Biswas B, Bhushan S, Rajesh A, Suraj SK, Lu Y, Meinhardt A, Yenugu S. Uropathogenic Escherichia coli (UPEC) induced antimicrobial gene expression in the male reproductive tract of rat: evaluation of the potential of Defensin 21 to limit infection. Andrology. 2015;3(2):368–75. https://doi.org/10.1111/andr.12012.
Article CAS PubMed Google Scholar
Wu H, Wang F, Tang D, Han D. Mumps orchitis: clinical aspects and mechanisms. Front Immunol. 2021. https://doi.org/10.3389/fimmu.2021.582946.
Article PubMed PubMed Central Google Scholar
Fijak M, Pilatz A, Hedger MP, Nicolas N, Bhushan S, Michel V, Tung KSK, Schuppe H-C, Meinhardt A. Infectious, inflammatory and ‘autoimmune’ male factor infertility: how do rodent models inform clinical practice? Hum Reprod Update. 2018;24(4):416–41. https://doi.org/10.1093/humupd/dmy009.
Article CAS PubMed PubMed Central Google Scholar
Olesen IA, Andersson A-M, Aksglaede L, Skakkebaek NE. Rajpert–de Meyts E, Joergensen N, Juul A. Clinical, genetic, biochemical, and testicular biopsy findings among 1,213 men evaluated for infertility. Fertil Steril. 2017;107(1):74-82.e77. https://doi.org/10.1016/j.fertnstert.2016.09.015.
Missassi G, dos Santos Borges C, de Lima Rosa J, Villela e Silva P, da Cunha Martins A, Barbosa F, De Grava Kempinas W, Persichini T. Chrysin administration protects against oxidative damage in varicocele‐induced adult rats. Oxid Med Cell Longev. 2017;2017(1):2172981 https://doi.org/10.1155/2017/2172981.
Zhao S, Zhu W, Xue S, Han D. Testicular defense systems: immune privilege and innate immunity. Cell Mol Immunol. 2014;11(5):428–37. https://doi.org/10.1038/cmi.2014.38.
Article PubMed PubMed Central Google Scholar
Cheng CY, Mruk DD, Sibley DR. The blood-testis barrier and its implications for male contraception. Pharmacol Rev. 2012;64(1):16–64. https://doi.org/10.1124/pr.110.002790.
Article CAS PubMed PubMed Central Google Scholar
Ilani N, Armanious N, Lue YH, Swerdloff RS, Baravarian S, Adler A, Tsang C, Jia Y, Cui YG, Wang XH, et al. Integrity of the blood-testis barrier in healthy men after suppression of spermatogenesis with testosterone and levonorgestrel. Hum Reprod. 2012;27(12):3403–11. https://doi.org/10.1093/humrep/des340.
Article CAS PubMed PubMed Central Google Scholar
Huang X, Fu Y, Wang S, Guo Q, Wu Y, Zheng X, Wang J, Wu S, Shen L, Wei G. 2,2′,4,4′-tetrabromodiphenyl ether exposure disrupts blood-testis barrier integrity through CMA-mediated ferroptosis. Sci Total Environ. 2024. https://doi.org/10.1016/j.scitotenv.2024.174738.
Article PubMed PubMed Central Google Scholar
Li X-W, Li S, Yang Y, Talukder M, Xu X-W, Li C-X, Zhang C, Li X-N, Li J-L. The FAK/occludin/ZO-1 complex is critical for cadmium-induced testicular damage by disruption of the integrity of the blood-testis barrier in chickens. J Hazard Mater. 2024. https://doi.org/10.1016/j.jhazmat.2024.134126.
Article PubMed PubMed Central Google Scholar
Huang C, Zhang W, Sun A, Zhang X, Guo J, Ji R, Qiao L, Sun X, Zhao D. Methane ameliorates lipopolysaccharide-induced acute orchitis by anti-inflammatory, antioxidative, and antiapoptotic effects via regulation of the PK2/PKR1 pathway. Oxid Med Cell Longev. 2020;2020: 2020:1–11. https://doi.org/10.1155/2020/7075836.
Cheng N, Liang Y, Du X, Ye RD. Serum amyloid A promotes LPS clearance and suppresses LPS-induced inflammation and tissue injury. EMBO Rep 2018;19(10). https://doi.org/10.15252/embr.201745517.
Lu Y, Chen H, Chen Y, Zhao L, Hou S. Accumulated LPS induced by colitis altered the activities of vitamin D-metabolizing hydroxylases and decreased the generation of 25-hydroxyvitamin D. Chemico-Biological Interactions. 2024;395:395. https://doi.org/10.1016/j.cbi.2024.110997.
Yu X, Lan P, Hou X, Han Q, Lu N, Li T, Jiao C, Zhang J, Zhang C, Tian Z. HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production. J Hepatol. 2017;66(4):693–702. https://doi.org/10.1016/j.jhep.2016.12.018.
Article CAS PubMed Google Scholar
Ciesielska A, Matyjek M, Kwiatkowska K. TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling. Cell Mol Life Sci. 2020;78(4):1233–61. https://doi.org/10.1007/s00018-020-03656-y.
Article CAS PubMed PubMed Central Google Scholar
Pereira M, Durso DF, Bryant CE, Kurt-Jones EA, Silverman N, Golenbock DT, Gazzinelli RT. The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways. Cell Rep. 2022. https://doi.org/10.1016/j.celrep.2022.111225.
Article PubMed PubMed Central Google Scholar
Zeng R, Jin C, Zheng C, Li S, Qian S, Pan J, Wang L, Zhao J, Qin L. OCT4 represses inflammation and cell injury during orchitis by regulating CIP2A expression. Front Cell Dev Biol. 2021;9: 683209. https://doi.org/10.3389/fcell.2021.683209.
Article PubMed PubMed Central Google Scholar
Chen L, Zheng L, Chen P, Liang G. Myeloid differentiation primary response protein 88 (MyD88): the central hub of TLR/IL-1R signaling. J Med Chem. 2020;63(22):13316–29. https://doi.org/10.1021/acs.jmedchem.0c00884.
Article CAS PubMed Google Scholar
Kuang P, Guo H, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Sodium fluoride impairs splenic innate immunity via inactivation of TLR2/MyD88 signaling pathway in mice. Chemosphere. 2019;237:237. https://doi.org/10.1016/j.chemosphere.2019.124437.
Wang Z, Li L, Yan H, Li W, Pang Y, Yuan Y. Salidroside ameliorates furan-induced testicular inflammation in relation to the gut-testis axis and intestinal apoptosis. J Agric Food Chem. 2023;71(46):17968–87. https://doi.org/10.1021/acs.jafc.3c06587.
Article CAS PubMed Google Scholar
Yang J, Zhang M, Luo Y, Xu F, Gao F, Sun Y, Yang B, Kuang H. Protopine ameliorates OVA-induced asthma through modulatingTLR4/MyD88/NF-κB pathway and NLRP3 inflammasome-mediated pyroptosis. Phytomedicine. 2024;126:126. https://doi.org/10.1016/j.phymed.2024.155410.
Dang X, He B, Ning Q, Liu Y, Guo J, Niu G, Chen M. Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2/HO-1 and inhibition of the NF-κB pathways. Respir Res. 2020. https://doi.org/10.1186/s12931-020-01358-4.
Article PubMed PubMed Central Google Scholar
Meng M, Huo R, Wang Y, Ma N, Shi X, Shen X, Chang G. Lentinan inhibits oxidative stress and alleviates LPS-induced inflammation and apoptosis of BMECs by activating the Nrf2 signaling pathway. Int J Biol Macromol. 2022;222:2375–91. https://doi.org/10.1016/j.ijbiomac.2022.10.024.
Article CAS PubMed Google Scholar
Bhushan S, Tchatalbachev S, Klug Jr, Fijak M, Pineau C, Chakraborty T, Meinhardt A. Uropathogenic Escherichia coli block MyD88-dependent and activate MyD88-independent signaling pathways in rat testicular cells. J Immunol. 2008;180(8):5537–47. https://doi.org/10.4049/jimmunol.180.8.5537.
Article CAS PubMed Google Scholar
Cai Z, Zhang Y, Yang L, Ma C, Fei Y, Ding J, Song W, Tong W-M, Niu Y, Li H. ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood–testis barrier integrity. Cell Mol Biol Lett. 2022;27(1): 101. https://doi.org/10.1186/s11658-022-00404-x.
Article CAS PubMed PubMed Central Google Scholar
Pindar C, Viau RA. Staphylococcus haemolyticus epididymo-orchitis and bacteraemia: a case report. JMM Case Rep. 2018;5(7): e005157. https://doi.org/10.1099/jmmcr.0.005157.
Article PubMed PubMed Central Google Scholar
Adler S. Mumps orchitis – attention should be paid to complete immunization. Aktuelle Urol. 2007;38(2):85–6. https://doi.org/10.1055/s-2007-973917.
Collodel G, Moretti E, Brecchia G, Kuzelova L, Arruda J, Mourvaki E, Castellini C. Cytokines release and oxidative status in semen samples from rabbits treated with bacterial lipopolysaccharide. Theriogenology. 2015;83(7):1233–40. https://doi.org/10.1016/j.theriogenology.2015.01.008.
Article CAS PubMed Google Scholar
Hou B, Wang F, Liu T, Wang Z. Reproductive toxicity of polystyrene microplastics: in vivo experimental study on testicular toxicity in mice. J Hazard Mater. 2021;405: 124028. https://doi.org/10.1016/j.jhazmat.2020.124028.
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