Preeclampsia is Associated with Altered Expression of Ferroptosis Biomarkers in Placental but not Maternal Vasculature

Muckenthaler MU, Rivella S, Hentze MW, Galy B. A red carpet for iron metabolism. Cell. 2017;168:344–61.

CAS  PubMed  PubMed Central  Google Scholar 

Centers for Disease Control and Prevention. Iron deficiency–United States, 1999–2000. MMWR Morb Mortal Wkly Rep. 2002;51:897–9.

Google Scholar 

Allen LH. Anemia and iron deficiency: effects on pregnancy outcome. Am J Clin Nutr. 2000;71:1280S-S1284.

CAS  PubMed  Google Scholar 

Dewey KG, Oaks BM. U-shaped curve for risk associated with maternal hemoglobin, iron status, or iron supplementation. Am J Clin Nutr. 2017;106:1694S-S1702.

PubMed  PubMed Central  Google Scholar 

Fisher AL, Nemeth E. Iron homeostasis during pregnancy. Am J Clin Nutr. 2017;106:1567S-S1574.

PubMed  PubMed Central  Google Scholar 

Rayman MP, Barlis J, Evans RW, Redman CW, King LJ. Abnormal iron parameters in the pregnancy syndrome preeclampsia. Am J Obstet Gynecol. 2002;187:412–8.

CAS  PubMed  Google Scholar 

Ng SW, Norwitz SG, Norwitz ER. The impact of iron overload and ferroptosis on reproductive disorders in humans: implications for preeclampsia. Int J Mol Sci. 2019;20.

Feng H, Stockwell BR. Unsolved mysteries: how does lipid peroxidation cause ferroptosis? PLoS Biol. 2018;16:e2006203.

PubMed  PubMed Central  Google Scholar 

Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 2017;171:273–85.

CAS  PubMed  PubMed Central  Google Scholar 

Zheng J, Conrad M. The metabolic underpinnings of ferroptosis. Cell Metab. 2020;32:920–37.

CAS  PubMed  Google Scholar 

Ursini F, Maiorino M, Valente M, Ferri L, Gregolin C. Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides. Biochim Biophys Acta. 1982;710:197–211.

CAS  PubMed  Google Scholar 

Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature. 2019;575:693–8.

CAS  PubMed  Google Scholar 

Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 2019;575:688–92.

CAS  PubMed  PubMed Central  Google Scholar 

Ayala A, Munoz MF, Arguelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev. 2014;2014:360438.

PubMed  PubMed Central  Google Scholar 

Jang EJ, Kim DH, Lee B, Lee EK, Chung KW, Moon KM, et al. Activation of proinflammatory signaling by 4-hydroxynonenal-Src adducts in aged kidneys. Oncotarget. 2016;7:50864–74.

PubMed  PubMed Central  Google Scholar 

Dixon SJ, Stockwell BR. The role of iron and reactive oxygen species in cell death. Nat Chem Biol. 2014;10:9–17.

CAS  PubMed  Google Scholar 

Gutierrez-Aguirre CH, Garcia-Lozano JA, Trevino-Montemayor OR, Iglesias-Benavides JL, Cantu-Rodriguez OG, Gonzalez-Llano O, et al. Comparative analysis of iron status and other hematological parameters in preeclampsia. Hematology. 2017;22:36–40.

CAS  PubMed  Google Scholar 

Uzun H, Benian A, Madazli R, Topcuoglu MA, Aydin S, Albayrak M. Circulating oxidized low-density lipoprotein and paraoxonase activity in preeclampsia. Gynecol Obstet Invest. 2005;60:195–200.

CAS  PubMed  Google Scholar 

Staff AC, Johnsen GM, Dechend R, Redman CWG. Preeclampsia and uteroplacental acute atherosis: immune and inflammatory factors. J Reprod Immunol. 2014;101–102:120–6.

PubMed  Google Scholar 

Brown MA, Magee LA, Kenny LC, Karumanchi SA, McCarthy FP, Saito S, et al. Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice. Hypertension. 2018;72:24–43.

CAS  PubMed  Google Scholar 

Alnaes-Katjavivi P, Lyall F, Roald B, Redman CW, Staff AC. Acute atherosis in vacuum suction biopsies of decidua basalis: an evidence based research definition. Placenta. 2016;37:26–33.

PubMed  Google Scholar 

Krikun G, Mor G, Alvero A, Guller S, Schatz F, Sapi E, et al. A novel immortalized human endometrial stromal cell line with normal progestational response. Endocrinology. 2004;145:2291–6.

CAS  PubMed  Google Scholar 

Straszewski-Chavez SL, Abrahams VM, Alvero AB, Aldo PB, Ma Y, Guller S, et al. The isolation and characterization of a novel telomerase immortalized first trimester trophoblast cell line, Swan 71. Placenta. 2009;30:939–48.

CAS  PubMed  PubMed Central  Google Scholar 

Krikun G, Mor G, Huang J, Schatz F, Lockwood CJ. Metalloproteinase expression by control and telomerase immortalized human endometrial endothelial cells. Histol Histopathol. 2005;20:719–24.

CAS  PubMed  Google Scholar 

Hombach-Klonisch S, Kehlen A, Fowler PA, Huppertz B, Jugert JF, Bischoff G, et al. Regulation of functional steroid receptors and ligand-induced responses in telomerase-immortalized human endometrial epithelial cells. J Mol Endocrinol. 2005;34:517–34.

CAS  PubMed  Google Scholar 

Tang B, Guller S, Gurpide E. Cyclic adenosine 3’,5’-monophosphate induces prolactin expression in stromal cells isolated from human proliferative endometrium. Endocrinology. 1993;133:2197–203.

CAS  PubMed  Google Scholar 

Ng SW, Lee C, Ng A, Ng SK, Arcuri F, House MD, et al. Ferroportin expression and regulation in human placenta/fetal membranes: implications for ferroptosis and adverse pregnancy outcomes. Reprod Biol. 2023;23:100816.

CAS  PubMed  Google Scholar 

Norwitz ER, Tsen LC, Park JS, Fitzpatrick PA, Dorfman DM, Saade GR, et al. Discriminatory proteomic biomarker analysis identifies free hemoglobin in the cerebrospinal fluid of women with severe preeclampsia. Am J Obstet Gynecol. 2005;193:957–64.

CAS  PubMed  Google Scholar 

Staff AC, Fjeldstad HE, Fosheim IK, Moe K, Turowski G, Johnsen GM, et al. Failure of physiological transformation and spiral artery atherosis: their roles in preeclampsia. Am J Obstet Gynecol. 2022;226:S895–906.

CAS  PubMed  Google Scholar 

Cheung K, Ma L, Wang G, Coe D, Ferro R, Falasca M, et al. CD31 signals confer immune privilege to the vascular endothelium. Proc Natl Acad Sci U S A. 2015;112:E5815–24.

CAS  PubMed  PubMed Central  Google Scholar 

Goksu Erol AY, Nazli M, Elis YS. Significance of platelet endothelial cell adhesion molecule-1 (PECAM-1) and intercellular adhesion molecule-1 (ICAM-1) expressions in preeclamptic placentae. Endocrine. 2012;42:125–31.

PubMed  Google Scholar 

Liu H, Li Y, Zhang J, Rao M, Liang H, Liu G. The defect of both angiogenesis and lymphangiogenesis is involved in preeclampsia. Placenta. 2015;36:279–86.

CAS  PubMed  Google Scholar 

Roberts JM, Escudero C. The placenta in preeclampsia. Preg Hypertens. 2012;2:72–83.

CAS  Google Scholar 

Phipps EA, Thadhani R, Benzing T, Karumanchi SA. Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nat Rev Nephrol. 2019;15:275–89.

PubMed  PubMed Central  Google Scholar 

Tomimatsu T, Mimura K, Endo M, Kumasawa K, Kimura T. Pathophysiology of preeclampsia: an angiogenic imbalance and long-lasting systemic vascular dysfunction. Hypertens Res. 2017;40:305–10.

CAS  PubMed  Google Scholar 

Chambers JC, Fusi L, Malik IS, Haskard DO, De Swiet M, Kooner JS. Association of maternal endothelial dysfunction with preeclampsia. JAMA. 2001;285:1607–12.

CAS  PubMed  Google Scholar 

Lopes-Ramos CM, Paulson JN, Chen CY, Kuijjer ML, Fagny M, Platig J, et al. Regulatory network changes between cell lines and their tissues of origin. BMC Genom. 2017;18:723.

Google Scholar 

Ertel A, Verghese A, Byers SW, Ochs M, Tozeren A. Pathway-specific differences between tumor cell lines and normal and tumor tissue cells. Mol Cancer. 2006;5:55.

PubMed  PubMed Central  Google Scholar 

Gudipaty SA, Conner CM, Rosenblatt J, Montell DJ. Unconventional ways to live and die: cell death and survival in development, homeostasis, and disease. Annu Rev Cell Dev Biol. 2018;34:311–32.

CAS  PubMed  PubMed Central  Google Scholar 

Tang D, Kang R, Berghe TV,

Comments (0)

No login
gif