Malireddi, R. K. S., Kesavardhana, S. & Kanneganti, T. D. ZBP1 and TAK1: master regulators of NLRP3 inflammasome/pyroptosis, apoptosis, and necroptosis (PAN-optosis). Front. Cell. Infect. Microbiol. 9, 406 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weir, A. & Vince, J. E. No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death. Biochem. J. 479, 1083–1102 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gaidt, M. M. & Hornung, V. The NLRP3 inflammasome renders cell death pro-inflammatory. J. Mol. Biol. 430, 133–141 (2018).

Article  CAS  PubMed  Google Scholar 

Samson, A. L. et al. MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis. Nat. Commun. 11, 3151 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Conos, S. A. et al. Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. Proc. Natl Acad. Sci. USA 114, E961–E969 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vince, J. E. et al. The mitochondrial apoptotic effectors BAX/BAK activate caspase-3 and -7 to trigger NLRP3 inflammasome and caspase-8 driven IL- 1β activation. Cell Rep. 25, 2339–2353.e4 (2018).

Article  CAS  PubMed  Google Scholar 

Zhang, Z. et al. Distinct changes in endosomal composition promote NLRP3 inflammasome activation. Nat. Immunol. 24, 30–41 (2023).

Article  CAS  PubMed  Google Scholar 

Micheau, O. & Tschopp, J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114, 181–190 (2003).

Article  CAS  PubMed  Google Scholar 

Oh, S. et al. Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis. Cell. Mol. Immunol. 20, 1513–1526 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sundaram, B. et al. NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation. Cell 187, 4061–4077.e17 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee, S. et al. AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. Nature 597, 415–419 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han, J. H. et al. NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress. Nat. Commun. 15, 1739 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karki, R. et al. Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes. Cell 184, 149–168.e17 (2021).

Article  CAS  PubMed  Google Scholar 

Kuriakose, T. et al. ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways. Sci. Immunol. 1, aag2045 (2016).

Article  PubMed  PubMed Central  Google Scholar