Quigley RM, Kearney M, Kennedy OD, Duncan HF. Tissue engineering approaches for dental pulp regeneration: the development of novel bioactive materials using pharmacological epigenetic inhibitors. Bioact Mater. 2024;40:182–211.

CAS  PubMed  PubMed Central  Google Scholar 

Pisciotta A, Carnevale G, Meloni S, Riccio M, De Biasi S, Gibellini L, et al. Human dental pulp stem cells (hDPSCs): isolation, enrichment and comparative differentiation of two sub-populations. BMC Dev Biol. 2015;15:14.

Article  PubMed  PubMed Central  Google Scholar 

Mattei V, Martellucci S, Pulcini F, Santilli F, Sorice M, Delle Monache S. Regenerative potential of DPSCs and revascularization: direct, paracrine or autocrine effect? Stem Cell Rev Rep. 2021;17(5):1635–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gan L, Liu Y, Cui D, Pan Y, Zheng L, Wan M. Dental tissue-derived human mesenchymal stem cells and their potential in therapeutic application. Stem Cells Int. 2020;2020:8864572.

Article  PubMed  PubMed Central  Google Scholar 

Li M, Sun X, Ma L, Jin L, Zhang W, Xiao M, et al. SDF-1/CXCR4 axis induces human dental pulp stem cell migration through FAK/PI3K/Akt and GSK3β/β-catenin pathways. Sci Rep. 2017;7:40161.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zaim M, Karaman S, Cetin G, Isik S. Donor age and long-term culture affect differentiation and proliferation of human bone marrow mesenchymal stem cells. Ann Hematol. 2012;91(8):1175–86.

Article  PubMed  Google Scholar 

Alraies A, Alaidaroos NY, Waddington RJ, Moseley R, Sloan AJ. Variation in human dental pulp stem cell ageing profiles reflect contrasting proliferative and regenerative capabilities. BMC Cell Biol. 2017;18(1):12.

Article  PubMed  PubMed Central  Google Scholar 

Chen Q, Shou P, Zheng C, Jiang M, Cao G, Yang Q, et al. Fate decision of mesenchymal stem cells: adipocytes or osteoblasts? Cell Death Differ. 2016;23(7):1128–39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma D, Ma Z, Zhang X, Wang W, Yang Z, Zhang M, et al. Effect of age and extrinsic microenvironment on the proliferation and osteogenic differentiation of rat dental pulp stem cells in vitro. J Endod. 2009;35(11):1546–53.

Article  PubMed  Google Scholar 

Li X, Feng L, Zhang C, Wang J, Wang S, Hu L. Insulin-like growth factor binding proteins 7 prevents dental pulp-derived mesenchymal stem cell senescence via metabolic downregulation of p21. Sci China Life Sci. 2022;65(11):2218–32.

Article  CAS  PubMed  Google Scholar 

He X, Yang Z, Chu XY, Li YX, Zhu B, Huang YX, et al. ROR2 downregulation activates the MSX2/NSUN2/p21 regulatory axis and promotes dental pulp stem cell senescence. Stem cells (Dayton, Ohio). 2022;40(3):290–302.

Article  PubMed  Google Scholar 

Gao Y, Qiao X, Liu Z, Zhang W. The role of E2F2 in cancer progression and its value as a therapeutic target. Front Immunol. 2024;15:1397303.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu H, Chen L, Xiao W, Liu J, Long C, Zhan W, et al. Alteration of E2F2 expression in governing endothelial cell senescence. Genes Basel. 2022. https://doi.org/10.3390/genes13091522.

Article  PubMed  PubMed Central  Google Scholar 

Iglesias-Ara A, Zenarruzabeitia O, Fernandez-Rueda J, Sánchez-Tilló E, Field SJ, Celada A, et al. Accelerated DNA replication in E2F1- and E2F2-deficient macrophages leads to induction of the DNA damage response and p21(CIP1)-dependent senescence. Oncogene. 2010;29(41):5579–90.

Article  CAS  PubMed  Google Scholar 

Lin QY, Wang JQ, Wu LL, Zheng WE, Chen PR. miR-638 represses the stem cell characteristics of breast cancer cells by targeting E2F2. Breast cancer (Tokyo, Japan). 2020;27(1):147–58.

Article  PubMed  Google Scholar 

Suzuki DE, Nakahata AM, Okamoto OK. Knockdown of E2F2 inhibits tumorigenicity, but preserves stemness of human embryonic stem cells. Stem Cells Dev. 2014;23(11):1266–74.

Article  CAS  PubMed  Google Scholar 

Huang Y, Zeng J, Liu T, Xu Q, Song X, Zeng J. E2F2/MUC1 enhances cell stemness of hepatocellular carcinoma by regulating the Notch signaling pathway. Dig Dis Sci. 2025;70(9):3056–65.

Article  CAS  PubMed  Google Scholar 

Kim JH, Kim WK, Sung YK, Kwack MH, Song SY, Choi JS, et al. The molecular mechanism underlying the proliferating and preconditioning effect of vitamin C on adipose-derived stem cells. Stem Cells Dev. 2014;23(12):1364–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Menicanin D, Bartold PM, Zannettino AC, Gronthos S. Identification of a common gene expression signature associated with immature clonal mesenchymal cell populations derived from bone marrow and dental tissues. Stem Cells Dev. 2010;19(10):1501–10.

Article  CAS  PubMed  Google Scholar 

Luo H, Liu W, Zhang Y, Yang Y, Jiang X, Wu S, et al. METTL3-mediated m(6)A modification regulates cell cycle progression of dental pulp stem cells. Stem Cell Res Ther. 2021;12(1):159.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ko CS, Chen JH, Su WT. Stem cells from human exfoliated deciduous teeth: a concise review. Curr Stem Cell Res Ther. 2020;15(1):61–76.

Article  CAS  PubMed  Google Scholar 

Shi X, Mao J, Liu Y. Pulp stem cells derived from human permanent and deciduous teeth: biological characteristics and therapeutic applications. Stem Cells Transl Med. 2020;9(4):445–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang H, Li W, Yang H, Cao Y, Ge L, Shi R, et al. FAM96B inhibits the senescence of dental pulp stem cells. Cell Biol Int. 2020;44(5):1193–203.

Article  CAS  PubMed  Google Scholar 

Coutts AS, Munro S, La Thangue NB. Functional interplay between E2F7 and ribosomal rRNA gene transcription regulates protein synthesis. Cell Death Dis. 2018;9(5):577.

Article  PubMed  PubMed Central  Google Scholar 

Hua R, Chu Q, Guo F, Chen Q, Li M, Zhou X, et al. DNM3OS enhances the apoptosis and senescence of spermatogonia associated with nonobstructive azoospermia by providing miR-214-5p and decreasing E2F2 expression. Anal Cell Pathol (Amst). 2023;2023:1477658.

Article  PubMed  PubMed Central  Google Scholar 

Zhang Q, Wu Y, Guan Y, Ling F, Li Y, Niu Y. Epigallocatechin gallate prevents senescence by alleviating oxidative stress and inflammation in WI-38 human embryonic fibroblasts. RSC Adv. 2019;9(46):26787–98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu R, Shen X, Si Y, Fu Y, Zhu W, Xiao T, et al. MicroRNA-31a-5p from aging BMSCs links bone formation and resorption in the aged bone marrow microenvironment. Aging Cell. 2018;17(4):e12794.

Article  PubMed  PubMed Central  Google Scholar 

Ding N, Geng B, Li Z, Yang Q, Yan L, Wan L, et al. Fluid shear stress promotes osteoblast proliferation through the NFATc1-ERK5 pathway. Connect Tissue Res. 2019;60(2):107–16.

Article  CAS  PubMed  Google Scholar 

Liu S, Zhuo L, Wang J, Zhang Q, Li Q, Li G, et al. METTL3 plays multiple functions in biological processes. Am J Cancer Res. 2020;10(6):1631–46.

CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Chen Y, Xiao H, Liu Z, Liu X, Feng Z, et al. METTL3-mediated m6A modification increases Hspa1a stability to inhibit osteoblast aging. Cell Death Discov. 2024;10(1):155.

Article