Nyaga DM, Vickers MH, Jefferies C, Fadason T, O’Sullivan JM. Untangling the genetic link between type 1 and type 2 diabetes using functional genomics. Sci Rep. 2021;11:13871.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cole JB, Florez JC. Genetics of diabetes mellitus and diabetes complications. Nat Rev Nephrol. 2020;16(7):377–90.

Article  PubMed  PubMed Central  Google Scholar 

Xia Q, Grant SFA. The genetics of human obesity. Ann NY Acad Sci. 2013;1281(1):178–90.

Article  CAS  PubMed  Google Scholar 

Singh RK, Kumar P, Mahalingam K. Molecular genetics of human obesity: a comprehensive review. C R Biologies. 2017;340(2):87–108.

Article  PubMed  Google Scholar 

Ramakrishnan G, Beriwal P, Sangam, Chandra NC. Low density lipoproteinemia in obese and type-2 diabetics from association of IR and LDLR. Diabetes Obes Int J. 2019;4(1):16000194.

Google Scholar 

Suneja S, Ramakrishnan G, Tandon N, Chandra NC. Modulation by insulin of the co-localized LDL receptor in normal and Type-I Diabetic subjects. Int J Clin Med. 2011;2(3):231–45.

Article  CAS  Google Scholar 

Ramakrishnan G, Arjuman A, Suneja S, Das C, Chandra NC. The association between insulin and low-density lipoprotein receptors. Diab Vasc Dis Res. 2012;9(3):196–204.

Article  PubMed  Google Scholar 

Zhu L, Wu G, Yang X, Jia X, Li J, Bai X, et al. Low density lipoprotein mimics insulin action on autophagy and glucose uptake in endothelial cells. Sci Rep. 2019;9:3020.

Article  PubMed  PubMed Central  Google Scholar 

Chandra NC. Atherosclerosis and carcinoma: Two facets of dysfunctional cholesterol homeostasis. J Biochem Mol Toxicol. 2020;34(12):e22595.

Article  CAS  PubMed  Google Scholar 

Saxena N, Chandra NC. Cholesterol: a prelate in cell nucleus and its serendipity. Curr Mol Med. 2020;20(9):1–16.

Google Scholar 

Chandra NC, Kaur AP, Talukdar A, Saxena, N, Sankanagaudar S. CHOLESTEROL: a potential target for intervention in anti-cancer therapy. Chapter-3, Frontiers in Clinical Drug Research - Anti-Cancer Agents. 2021; 7: 1–48. Editor: Atta-ur-Rahman, FRS. Bentham Publication.

Escribano O, Beneit N, Rubio-Longás C, López-Pastor AR, Gómez-Hernández A. The role of insulin receptor isoforms in diabetes and its metabolic and vascular complications. J Diabetes Res. 2017;2017:1403206.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heni M, Hennenlotter J, Scharpf M, Lutz SZ, Schwentner C, Todenhöfer T, et al. Insulin receptor isoforms A and B as well as insulin receptor substrates-1 and -2 are differentially expressed in prostate cancer. PLoS ONE. 2012;7:e50953.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Malaguarnera RA, Belfiore A. The insulin receptor: a new target for cancer therapy. Front Endocrinol (Lausanne). 2011;2:93.

Article  PubMed  Google Scholar 

Leibiger B, Leibiger IB, Moede T, Kemper S, Kulkarni RN, Kahn CR, et al. Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. Mol Cell. 2001;7(3):559–70.

Article  CAS  PubMed  Google Scholar 

Petersen MC, Shulman GI. Mechanisms of Insulin action and insulin resistance. Physiol Rev. 2018;98(4):2133–223.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beriwal P, Chandra NC. Hyperlipidimia, hyperleptinemia and insulin resistance: Intercorrelation with obesity. Diabetes Obes Int J. 2020;5(1):16000223.

Google Scholar 

Beriwal P, Chandra NC. Human Obesity: a noxious sequel of inverse intents of ligands and receptors. Diabetes Obes Int J. 2019;4(4):16000217.

Google Scholar 

Yadav NK, Arjuman A, Chandra NC. Role of leptin on the expression of low density lipoprotein receptor. Indian J Med Res. 2014;140(4):524–30.

CAS  PubMed  PubMed Central  Google Scholar 

Brown MS, Goldstein JL. Regulation of the activity of the low density lipoprotein receptor in human fibroblasts. Cell. 1975;6(3):307–16.

Article  CAS  PubMed  Google Scholar 

Leon-Cabrera S, Solís-Lozano L, Suárez-Álvarez K, González-Chávez A, Béjar YL, Robles-Díaz G, et al. Hyperleptinemia is associated with parameters of low-grade systemic inflammation and metablic dysfunction in obese human beings. Front Integr Neurosci. 2013;7:62.

Article  PubMed  PubMed Central  Google Scholar 

Canale MP, di Villahermosa SM, Martino G, Rovella V, Noce A, De Lorenzo A, et al. Obesity-related metabolic syndrome: mechanisms of sympathetic overactivity. Int J Endocrinol. 2013;2013:865965.

Article  PubMed  PubMed Central  Google Scholar 

Shebl TH, Azeem NEDA, Younis HA, Soliman AM, Ashmawy AM, Ali MMN. Relationship between serum leptin concentration and insulin resistance syndrome in patients with type 2 diabetes mellitus. J Curr Med Res Pract. 2017;2(2):125–32.

Article  Google Scholar 

Amitani M, Asakawa A, Amitani H, Inui A. The role of leptin in the control of insulin-glucose axis. Front Neurosci. 2013;7:51.

Article  PubMed  PubMed Central  Google Scholar 

Al-Goblan AS, Al-Alfi MA, Khan MZ. Mechanism linking diabetes mellitus and obesity. Diabetes, Metabolic Syndrome Obes. 2014;7:587–91.

Article  Google Scholar 

Eckel RH, Kahn SE, Ferrannini E, Goldfine AB, Nathan DM, Schwartz MW, et al. Obesity and type 2 diabetes: What can be unified and what needs to be individualized? J Clin Endocrinol Metab. 2011;96(6):1654–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

D’Elia L, Strazzullo P, Lacone R, Russo O, Galletti F. Leptin levels predict the development of insulin resistance in a sample of adult men–the Olivetti heart study. Nutr Metab Cardiovasc Dis. 2019;29(1):39–44.

Article  PubMed  Google Scholar 

Moonishaa TM, Nanda SK, Shamraj M, Sivaa R, Sivakumar P, Ravichandran K. Evaluation of leptin as a marker of insulin resistance in type 2 diabetes mellitus. Int J App Basic Med Res. 2017;7(3):176–80.

Article  CAS  Google Scholar 

Arakane F, Kallen CB, Watari H, Foster JA, Sepuri NB, Pain D, et al. The mechanism of action of steroidogenic acute regulatory protein (StAR). StAR acts on the outside of mitochondria to stimulate steroidogenesis. J Biol Chem. 1998;273(26):16339–45.

Article  CAS  PubMed  Google Scholar 

Jenster G, Spencer TE, Burcin MM, Tsai SY, Tsai M-J, O’Malley BW. Steroid receptor induction of gene transcription: a two-step model. PNAS. 1997;94(15):7879–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Selvaraj V, Stocco DM, Tu LN. Minireview: translocator protein (TSPO) and steroidogenesis: a reappraisal. Mol Endocrinol. 2015;29(4):490–501.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Corsi L, Geminiani E, Baraldi M. Peripheral benzodiazepine receptor (PBR): New insight in cell proliferation and cell differentiation review. Curr Clin Pharmacol. 2008;3(1):38–45.

Article  CAS  PubMed  Google Scholar 

Albi E, Magni MV. The presence and the role of chromatin cholesterol in rat liver regeneration. J Hepatol. 2002;36(3):395–400.

Article  CAS  PubMed  Google Scholar 

Albi E, Cataldi S, Rossi G, Magni MV. A possible role of cholesterol-sphingomyelin/phosphatidylcholine in nuclear matrix during rat liver regeneration. J Hepatol. 2003;38(5):623–8.

Article  CAS  PubMed  Google Scholar 

Chen HW. Role of cholesterol metabolism in cell growth. Fed Proc. 1984;43(1):126–30.