Majhail NS, Farnia SH, Carpenter PA, Champlin RE, Crawford S, Marks DI, et al. Indications for autologous and allogeneic hematopoietic cell transplantation: guidelines from the American Society for Blood and Marrow Transplantation. Biol Blood Marrow Transplant. 2015;21:1863–9. https://doi.org/10.1016/j.bbmt.2015.07.032.
Article PubMed PubMed Central Google Scholar
Malard F, Holler E, Sandmaier BM, Huang H, Mohty M. Acute graft-versus-host disease. Nat Rev Dis Prim. 2023;9:27. https://doi.org/10.1038/s41572-023-00438-1.
Ramachandran V, Kolli SS, Strowd LC. Review of graft-versus-host disease. Dermatol Clin. 2019;37:569–82. https://doi.org/10.1016/j.det.2019.05.014.
Article CAS PubMed Google Scholar
Jacobson P, Uberti J, Davis W, Ratanatharathorn V. Tacrolimus: a new agent for the prevention of graft-versus-host disease in hematopoietic stem cell transplantation. Bone Marrow Transplant. 1998;22:217–25. https://doi.org/10.1038/sj.bmt.1701331.
Article CAS PubMed Google Scholar
Przepiorka D, Saliba R, Cleary K, Fischer H, Tonai R, Fritsche H, et al. Tacrolimus does not abrogate the increased risk of acute graft-versus-host disease after unrelated-donor marrow transplantation with allelic mismatching at HLA-DRB1 and HLA-DQB1. Biol Blood Marrow Transplant. 2000;6:190–7. https://doi.org/10.1016/s1083-8791(00)70042-5.
Article CAS PubMed Google Scholar
Mori T, Aisa Y, Nakazato T, Yamazaki R, Shimizu T, Mihara A, et al. Tacrolimus and methotrexate for the prophylaxis of graft-versus-host disease after unrelated donor cord blood transplantation for adult patients with hematologic malignancies. Transplant Proc. 2007;39:1615–9. https://doi.org/10.1016/j.transproceed.2006.12.042.
Article CAS PubMed Google Scholar
Capron A, Mourad M, De Meyer M, De Pauw L, Eddour DC, Latinne D, et al. CYP3A5 and ABCB1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation. Pharmacogenomics. 2010;11:703–14. https://doi.org/10.2217/pgs.10.43.
Article CAS PubMed Google Scholar
Zuo X, Ng CM, Barrett JS, Luo A, Zhang B, Deng C, et al. Effects of CYP3A4 and CYP3A5 polymorphisms on tacrolimus pharmacokinetics in Chinese adult renal transplant recipients: a population pharmacokinetic analysis. Pharmacogenet Genom. 2013;23:251–61. https://doi.org/10.1097/FPC.0b013e32835fcbb6.
Campagne O, Mager DE, Brazeau D, Venuto RC, Tornatore KM. Tacrolimus population pharmacokinetics and multiple CYP3A5 genotypes in black and white renal transplant recipients. J Clin Pharmacol. 2018;58:1184–95. https://doi.org/10.1002/jcph.1118.
Article CAS PubMed PubMed Central Google Scholar
Zhu J, Patel T, Miller JA, Torrice CD, Aggarwal M, Sketch MR, et al. Influence of germline genetics on tacrolimus pharmacokinetics and pharmacodynamics in allogeneic hematopoietic stem cell transplant patients. Int J Mol Sci. 2020;21:858. https://doi.org/10.3390/ijms21030858.
Article CAS PubMed PubMed Central Google Scholar
Seligson ND, Zhang X, Zemanek MC, Johnson JA, VanGundy Z, Wang D, et al. CYP3A5 influences oral tacrolimus pharmacokinetics and timing of acute kidney injury following allogeneic hematopoietic stem cell transplantation. Front Pharmacol. 2023;14:1334440. https://doi.org/10.3389/fphar.2023.1334440.
Article CAS PubMed Google Scholar
Ram R, Storer B, Mielcarek M, Sandmaier BM, Maloney DG, Martin PJ, et al. Association between calcineurin inhibitor blood concentrations and outcomes after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2012;18:414–22. https://doi.org/10.1016/j.bbmt.2011.08.016.
Article CAS PubMed Google Scholar
Ganetsky A, Shah A, Miano TA, Hwang WT, He J, Loren AW, et al. Higher tacrolimus concentrations early after transplant reduce the risk of acute GvHD in reduced-intensity allogeneic stem cell transplantation. Bone Marrow Transplant. 2016;51:568–72. https://doi.org/10.1038/bmt.2015.323.
Article CAS PubMed Google Scholar
Hagen PA, Adams W, Smith S, Tsai S, Stiff P. Low mean post-transplantation tacrolimus levels in weeks 2–3 correlate with acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation from related and unrelated donors. Bone Marrow Transplant. 2019;54:155–8. https://doi.org/10.1038/s41409-018-0267-5.
Article CAS PubMed Google Scholar
Sharma N, Zhao Q, Ni B, Elder P, Puto M, Benson DM, et al. Effect of early post-transplantation tacrolimus concentration on the risk of acute graft-versus-host disease in allogenic stem cell transplantation. Cancers (Basel). 2021;13:613. https://doi.org/10.3390/cancers13040613.
Article CAS PubMed PubMed Central Google Scholar
Morishita T, Okabe M, Kawaguchi Y, Lee Y, Ohbiki M, Osaki M, et al. Higher peak tacrolimus concentrations after allogeneic hematopoietic stem cell transplantation increase the risk of endothelial cell damage complications. Biol Blood Marrow Transplant. 2018;24:2509–16. https://doi.org/10.1016/j.bbmt.2018.07.029.
Article CAS PubMed Google Scholar
Abramson MH, Gutgarts V, Zheng J, Maloy MA, Ruiz JD, Scordo M, et al. Acute kidney injury in the modern era of allogeneic hematopoietic stem cell transplantation. Clin J Am Soc Nephrol. 2021;16:1318–27. https://doi.org/10.2215/CJN.19801220.
Article CAS PubMed PubMed Central Google Scholar
Yao JM, Yang D, Clark MC, Otoukesh S, Cao T, Ali H, et al. Tacrolimus initial steady state level in post-transplant cyclophosphamide-based GvHD prophylaxis regimens. Bone Marrow Transplant. 2022;57:232–42. https://doi.org/10.1038/s41409-021-01528-y.
Article CAS PubMed Google Scholar
Mori T, Kato J, Shimizu T, Aisa Y, Nakazato T, Yamane A, et al. Effect of early posttransplantation tacrolimus concentration on the development of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation from unrelated donors. Biol Blood Marrow Transplant. 2012;18:229–34. https://doi.org/10.1016/j.bbmt.2011.06.008.
Article CAS PubMed Google Scholar
Prograf (tacrolimus) [package insert]. Northbrook, IL: Astellas Pharma US, Inc.; 2023.
Zhu J, Campagne O, Torrice CD, Flynn G, Miller JA, Patel T, et al. Evaluation of the performance of a prior tacrolimus population pharmacokinetic kidney transplant model among adult allogeneic hematopoietic stem cell transplant patients. Clin Transl Sci. 2021;14:908–18. https://doi.org/10.1111/cts.12956.
Article CAS PubMed PubMed Central Google Scholar
Maynard RD, Bates P, Korpi-Steiner N. Monitoring tacrolimus toxicity following Paxlovid administration in a liver transplant patient. Pract Lab Med. 2023;36: e00322. https://doi.org/10.1016/j.plabm.2023.e00322.
Article CAS PubMed PubMed Central Google Scholar
Birdwell KA, Decker B, Barbarino JM, Peterson JF, Stein CM, Sadee W, et al. Clinical pharmacogenetics implementation consortium (CPIC) guidelines for CYP3A5 genotype and tacrolimus dosing. Clin Pharmacol Ther. 2015;98:19–24. https://doi.org/10.1002/cpt.113.
Article CAS PubMed PubMed Central Google Scholar
Caudle KE, Dunnenberger HM, Freimuth RR, Peterson JF, Burlison JD, Whirl-Carrillo M, et al. Standardizing terms for clinical pharmacogenetic test results: consensus terms from the Clinical Pharmacogenetics Implementation Consortium (CPIC). Genet Med. 2017;19:215–23. https://doi.org/10.1038/gim.2016.87.
R Core Team R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. 2023. https://www.R-project.org/. Cited 5 Nov 2024.
Sanghavi K, Ribbing J, Rogers JA, Ahmed MA, Karlsson MO, Holford N, et al. Covariate modeling in pharmacometrics: general points for consideration. CPT Pharmacomet Syst Pharmacol. 2024;13:710–28. https://doi.org/10.1002/psp4.13115.
Jacobson P, Ng J, Ratanatharathorn V, Uberti J, Brundage RC. Factors affecting the pharmacokinetics of tacrolimus (FK506) in hematopoietic cell transplant (HCT) patients. Bone Marrow Transplant. 2001;28:753–8. https://doi.org/10.1038/sj.bmt.1703224.
Article CAS PubMed Google Scholar
Elens L, Hesselink DA, Bouamar R, Budde K, de Fijter JW, De Meyer M, et al. Impact of POR*28 on the pharmacokinetics of tacrolimus and cyclosporine A in renal transplant patients. Ther Drug Monit. 2014;36:71–9. https://doi.org/10.1097/FTD.0b013e31829da6dd.
Comments (0)