Arno, V., & Masato, Y. (2020). Regulation of AQP4 in the central nervous system. International Journal of Molecular Sciences, 21(5), 1603.
Arslan, K., & Sultan Sahin, A. (2024). Prognostic value of systemic immune-inflammation index and systemic inflammatory response index on functional status and mortality in patients with critical acute ischemic stroke. Tohoku Journal of Experience Medicine, 2024.
Banerjee, A., Ghatak, S., & Sikdar, S. K. (2016). l-Lactate mediates neuroprotection against ischaemia by increasing TREK1 channel expression in rat hippocampal astrocytes in vitro. Journal of Neurochemistry, 138(2), 265–281.
Article CAS PubMed Google Scholar
Beylerli, O., Gareev, I., Beilerli, A., et al. (2024). The function of astrocytes in cerebral infarction and potential therapeutic approaches. Brain Hemorrhages, 2024.
Bhatt, M., Sharma, M., & Das, B. (2024). The role of inflammatory cascade and reactive astrogliosis in glial scar formation post-spinal cord injury. Cellular and Molecular Neurobiology, 44(1), 78.
Article CAS PubMed Google Scholar
Chen, W., Su, G., Chai, M., et al. (2025). Astrogliosis and glial scar in ischemic stroke—Focused on mechanism and treatment. Experimental Neurology, 385, Article 115131.
Article CAS PubMed Google Scholar
Chen, Z., Yuan, Z., Yang, S., et al. (2023). Brain energy metabolism: Astrocytes in neurodegenerative diseases. CNS Neuroscience & Therapeutics, 29(1), 24–36.
Chengfeng, S., Luyi, L., Lekang, Y, et al. (2022). Acutely inhibiting AQP4 with TGN-020 improves functional outcome by attenuating edema and peri-infarct astrogliosis after cerebral ischemia. Frontiers in Immunology, 13.
Crane, J. M., Tajima, M., & Verkman, A. S. (2010). Live-cell imaging of aquaporin-4 diffusion and interactions in orthogonal arrays of particles. Neuroscience, 168(4), 892–902.
Article CAS PubMed Google Scholar
Fan, Y. Y., & Huo, J. (2021). A1/A2 astrocytes in central nervous system injuries and diseases: Angels or devils? Neurochemistry International, 148, Article 105080.
Article CAS PubMed Google Scholar
Feng, X. F., Li, M. C., Lin, Z. Y., et al. (2023). Tetramethylpyrazine promotes stroke recovery by inducing the restoration of neurovascular unit and transformation of A1/A2 reactive astrocytes. Frontiers in Cellular Neuroscience, 17, 1125412.
Article CAS PubMed PubMed Central Google Scholar
Gava-Junior, G., Ferreira, S. A., Roque, C., et al. (2023). High-frequency repetitive magnetic stimulation rescues ischemia-injured neurons through modulation of glial-derived neurotrophic factor present in the astrocyte’s secretome. Journal of Neurochemistry, 164(6), 813–828.
Article CAS PubMed Google Scholar
Haas, S. J., Zhou, X., Machado, V., et al. (2016). Expression of Tgfβ1 and inflammatory markers in the 6-hydroxydopamine mouse model of Parkinson’s disease. Frontiers in Molecular Neuroscience, 9, 7.
Article PubMed PubMed Central Google Scholar
Hao, J. Q., He, X. Y., Yang, X., et al. (2022). Acetazolamide alleviate cerebral edema induced by ischemic stroke through inhibiting the expression of AQP4 mRNA. Neurocritical Care, 36(1), 97–105.
Article CAS PubMed Google Scholar
Hu, R., Dun, X., Singh, L., et al. (2024). Runx2 regulates peripheral nerve regeneration to promote Schwann cell migration and re-myelination. Neural Regeneration Research, 19(7), 1575–1583.
Article CAS PubMed Google Scholar
Huang, R. L., Yuan, Y., Tu, J., et al. (2014). Opposing TNF-α/IL-1β- and BMP-2-activated MAPK signaling pathways converge on Runx2 to regulate BMP-2-induced osteoblastic differentiation. Cell Death & Disease, 5(4), Article e1187.
Komori, T. (2019). Regulation of proliferation, differentiation and functions of osteoblasts by Runx2. International Journal of Molecular Science, 20(7).
Li, L., Dong, L., Xiao, Z., et al. (2020). Integrated analysis of the proteome and transcriptome in a MCAO mouse model revealed the molecular landscape during stroke progression. Journal of Advanced Research, 24, 13–27.
Article CAS PubMed PubMed Central Google Scholar
Li, P., Yao, Y., Ma, Y., et al. (2021). MiR-30a-5p ameliorates LPS-induced inflammatory injury in human A549 cells and mice via targeting RUNX2. Innate Immunity, 27(1), 41–49.
Li, W., Zhang, Y., Yang, F., et al. (2024). Molecular mechanism by which TRPC6 regulates calcium signaling and neuroinflammation in the onset and development of ischemic stroke: A review. Alternative Therapies in Health and Medicine, 30(8), 170–175.
Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., et al. (2017). Neurotoxic reactive astrocytes are induced by activated microglia. Nature, 541(7638), 481–487.
Article CAS PubMed PubMed Central Google Scholar
Lisda, A. (2021).Glial fibrillary acidic protein (GFAP): Neuroinflammation biomarker in acute ischemic stroke. Journal of Inflammation Research, 2021, 7501–7506.
Liu, H., Qiu, G., Zhuo, F., et al. (2015). Lost polarization of aquaporin4 and dystroglycan in the core lesion after traumatic brain injury suggests functional divergence in evolution. BioMed Research International, 2015, Article 471631.
Article PubMed PubMed Central Google Scholar
Liu, Y., Hu, P., Cheng, H., et al. (2025). The impact of glycolysis on ischemic stroke: From molecular mechanisms to clinical applications. Frontiers in Neurology, 16, 1514394.
Article PubMed PubMed Central Google Scholar
Lu, L., Ye, J., Yi, D., et al. (2024). Runx2 suppresses astrocyte activation and Astroglial scar formation after spinal cord injury in mice. Molecular Neurobiology, 61(12), 10820–10829.
Article CAS PubMed PubMed Central Google Scholar
Lu, W., & Wen, J. (2025). Metabolic reprogramming and astrocytes polarization following ischemic stroke. Free Radical Biology & Medicine, 228, 197–206.
Nadia, S., Negar, Z., Shervin, B., et al. (2024). Aquaporin-4 deletion leads to reduced infarct volume and increased peri-infarct astrocyte reactivity in a mouse model of cortical stroke. The Journal of Physiology, 602(13), 3151–3168.
Nie, Y., Wen, L., Li, H., et al. (2022). Tanhuo formula inhibits astrocyte activation and apoptosis in acute ischemic stroke. Frontier PharMCAOl, 13, Article 859244.
Okawa, S., Nicklas, S., Zickenrott, S., et al. (2016). A generalized gene-regulatory network model of stem cell differentiation for predicting lineage specifiers. Stem Cell Reports, 7(3), 307–315.
Article CAS PubMed PubMed Central Google Scholar
Patabendige, A., Singh, A., Jenkins, S., et al. (2021). Astrocyte activation in neurovascular damage and repair following ischaemic stroke. International Journal of Molecular Science, 22(8).
Patrick, R., Pando, B. D., Yang, C., et al. (2025). Focal adhesion kinase mediates microvascular leakage and endothelial barrier dysfunction in ischemia-reperfusion injury. Microvascular Research, 159, Article 104791.
Article CAS PubMed Google Scholar
Qiao, Y., Liu, H., He, C., et al. (2024). ApoE mimic peptide COG1410 reduces Aβ deposition and improves cognitive function by inducing the transformation of A1/A2 reactive astrocytes and increasing the BDNF concentration in brain of APP/PS1 double transgenic mice. Neuroscience, 537, 116–125.
Article CAS PubMed Google Scholar
Seo, W., & Taniuchi, I. (2020). The roles of RUNX family proteins in development of immune cells. Molecules and Cells, 43(2), 107–113.
CAS PubMed PubMed Central Google Scholar
Sharma, A., Aylar, D., Lee, Y., et al. (2024). Extracellular CIRP induces neurotoxic A1 astrocytes via TREM-1 in Alzheimer’s disease. Alzheimer’s & Dementia, 20, Article e094835.
Shi, Y., Yi, C., Li, X., et al. (2017). Overexpression of Mitofusin2 decreased the reactive astrocytes proliferation in vitro induced by oxygen-glucose deprivation/reoxygenation. Neuroscience Letters, 639, 68–73.
Article CAS PubMed Google Scholar
Vasseur, P., Devaure, I., Sellier, J., et al. (2014). High plasma levels of the pro-inflammatory cytokine IL-22 and the anti-inflammatory cytokines IL-10 and IL-1ra in acute pancreatitis. Pancreatology, 14(6), 465–469.
Article CAS PubMed Google Scholar
Vella, J., Zammit, C., di Giovanni, G., et al. (2015). The central role of aquaporins in the pathophysiology of ischemic stroke. Frontiers in Cellular Neuroscience, 9, 108.
Comments (0)