Worldwide around 8.6 million people get TB, out of which 1.3 million people die from the disease every year. World Health Organization has identified that TB now a day becomes a critical global public health problem with major cause of mortality in various underdeveloped countries. Immunosuppressive diseases indirectly make the patients susceptible to tuberculosis [12]. According to an estimate 10–30% of TB patients also suffer from Diabetes Mellitus, which showed a significant association between tuberculosis and diabetes [13].

In this study we investigate the association of DM and TB and explore the effect of therapeutics on blood glucose level, C-reactive protein and erythrocyte sedimentation rate (ESR) in TB patients as measure of inflammation, furthermore, the association of the diabetes and TB was also discovered by checking blood glucose level of TB patients before and after therapy. In the current it was observed that the treatment doesn’t affect the blood glucose level among the TB patients. However, treatment decreases the frequency of CRP positive patients and increases the ESR among the TB patients. Reduction in serum CRP level and elevation in ESR has also noticed earlier [14]. Low CRP level and high ESR has also been observed previously in another study [15].

The Gender wise clinical assessment of our study reveals that the various parameters are not influenced by the treatment among both gender. However, the frequency of CRP positive patients was relatively high among the female. The mean ESR value was also observed higher among the female as compared to male. According to a previous investigation, gender and age were not found to have any influence on the ESR and CRP values [15]. Earlier it has been shows the ESR values are usually higher in females as compared to males and rises with age, whereas the values of CRP changes minimally with age [16].

Similarly, the various clinical parameters were also assessed among the different age groups of TB patients following treatment. The patients were classified in three age groups. The clinical evaluation of TB patients from different age groups shows that various parameters i.e. RBS, ESR and CRP do not alter following Myrin-P-Forte and Myrin-P-Forte Plus Streptomycin treatment. However, the frequency of CRP positive patients was comparatively high among the TB patients of age group < 25 and > 50. The mean ESR values were found relatively high among the age group below 50 years. Overall age in correlation with treatment does not affect the ESR and CRP, however, in patient above 50 the frequency of CRP positive patients lowers a little after the treatment. The glucose level was much higher among the TB patients of age above 50 years but do not change after treatment. These are in line with the earlier findings that show no correlation between the age, CRP and ESR among the TB patients [15].

The TB patients were receiving either Myrin P Forte or Myrin P Forte plus streptomycin. It was observed that neither of the therapeutic regime affect the various clinical parameters among the TB patients. However, TB patients who were receiving Myrin P Forte were relatively more hyperglycemic and have also comparatively high frequency of CRP positive cases. Along with TB patients were also found to suffer from other clinical complications including diabetes, Gastro enteritis and Hypertensive. Following treatment, it was determined that there is a significant decline in the cases of CRP positive in TB patients who were also suffering from other clinical manifestation. However, ESR and RBS were not influenced following the treatment among the TB patients either suffering or not from other clinical complications. The effect of treatment in association with diabetes was also assessed among the TB patients. A significant reduction in the frequency of CRP positive cases was noticed among the TB patients who were also suffering from diabetes. It means that treatment improves CRP in TB patients with diabetes.

Furthermore, our study reveals significant frequency of diabetes among the TB patients (21.42%), this showed that there is significant correlation between the two. The frequency was relatively higher in females (28%) as compared males (16.12%). Similarly, diabetic frequency also higher among the patients above 50 years. Various earlier studies have demonstrated the correlation of diabetes and TB based on various aspects. The correlation of TB and diabetes in older age patients has been studied earlier [17, 18]. It was also described earlier that diabetes is more common in TB patients as compared to control subjects with profound reduction in hyperglycemia following anti-TB treatment Alisjahbana et al. [18]. It has also been that DM increases the incidence of TB and also negatively affects the therapeutic outcomes for the TB [19].