Calcitonin promotes osteogenic differentiation through CREB-mediated transcriptional upregulation of osteopontin in human periodontal ligament stem cells

Huang TH, Chen JY, Suo WH, Shao WR, Huang CY, Li MT, et al. Unlocking the future of periodontal regeneration: an interdisciplinary approach to tissue engineering and advanced therapeutics. Biomedicines. 2024;12(5)

Bianchi S, Mancini L, Torge D, Cristiano L, Mattei A, Varvara G, et al. Bio-Morphological reaction of human periodontal ligament fibroblasts to different types of dentinal derivates: in vitro study. Int J Mol Sci. 2021;22(16)

Radmand F, Baseri M, Farsadbakhsh M, Azimi A, Dizaj SM, Sharifi S. A novel perspective on tissue engineering potentials of periodontal ligament stem cells. Open Dent J. 2022;16

Kumar PM, Thakkar R. Periodontal ligament and bone marrow derived stem cells in periodontal regeneration—a systematic review. J Oral Max Surg Med. 2024;36(5):665–71.

Google Scholar 

Alves L, Machado V, Botelho J, Mendes JJ, Cabral JMS, da Silva CL, et al. Enhanced proliferative and osteogenic potential of periodontal ligament stromal cells. Biomedicines. 2023;11(5)

Chaikiawkeaw D, Khorattanakulchai N, Nammultriputtar K, Rattanapisit K, Everts V, Kubera A, et al. Osteopontin induces osteogenic differentiation by human periodontal ligament cells via calcium binding domain-activin receptor-like kinase (ALK-1) interaction. J Periodontol. 2022;93(2):E13–23.

CAS  PubMed  Google Scholar 

Xie JB, Guo J, Kanwal Z, Wu MZ, Lv XY, Ibrahim NA, et al. Calcitonin and bone physiology: in vitro, in vivo, and clinical investigations. Int J Endocrinol. 2020;2020

Wei YB, Ye Q, Tang Z, Tian G, Zhu Q, Gao HC, et al. Calcitonin induces collagen synthesis and osteoblastic differentiation in human periodontal ligament fibroblasts. Arch Oral Biol. 2017;74:114–22.

CAS  PubMed  Google Scholar 

Tian G, Zhang G, Tan YH. Calcitonin gene-related peptide stimulates BMP-2 expression and the differentiation of human osteoblast-like cells. Acta Pharmacol Sin. 2013;34(11):1467–74.

CAS  PubMed  PubMed Central  Google Scholar 

Chowdhury MAR, An J, Jeong S. the pleiotropic face of CREB family transcription factors. Mol Cells. 2023;46(7):399–413.

CAS  PubMed  PubMed Central  Google Scholar 

Benchoula K, Parhar IS, Madhavan P, Hwa WE. CREB nuclear transcription activity as a targeting factor in the treatment of diabetes and diabetes complications. Biochem Pharmacol. 2021;188

Berglund LM, Lyssenko V, Ladenvall C, Kotova O, Edsfeldt A, Pilgaard K, et al. Glucose-dependent insulinotropic polypeptide stimulates osteopontin expression in the vasculature via endothelin-1 and CREB. Diabetes. 2016;65(1):239–54.

CAS  PubMed  Google Scholar 

Bianchi S, Bernardi S, Mattei A, Cristiano L, Mancini L, Torge D, et al. Morphological and biological evaluations of human periodontal ligament fibroblasts in contact with different bovine bone grafts treated with low-temperature deproteinisation protocol. Int J Mol Sci 2022;23(9)

Bianchi S, Bernardi S, Simeone D, Torge D, Macchiarelli G, Marchetti E. Proliferation and morphological assessment of human periodontal ligament fibroblast towards bovine pericardium membranes: an in vitro study. Materials 2022;15(23)

Everett LJ, Le Lay J, Lukovac S, Bernstein D, Steger DJ, Lazar MA, et al. Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver. Bmc Genom. 2013;14

Tsuchida S, Nakayama T. Periodontal tissue regeneration therapy using stem cells. Stem Cell Rev Rep. 2023;19(3):825–6.

PubMed  Google Scholar 

Paul S, Paul S. Controlling the self-assembly of human calcitonin: a theoretical approach using molecular dynamics simulations. Phys Chem Chem Phys. 2021;23(26):14496–510.

CAS  PubMed  Google Scholar 

Roy A, Thulasiraman S, Panneerselvam E, Doss GT, Selvaraj MN, Ganesh SK, et al. Evaluation of the efficacy of salmon calcitonin nasal spray on bone healing following open reduction and internal fixation of mandibular fractures—a randomized controlled trial. J Cranio Maxill Surg. 2021;49(12):1151–7.

Google Scholar 

Alatabi HSH, Tobji S, Haouas Z. Effects of calcitonin administration on the amount of bone formation after sutural expansion using micro-CT. J Craniofac Surg. 2023;34(8):2556–9.

PubMed  Google Scholar 

Hsiao CY, Chen TH, Chu TH, Ting YN, Tsai PJ, Shyu JF. Calcitonin induces bone formation by increasing expression of Wnt10b in osteoclasts in ovariectomy-induced osteoporotic rats. Front Endocrinol. 2020;11

Yu P, Xie J, Chen Y, Liu JM, Liu YP, Bi B, et al. A thermo-sensitive injectable hydroxypropyl chitin hydrogel for sustained salmon calcitonin release with enhanced osteogenesis and hypocalcemic effects. J Mater Chem B. 2020;8(2):270–81.

CAS  PubMed  Google Scholar 

Ahmadipour S, Varshosaz J, Hashemibeni B, Safaeian L, Manshaei M, Sarmadi A. Calcitonin-loaded octamaleimic acid-silsesquioxane nanoparticles in hydrogel scaffold support osteoinductivity in bone regeneration. Pharm Dev Technol. 2021;26(2):220–32.

CAS  PubMed  Google Scholar 

Foster BL, Ao M, Salmon CR, Chavez MB, Kolli TN, Tran AB, et al. Osteopontin regulates dentin and alveolar bone development and mineralization. Bone. 2018;107:196–207.

CAS  PubMed  Google Scholar 

Carvalho MS, Silva JC, Hoff CM, Cabral JMS, Linhardt RJ, da Silva CL, et al. Loss and rescue of osteocalcin and osteopontin modulate osteogenic and angiogenic features of mesenchymal stem/stromal cells. J Cell Physiol. 2020;235(10):7496–515.

CAS  PubMed  Google Scholar 

Ohta Y, Nakagawa K, Imai Y, Katagiri T, Koike T, Takaoka K. Cyclic AMP enhances smad-mediated BMP signaling through PKA-CREB pathway. J Bone Miner Metab. 2008;26(5):478–84.

CAS  PubMed  Google Scholar 

Chang ML, Lin H, Fu HD, Wang J, Yang Y, Wan ZQ, et al. CREB activation affects mesenchymal stem cell migration and differentiation in periodontal tissues due to orthodontic force. Int J Biochem Cell B. 2020;129

Su S, Zhu Y, Li S, Liang Y, Zhang J. The transcription factor cyclic adenosine 3’,5’-monophosphate response element-binding protein enhances the odonto/osteogenic differentiation of stem cells from the apical papilla. Int Endod J. 2017;50(9):885–94.

CAS  PubMed  Google Scholar 

Xu JK, Wang JL, Chen XD, Li Y, Mi J, Qin L. The effects of calcitonin gene-related peptide on bone homeostasis and regeneration. Curr Osteoporos Rep. 2020;18(6):621–32.

PubMed  Google Scholar 

Zhang HY, Kong QB, Wang J, Jiang YF, Hua H. Complex roles of cAMP-PKA-CREB signaling in cancer. Exp Hematol Oncol. 2020;9(1)

Deng L, Li XL, Ren XH, Lai S, Zhu YS, Li J, et al. A grooved porous hydroxyapatite scaffold induces osteogenic differentiation via regulation of PKA activity by upregulating miR-129-5p expression. J Periodontal Res. 2022;57(6):1238–55.

CAS  PubMed  Google Scholar 

Gao X, Zhang XJ, Cui LL, Chen R, Zhang C, Xue J, et al. Ginsenoside Rb1 promotes motor functional recovery and axonal regeneration in post-stroke mice through cAMP/PKA/CREB signaling pathway. Brain Res Bull. 2020;154:51–60.

CAS  PubMed  Google Scholar 

Qi YC, Duan GZ, Mao W, Liu Q, Zhang YL, Li PF. Taurochenodeoxycholic acid mediates cAMP-PKA-CREB signaling pathway. Chin J Nat Medicines. 2020;18(12):898–906.

CAS  Google Scholar 

Ren N, Liang N, Dong MW, Feng ZC, Meng L, Sun CH, et al. Stem cell membrane-encapsulated zeolitic imidazolate framework-8: a targeted nano-platform for osteogenic differentiation. Small. 2022;18(26)

Zhu J, Chen YH, Ji JJ, Lu CX, Liu ZF. Calcitonin gene-related peptide inhibits neuronal apoptosis in heatstroke rats via PKA/p-CREB pathway. Chin J Traumatol. 2024;27(1):18–26.

CAS  PubMed  Google Scholar 

Afroz S, Arakaki R, Iwasa T, Waskitho A, Oshima M, Matsuka Y. Role of CGRP in neuroimmune interaction via NF-κB signaling genes in glial cells of trigeminal ganglia. Int J Mol Sci. 2020;21(17)

Amin LE, Salama N. Osteoprotective effect of enamel matrix derivatives on the regeneration of mandibular defects in experimentally glucocorticoid-induced osteoporosis. Int J Dent. 2021;2021

Hou P, Sun Y, Yang WC, Wu HL, Sun LY, Xiu XJ, et al. Magnesium promotes osteogenesis via increasing OPN expression and activating CaM/CaMKIV/CREB1 pathway. J Biomed Mater Res B. 2022;110(7):1594–603.

CAS  Google Scholar 

Bianchi S, Torge D, Rinaldi F, Piattelli M, Bernardi S, Varvara G. Platelets’ role in dentistry: from oral pathology to regenerative potential. Biomedicines 2022;10(2)

Comments (0)

No login
gif