Swatek, K. N. & Komander, D. Ubiquitin modifications. Cell Res. 26, 399–422 (2016).
Article CAS PubMed PubMed Central Google Scholar
Cohen, M. S. & Chang, P. Insights into the biogenesis, function, and regulation of ADP-ribosylation. Nat. Chem. Bio.l 14, 236–243 (2018).
Dikic, I. & Schulman, B. A. An expanded lexicon for the ubiquitin code. Nat. Rev. Mol. Cell Biol. 24, 273–287 (2023).
Article CAS PubMed Google Scholar
Zhang, Y. et al. RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. Nat. Cell Biol. 13, 623–629 (2011).
Article CAS PubMed Google Scholar
Perrard, J. & Smith, S. Multiple E3 ligases control tankyrase stability and function. Nat. Commun. 14, 7208 (2023).
Article CAS PubMed PubMed Central Google Scholar
DaRosa, P. A. et al. Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal. Nature 517, 223–226 (2015).
Article CAS PubMed Google Scholar
Yang, C. S. et al. Ubiquitin Modification by the E3 Ligase/ADP-ribosyltransferase Dtx3L/Parp9. Mol. Cell 66, 503–516 (2017).
Article CAS PubMed PubMed Central Google Scholar
Zhu, K. et al. DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates. Sci. Adv. 8, eadd4253 (2022).
Article CAS PubMed PubMed Central Google Scholar
Bejan, D. S., Lacoursiere, R. E., Pruneda, J. N. & Cohen, M. S. Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-ribose. EMBO J. 44, 2211–2231 (2025).
Article CAS PubMed PubMed Central Google Scholar
Kolvenbach, A. et al. Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation. Nat. Chem. Biol. https://doi.org/10.1038/s41589-025-01974-5 (2025).
Perrard, J., Gao, K., Ring, K. & Smith, S. Deltex and RING-UIM E3 ligases cooperate to create a ubiquitin-ADP-ribose hybrid mark on tankyrase, promoting its stabilization. Sci. Adv. 5, eadx7172 (2025).
Lacoursiere, R. E. et al. A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation. Preprint at bioRxiv https://doi.org/10.1101/2025.05.11.653360 (2025).
Kloet, M. S. et al. Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose. Nat. Commun. 16, 6319 (2025).
Article CAS PubMed PubMed Central Google Scholar
Longarini, E. J. et al. Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling. Mol. Cell 83, 1743–1760 (2023).
Comments (0)