Saginala K, Barsouk A, Aluru JS, Rawla P, Barsouk A. Epidemiology of melanoma. Med Sci. 2021;9:63.
Huang J, Chan SC, Ko S, Lok V, Zhang L, Lin X, et al. Global incidence, mortality, risk factors and trends of melanoma: a systematic analysis of registries. Am J Clin Dermatol. 2023;24:965–75.
American Cancer Society. Survival rates for melanoma skin cancer. 2025. Available from: https://www.cancer.org/cancer/types/melanoma-skin-cancer/detection-diagnosis-staging/survival-rates-for-melanoma-skin-cancer-by-stage.html. Accessed 01 Mar 2025.
Carlino MS, Larkin J, Long GV. Immune checkpoint inhibitors in melanoma. Lancet. 2021;398:1002–14.
Article CAS PubMed Google Scholar
Li Y, Liang X, Li H, Chen X. Comparative efficacy and safety of immune checkpoint inhibitors for unresectable advanced melanoma: a systematic review and network meta-analysis. Int Immunopharmacol. 2023;115: 109657.
Article CAS PubMed Google Scholar
Seth R, Messersmith H, Kaur V, Kirkwood JM, Kudchadkar R, McQuade JL, et al. Systemic therapy for melanoma: ASCO guideline. J Clin Oncol. 2020;38:3947–70.
Article CAS PubMed Google Scholar
Seth R, Agarwala SS, Messersmith H, Alluri KC, Ascierto PA, Atkins MB, et al. Systemic therapy for melanoma: ASCO guideline update. J Clin Oncol. 2023;41:4794–820.
Article CAS PubMed Google Scholar
Cancer Council Australia. Clinical practice guidelines for the diagnosis and management of melanoma. 2021. Available from: https://www.cancer.org.au/clinical-guidelines/skin-cancer/melanoma. Accessed 01 Mar 2025.
Michielin O, Van Akkooi ACJ, Ascierto PA, Dummer R, Keilholz U, Committee EG. Cutaneous melanoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2019;30:1884–901.
Article CAS PubMed Google Scholar
Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, et al. European consensus-based interdisciplinary guideline for melanoma. Part 2: treatment-update 2022. Eur J Cancer. 2022;170:256–84.
Therapeutic Goods Administration. Australian public assessment report for Keytruda. Canberra: Australian Government Department of Health and Aged Care; 2023.
Pharmaceutical Benefits Scheme. Public summary document: March 2015 PBAC Meeting. Canberra: Australian Government Department of Health and Aged Care; 2015.
Pharmaceutical Benefits Scheme. PBS expenditure and prescriptions. Available from: https://m.pbs.gov.au/info/statistics/expenditure-prescriptions/pbs-expenditure-and-prescriptions.html. Accessed 01 Mar 2025.
Tuffaha HW, Scuffham PA. The Australian managed entry scheme: are we getting it right? Pharmacoeconomics. 2018;36:555–65.
Robert C, Schachter J, Long GV, Arance A, Grob JJ, Mortier L, et al. Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med. 2015;372:2521–32.
Article CAS PubMed Google Scholar
Donia M, Kimper-Karl ML, Høyer KL, Bastholt L, Schmidt H, Svane IM. The majority of patients with metastatic melanoma are not represented in pivotal phase III immunotherapy trials. Eur J Cancer. 2017;74:89–95.
Machado MADÁ, de Moura CS, Chan K, Curtis JR, Hudson M, Abrahamowicz M, et al. Real-world analyses of therapy discontinuation of checkpoint inhibitors in metastatic melanoma patients. Sci Rep. 2020;10:14607.
Article CAS PubMed PubMed Central Google Scholar
Jang SR, Nikita N, Banks J, Keith SW, Johnson JM, Wilson M, et al. Association between sex and immune checkpoint inhibitor outcomes for patients with melanoma. JAMA Netw Open. 2021;4: e2136823.
Article PubMed PubMed Central Google Scholar
Cowey CL, Scherrer E, Boyd M, Aguilar KM, Beeks A, Krepler C. Pembrolizumab utilization and clinical outcomes among patients with advanced melanoma in the US community oncology setting: an updated analysis. J Immunother. 2021;44:224–33.
Article CAS PubMed PubMed Central Google Scholar
Casarotto E, Chandwani S, Mortier L, Dereure O, Dutriaux C, Dalac S, et al. Real-world effectiveness of pembrolizumab in advanced melanoma: analysis of a French national clinicobiological database. Immunotherapy. 2021;13:905–16.
Article CAS PubMed Google Scholar
Mohr P, Scherrer E, Assaf C, Bender M, Berking C, Chandwani S, et al. Real-world therapy with pembrolizumab: outcomes and surrogate endpoints for predicting survival in advanced melanoma patients in Germany. Cancers. 2022;14:1804.
Article PubMed PubMed Central Google Scholar
Hribernik N, Boc M, Ocvirk J, Knez-Arbeiter J, Mesti T, Ignjatovic M, et al. Retrospective analysis of treatment-naive Slovenian patients with metastatic melanoma treated with pembrolizumab: real-world experience. Radiol Oncol. 2020;54:119–27.
Article PubMed PubMed Central Google Scholar
Ab Rahman AS, Strother RM, Paddison J. New Zealand national retrospective cohort study of survival outcomes of patients with metastatic melanoma receiving immune-checkpoint inhibitors. Asia Pac J Clin Oncol. 2023;19:179–86.
Angeles MR, Crosland P, Hensher M. Challenges for Medicare and universal health care in Australia since 2000. Med J Aust. 2023;218:322–9.
Mellish L, Karanges EA, Litchfield MJ, Schaffer AL, Blanch B, Daniels BJ, et al. The Australian Pharmaceutical Benefits Scheme data collection: a practical guide for researchers. BMC Res Notes. 2015;8:634.
Article PubMed PubMed Central Google Scholar
Australian Bureau of Statistics. Microdata: Person Level Integrated Data Asset (PLIDA) [DataLab].
Von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007;370:1453–7.
Kim H, Comey S, Hausler K, Cook G. A real world example of coverage with evidence development in Australia: ipilimumab for the treatment of metastatic melanoma. J Pharm Policy Pract. 2018;11:4.
Article PubMed PubMed Central Google Scholar
Australian Bureau of Statistics. Socio-economic indexes for areas. Available from: https://www.abs.gov.au/websitedbs/censushome.nsf/home/seifa. Accessed 01 Mar 2025.
Australian Bureau of Statistics. Remoteness areas. Available from: https://www.abs.gov.au/statistics/standards/australian-statistical-geography-standard-asgs-edition-3/jul2021-jun2026/remoteness-structure/remoteness-areas. Accessed 01 Mar 2025.
Pratt NL, Kerr M, Barratt JD, Kemp-Casey A, Ellett LMK, Ramsay E, et al. The validity of the Rx-Risk comorbidity index using medicines mapped to the Anatomical Therapeutic Chemical (ATC) classification system. BMJ Open. 2018;8: e021122.
Article PubMed PubMed Central Google Scholar
Cancer Institute NSW. List of notifiable ICD–10 12th ed. topography codes. Available from: https://www.cancer.nsw.gov.au/research-and-data/cancer-data-and-statistics/information-for-patients-clinicians-and-notifiers/submit-cancer-cases-to-the-nsw-cancer-registry/list-of-notifiable-icd-10-am-12th-edition-topograp. Accessed 01 Mar 2025.
Strohbehn GW, Holleman R, Burns J, Klamerus ML, Kelley MJ, Kerr EA, et al. Adoption of extended-interval dosing of single-agent pembrolizumab and comparative effectiveness vs standard dosing in time-to-treatment discontinuation. JAMA Oncol. 2022;8:1663–7.
Article PubMed PubMed Central Google Scholar
Cancer Institute NSW. eVIQ: management of immune-related adverse events (irAEs). Available from: https://www.eviq.org.au/clinical-resources/side-effect-and-toxicity-management/immunological/1993-management-of-immune-related-adverse-events. Accessed 01 Mar 2025.
Iyer PC, Cabanillas ME, Waguespack SG, Hu MI, Thosani S, Lavis VR, et al. Immune-related thyroiditis with immune checkpoint inhibitors. Thyroid. 2018;28:1243–51.
Article CAS PubMed PubMed Central Google Scholar
Jin K-T, Wang S-B, Ying X-J, Lan H-R, Lv J-Q, Zhang L-H, et al. Immune-mediated adverse effects of immune-checkpoint inhibitors and their management in cancer. Immunol Lett. 2020;221:61–71.
Article CAS PubMed Google Scholar
Goyal G, Goyal LD, Singla H, Arora K, Kaur H. Subclinical hypothyroidism and associated cardiovascular risk factor in perimenopausal females. J Midlife Health. 2020;11:6–11.
PubMed PubMed Central Google Scholar
Robert C, Ribas A, Schachter J, Arance A, Grob J-J, Mortier L, et al. Pembrolizumab versus ipilimumab in advanced melanoma (KEYNOTE-006): post-hoc 5-year results from an open-label, multicentre, randomised, controlled, phase 3 study. Lancet Oncol. 2019;20:1239–51.
Article CAS PubMed Google Scholar
Long GV, Carlino MS, McNeil C, Ribas A, Gaudy-Marqueste C, Schachter J, et al. Pembrolizumab versus ipilimumab for advanced melanoma: 10-year follow-up of the phase III KEYNOTE-006 study. Ann Oncol. 2024;35:1191–9.
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