Hayflick, L. & Moorhead, P. S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585–621 (1961).
Article CAS PubMed Google Scholar
Dimri, G. P. et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA 92, 9363–9367 (1995).
Article CAS PubMed PubMed Central Google Scholar
Collado, M. & Serrano, M. Senescence in tumours: evidence from mice and humans. Nat. Rev. Cancer 10, 51–57 (2010).
Article CAS PubMed PubMed Central Google Scholar
Gems, D. & Kern, C. C. Is ‘cellular senescence’ a misnomer? Geroscience 44, 2461–2469 (2022).
Article CAS PubMed PubMed Central Google Scholar
Baker, D. J. et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479, 232–236 (2011).
Article CAS PubMed PubMed Central Google Scholar
Moiseeva, V. et al. Context-dependent roles of cellular senescence in normal, aged, and disease states. FEBS J. 290, 1161–1185 (2023).
Article CAS PubMed Google Scholar
Di Micco, R., Krizhanovsky, V., Baker, D. & d’Adda di Fagagna, F. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat. Rev. Mol. Cell Biol. 22, 75–95 (2021).
Muñoz-Espín, D. et al. Programmed cell senescence during mammalian embryonic development. Cell 155, 1104–1118 (2013).
Storer, M. et al. Senescence is a developmental mechanism that contributes to embryonic growth and patterning. Cell 155, 1119–1130 (2013).
Article CAS PubMed Google Scholar
Gorgoulis, V. et al. Cellular senescence: defining a path forward. Cell 179, 813–827 (2019).
Article CAS PubMed Google Scholar
Brighton, P. J. et al. Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium. eLife 6, e31274 (2017).
Article PubMed PubMed Central Google Scholar
Chiche, A. et al. Injury-induced senescence enables in vivo reprogramming in skeletal muscle. Cell Stem Cell 20, 407–414.e4 (2017).
Article CAS PubMed Google Scholar
Mosteiro, L. et al. Tissue damage and senescence provide critical signals for cellular reprogramming in vivo. Science 354, aaf4445 (2016).
Xu, M. et al. Senolytics improve physical function and increase lifespan in old age. Nat. Med. 24, 1246–1256 (2018).
Article CAS PubMed PubMed Central Google Scholar
de Magalhães, J. P. Senolytics under scrutiny in the quest to slow aging. Nat. Biotechnol. 43, 1413–1415 (2025).
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