Albensi, B. C. (2019). What is nuclear factor kappa B (NF-κB) doing in and to the mitochondrion? Front Cell Dev Biol., 7, 154.
PubMed PubMed Central Google Scholar
An, S. S., Shim, K. H., Kang, S., Kim, Y. K., Subedi, L., Cho, H., Hong, S. M., Tan, M. A., Jeon, R., Chang, K. A., & Kim, S. Y. (2022). The potential anti-amyloidogenic candidate, SPA1413, for AD. British Journal of Pharmacology, 179(5), 1033–48.
Andrabi, S. M., Sharma, N. S., Karan, A., Shahriar, S. S., Cordon, B., Ma, B., & Xie, J. (2023). Nitric oxide: Physiological functions, delivery, and biomedical applications. Advanced Science, 10(30), 2303259.
CAS PubMed PubMed Central Google Scholar
Ariyani, W., Miyazaki, W., & Koibuchi, N. (2019). A novel mechanism of S-equol action in neurons and astrocytes: The possible involvement of GPR30/GPER1. International Journal of Molecular Sciences, 20(20), 5178.
CAS PubMed PubMed Central Google Scholar
Atia, A., Alrawaiq, N., & Abdullah, A. (2014). A review of NAD(P)H: Quinone oxidoreductase 1 (NQO1); a multifunctional antioxidant enzyme. Journal of Applied Pharmaceutical Science, 4(12), 118–122.
Bertrand, S. J., Hu, C., Aksenova, M. V., Mactutus, C. F., & Booze, R. M. (2015). HIV-1 Tat and cocaine mediated synaptopathy in cortical and midbrain neurons is prevented by the isoflavone Equol. Frontiers in Microbiology, 6, 894.
PubMed PubMed Central Google Scholar
Biswas, K. (2023). Microglia mediated neuroinflammation in neurodegenerative diseases: A review on the cell signaling pathways involved in microglial activation. Journal of Neuroimmunology, 383, Article 578180.
Bustamante-Barrientos, F. A., Méndez-Ruette, M., Ortloff, A., Luz-Crawford, P., Rivera, F. J., Figueroa, C. D., Molina, L., & Bátiz, L. F. (2021). The impact of estrogen and estrogen-like molecules in neurogenesis and neurodegeneration: Beneficial or harmful? Frontiers in Cellular Neuroscience, 15, 636176.
CAS PubMed PubMed Central Google Scholar
Chakrabarti, M., Haque, A., Banik, N. L., Nagarkatti, P., Nagarkatti, M., & Ray, S. K. (2014). Estrogen receptor agonists for attenuation of neuroinflammation and neurodegeneration. Brain Research Bulletin, 109, 22–31.
CAS PubMed PubMed Central Google Scholar
Chung, K. K., & David, K. K. (2010). Emerging roles of nitric oxide in neurodegeneration. Nitric Oxide, 22(4), 290–295.
Cipriano, G. L., Mazzon, E., & Anchesi, I. (2024). Estrogen receptors: A new frontier in AD therapy. International Journal of Molecular Sciences, 25(16), 9077.
CAS PubMed PubMed Central Google Scholar
Dash, U. C., Bhol, N. K., Swain, S. K., Samal, R. R., Nayak, P. K., Raina, V., Panda, S. K., Kerry, R. G., Duttaroy, A. K., & Jena, A. B. (2024). Oxidative stress and inflammation in the pathogenesis of neurological disorders: Mechanisms and implications. Acta Pharmaceutica Sinica B, 16, 15.
Dinkova-Kostova, A. T., & Talalay, P. (2010). NAD(P)H: Quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector. Archives of Biochemistry and Biophysics, 501(1), 116–123.
CAS PubMed PubMed Central Google Scholar
Dugger, B. N., & Dickson, D. W. (2017). Pathology of neurodegenerative diseases. Cold Spring Harbor Perspectives in Biology, 9(7), Article a028035.
PubMed PubMed Central Google Scholar
Dujardin, K. (2007). Apathy and neurodegenerative diseases: Pathophysiology, diagnostic evaluation, and treatment. Revue Neurologique, 163(5), 513–521.
Farahani, A., Farahani, A., Kashfi, K., & Ghasemi, A. (2025). Inducible nitric oxide synthase (iNOS): More than an inducible enzyme? Rethinking the classification of NOS isoforms. Pharmacological Research, 216, 107781.
PubMed PubMed Central Google Scholar
Feigin, V. L., Vos, T., Nichols, E., Owolabi, M. O., Carroll, W. M., Dichgans, M., Deuschl, G., Parmar, P., Brainin, M., & Murray, C. (2020). The global burden of neurological disorders: Translating evidence into policy. The Lancet Neurology, 19(3), 255–265.
Fulda, S., Gorman, A. M., Hori, O., & Samali, A. (2010). Cellular stress responses: Cell survival and cell death. International Journal of Cell Biology, 1, Article 214074.
Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010). Mechanisms underlying inflammation in neurodegeneration. Cell, 140(6), 918–934.
CAS PubMed PubMed Central Google Scholar
Gong, G., Ganesan, K., Wan, Y., Liu, Y., Huang, Y., Luo, Y., Wang, X., Zhang, Z., & Zheng, Y. (2024). Unveiling the neuroprotective properties of isoflavones: Current evidence, molecular mechanisms and future perspectives. Critical Reviews in Food Science and Nutrition, 18, 1–37.
Gong, Y., Lv, J., Pang, X., Zhang, S., Zhang, G., Liu, L., Wang, Y., & Li, C. (2023). Advances in the metabolic mechanism and functional characteristics of equol. Foods., 12(12), 2334.
CAS PubMed PubMed Central Google Scholar
González-Arenas, A., Hansberg-Pastor, V., Hernández-Hernández, O. T., González-García, T. K., Henderson-Villalpando, J., Lemus-Hernández, D., Cruz-Barrios, A., Rivas-Suárez, M., & Camacho-Arroyo, I. (2012). Estradiol increases cell growth in human astrocytoma cell lines through ERα activation and its interaction with SRC-1 and SRC-3 coactivators. Biochimica et Biophysica Acta Molecular Cell Research, 1823(2), 379–86.
Hernandes, M. S., & Britto, L. R. G. (2012). NADPH oxidase and neurodegeneration. Current Neuropharmacology, 10(4), 321–327.
CAS PubMed PubMed Central Google Scholar
Houldsworth, A. (2024). Role of oxidative stress in neurodegenerative disorders: A review of reactive oxygen species and prevention by antioxidants. Brain Communications, 6(1), 356.
Hu, X., Li, J., Fu, M., Zhao, X., & Wang, W. (2021). The JAK/STAT signaling pathway: From bench to clinic. Signal Transduction and Targeted Therapy, 6(1), 402.
PubMed PubMed Central Google Scholar
Jain, M., Singh, M. K., Shyam, H., Mishra, A., Kumar, S., Kumar, A., & Kushwaha, J. (2021). Role of JAK/STAT in the neuroinflammation and its association with neurological disorders. Annals of Neurosciences, 28(3–4), 191–200.
Johnson, S. L., Kirk, R. D., DaSilva, N. A., Ma, H., Seeram, N. P., & Bertin, M. J. (2019). Polyphenol microbial metabolites exhibit gut and blood–brain barrier permeability and protect murine microglia against LPS-induced inflammation. Metabolites, 9(4), 78.
CAS PubMed PubMed Central Google Scholar
Johnson, S. L., Park, H. Y., Vattem, D. A., Grammas, P., Ma, H., & Seeram, N. P. (2020). Equol, a blood–brain barrier permeable gut microbial metabolite of dietary isoflavone daidzein, exhibits neuroprotective effects against neurotoxins induced toxicity in human neuroblastoma SH-SY5Y cells and Caenorhabditis elegans. Plant Foods for Human Nutrition, 75(4), 512–517.
Kelley, N., Jeltema, D., Duan, Y., & He, Y. (2019). The NLRP3 inflammasome: An overview of mechanisms of activation and regulation. International Journal of Molecular Sciences, 20(13), 3328.
CAS PubMed PubMed Central Google Scholar
Koszegi, Z., & Cheong, R. Y. (2022). Targeting the non-classical estrogen pathway in neurodegenerative diseases and brain injury disorders. Frontiers in Endocrinology, 13, Article 999236.
PubMed PubMed Central Google Scholar
Lamptey, R. N., Chaulagain, B., Trivedi, R., Gothwal, A., Layek, B., & Singh, J. (2022). A review of the common neurodegenerative disorders: Current therapeutic approaches and the potential role of nanotherapeutics. International Journal of Molecular Sciences, 23(3), 1851.
CAS PubMed PubMed Central Google Scholar
Li, B. J. (2019). Advances in exploring equol production and application. Journal of Food Processing and Preservation, 43(11), Article e14205.
Li, L., Wu, W., Huang, W., Hu, G., Yuan, W., & Li, W. (2013). NF-κB RNAi decreases the Bax/Bcl-2 ratio and inhibits TNF-α-induced apoptosis in human alveolar epithelial cells. Inflammation Research, 62, 387–397.
Li, X., Feng, X., Sun, X., Hou, N., Han, F., & Liu, Y. (2022). Global, regional, and national burden of AD and other dementias, 1990–2019. Frontiers in Aging Neuroscience, 14, Article 937486.
PubMed PubMed Central Google Scholar
Liang, W., Han, B., Hai, Y., Liu, Y., Liu, X., Yang, J., Sun, D., & Yin, P. (2022). The role of microglia/macrophages activation and TLR4/NF-κB/MAPK pathway in distraction spinal cord injury-induced inflammation. Frontiers in Cellular Neuroscience, 16, 926453.
CAS PubMed PubMed Central Google Scholar
Liang, Y., Fu, W., Tang, Y., Ye, H., Wang, Y., Sun, C., Xiang, Y., Xiong, W., Cui, M., Chen, Y., & Wang, T. (2025). Selective activation of G protein–coupled estrogen receptor 1 (GPER1) reduces ER stress and pyroptosis via AMPK signaling pathway in experimental subarachnoid hemorrhage. Molecular Neurobiology, 62(1), 871–84.
Liu, T., Zhang, L., Joo, D., & Sun, S. C. (2017). NF-κB signaling in inflammation. Signal Transduction and Targeted Therapy, 2(1), 1–9.
Comments (0)