Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA (2012) NedergaardM. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med 4(147):147ra111. https://doi.org/10.1126/scitranslmed.3003748
Article CAS PubMed PubMed Central Google Scholar
Beschorner N, Nedergaard M (2024) Glymphatic system dysfunction in neurodegenerative diseases. Curr Opin Neurol 37(2):182–188. https://doi.org/10.1097/WCO.0000000000001252
Article CAS PubMed Google Scholar
Albayram MS, Smith G, Tufan F, Tuna IS, Bostancıklıoğğlu M, Zile M, Albayram O (2022) Non-invasive MRimaging of human brain lymphatic networks with connections to cervical lymph nodes. Nat Commun 13(1):203. https://doi.org/10.1038/s41467-021-27887-0
Article CAS PubMed PubMed Central Google Scholar
Mestre H, Mori Y, Nedergaard M (2020) The brain's glymphatic system: current controversies. Trends Neurosci 43(7):458–466. https://doi.org/10.1016/j.tins.2020.04.003
Article CAS PubMed PubMed Central Google Scholar
Rasmussen MK, Mestre H, Nedergaard M (2018) The glymphatic pathway inneurological disorders. Lancet Neurol 17(11):1016–1024
Article CAS PubMed PubMed Central Google Scholar
Kress BT, Iliff JJ, Xia M, Wang M, Wei HS, Zeppenfeld D, Xie L, Kang H, Xu Q, Liew JA, Plog BA, Ding F, Deane R, Nedergaard M (2014) Impairment of paravascular clearance pathways in the aging brain. Ann Neurol 76(6):845–861. https://doi.org/10.1002/ana.24271
Article CAS PubMed PubMed Central Google Scholar
Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris TH, Kipnis J (2015) Structural and functional features of central nervous system lymphatic vessels. Nature 523(7560):337–341. https://doi.org/10.1038/nature14432
Article CAS PubMed PubMed Central Google Scholar
Absinta M, HaSK, Nair G, Sati P, Luciano NJ, Palisoc M, Louveau A, Zaghloul KA, Pittaluga S, Kipnis J, Reich DS (2017) Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI. Elife 6:e29738. https://doi.org/10.7554/eLife.29738
Article PubMed PubMed Central Google Scholar
Ringstad G, Eide PK (2020) Cerebrospinal fluid tracer efflux toparasagittal dura in humans. Nat Commun 11(1):354. https://doi.org/10.1038/s41467-019-14195-x
Article CAS PubMed PubMed Central Google Scholar
Da Mesquita S, Papadopoulos Z, Dykstra T, Brase L, Farias FG, Wall M, Jiang H, Kodira CD, de Lima KA, Herz J, Louveau A, Goldman DH, Salvador AF, Onengut-Gumuscu S, Farber E, Dabhi N, Kennedy T, Milam MG, Baker W, Smirnov I, Rich SS, Dominantly Inherited Alzheimer Network, Benitez BA, Karch CM, Perrin RJ, Farlow M, Chhatwa CJP, Holtzman DM, Cruchaga C, Harari O, Kipnis J (2021) Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy. Nature 593(7858):255–260. https://doi.org/10.1038/s41586-021-03489-0
Article CAS PubMed PubMed Central Google Scholar
Zou W, Pu T, Feng W, Lu M, Zheng Y, Du R, Xiao M, Hu G (2019) Blocking meningeal lymphatic drainage aggravates Parkinson's disease-like pathology in mice overexpressing mutated α-synuclein. Transl Neurodegener 8:7. https://doi.org/10.1186/s40035-019-0147-y
Article PubMed PubMed Central Google Scholar
Bolte AC, Dutta AB, Hurt ME, Smirnov I, Kovacs MA, McKee CA, Ennerfelt HE, Shapiro D, Nguyen BH, Frost EL, Lammert CR, Kipnis J, Lukens JR (2020) Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis. Nat Commun 11(1):4524. https://doi.org/10.1038/s41467-020-18113-4
Article CAS PubMed PubMed Central Google Scholar
Ringstad G, Valnes LM, Dale AM, Pripp AH, Vatnehol SS, Emblem KE, Mardal KA, Eide PK (2018) Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. JCI Insight 3(13):e121537. https://doi.org/10.1172/jci.insight.121537
Article PubMed PubMed Central Google Scholar
Naganawa S, Taoka T (2022) The glymphatic system: a review of the challenges in visualizing its structure and function with MR imaging. Magn Reson Med Sci 21(1):182–194. https://doi.org/10.2463/mrms.rev.2020-0122
Article CAS PubMed Google Scholar
Yu L, Hu X, Li H, Zhao Y (2022) Perivascular spaces, glymphatic system and MR. Front Neurol 13:844938. https://doi.org/10.3389/fneur.2022.844938
Article PubMed PubMed Central Google Scholar
Nedergaard M, Neuroscience (2013) Garbage truck of the brain. Science 340(6140):1529–1530. https://doi.org/10.1126/science.1240514.1240514
Article CAS PubMed PubMed Central Google Scholar
Fultz NE, Bonmassar G, Setsompop K, Stickgold RA, Rosen BR, Polimeni JR, Lewis LD (2019) Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations inhuman sleep. Science 366(6465):628–631. https://doi.org/10.1126/science.aax5440
Article CAS PubMed PubMed Central Google Scholar
Zimmermann J, Boudriot C, Eipert C, Hoffmann G, Nuttall R, Schneider S, Schmitzer L, Kufer J, Kaczmarz S, Hedderich DM, Ranft A, Golkowski D, Priller J, Zimmer C, Ilg Rüdiger, Schneider G, Preibisch C Sorg C Benedikt Zott. Total cerebral bloodvolume changes drive macroscopic cerebrospinal fluid flux in humans bioRxiv 2023.04.13.536674. https://doi.org/10.1101/2023.04.13.536674
Zhou Y, Cai J, Zhang W, Gong X, Yan S, Zhang K, Luo Z, Sun J, Jiang Q, Lou M (2020) Impairment of the glymphatic pathway and putative meningeal lymphatic vessels in the aging human. Ann Neurol 87:357–369. https://doi.org/10.1002/ana.25670
Article CAS PubMed Google Scholar
Jacob L, Neto JB, Lenck S, Corcy C, Benbelkacem F, Geraldo LH, Xu Y, Thomas J-M, Kamouh M-RE, Spajer M, Potier M-C, Haik S, Kalamarides M, Stankoff B (2022) Conserved meningeal lymphatic drainage circuits in mice and humans. J Exp Med 219(8):e20220035. https://doi.org/10.1084/jem.20220035
Article CAS PubMed PubMed Central Google Scholar
Absinta M, Ha SK, Nair G, Sati P, Luciano NJ, Palisoc M, Louveau A, Zaghloul KA, Pittaluga S, Kipnis J, Reich DS (2017) Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI. Elife 6:e29738. https://doi.org/10.7554/eLife.29738
Article PubMed PubMed Central Google Scholar
Ringstad G, Eide PK (2024) Glymphatic-lymphatic coupling: assessment of the evidence from magnetic resonance imaging of humans. Cell Mol Life Sci 81:131. https://doi.org/10.1007/s00018-024-05141-2
Article CAS PubMed PubMed Central Google Scholar
Shah T, Leurgans SE, Mehta RI, Yang J, Galloway CA, de Mesy Bentley KL, Schneider JA, Mehta RI (2023) Arachnoid granulations are lymphaticconduits that communicate with bone marrow and dura-arachnoid stroma. J Exp Med 220(2):e20220618. https://doi.org/10.1084/jem.20220618
Article CAS PubMed Google Scholar
Avram M, Brandl F, Cabello J, Leucht C, Scherr M, Mustafa M, Leucht S, Ziegler S, Sorg C (2019) Reduced striatal dopamine synthesis capacity in patients with schizophrenia during remission of positive symptoms. Brain: J Neurology 142(6):1813–1826. https://doi.org/10.1093/brain/awz093
Isensee F, Jaeger PF, Kohl SAA, Petersen J, Maier-Hein KH (2021) nnU-Net: a self-configuring method for deep learning-based biomedical image segmentation. Nat Methods 18(2):203–211. https://doi.org/10.1038/s41592-020-01008-z
Article CAS PubMed Google Scholar
Modat M, Ridgway GR, Taylor ZA, Lehmann M, Barnes J, Hawkes DJ, Fox NC, Ourselin S (2010) Fast free-form deformation using graphics processing units. Comput Methods Programs Biomed 98(3):278–284. https://doi.org/10.1016/j.cmpb.2009.09.002f
Comments (0)