GBD 2019 Stroke Collaborators (2021) Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol 20(10):795–820. https://doi.org/10.1016/S1474-4422(21)00252-0

Tsao CW, Aday AW, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, Baker-Smith CM, Beaton AZ, Boehme AK, Buxton AE, Commodore-Mensah Y, Elkind MSV, Evenson KR, Eze-Nliam C, Fugar S, Generoso G, Heard DG, Hiremath S, Ho JE, Kalani R, Kazi DS, Ko D, Levine DA, Liu J, Ma J, Magnani JW, Michos ED, Mussolino ME, Navaneethan SD, Parikh NI, Poudel R, Rezk-Hanna M, Roth GA, Shah NS, St-Onge MP, Thacker EL, Virani SS, Voeks JH, Wang NY, Wong ND, Wong SS, Yaffe K, Martin SS, American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee (2023) Heart Disease and Stroke Statistics-2023 update: a report from the American Heart Association. Circulation 147(8):e93-e621. https://doi.org/10.1161/CIR.0000000000001123. Epub 2023 Jan 25. Erratum in: Circulation. 2023 Feb 21;147(8):e622. https://doi.org/10.1161/CIR.0000000000001137. Erratum in: Circulation. 2023 Jul 25;148(4):e4. https://doi.org/10.1161/CIR.0000000000001167

Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE 3rd (1993) Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 24(1):35–41. https://doi.org/10.1161/01.str.24.1.35

Ntaios G (2020) Embolic stroke of undetermined source: JACC review topic of the week. J Am Coll Cardiol 75(3):333–340. https://doi.org/10.1016/j.jacc.2019.11.024

Article  PubMed  CAS  Google Scholar 

Rybak K, D Ancona G, Glück S, Haerer W, Goss F (2023) SPIDER-AF Investigators. Detection of atrial fibrillation using an implantable loop recorder in patients with previous cryptogenic stroke: the SPIDER-AF registry (Stroke Prevention by Increasing DEtection Rates of Atrial Fibrillation). Clin Res Cardiol 112(12):1848–1859. https://doi.org/10.1007/s00392-023-02283-4

Goette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D’Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim YH, Lip GY, Ma CS, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S (2017) EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication. Heart Rhythm 14(1):e3–e40. https://doi.org/10.1016/j.hrthm.2016.05.028

Article  PubMed  Google Scholar 

Kariki O, Vlachos K, Dragasis S, Tsetika EG, Perlepe K, Saplaouras A, Nyktari E, Efremidis M, Letsas KP (2023) Atrial cardiomyopathy: diagnosis, clinical implications and unresolved issues in anticoagulation therapy. J Electrocardiol 76:1–10. https://doi.org/10.1016/j.jelectrocard.2022.10.012

Article  PubMed  Google Scholar 

Gentille-Lorente D, Hernández-Pinilla A, Satue-Gracia E, Muria-Subirats E, Forcadell-Peris MJ, Gentille-Lorente J, Ballesta-Ors J, Martín-Lujan FM, Clua-Espuny JL (2023) Echocardiography and electrocardiography in detecting atrial cardiomyopathy: a promising path to predicting cardioembolic strokes and atrial fibrillation. J Clin Med 12(23):7315. https://doi.org/10.3390/jcm12237315.PMID:38068367;PMCID:PMC10707718

Article  PubMed  PubMed Central  Google Scholar 

Cameli M, Caputo M, Mondillo S, Ballo P, Palmerini E, Lisi M, Marino E, Galderisi M (2009) Feasibility and reference values of left atrial longitudinal strain imaging by two-dimensional speckle tracking. Cardiovasc Ultrasound 8(7):6. https://doi.org/10.1186/1476-7120-7-6.PMID:19200402;PMCID:PMC2652427

Article  Google Scholar 

Hong J, Gu X, An P, Luo T, Lv Q, Kang J, He Y, Hu R, Liu X, Ma C (2013) Left atrial functional remodeling in lone atrial fibrillation: a two-dimensional speckle tracking echocardiographic study. Echocardiography 30(9):1051–1060. https://doi.org/10.1111/echo.12200

Article  PubMed  Google Scholar 

Shang Z, Su D, Cong T, Sun Y, Liu Y, Chen N, Yang J (2017) Assessment of left atrial mechanical function and synchrony in paroxysmal atrial fibrillation with two-dimensional speckle tracking echocardiography. Echocardiography 34(2):176–183. https://doi.org/10.1111/echo.13434

Article  PubMed  Google Scholar 

Henein M, Zhao Y, Henein MY, Lindqvist P (2012) Disturbed left atrial mechanical function in paroxysmal atrial fibrillation: a speckle tracking study. Int J Cardiol 155(3):437–441. https://doi.org/10.1016/j.ijcard.2011.10.007

Article  PubMed  Google Scholar 

Tsai WC, Lee CH, Lin CC, Liu YW, Huang YY, Li WT, Chen JY, Lin LJ (2009) Association of left atrial strain and strain rate assessed by speckle tracking echocardiography with paroxysmal atrial fibrillation. Echocardiography 26(10):1188–1194. https://doi.org/10.1111/j.1540-8175.2009.00954.x

Article  PubMed  Google Scholar 

Machino-Ohtsuka T, Seo Y, Tada H, Ishizu T, Machino T, Yamasaki H, Igarashi M, Xu D, Sekiguchi Y, Aonuma K (2011) Left atrial stiffness relates to left ventricular diastolic dysfunction and recurrence after pulmonary vein isolation for atrial fibrillation. J Cardiovasc Electrophysiol 22(9):999–1006. https://doi.org/10.1111/j.1540-8167.2011.02049.x

Article  PubMed  Google Scholar 

Tops LF, Delgado V, Bertini M, Marsan NA, Den Uijl DW, Trines SA, Zeppenfeld K, Holman E, Schalij MJ, Bax JJ (2011) Left atrial strain predicts reverse remodeling after catheter ablation for atrial fibrillation. J Am Coll Cardiol 57(3):324–331. https://doi.org/10.1016/j.jacc.2010.05.063

Article  PubMed  Google Scholar 

Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, Boriani G, Castella M, Dan GA, Dilaveris PE, Fauchier L, Filippatos G, Kalman JM, La Meir M, Lane DA, Lebeau JP, Lettino M, Lip GYH, Pinto FJ, Thomas GN, Valgimigli M, Van Gelder IC, Van Putte BP, Watkins CL; ESC Scientific Document Group (2021) 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J 42(5):373–498. https://doi.org/10.1093/eurheartj/ehaa612. Erratum in: Eur Heart J. 2021 Feb 1;42(5):507. https://doi.org/10.1093/eurheartj/ehaa798. Erratum in: Eur Heart J. 2021 Feb 1;42(5):546–547. https://doi.org/10.1093/eurheartj/ehaa945. Erratum in: Eur Heart J. 2021 Oct 21;42(40):4194. https://doi.org/10.1093/eurheartj/ehab648

Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, Biller J, Brown M, Demaerschalk BM, Hoh B, Jauch EC, Kidwell CS, Leslie-Mazwi TM, Ovbiagele B, Scott PA, Sheth KN, Southerland AM, Summers DV, Tirschwell DL (2019) Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 50(12):e344-e418. https://doi.org/10.1161/STR.0000000000000211. Epub 2019 Oct 30. Erratum in: Stroke. 2019 Dec;50(12):e440-e441. https://doi.org/10.1161/STR.0000000000000215

Hart RG, Diener HC, Coutts SB, Easton JD, Granger CB, O’Donnell MJ, Sacco RL, Connolly SJ, Cryptogenic Stroke/ESUS International Working Group (2014) Embolic strokes of undetermined source: the case for a new clinical construct. Lancet Neurol 13(4):429–438. https://doi.org/10.1016/S1474-4422(13)70310-7

Article  PubMed  Google Scholar 

Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 28(1):1–39.e14. https://doi.org/10.1016/j.echo.2014.10.003

Article  PubMed  Google Scholar 

Badano LP, Kolias TJ, Muraru D, Abraham TP, Aurigemma G, Edvardsen T, D’Hooge J, Donal E, Fraser AG, Marwick T, Mertens L, Popescu BA, Sengupta PP, Lancellotti P, Thomas JD, Voigt JU, Industry representatives; Reviewers: this document was reviewed by members of the 2016–2018 EACVI Scientific Documents Committee (2018) Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging. Eur Heart J Cardiovasc Imaging 19(6):591–600. https://doi.org/10.1093/ehjci/jey042. Erratum in: Eur Heart J Cardiovasc Imaging. 2018 Jul 1;19(7):830–833. https://doi.org/10.1093/ehjci/jey071

Freedman B, Potpara TS, Lip GY (2016) Stroke prevention in atrial fibrillation. Lancet 388(10046):806–817. https://doi.org/10.1016/S0140-6736(16)31257-0

Article  PubMed  Google Scholar 

Schnabel RB, Haeusler KG, Healey JS, Freedman B, Boriani G, Brachmann J, Brandes A, Bustamante A, Casadei B, Crijns HJGM, Doehner W, Engström G, Fauchier L, Friberg L, Gladstone DJ, Glotzer TV, Goto S, Hankey GJ, Harbison JA, Hobbs FDR, Johnson LSB, Kamel H, Kirchhof P, Korompoki E, Krieger DW, Lip GYH, Løchen ML, Mairesse GH, Montaner J, Neubeck L, Ntaios G, Piccini JP, Potpara TS, Quinn TJ, Reiffel JA, Ribeiro ALP, Rienstra M, Rosenqvist M, Themistoclakis S, Sinner MF, Svendsen JH, Van Gelder IC, Wachter R, Wijeratne T, Yan B (2019) Searching for atrial fibrillation poststroke: a white paper of the AF-SCREEN International Collaboration. Circulation 140(22):1834–1850. https://doi.org/10.1161/CIRCULATIONAHA.119.040267. Erratum. In: Circulation. 2020 Feb 25;141(8):e99. https://doi.org/10.1161/CIR.0000000000000762

Jordan K, Yaghi S, Poppas A, Chang AD, Mac Grory B, Cutting S, Burton T, Jayaraman M, Tsivgoulis G, Sabeh MK, Merkler AE, Kamel H, Elkind MSV, Furie K, Song C (2019) Left atrial volume index is associated with cardioembolic stroke and atrial fibrillation detection after embolic stroke of undetermined source. Stroke 50(8):1997–2001. https://doi.org/10.1161/STROKEAHA.119.025384

Article  PubMed  PubMed Central  Google Scholar 

Kawakami H, Ramkumar S, Pathan F, Wright L, Marwick TH (2020) Use of echocardiography to stratify the risk of atrial fibrillation: comparison of left atrial and ventricular strain. Eur Heart J Cardiovasc Imaging 21(4):399–407. https://doi.org/10.1093/ehjci/jez240

Article  PubMed  Google Scholar 

Goldberger JJ, Arora R, Green D, Greenland P, Lee DC, Lloyd-Jones DM, Markl M, Ng J, Shah SJ (2015) Evaluating the atrial myopathy underlying atrial fibrillation: identifying the arrhythmogenic and thrombogenic substrate. Circulation 132(4):278–291. https://doi.org/10.1161/CIRCULATIONAHA.115.016795

Article  PubMed  PubMed Central  Google Scholar 

Bhat A, Chen HHL, Khanna S, Mahajan V, Gupta A, Burdusel C, Wolfe N, Lee L, Gan GCH, Dobbins T, MacIntyre CR, Tan TC (2022) Diagnostic and prognostic value of left atrial function in identification of cardioembolism and prediction of outcomes in patients with cryptogenic stroke. J Am Soc Echocardiogr 35(10):1064–1076. https://doi.org/10.1016/j.echo.2022.05.018

Article  PubMed  Google Scholar 

Brambatti M, Connolly SJ, Gold MR, Morillo CA, Capucci A, Muto C, Lau CP, Van Gelder IC, Hohnloser SH, Carlson M, Fain E, Nakamya J, Mairesse GH, Halytska M, Deng WQ, Israel CW, Healey JS, ASSERT Investigators (2014) Temporal relationship between subclinical atrial fibrillation and embolic events. Circulation 129(21):2094–2099. https://doi.org/10.1161/CIRCULATIONAHA.113.007825

Article  PubMed  Google Scholar 

Martin DT, Bersohn MM, Waldo AL, Wathen MS, Choucair WK, Lip GY, Ip J, Holcomb R, Akar JG, Halperin JL (2015) IMPACT Investigators. Randomized trial of atrial arrhythmia monitoring to guide anticoagulation in patients with implanted defibrillator and cardiac resynchronization devices. Eur Heart J 36(26):1660–1668. https://doi.org/10.1093/eurheartj/ehv115

Article  PubMed  Google Scholar 

Deferm S, Bertrand PB, Churchill TW, Sharma R, Vandervoort PM, Schwamm LH, Yoerger Sanborn DM (2021) Left atrial mechanics assessed early during hospitalization for cryptogenic stroke are associated with occult atrial fibrillation: a speckle-tracking strain echocardiography study. J Am Soc Echocardiogr 34(2):156–165. https://doi.org/10.1016/j.echo.2020.09.009

Article  PubMed  Google Scholar 

Kallergis EM, Manios EG, Kanoupakis EM, Mavrakis HE, Arfanakis DA, Maliaraki NE, Lathourakis CE, Chlouverakis GI, Vardas PE (2008) Extracellular matrix alterations in patients with paroxysmal and persistent atrial fibrillation: biochemical assessment of collagen type-I turnover. J Am Coll Cardiol 52(3):211–215. https://doi.org/10.1016/j.jacc.2008.03.045

Article  PubMed  CAS  Google Scholar 

Yoshihara F, Nishikimi T, Sasako Y, Hino J, Kobayashi J, Minatoya K, Bando K, Kosakai Y, Horio T, Suga S, Kawano Y, Matsuoka H, Yutani C, Matsuo H, Kitamura S, Ohe T, Kangawa K (2002) Plasma atrial natriuretic peptide concentration inversely correlates with left atrial collagen volume fraction in patients with atrial fibrillation: plasma ANP as a possible biochemical marker to predict the outcome of the maze procedure. J Am Coll Cardiol 39(2):288–294. https://doi.org/10.1016/s0735-1097(01)01719-3

Article