Aranaz I, Alcántara AR, Civera MC, Arias C, Elorza B, Caballero AH, Acosta N, Aranaz I, Alcántara AR, Civera MC, Arias C, Elorza B, Caballero AH, Acosta N. Chitosan: an overview of its properties and applications. Polymers. 2021;13(19):3256.
CAS PubMed PubMed Central Google Scholar
Muzzarelli RAA, Boudrant J, Meyer D, Manno N, DeMarchis M, Paoletti MG. Current views on fungal chitin/chitosan, human chitinases, food preservation, glucans, pectins and inulin: a tribute to Henri Braconnot, precursor of the carbohydrate polymers science, on the chitin bicentennial. Carbohydr Polym. 2012;87:995–1012.
Morin-Crini N, Lichtfouse E, Torri G, Crini G. Fundamentals and applications of chitosan. 2019.
Hudson SM, Smith C. Polysaccharides: chitin and chitosan: chemistry and technology of Thei. In: Biopolymers from renewable resources. 1998.
Jasim RAF. Medical pharmaceutical, and biomedical applications of chitosan: a review. Med J Babylon. 2021;18:291–4.
Mikušová V, Mikuš P, Mikušová V, Mikuš P. Advances in chitosan-based nanoparticles for drug delivery. Int J Mol Sci. 2021;22(17):9652.
PubMed PubMed Central Google Scholar
Zhou J, Zhou L, Chen Z-Y, Sun J, Guo X-W, Wang H-R, Zhang X-Y, Liu Z-R, Liu J, Zhang K, Zhang X. Remineralization and bacterial inhibition of early enamel caries surfaces by carboxymethyl chitosan lysozyme nanogels loaded with antibacterial drugs. J Dent. 2025;152:105489.
Haider A, Khan S, Iqbal DN, Shrahili M, Haider S, Mohammad K, Mohammad A, Rizwan M, Kanwal Q, Mustafa G. Advances in chitosan-based drug delivery systems: a comprehensive review for therapeutic applications. Eur Polym J. 2024. https://doi.org/10.1016/j.eurpolymj.2024.112983.
Elsabee MZ, Morsi RE, Al-Sabagh AM. Surface active properties of chitosan and its derivatives. Colloids Surf B Biointerfaces. 2009;74:1–16.
Cele ZED, Somboro AM, Amoako DG, Ndlandla LF, Balogun MO. Fluorinated quaternary chitosan derivatives: synthesis, characterization, antibacterial activity, and killing kinetics. ACS Omega. 2020;5:29657–66.
CAS PubMed PubMed Central Google Scholar
Pokhrel S, Yadav PN. Functionalization of chitosan polymer and their applications. J Macromol Sci Part A. 2019;56:450–75.
Joseph JM, Gigliobianco MR, Firouzabadi BM, Censi R, Martino PD, Joseph JM, Gigliobianco MR, Firouzabadi BM, Censi R, Di Martino P. Nanotechnology as a versatile tool for 19F-MRI agent’s formulation: a glimpse into the use of perfluorinated and fluorinated compounds in nanoparticles. Pharmaceutics. 2022;14(2):382.
CAS PubMed PubMed Central Google Scholar
Xia R, Zheng X, Li C, Yuan X, Wang J, Xie Z, Jing X. Nanoscale covalent organic frameworks with donor–acceptor structure for enhanced photothermal ablation of tumors. ACS Nano. 2021;15:7638–48.
Hao X, Jiang B, Wu J, Xiang D, Xiong Z, Li C, Li Z, He S, Tu C, Li Z. Nanomaterials for bone metastasis. J Control Release. 2024;373:640–51.
Feng C, Wang Y, Xu J, Zheng Y, Zhou W, Wang Y, Luo C. Precisely tailoring molecular structure of doxorubicin prodrugs to enable stable nanoassembly, rapid activation, and potent antitumor effect. Pharmaceutics. 2024. https://doi.org/10.3390/pharmaceutics16121582.
PubMed PubMed Central Google Scholar
Guo L, Fu Z, Li H, Wei R, Guo J, Wang H, Qi J. Smart hydrogel: a new platform for cancer therapy. Adv Colloid Interface Sci. 2025;340:103470.
Yuan H, Chen Y, Hu Y, Li Y, Zhang H, Zhang S, Chen Q, Zhou W, Sun J, He Z, Wang Y, Luo C. Disulfide bond-driven nanoassembly of lipophilic epirubicin prodrugs for breast cancer therapy. J Pharm Invest. 2025;2025:1–14.
Cohen E, Poverenov E. Hydrophilic Chitosan Derivatives: Synthesis And Applications. Chem Eur J. 2022;28:e202202156.
Gzyra-Jagieła K, Pęczek B, Wiśniewska-Wrona M, Gutowska N. Physicochemical properties of chitosan and its degradation products, chitin and chitosan. 2019.
Xin J, Lu X, Cao J, Wu W, Liu Q, Wang D, Zhou X, Ding D. Fluorinated organic polymers for cancer drug delivery. Adv Mater. 2024. https://doi.org/10.1002/adma.202404645.
Hamdi M, Nasri R, Hajji S, Nigen M, Li S, Nasri M. Acetylation degree, a key parameter modulating chitosan rheological, thermal and film-forming properties. Food Hydrocolloids. 2019;87:48–60.
Cui Z, Drioli E, Lee YM. Recent progress in fluoropolymers for membranes. Prog Polym Sci. 2014;39:164–98.
Mohseni M, Lahiri SK, Nadaraja AV, Sundararaj U, Golovin K. Durable and comfortable superoleophobic fabrics utilizing ultra-short-chain fluorinated surface chemistry. Chem Eng J. 2023;471:144726.
Hosseinnejad M, Jafari SM. Evaluation of different factors affecting antimicrobial properties of chitosan. Int J Biol Macromol. 2016;85:467–75.
Kiran NS, Yashaswini C, Chatterjee A, Prajapati B. Impact of gastrointestinal dysbiosis on tryptophan metabolism and neurological cancer progression. Med Oncol. 2025;42:412.
AlAsmari AF, Ali N, Alharbi M, Alqahtani F, Alasmari F, Almoqbel D, AlSwayyed M, Alshammari A, Alanazi MM, Alhoshani A, Al-Harbi NO. Geraniol ameliorates doxorubicin-mediated kidney injury through alteration of antioxidant status, inflammation, and apoptosis: potential roles of NF-κB and Nrf2/Ho-1. Nutrients. 2022. https://doi.org/10.3390/nu14081620.
PubMed PubMed Central Google Scholar
Dudhat K, Pirojiya H, Bhalala K, Mori D, Prajapati B. Phospholipid-drug conjugates in cancer therapy: emerging paradigms and future directions. AAPS PharmSciTech. 2025;26:190.
Patel P, Gondhiya A, Vadia N, Kapoor DU, Prajapati BG. Functionalized curcumin-loaded mesoporous nanoparticulate drug delivery system for oral cancer: formulation design, optimization, and in vitro & in vivo evaluation. Biomed Mater Devices. 2025;2025:1–17.
Patel HJ, Sharma JB, Kapoor DU, Prajapati BG. Nanocrystal drug delivery systems significantly enhance the therapeutic efficacy of anticancer agents. Biomed Mater Devices. 2025;2025:1–18.
Pandya T, Joshi D, Presswala Z, Kulkarni M, Patel R, Patel S, Bhattacharya S, Prajapati BG. Advanced therapeutic strategies using thermo-sensitive chitosan/pectin hydrogel in the treatment of multiple cancers. Carbohydr Polym. 2025;357:123454.
Kumar A, Yadav S, Pramanik J, Sivamaruthi BS, Jayeoye TJ, Prajapati BG, Chaiyasut C. Chitosan-based composites: development and perspective in food preservation and biomedical applications. Polymers. 2023. https://doi.org/10.3390/polym15153150.
PubMed PubMed Central Google Scholar
Narmani A, Jafari SM. Chitosan-based nanodelivery systems for cancer therapy: recent advances. Carbohydr Polym. 2021;272:118464.
Suarato G, Li W, Meng Y. Role of pH-responsiveness in the design of chitosan-based cancer nanotherapeutics: a review. Biointerphases. 2016. https://doi.org/10.1116/1.4944661.
Begum RF, Singh S, Prajapati B, Sumithra M, Patel RJ. Advanced targeted drug delivery of bioactive agents fortified with graft chitosan in management of cancer: a review. Curr Med Chem. 2025;32:3759–89.
Sa P, Sahoo SK, Dilnawaz F. Responsive role of nanomedicine in the tumor microenvironment and cancer drug resistance. Curr Med Chem. 2023. https://doi.org/10.2174/0929867329666220922111336.
Yin L, Zhong Z. Nanoparticles. In: Biomaterials science. 2020.
Cheng X, Zeng X, Zheng Y, Wang X, Tang R. Surface-fluorinated and pH-sensitive carboxymethyl chitosan nanoparticles to overcome biological barriers for improved drug delivery in vivo. Carbohydr Polym. 2019;208:59–69.
Lepoittevin B, Elzein T, Dragoe D, Bejjani A, Lemée F, Levillain J, Bazin P, Roger P, Dez I. Hydrophobization of chitosan films by surface grafting with fluorinated polymer brushes. Carbohydr Polym. 2019;205:437–46.
Wang J, Yang F, Lu D-Q, Wang X, Li J, Fu Q, Li R, Wu D, Liu D, Xu A, Guan D. Synthesis, characterization, and application of films made from highly substituted N-perfluoroacylated chitosan. Int J Biol Macromol. 2024;282:136716.
Belabassi Y, Moreau J, Gheran V, Henoumont C, Robert A, Callewaert M, Rigaux G, Cadiou C, Elst LV, Laurent S, Muller RN, Dinischiotu A, Voicu SN, Chuburu F. Synthesis and characterization of pegylated and fluorinated chitosans: application to the synthesis of targeted nanoparticles for drug delivery. Biomacromol. 2017;18:2756–66.
Furtado GTFDS, Fideles TB, Cruz RDCAL, Souza JWDL, Rodriguez Barbero MA, Fook MVL. Chitosan/NaF particles prepared via ionotropic gelation: evaluation of particles size and morphology. Mater Res. 2018;21:e20180101.
Van Bavel N, Issler T, Pang L, Anikovskiy M, Prenner EJ. A simple method for synthesis of chitosan nanoparticles with ionic gelation and homogenization. Molecules. 2023;28:4328.
PubMed PubMed Central Google Scholar
Dong Y, Ng WK, Shen S, Kim S, Tan RBH. Scalable ionic gelation synthesis of chitosan nanoparticles for drug delivery in static mixers. Carbohydr Polym. 2013;94:940–5.
Comments (0)