Chappell LC, Cluver CA, Kingdom J, Tong S. Pre-eclampsia. Lancet. 2021;398(10297):341–54.
Han C, Chen YY, Dong JF. Prothrombotic state associated with preeclampsia. Curr Opin Hematol. 2021;28(5):323–30.
CAS PubMed PubMed Central Google Scholar
Kasture V, Sahay A, Joshi S. Cell death mechanisms and their roles in pregnancy related disorders. Adv Protein Chem Struct Biol. 2021;126:195–225.
Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060–72.
CAS PubMed PubMed Central Google Scholar
Wang Q, Xiong Z, Wang B, Wang W, Zheng H. Ferroptosis and preeclampsia: genetic analysis of potential biomarkers and therapeutic targets. Biochem Genet. 2024;62(2):853–75.
Rao RC, Dou Y. Hijacked in cancer: the KMT2 (MLL) family of methyltransferases. Nat Rev Cancer. 2015;15(6):334–46.
CAS PubMed PubMed Central Google Scholar
Ford DJ, Dingwall AK. The cancer COMPASS: navigating the functions of MLL complexes in cancer. Cancer Genet. 2015;208(5):178–91.
Xu J, Li L, Xiong J, Dendekker A, Ye A, Karatas H, et al. MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program. Cell Discov. 2016;2:16008.
CAS PubMed PubMed Central Google Scholar
Wu J, Qin C, Tian F, Liu X, Hu J, Wu F, et al. Epigenetic drug screening for trophoblast syncytialization reveals a novel role for MLL1 in regulating fetoplacental growth. BMC Med. 2024;22(1):57.
CAS PubMed PubMed Central Google Scholar
Li L, He H, Zheng Z, Zhao X. MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis. Biol Direct. 2024;19(1):133.
PubMed PubMed Central Google Scholar
Harrigan JA, Jacq X, Martin NM, Jackson SP. Deubiquitylating enzymes and drug discovery: emerging opportunities. Nat Rev Drug Discov. 2018;17(1):57–78.
Sun J, Shi X, Mamun MA, Gao Y. The role of deubiquitinating enzymes in gastric cancer. Oncol Lett. 2020;19(1):30–44.
Xu J, Guo R, Wen N, Li L, Yi Y, Chen J, et al. FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis. PLoS Biol. 2023;21(12):e3002446.
CAS PubMed PubMed Central Google Scholar
Zhang H, Han Y, Xiao W, Gao Y, Sui Z, Ren P, et al. USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1. Cell Death Dis. 2023;14(11):730.
PubMed PubMed Central Google Scholar
Wu X, Hong J, Hong L. The deubiquitinating enzyme USP4 promotes trophoblast dysfunction by stabilizing RYBP. Cell Biochem Biophys. 2025;83(1):929–39.
Kirsch K, Zeke A, Tőke O, Sok P, Sethi A, Sebő A, et al. Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38. Nat Commun. 2020;11(1):5769.
CAS PubMed PubMed Central Google Scholar
Lau E, Kluger H, Varsano T, Lee K, Scheffler I, Rimm DL, et al. PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Cell. 2012;148(3):543–55.
CAS PubMed PubMed Central Google Scholar
Xiao S, Guo L, Zhang M, Hu R, Liu R. Low-dose aspirin May prevent preeclampsia by inhibiting the expression of ATF2. Endocr Metab Immune Disord Drug Targets. 2023;23(5):702–10.
Roberge S, Giguère Y, Villa P, Nicolaides K, Vainio M, Forest JC, et al. Early administration of low-dose aspirin for the prevention of severe and mild preeclampsia: a systematic review and meta-analysis. Am J Perinatol. 2012;29(7):551–6.
Tian X, Zheng L, Ma J, Xu Y, Zhang Y, Pi Y. Inhibition of LAMP3 mediates the protective effect of vitamin D against hypoxia/reoxygenation in trophoblast cells. Braz J Med Biol Res. 2023;56:e12816.
CAS PubMed PubMed Central Google Scholar
Zhang Y, Lu Y, Jin L. Iron metabolism and ferroptosis in physiological and pathological pregnancy. Int J Mol Sci. 2022;23(16):9395.
Ding Y, Yang X, Han X, Shi M, Sun L, Liu M, Zhang P, Huang Z, Yang X, Li R: Ferroptosis-related gene expression in the pathogenesis of preeclampsia. Front Genet 2022;13:927869.
You Y, Qian Z, Jiang Y, Chen L, Wu D, Liu L, et al. Insights into the pathogenesis of gestational and hepatic diseases: the impact of ferroptosis. Front Cell Dev Biol. 2024;12:1482838.
PubMed PubMed Central Google Scholar
Zhang H, He Y, Wang JX, Chen MH, Xu JJ, Jiang MH, et al. miR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia. Redox Biol. 2020;29:101402.
Castiglioni S, Di Fede E, Bernardelli C, Lettieri A, Parodi C, Grazioli P et al. KMT2A: umbrella gene for multiple diseases. Genes (Basel). 2022;13(3).
Fang Y, Zhang D, Hu T, Zhao H, Zhao X, Lou Z, et al. KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation. Cancer Med. 2019;8(7):3544–52.
CAS PubMed PubMed Central Google Scholar
Lin W, Francis JM, Li H, Gao X, Pedamallu CS, Ernst P, et al. Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets. Cancer Biol Ther. 2016;17(12):1274–81.
CAS PubMed PubMed Central Google Scholar
Scheiflinger A, Al-Gboore S, Jank BJ, Brkic F, Kadletz-Wanke L, Kenner L, et al. High USP4 mRNA is associated with an HPV-positive status in head and neck squamous cell carcinoma patients. J Cancer Res Clin Oncol. 2023;149(12):10675–83.
CAS PubMed PubMed Central Google Scholar
Yun SI, Kwak C, Lee SY, Shin S, Oh C, Kim JS, et al. Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells. Faseb J. 2023;37(5):e22900.
Kang S, Liu S, Dong X, Li H, Qian Y, Dai A et al. USP4 depletion-driven RAB7A ubiquitylation impairs autophagosome-lysosome fusion and aggravates periodontitis. Autophagy. 2024;1–18.
Mao M, Xia Q, Zhan G, Bing H, Zhang C, Wang J, et al. Vialinin A alleviates oxidative stress and neuronal injuries after ischaemic stroke by accelerating Keap1 degradation through inhibiting USP4-mediated deubiquitination. Phytomedicine. 2024;124:155304.
Lopez-Bergami P, Lau E, Ronai Z. Emerging roles of ATF2 and the dynamic AP1 network in cancer. Nat Rev Cancer. 2010;10(1):65–76.
CAS PubMed PubMed Central Google Scholar
Chen M, Liu Y, Yang Y, Qiu Y, Wang Z, Li X, et al. Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: implications in cancer immunotherapy. Genes Dis. 2022;9(4):981–99.
Meng H, Li J, Sun H, Lin Y, Xu H, Zhang N. The transcription factor ATF2 promotes gastric cancer progression by activating the METTL3/cyclin D1 pathway. Drug Dev Res. 2023;84(6):1325–34.
Lu Z, Xu J, Li J. The transcription factor ATF2 accelerates clear cell renal cell carcinoma progression through activating the PLEKHO1/NUS1 pathway. Mol Carcinog. 2025;64(4):617–28.
Xiao S, Guo L, Zhang M, Hu R, Liu R. Low-dose aspirin may prevent preeclampsia by inhibiting the expression of ATF2. Endocr Metab Immune Disord Drug Targets. 2023;23(5):702–10.
Matsui H, Iriyama T, Sayama S, Inaoka N, Suzuki K, Yoshikawa M et al. Elevated placental histone H3K4 methylation via upregulated histone methyltransferases SETD1A and SMYD3 in preeclampsia and its possible involvement in hypoxia-induced pathophysiological process. Placenta. 2021;115(60– 9.
Sheng W, Gu Y, Chu X, Morgan JA, Cooper DB, Lewis DF, et al. Upregulation of histone H3K9 methylation in fetal endothelial cells from preeclamptic pregnancies. J Cell Physiol. 2021;236(3):1866–74.
Comments (0)