Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, Wrensch MR, Barnholtz-Sloan JS (2014) The epidemiology of glioma in adults: a “state of the science” review. Neuro Oncol 16:896–913. https://doi.org/10.1093/neuonc/nou087
Article CAS PubMed PubMed Central Google Scholar
Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW (2016) The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131:803–820. https://doi.org/10.1007/s00401-016-1545-1
Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol 23:1231–1251. https://doi.org/10.1093/neuonc/noab106
Article CAS PubMed PubMed Central Google Scholar
Plog BA, Nedergaard M (2018) The glymphatic system in central nervous system health and disease: past, present, and future. Annu Rev Pathol 13:379–394. https://doi.org/10.1146/annurev-pathol-051217-111018
Article CAS PubMed PubMed Central Google Scholar
Zhang J, Liu S, Wu Y, Tang Z, Wu Y, Qi Y, Dong F, Wang Y (2024) Enlarged perivascular space and index for diffusivity along the perivascular space as emerging neuroimaging biomarkers of neurological diseases. Cell Mol Neurobiol 44:14. https://doi.org/10.1007/s10571-023-01440-7
Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M (2012) A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med 4:147ra111. https://doi.org/10.1126/scitranslmed.3003748
Article CAS PubMed PubMed Central Google Scholar
Iliff JJ, Lee H, Yu M, Feng T, Logan J, Nedergaard M, Benveniste H (2013) Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest 123:1299–1309. https://doi.org/10.1172/jci67677
Article CAS PubMed PubMed Central Google Scholar
Iliff JJ, Chen MJ, Plog BA, Zeppenfeld DM, Soltero M, Yang L, Singh I, Deane R, Nedergaard M (2014) Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. J Neurosci 34:16180–16193. https://doi.org/10.1523/jneurosci.3020-14.2014
Article PubMed PubMed Central Google Scholar
Taoka T, Masutani Y, Kawai H, Nakane T, Matsuoka K, Yasuno F, Kishimoto T, Naganawa S (2017) Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases. Jpn J Radiol 35:172–178. https://doi.org/10.1007/s11604-017-0617-z
Hsu JL, Wei YC, Toh CH, Hsiao IT, Lin KJ, Yen TC, Liao MF, Ro LS (2023) Magnetic resonance images implicate that glymphatic alterations mediate cognitive dysfunction in Alzheimer disease. Ann Neurol 93:164–174. https://doi.org/10.1002/ana.26516
Cai X, Chen Z, He C, Zhang P, Nie K, Qiu Y, Wang L, Wang L, Jing P, Zhang Y (2023) Diffusion along perivascular spaces provides evidence interlinking compromised glymphatic function with aging in Parkinson’s disease. CNS Neurosci Ther 29:111–121. https://doi.org/10.1111/cns.13984
Article CAS PubMed Google Scholar
Ma X, Li S, Li C, Wang R, Chen M, Chen H, Su W (2021) Diffusion tensor imaging along the perivascular space index in different stages of Parkinson’s disease. Front Aging Neurosci 13:773951. https://doi.org/10.3389/fnagi.2021.773951
Article CAS PubMed PubMed Central Google Scholar
Park JH, Bae YJ, Kim JS, Jung WS, Choi JW, Roh TH, You N, Kim SH, Han M (2023) Glymphatic system evaluation using diffusion tensor imaging in patients with traumatic brain injury. Neuroradiology 65:551–557. https://doi.org/10.1007/s00234-022-03073-x
Zhang W, Zhou Y, Wang J, Gong X, Chen Z, Zhang X, Cai J, Chen S, Fang L, Sun J, Lou M (2021) Glymphatic clearance function in patients with cerebral small vessel disease. Neuroimage 238:118257. https://doi.org/10.1016/j.neuroimage.2021.118257
Cacciaguerra L, Carotenuto A, Pagani E, Mistri D, Radaelli M, Martinelli V, Filippi M, Rocca MA (2022) Magnetic resonance imaging evaluation of perivascular space abnormalities in neuromyelitis optica. Ann Neurol 92:173–183. https://doi.org/10.1002/ana.26419
Article PubMed PubMed Central Google Scholar
Toh CH, Siow TY (2021) Factors associated with dysfunction of glymphatic system in patients with glioma. Front Oncol 11:744318. https://doi.org/10.3389/fonc.2021.744318
Article CAS PubMed PubMed Central Google Scholar
Zhu H, Xie Y, Li L, Liu Y, Li S, Shen N, Zhang J, Yan S, Liu D, Li Y, Zhu W (2023) Diffusion along the perivascular space as a potential biomarker for glioma grading and isocitrate dehydrogenase 1 mutation status prediction. Quant Imaging Med Surg 13:8259–8273. https://doi.org/10.21037/qims-23-541
Article PubMed PubMed Central Google Scholar
Zeng S, Huang Z, Zhou W, Ma H, Wu J, Zhao C, Yang Z, Qiu H, Chu J (2024) Noninvasive evaluation of the glymphatic system in diffuse gliomas using diffusion tensor image analysis along the perivascular space. J Neurosurg 142(1):187–196. https://doi.org/10.3171/2024.4.JNS232724
Liang W, Sun W, Li C, Zhou J, Long C, Li H, Xu D, Xu H (2025) Glymphatic system dysfunction and cerebrospinal fluid retention in gliomas: evidence from perivascular space diffusion and volumetric analysis. Cancer Imaging 25:51. https://doi.org/10.1186/s40644-025-00868-y
Article CAS PubMed PubMed Central Google Scholar
Dubois LG, Campanati L, Righy C, D’Andrea-Meira I, Spohr TC, Porto-Carreiro I, Pereira CM, Balça-Silva J, Kahn SA, DosSantos MF, Oliveira MA, Ximenes-da-Silva A, Lopes MC, Faveret E, Gasparetto EL, Moura-Neto V (2014) Gliomas and the vascular fragility of the blood brain barrier. Front Cell Neurosci 8:418. https://doi.org/10.3389/fncel.2014.00418
Article PubMed PubMed Central Google Scholar
Ahmed MH, Canney M, Carpentier A, Thanou M, Idbaih A (2023) Unveiling the enigma of the blood-brain barrier in glioblastoma: current advances from preclinical and clinical studies. Curr Opin Oncol 35:522–528. https://doi.org/10.1097/cco.0000000000000990
Article CAS PubMed PubMed Central Google Scholar
Mestre H, Tithof J, Du T, Song W, Peng W, Sweeney AM, Olveda G, Thomas JH, Nedergaard M, Kelley DH (2018) Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension. Nat Commun 9:4878. https://doi.org/10.1038/s41467-018-07318-3
Article CAS PubMed PubMed Central Google Scholar
Abrigo JM, Fountain DM, Provenzale JM, Law EK, Kwong JSW, Hart MG, Tam WWS (2018) Magnetic resonance perfusion for differentiating low-grade from high-grade gliomas at first presentation. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD011551.pub2
Article PubMed PubMed Central Google Scholar
van Santwijk L, Kouwenberg V, Meijer F, Smits M, Henssen D (2022) A systematic review and meta-analysis on the differentiation of glioma grade and mutational status by use of perfusion-based magnetic resonance imaging. Insights Imaging 13:102. https://doi.org/10.1186/s13244-022-01230-7
Article PubMed PubMed Central Google Scholar
Paldino MJ, Barboriak DP (2009) Fundamentals of quantitative dynamic contrast-enhanced MR imaging. Magn Reson Imaging Clin N Am 17:277–289. https://doi.org/10.1016/j.mric.2009.01.007
Tofts PS, Brix G, Buckley DL, Evelhoch JL, Henderson E, Knopp MV, Larsson HB, Lee TY, Mayr NA, Parker GJ, Port RE, Taylor J, Weisskoff RM (1999) Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 10:223–232. 10.1002/(sici)1522-2586(199909)10:3%3c223::aid-jmri2%3e3.0.co;2-s
Walker-Samuel S, Leach MO, Collins DJ (2006) Evaluation of response to treatment using DCE-MRI: the relationship between initial area under the gadolinium curve (IAUGC) and quantitative pharmacokinetic analysis. Phys Med Biol 51:3593–3602. https://doi.org/10.1088/0031-9155/51/14/021
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