Associations of the Charlson comorbidity index with asthma and mortality (NHANES 2007–2018): a cross-sectional study

Bergeron C, Tulic MK, Hamid Q. Airway remodelling in asthma: from benchside to clinical practice. Can Respir J. 2010;17(4):e85–93.

PubMed  PubMed Central  Google Scholar 

Mims JW. Asthma: definitions and pathophysiology. Int Forum Allergy Rhinol. 2015;5(Suppl 1):S2-6.

PubMed  Google Scholar 

Ray A, Kolls JK. Neutrophilic inflammation in asthma and association with disease severity. Trends Immunol. 2017;38(12):942–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Komlósi ZI, van de Veen W, Kovács N, Szűcs G, Sokolowska M, O’Mahony L, et al. Cellular and molecular mechanisms of allergic asthma. Mol Aspects Med. 2022;85:100995.

Article  PubMed  Google Scholar 

Lambrecht BN, Hammad H. The immunology of asthma. Nat Immunol. 2015;16(1):45–56.

Article  CAS  PubMed  Google Scholar 

Global regional. National deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the global burden of disease study 2015. Lancet Respir Med. 2017;5(9):691–706.

Article  Google Scholar 

Global burden of chronic respiratory diseases and risk factors. 1990–2019: an update from the global burden of disease study 2019. EClinicalMedicine. 2023;59:101936.

Article  Google Scholar 

Dharmage SC, Perret JL, Custovic A. Epidemiology of asthma in children and adults. Front Pediatr. 2019;7:246.

Article  PubMed  PubMed Central  Google Scholar 

Gibson PG, McDonald VM, Granchelli A, Olin JT. Asthma and comorbid conditions-pulmonary comorbidity. The Journal of Allergy and Clinical Immunology: In Practice. 2021;9(11):3868–75.

PubMed  Google Scholar 

McDonald VM, Hiles SA, Godbout K, Harvey ES, Marks GB, Hew M, et al. Treatable traits can be identified in a severe asthma registry and predict future exacerbations. Respirology. 2019;24(1):37–47.

Article  PubMed  Google Scholar 

Audenet F, Audouin M, Drouin SJ, Comperat E, Mozer P, Chartier-Kastler E, et al. Charlson score as a single pertinent criterion to select candidates for active surveillance among patients with small renal masses. World J Urol. 2014;32(2):513–8.

Article  PubMed  Google Scholar 

Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–83.

Article  CAS  PubMed  Google Scholar 

Jouffroy R, Parfait PA, Gilbert B, Tourtier JP, Bloch-Laine E, Ecollan P, et al. Relationship between prehospital modified Charlson comorbidity index and septic shock 30-day mortality. Am J Emerg Med. 2022;60:128–33.

Article  PubMed  Google Scholar 

Hemmelgarn BR, Manns BJ, Quan H, Ghali WA. Adapting the Charlson comorbidity index for use in patients with ESRD. Am J Kidney Dis. 2003;42(1):125–32.

Article  PubMed  Google Scholar 

Tattersall MC, Guo M, Korcarz CE, Gepner AD, Kaufman JD, Liu KJ, et al. Asthma predicts cardiovascular disease events: the multi-ethnic study of atherosclerosis. Arterioscler Thromb Vasc Biol. 2015;35(6):1520–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brumpton BM, Camargo CA Jr., Romundstad PR, Langhammer A, Chen Y, Mai XM. Metabolic syndrome and incidence of asthma in adults: the HUNT study. Eur Respir J. 2013;42(6):1495–502.

Ji J, Shu X, Li X, Sundquist K, Sundquist J, Hemminki K. Cancer risk in hospitalised asthma patients. Br J Cancer. 2009;100(5):829–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iribarren C, Tolstykh IV, Miller MK, Sobel E, Eisner MD. Adult asthma and risk of coronary heart disease, cerebrovascular disease, and heart failure: a prospective study of 2 matched cohorts. Am J Epidemiol. 2012;176(11):1014–24.

Article  PubMed  Google Scholar 

Ingebrigtsen TS, Marott JL, Vestbo J, Nordestgaard BG, Lange P. Coronary heart disease and heart failure in asthma, COPD and asthma-COPD overlap. BMJ Open Respir Res. 2020;7(1):e000470. https://doi.org/10.1136/bmjresp-2019-000470

Article  Google Scholar 

Jiang Y, Huang X, Yu D, Xu C, Wang Y, Wang X, et al. Asthma and the risk of cardiovascular diseases and mortality: a meta-analysis of cohort studies. Ther Adv Respir Dis. 2025;19:17534666251333965.

Article  PubMed  PubMed Central  Google Scholar 

Cardet JC, Ash S, Kusa T, Camargo CA Jr., Israel E. Insulin resistance modifies the association between obesity and current asthma in adults. Eur Respir J. 2016;48(2):403–10.

Yeh HC, Punjabi NM, Wang NY, Pankow JS, Duncan BB, Cox CE, et al. Cross-sectional and prospective study of lung function in adults with type 2 diabetes: the atherosclerosis risk in communities (ARIC) study. Diabetes Care. 2008;31(4):741–6.

Article  PubMed  Google Scholar 

Kanazawa H, Yoshikawa J. Accelerated decline in lung function and impaired reversibility with salbutamol in asthmatic patients with chronic hepatitis C virus infection: a 6-year follow-up study. Am J Med. 2004;116(11):749–52.

Article  CAS  PubMed  Google Scholar 

Nakashima T, Yokoyama A, Ohnishi H, Yamasaki M, Shiode M, Haruta Y, et al. Chronic hepatitis C virus infection is associated with more severe asthma. Allergol Int. 2011;60(3):299–304.

Article  PubMed  Google Scholar 

Alashkar Alhamwe B, Yuskaeva K, Wulf F, Trinkmann F, Kriegsmann M, Thomas M, et al. Peripheral inflammation featuring eosinophilia or neutrophilia is associated with the survival and infiltration of eosinophils within the tumor among various histological subgroups of patients with NSCLC. Int J Mol Sci. 2024;25(17):9552. https://doi.org/10.3390/ijms25179552

Article  CAS  Google Scholar 

He MM, Lo CH, Wang K, Polychronidis G, Wang L, Zhong R, et al. Immune-mediated diseases associated with cancer risks. JAMA Oncol. 2022;8(2):209–19.

Article  PubMed  Google Scholar 

Bekaert S, Rocks N, Vanwinge C, Noel A, Cataldo D. Asthma-related inflammation promotes lung metastasis of breast cancer cells through CCL11-CCR3 pathway. Respir Res. 2021;22(1):61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Su YL, Chou CL, Rau KM, Lee CT. Asthma and risk of prostate cancer: a population-based case-cohort study in Taiwan. Medicine (Baltimore). 2015;94(36):e1371.

Article  CAS  PubMed  Google Scholar 

Vesterinen E, Pukkala E, Timonen T, Aromaa A. Cancer incidence among 78,000 asthmatic patients. Int J Epidemiol. 1993;22(6):976–82.

Article  CAS  PubMed  Google Scholar 

Charlson ME, Carrozzino D, Guidi J, Patierno C. Charlson comorbidity index: a critical review of clinimetric properties. Psychother Psychosom. 2022;91(1):8–35.

Article  PubMed  Google Scholar 

Adrish M, Hanania NA. Asthma and cardiovascular disease: a bidirectional association? Respirology. 2023;28(3):217–9.

Article  PubMed  Google Scholar 

Wu TD, Brigham EP, Keet CA, Brown TT, Hansel NN, McCormack MC. Association between Prediabetes/Diabetes and asthma exacerbations in a Claims-Based obese asthma cohort. J Allergy Clin Immunol Pract. 2019;7(6):1868–e735.

Article  PubMed  PubMed Central  Google Scholar 

Woo A, Lee SW, Koh HY, Kim MA, Han MY, Yon DK. Incidence of cancer after asthma development: 2 independent population-based cohort studies. J Allergy Clin Immunol. 2021;147(1):135–43.

Article  CAS  PubMed  Google Scholar 

Yu S, Lee SC, Hong JH, Han CH, Park SC, Jung JY. Cardiovascular and cerebrovascular mortality in patients with preceding asthma exacerbation. Respirology. 2023;28(3):281–6.

Article  PubMed  Google Scholar 

Cazzola M, Rogliani P, Ora J, Calzetta L, Matera MG. Asthma and comorbidities: recent advances. Pol Arch Intern Med. 2022;132(4):16250.

Lemmetyinen RE, Toppila-Salmi SK, But A, Renkonen R, Pekkanen J, Haukka J, et al. Comorbidities associated with adult asthma: a population-based matched cohort study in Finland. BMJ Open Respir Res. 2024;11(1):e001959. https://doi.org/10.1136/bmjresp-2023-001959

Article  PubMed  PubMed Central 

Comments (0)

No login
gif