Stener-Victorin E, et al. Polycystic ovary syndrome. Nat Rev Dis Primers. 2024;10(1):27.
Yang J, Chen C. Hormonal changes in PCOS. J Endocrinol, 2024. 261(1).
Tay CT, et al. 2023 international evidence-based polycystic ovary syndrome guideline update: insights from a systematic review and meta-analysis on elevated clinical cardiovascular disease in polycystic ovary syndrome. J Am Heart Assoc. 2024;13(16):e033572.
PubMed PubMed Central Google Scholar
Teede HJ, et al. Recommendations from the 2023 international Evidence-based guideline for the assessment and management of polycystic ovary syndrome. J Clin Endocrinol Metab. 2023;108(10):2447–69.
CAS PubMed PubMed Central Google Scholar
Kulkarni S, et al. Polycystic ovary syndrome: current scenario and future insights. Drug Discov Today. 2023;28(12):103821.
Yuan S, et al. Endoplasmic reticulum stress and therapeutic strategies in metabolic, neurodegenerative diseases and cancer. Mol Med. 2024;30(1):40.
CAS PubMed PubMed Central Google Scholar
Zhang R, et al. Endoplasmic reticulum stress in diabetic kidney disease: adaptation and apoptosis after three UPR pathways. Apoptosis. 2023;28(7–8):977–96.
So JS. Roles of endoplasmic reticulum stress in immune responses. Mol Cells. 2018;41(8):705–16.
CAS PubMed PubMed Central Google Scholar
Gómez AM, Bartelt A. Endocrine communication of endoplasmic reticulum stress. BioEssays. 2023;45(8):e2300093.
Zhang Y, Wang J. BRD4 absence inactivates endoplasmic reticulum stress to retard dehydroepiandrosterone-triggered ovarian granular cell apoptosis in polycystic ovary syndrome via GRP78. Tissue Cell. 2024;91:102531.
Niu Y, Wang N, Xu Q. Development of an endoplasmic reticulum Stress-Related diagnostic signature in polycystic ovary syndrome. Reprod Sci. 2025;32(1):238–50.
Takahashi N, et al. Activation of endoplasmic reticulum stress in granulosa cells from patients with polycystic ovary syndrome contributes to ovarian fibrosis. Sci Rep. 2017;7(1):10824.
PubMed PubMed Central Google Scholar
Sun HL et al. Does endoplasmic reticulum stress stimulate the apoptosis of granulosa cells in polycystic ovary syndrome? J Physiol Pharmacol, 2021. 72(5).
Jin J, et al. Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK. Hum Reprod. 2020;35(5):1145–58.
CAS PubMed PubMed Central Google Scholar
Brenjian S, et al. Resveratrol treatment in patients with polycystic ovary syndrome decreased pro-inflammatory and Endoplasmic reticulum stress markers. Am J Reprod Immunol. 2020;83(1):e13186.
Que Z, Lin CJ. One-Class SVM probabilistic outputs. IEEE Trans Neural Netw Learn Syst, 2024. Pp.
Hu J, Szymczak S. A review on longitudinal data analysis with random forest. Brief Bioinform, 2023. 24(2).
Liu Y, et al. LBCE-XGB: a XGBoost model for predicting linear B-Cell epitopes based on BERT embeddings. Interdiscip Sci. 2023;15(2):293–305.
Zareie B, et al. Outbreak detection algorithms based on generalized linear model: a review with new practical examples. BMC Med Res Methodol. 2023;23(1):235.
PubMed PubMed Central Google Scholar
Zhu B, et al. Androgens impair β-cell function in a mouse model of polycystic ovary syndrome by activating endoplasmic reticulum stress. Endocr Connect. 2021;10(3):265–72.
CAS PubMed PubMed Central Google Scholar
Koike H et al. Notch signaling induced by endoplasmic reticulum stress regulates cumulus-oocyte complex expansion in polycystic ovary syndrome. Biomolecules, 2022. 12(8).
Koike H, et al. Roles of endoplasmic reticulum stress in the pathophysiology of polycystic ovary syndrome. Front Endocrinol (Lausanne). 2023;14:1124405.
Ding H, et al. Endoplasmic reticulum stress-mediated ferroptosis in granulosa cells contributes to follicular dysfunction of polycystic ovary syndrome driven by hyperandrogenism. Reprod Biomed Online. 2024;49(3):104078.
Tossetta G et al. The role of NQO1 in ovarian cancer. Int J Mol Sci, 2023. 24(9).
Ross D, Siegel D. The diverse functionality of NQO1 and its roles in redox control. Redox Biol. 2021;41:101950.
CAS PubMed PubMed Central Google Scholar
Huang J, et al. Dysregulation of ferroptosis-related genes in granulosa cells associates with impaired oocyte quality in polycystic ovary syndrome. Front Endocrinol (Lausanne). 2024;15:1346842.
Atiomo W, et al. Expression of NAD(P)H Quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 2017;87(6):886.
Zhang W, et al. Regulation of TFEB activity and its potential as a therapeutic target against kidney diseases. Cell Death Discov. 2020;6:32.
CAS PubMed PubMed Central Google Scholar
Cui Z, et al. Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature. 2023;614(7948):572–9.
CAS PubMed PubMed Central Google Scholar
Gosis BS, et al. Inhibition of nonalcoholic fatty liver disease in mice by selective Inhibition of mTORC1. Science. 2022;376(6590):eabf8271.
CAS PubMed PubMed Central Google Scholar
Saito M, et al. Classical and desmosomal cadherins at a glance. J Cell Sci. 2012;125(Pt 11):2547–52.
CAS PubMed PubMed Central Google Scholar
Chen K, et al. Junction Plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma. Cancer Commun (Lond). 2021;41(4):316–32.
Zinkovsky D, Sood MR. Isolated JUP Plakoglobin gene mutation with left ventricular fibrosis in Familial arrhythmogenic right ventricular cardiomyopathy. J Cardiovasc Electrophysiol. 2023;34(10):2112–21.
Yang L, et al. Androgen dihydrotestosterone promotes bladder cancer cell proliferation and invasion via EPPK1-mediated MAPK/JUP signalling. Cell Death Dis. 2023;14(6):363.
CAS PubMed PubMed Central Google Scholar
Li D, et al. Lack of Plakoglobin in epidermis leads to keratoderma. J Biol Chem. 2012;287(13):10435–43.
CAS PubMed PubMed Central Google Scholar
Negoita F, et al. JUP/plakoglobin is regulated by salt-inducible kinase 2, and is required for insulin-induced signalling and glucose uptake in adipocytes. Cell Signal. 2020;76:109786.
He W, et al. Npy transcription is regulated by noncanonical STAT3 signaling in hypothalamic neurons: implication with lipotoxicity and obesity. Mol Cell Endocrinol. 2024;586:112179.
Cattaneo, S., et al., NPY and gene therapy for epilepsy: how, when,… and Y. Front Mol Neurosci, 2020. 13: p. 608001.
Urata Y, et al. Neuropeptide Y directly reduced apoptosis of granulosa cells, and the expression of NPY and its receptors in PCOS subjects. J Ovarian Res. 2023;16(1):182.
CAS PubMed PubMed Central Google Scholar
Mielnicki LM, Pruitt SC. Isolation and nucleotide sequence of a murine cDNA homologous to human activating transcription factor 4. Nucleic Acids Res. 1991;19(22):6332.
CAS PubMed PubMed Central Google Scholar
Wu D, Liang J. Activating transcription factor 4: a regulator of stress response in human cancers. Front Cell Dev Biol. 2024;12:1370012.
PubMed PubMed Central Google Scholar
Di F, et al. Activating transcriptional factor 4 correlated with obesity and insulin resistance in polycystic ovary syndrome. Gynecol Endocrinol. 2019;35(4):351–5.
Di F, et al. ATF4 contributes to ovulation via regulating COX2/PGE2 expression: a potential role of ATF4 in PCOS. Front Endocrinol (Lausanne). 2018;9:669.
Luan YY, et al. Immune regulation in polycystic ovary syndrome. Clin Chim Acta. 2022;531:265–72.
Shabbir S, et al. The interplay between androgens and the immune response in polycystic ovary syndrome. J Transl Med. 2023;21(1):259.
Comments (0)