through α2δ-1-bound NMDA receptors. Stroke 49(10):2464–2472. https://doi.org/10.1161/strokeaha.118.022330

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martel MA, Wyllie DJ, Hardingham GE (2009) In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death. Neuroscience 158(1):334–343. https://doi.org/10.1016/j.neuroscience.2008.01.080

Article  CAS  PubMed  Google Scholar 

Martin HG, Wang YT (2010) Blocking the deadly effects of the NMDA receptor in stroke. Cell 140(2):174–176. https://doi.org/10.1016/j.cell.2010.01.014

Article  CAS  PubMed  Google Scholar 

MartInez-Coria H, Arrieta-Cruz I, Cruz ME, López-Valdés HE (2021) Physiopathology of ischemic stroke and its modulation using memantine: evidence from preclinical stroke. Neural Regen Res 16(3):433–439. https://doi.org/10.4103/1673-5374.293129

Article  CAS  PubMed  Google Scholar 

Michel K, Krüger D, Schäuffele S, Zeller F, Demir IE, Theisen J, Schemann M (2021) Fast synaptic excitatory neurotransmission in the human submucosal plexus. Neurogastroenterol Motil 33(8):e14164. https://doi.org/10.1111/nmo.14164

Article  CAS  PubMed  Google Scholar 

Mira RG, Tapia-Rojas C, Pérez MJ, Jara C, Vergara EH, Quintanilla RA, Cerpa W (2019) Alcohol impairs hippocampal function: from NMDA receptor synaptic transmission to mitochondrial function. Drug Alcohol Depend 205:107628. https://doi.org/10.1016/j.drugalcdep.2019.107628