Pinto, V. L. & Sharma, S. in Statpearls (StatPearls Publishing Copyright © 2025, StatPearls Publishing LLC., 2025).

Chowdhury, O., Wedderburn, C. J., Duffy, D. & Greenough, A. CPAP Review. Eur. J. Pediatr. 171, 1441–1448 (2012).

Article  PubMed  Google Scholar 

Mamidi, R. R., MacDonald, K. D., Spindel, E. R. & McEvoy, C. T. Interventions to improve lung growth in premature infants. Paediatr. Respir. Rev. 58, S1526–0542 (2025).

Subramaniam, P., Ho, J. J. & Davis, P. G. Prophylactic or very early initiation of continuous positive airway pressure (CPAP) for preterm infants. Cochrane Database Syst. Rev. 10, CD001243 (2021).

PubMed  PubMed Central  Google Scholar 

Mayer, C. A., Martin, R. J. & MacFarlane, P. M. Increased airway reactivity in a neonatal mouse model of continuous positive airway pressure. Pediatr. Res. 78, 145–151 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Caffarelli, C., Gracci, S., Giannì, G. & Bernardini, R. Are babies born preterm high-risk asthma candidates? J. Clin. Med. 12, 5400 (2023).

Priante, E. et al. Respiratory outcome after preterm birth: a long and difficult journey. Am. J. Perinatol. 33, 1040–1042 (2016).

Article  PubMed  Google Scholar 

Pramana, I. A. & Neumann, R. P. Follow up care of the preterm infant. Ther. Umsch. 70, 648–652 (2013).

Article  PubMed  Google Scholar 

Zhang, E. Y., Bartman, C. M., Prakash, Y. S., Pabelick, C. M. & Vogel, E. R. Oxygen and mechanical stretch in the developing lung: risk factors for neonatal and pediatric lung disease. Front. Med. 10, 1214108 (2023).

Article  Google Scholar 

Schmölzer, G. M. et al. Non-invasive versus invasive respiratory support in preterm infants at birth: systematic review and meta-analysis. Br. Med. J. 348, g58 (2014).

Carvalho, C. G., Silveira, R. C. & Procianoy, R. S. Ventilator-induced lung injury in preterm infants. Rev. Bras. Ter. Intensiv. 25, 319–326 (2013).

Article  Google Scholar 

Keglowich, L. F. & Borger, P. The three A’s in asthma - airway smooth muscle, airway remodeling & angiogenesis. Open Respir. Med. J. 17, 70–80 (2015).

Article  Google Scholar 

Prakash, Y. S. Emerging concepts in smooth muscle contributions to airway structure and function: implications for health and disease. Am. J. Physiol. Lung Cell Mol. Physiol. 311, L1113–L1140 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Drake, L. Y. et al. Mechanical stretch promotes sustained proliferation and inflammation in developing human airway smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol. 329, L296–l306 (2025).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kelley, B. et al. Piezo channels in stretch effects on developing human airway smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol. 325, L542–L551 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feldman, C. H., Grotegut, C. A. & Rosenberg, P. B. The role of STIM1 and SOCE in smooth muscle contractility. Cell Calcium 63, 60–65 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zou, J. J., Gao, Y. D., Geng, S. & Yang, J. Role of STIM1/Orai1-mediated store-operated Ca2+ entry in airway smooth muscle cell proliferation. J. Appl. Physiol. 110, 1256–1263 (2011).

Article  CAS  PubMed  Google Scholar 

Yao, Y. et al. Role of STIM1 in stretch-induced signaling in human airway smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol. 327, L150–L159 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sathish, V. et al. Caveolin-1 regulation of store-operated Ca2+ influx in human airway smooth muscle. Eur. Respir. J. 40, 470–478 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Johnson, M. T. et al. STIM1 is a core trigger of airway smooth muscle remodeling and hyperresponsiveness in asthma. Proc. Natl. Acad. Sci. USA 119, e2114557118 (2022).

Spinelli, A. M. et al. Airway smooth muscle STIM1 and Orai1 are upregulated in asthmatic mice and mediate PDGF-activated SOCE, CRAC currents, proliferation, and migration. Pflug. Arch. 464, 481–492 (2012).

Article  CAS  Google Scholar 

Bartman, C. M., Matveyenko, A., Pabelick, C. & Prakash, Y. S. Cellular clocks in hyperoxia effects on [Ca2+]i regulation in developing human airway smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol. 320, L451–L466 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shaffer, T. H. & Wolfson, M. R. in Fetal and Neonatal Physiology (Fourth Edition) (Polin, R. A., Fox, W. W.& Abman, S. H. eds) 919–929 (W.B. Saunders, 2011).

Coste, B. et al. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 330, 55–60 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Douguet, D., Patel, A., Xu, A., Vanhoutte, P. M. & Honoré, E. Piezo ion channels in cardiovascular mechanobiology. Trends Pharm. Sci. 40, 956–970 (2019).

Article  CAS  PubMed  Google Scholar 

Fang, X. Z. et al. Structure, kinetic properties and biological function of mechanosensitive Piezo channels. Cell Biosci. 11, 13 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao, Q. et al. Structure and mechanogating mechanism of the Piezo1 channel. Nature 554, 487–492 (2018).

Article  CAS  PubMed  Google Scholar 

Zhao, Q., Zhou, H., Li, X. & Xiao, B. The mechanosensitive Piezo1 channel: a three-bladed propeller-like structure and a lever-like mechanogating mechanism. FEBS J. 286, 2461–2470 (2019).

Article  CAS  PubMed  Google Scholar 

Zhao, F. et al. Mechanosensitive ion channel Piezo1 signaling in the hall-marks of cancer: structure and functions. Cancers 14, 4955 (2022).

Shen, Y. et al. The roles of mechanosensitive ion channels and associated downstream MAPK signaling pathways in PDLC mechanotransduction. Mol. Med. Rep. 21, 2113–2122 (2020).

CAS  PubMed  PubMed Central  Google Scholar 

Tadge, T. et al. The role of Piezo1 and Piezo2 proteins in tissue engineering: a comprehensive review. Eng. Regener. 5, 170–185 (2024).

CAS  Google Scholar 

Coste, B. & Delmas, P. Piezo ion channels in cardiovascular functions and diseases. Circ. Res. 134, 572–591 (2024).

Article  CAS  PubMed  Google Scholar 

Pandya, H. C. et al. Spontaneous contraction of pseudoglandular-stage human airspaces is associated with the presence of smooth muscle-alpha-actin and smooth muscle-specific myosin heavy chain in recently differentiated fetal human airway smooth muscle. Biol. Neonate 89, 211–219 (2006).

Article  CAS  PubMed  Google Scholar 

Pandya, H. C., Snetkov, V. A., Twort, C. H., Ward, J. P. & Hirst, S. J. Oxygen regulates mitogen-stimulated proliferation of fetal human airway smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol. 283, L1220–L1230 (2002).

Article  CAS  PubMed  Google Scholar 

Thien, N. D., Hai-Nam, N., Anh, D. T. & Baecker, D. Piezo1 and its inhibitors: overview and perspectives. Eur. J. Med Chem. 273, 116502 (2024).

Article  CAS  PubMed  Google Scholar 

Alcaino, C., Knutson, K., Gottlieb, P. A., Farrugia, G. & Beyder, A. Mechanosensitive ion channel Piezo2 is inhibited by D-Gsmtx4. Channels 11, 245–253 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Drake, L. Y. et al. Functional role of glial-derived neurotrophic factor in a mixed allergen murine model of asthma. Am. J. Physiol. Lung Cell. Mol. Physiol. 326, L19–L28 (2024).

Article  PubMed  Google Scholar 

Bartman, C. M. et al. Exogenous hydrogen sulfide attenuates hyperoxia effects on neonatal mouse airways. Am. J. Physiol. Lung Cell Mol. Physiol. 326, L52–l64 (2024).

Article  PubMed  Google Scholar 

Ay, B., Prakash, Y. S., Pabelick, C. M. & Sieck, G. C. Store-operated Ca2+ entry in porcine airway smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol. 286