Vascular permeability mediates contralateral glymphatic dysfunction across glioma grades and IDH status

Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, Wrensch MR, Barnholtz-Sloan JS (2014) The epidemiology of glioma in adults: a “state of the science” review. Neuro Oncol 16:896–913. https://doi.org/10.1093/neuonc/nou087

Article  CAS  PubMed  PubMed Central  Google Scholar 

Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW (2016) The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131:803–820. https://doi.org/10.1007/s00401-016-1545-1

Article  PubMed  Google Scholar 

Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol 23:1231–1251. https://doi.org/10.1093/neuonc/noab106

Article  CAS  PubMed  PubMed Central  Google Scholar 

Plog BA, Nedergaard M (2018) The glymphatic system in central nervous system health and disease: past, present, and future. Annu Rev Pathol 13:379–394. https://doi.org/10.1146/annurev-pathol-051217-111018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Liu S, Wu Y, Tang Z, Wu Y, Qi Y, Dong F, Wang Y (2024) Enlarged perivascular space and index for diffusivity along the perivascular space as emerging neuroimaging biomarkers of neurological diseases. Cell Mol Neurobiol 44:14. https://doi.org/10.1007/s10571-023-01440-7

Article  Google Scholar 

Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M (2012) A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med 4:147ra111. https://doi.org/10.1126/scitranslmed.3003748

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iliff JJ, Lee H, Yu M, Feng T, Logan J, Nedergaard M, Benveniste H (2013) Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest 123:1299–1309. https://doi.org/10.1172/jci67677

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iliff JJ, Chen MJ, Plog BA, Zeppenfeld DM, Soltero M, Yang L, Singh I, Deane R, Nedergaard M (2014) Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. J Neurosci 34:16180–16193. https://doi.org/10.1523/jneurosci.3020-14.2014

Article  PubMed  PubMed Central  Google Scholar 

Taoka T, Masutani Y, Kawai H, Nakane T, Matsuoka K, Yasuno F, Kishimoto T, Naganawa S (2017) Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases. Jpn J Radiol 35:172–178. https://doi.org/10.1007/s11604-017-0617-z

Article  PubMed  Google Scholar 

Hsu JL, Wei YC, Toh CH, Hsiao IT, Lin KJ, Yen TC, Liao MF, Ro LS (2023) Magnetic resonance images implicate that glymphatic alterations mediate cognitive dysfunction in Alzheimer disease. Ann Neurol 93:164–174. https://doi.org/10.1002/ana.26516

Article  PubMed  Google Scholar 

Cai X, Chen Z, He C, Zhang P, Nie K, Qiu Y, Wang L, Wang L, Jing P, Zhang Y (2023) Diffusion along perivascular spaces provides evidence interlinking compromised glymphatic function with aging in Parkinson’s disease. CNS Neurosci Ther 29:111–121. https://doi.org/10.1111/cns.13984

Article  CAS  PubMed  Google Scholar 

Ma X, Li S, Li C, Wang R, Chen M, Chen H, Su W (2021) Diffusion tensor imaging along the perivascular space index in different stages of Parkinson’s disease. Front Aging Neurosci 13:773951. https://doi.org/10.3389/fnagi.2021.773951

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park JH, Bae YJ, Kim JS, Jung WS, Choi JW, Roh TH, You N, Kim SH, Han M (2023) Glymphatic system evaluation using diffusion tensor imaging in patients with traumatic brain injury. Neuroradiology 65:551–557. https://doi.org/10.1007/s00234-022-03073-x

Article  PubMed  Google Scholar 

Zhang W, Zhou Y, Wang J, Gong X, Chen Z, Zhang X, Cai J, Chen S, Fang L, Sun J, Lou M (2021) Glymphatic clearance function in patients with cerebral small vessel disease. Neuroimage 238:118257. https://doi.org/10.1016/j.neuroimage.2021.118257

Article  PubMed  Google Scholar 

Cacciaguerra L, Carotenuto A, Pagani E, Mistri D, Radaelli M, Martinelli V, Filippi M, Rocca MA (2022) Magnetic resonance imaging evaluation of perivascular space abnormalities in neuromyelitis optica. Ann Neurol 92:173–183. https://doi.org/10.1002/ana.26419

Article  PubMed  PubMed Central  Google Scholar 

Toh CH, Siow TY (2021) Factors associated with dysfunction of glymphatic system in patients with glioma. Front Oncol 11:744318. https://doi.org/10.3389/fonc.2021.744318

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu H, Xie Y, Li L, Liu Y, Li S, Shen N, Zhang J, Yan S, Liu D, Li Y, Zhu W (2023) Diffusion along the perivascular space as a potential biomarker for glioma grading and isocitrate dehydrogenase 1 mutation status prediction. Quant Imaging Med Surg 13:8259–8273. https://doi.org/10.21037/qims-23-541

Article  PubMed  PubMed Central  Google Scholar 

Zeng S, Huang Z, Zhou W, Ma H, Wu J, Zhao C, Yang Z, Qiu H, Chu J (2024) Noninvasive evaluation of the glymphatic system in diffuse gliomas using diffusion tensor image analysis along the perivascular space. J Neurosurg 142(1):187–196. https://doi.org/10.3171/2024.4.JNS232724

Article  PubMed  Google Scholar 

Liang W, Sun W, Li C, Zhou J, Long C, Li H, Xu D, Xu H (2025) Glymphatic system dysfunction and cerebrospinal fluid retention in gliomas: evidence from perivascular space diffusion and volumetric analysis. Cancer Imaging 25:51. https://doi.org/10.1186/s40644-025-00868-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dubois LG, Campanati L, Righy C, D’Andrea-Meira I, Spohr TC, Porto-Carreiro I, Pereira CM, Balça-Silva J, Kahn SA, DosSantos MF, Oliveira MA, Ximenes-da-Silva A, Lopes MC, Faveret E, Gasparetto EL, Moura-Neto V (2014) Gliomas and the vascular fragility of the blood brain barrier. Front Cell Neurosci 8:418. https://doi.org/10.3389/fncel.2014.00418

Article  PubMed  PubMed Central  Google Scholar 

Ahmed MH, Canney M, Carpentier A, Thanou M, Idbaih A (2023) Unveiling the enigma of the blood-brain barrier in glioblastoma: current advances from preclinical and clinical studies. Curr Opin Oncol 35:522–528. https://doi.org/10.1097/cco.0000000000000990

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mestre H, Tithof J, Du T, Song W, Peng W, Sweeney AM, Olveda G, Thomas JH, Nedergaard M, Kelley DH (2018) Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension. Nat Commun 9:4878. https://doi.org/10.1038/s41467-018-07318-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abrigo JM, Fountain DM, Provenzale JM, Law EK, Kwong JSW, Hart MG, Tam WWS (2018) Magnetic resonance perfusion for differentiating low-grade from high-grade gliomas at first presentation. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD011551.pub2

Article  PubMed  PubMed Central  Google Scholar 

van Santwijk L, Kouwenberg V, Meijer F, Smits M, Henssen D (2022) A systematic review and meta-analysis on the differentiation of glioma grade and mutational status by use of perfusion-based magnetic resonance imaging. Insights Imaging 13:102. https://doi.org/10.1186/s13244-022-01230-7

Article  PubMed  PubMed Central  Google Scholar 

Paldino MJ, Barboriak DP (2009) Fundamentals of quantitative dynamic contrast-enhanced MR imaging. Magn Reson Imaging Clin N Am 17:277–289. https://doi.org/10.1016/j.mric.2009.01.007

Article  PubMed  Google Scholar 

Tofts PS, Brix G, Buckley DL, Evelhoch JL, Henderson E, Knopp MV, Larsson HB, Lee TY, Mayr NA, Parker GJ, Port RE, Taylor J, Weisskoff RM (1999) Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 10:223–232. 10.1002/(sici)1522-2586(199909)10:3%3c223::aid-jmri2%3e3.0.co;2-s

Walker-Samuel S, Leach MO, Collins DJ (2006) Evaluation of response to treatment using DCE-MRI: the relationship between initial area under the gadolinium curve (IAUGC) and quantitative pharmacokinetic analysis. Phys Med Biol 51:3593–3602. https://doi.org/10.1088/0031-9155/51/14/021

Article 

Comments (0)

No login
gif