Balda MA, Anderson KL, Itzhak Y (2006) Adolescent and adult responsiveness to the incentive value of cocaine reward in mice: role of neuronal nitric oxide synthase (nNOS) gene. Neuropharmacology 51(2):341–349. https://doi.org/10.1016/j.neuropharm.2006.03.026
Article CAS PubMed Google Scholar
Barle EL, Looser R, Cerne M, Bechter R (2012) The value of acute toxicity testing of pharmaceuticals for estimation of human response. Regul Toxicol Pharmacol 62(3):412–418. https://doi.org/10.1016/j.yrtph.2012.01.005
Article CAS PubMed Google Scholar
Beaulieu JM, Gainetdinov RR (2011) The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev 63(1):182–217. https://doi.org/10.1124/pr.110.002642
Article CAS PubMed Google Scholar
Benoit-Marand M, Borrelli E, Gonon F (2001) Inhibition of dopamine release via presynaptic D2 receptors: time course and functional characteristics in vivo. J Neurosci 21(23):9134–9141. https://doi.org/10.1523/jneurosci.21-23-09134.2001
Article CAS PubMed PubMed Central Google Scholar
Benoit-Marand M, Ballion B, Borrelli E, Boraud T, Gonon F (2011) Inhibition of dopamine uptake by D2 antagonists: an in vivo study. J Neurochem 116(3):449–458. https://doi.org/10.1111/j.1471-4159.2010.07125.x
Article CAS PubMed Google Scholar
Borsellino P, Krider RI, Chea D, Grinnell R, Vida TA (2023) Ketamine and the disinhibition hypothesis: neurotrophic factor-mediated treatment of depression. Pharmaceuticals (Basel) 16(5):742. https://doi.org/10.3390/ph16050742
Article CAS PubMed PubMed Central Google Scholar
Capasso A, Loizzo A (2001) Purinoreceptors are involved in the control of acute morphine withdrawal. Life Sci 69(18):2179–2188. https://doi.org/10.1016/s0024-3205(01)01313-3
Article CAS PubMed Google Scholar
Chang L, Zhang K, Pu Y, Qu Y, Wang SM, Xiong Z, Ren Q, Dong C, Fujita Y, Hashimoto K (2019) Comparison of antidepressant and side effects in mice after intranasal administration of (R,S)-ketamine, (R)-ketamine, and (S)-ketamine. Pharmacol Biochem Behav 181:53–59. https://doi.org/10.1016/j.pbb.2019.04.008
Article CAS PubMed Google Scholar
Chen L, Lu W, Wang L, Xing X, Chen Z, Teng X, Zeng X, Muscarella AD, Shen Y, Cowan A, McReynolds MR, Kennedy BJ, Lato AM, Campagna SR, Singh M, Rabinowitz JD (2021) Metabolite discovery through global annotation of untargeted metabolomics data. Nat Methods 18(11):1377–1385. https://doi.org/10.1038/s41592-021-01303-3
Article CAS PubMed PubMed Central Google Scholar
Cheng Z, Peng Y, Wen J, Chen W, Pan W, Xu X, Lu X, Cai Q, Ge F, Fan Y, Wang J, Guan X (2023) Sex-specific metabolic signatures in methamphetamine addicts. Addict Biol 28(1):e13255. https://doi.org/10.1111/adb.13255
Article CAS PubMed Google Scholar
Darke S, Duflou J, Farrell M, Peacock A, Lappin J (2021) Characteristics and circumstances of death related to the self-administration of ketamine. Addiction (Abingdon, England) 116(2):339–345. https://doi.org/10.1111/add.15154
Dinis-Oliveira RJ (2019) Metabolism and metabolomics of opiates: a long way of forensic implications to unravel. J Forensic Leg Med 61:128–140. https://doi.org/10.1016/j.jflm.2018.12.005
Doke M, McLaughlin JP, Baniasadi H, Samikkannu T (2022) Sleep disorder and cocaine abuse impact purine and pyrimidine nucleotide metabolic signatures. Metabolites 12(9):869. https://doi.org/10.3390/metabo12090869
Article CAS PubMed PubMed Central Google Scholar
Domingo-Almenara X, Siuzdak G (2020) Metabolomics data processing using XCMS. Methods in Molecular Biology (Clifton, NJ) 2104:11–24. https://doi.org/10.1007/978-1-0716-0239-3_2
Du Y, Du L, Cao J, Hölscher C, Feng Y, Su H, Wang Y, Yun KM (2017) Levo-tetrahydropalmatine inhibits the acquisition of ketamine-induced conditioned place preference by regulating the expression of ERK and CREB phosphorylation in rats. Behav Brain Res 317:367–373. https://doi.org/10.1016/j.bbr.2016.10.001
Article CAS PubMed Google Scholar
Dudley E, Yousef M, Wang Y, Griffiths WJ (2010) Targeted metabolomics and mass spectrometry. Adv Protein Chem Struct Biol 80:45–83. https://doi.org/10.1016/b978-0-12-381264-3.00002-3
Article CAS PubMed Google Scholar
Ford CP (2014) The role of D2-autoreceptors in regulating dopamine neuron activity and transmission. Neuroscience 282:13–22. https://doi.org/10.1016/j.neuroscience.2014.01.025
Article CAS PubMed Google Scholar
Fraga-Corral M, Carpena M, Garcia-Oliveira P, Pereira AG, Prieto MA, Simal-Gandara J (2022) Analytical metabolomics and applications in health, environmental and food science. Crit Rev Anal Chem 52(4):712–734. https://doi.org/10.1080/10408347.2020.1823811
Article CAS PubMed Google Scholar
Fuertig R, Ceci A, Camus SM, Bezard E, Luippold AH, Hengerer B (2016) LC-MS/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain. Bioanalysis 8(18):1903–1917. https://doi.org/10.4155/bio-2016-0111
Article CAS PubMed Google Scholar
Fuxe K, Ferré S, Canals M, Torvinen M, Terasmaa A, Marcellino D, Goldberg SR, Staines W, Jacobsen KX, Lluis C, Woods AS, Agnati LF, Franco R (2005) Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function. Journal of Molecular Neuroscience : MN 26(2–3):209–220. https://doi.org/10.1385/jmn:26:2-3:209
Article CAS PubMed Google Scholar
Fuxe K, Marcellino D, Borroto-Escuela DO, Guescini M, Fernández-Dueñas V, Tanganelli S, Rivera A, Ciruela F, Agnati LF (2010) Adenosine-dopamine interactions in the pathophysiology and treatment of CNS disorders. CNS Neurosci Ther 16(3):e18-42. https://doi.org/10.1111/j.1755-5949.2009.00126.x
Article CAS PubMed PubMed Central Google Scholar
Gabach LA, Carlini VP, Monti MC, Maglio LE, De Barioglio SR, Perez MF (2013) Involvement of nNOS/NO/sGC/cGMP signaling pathway in cocaine sensitization and in the associated hippocampal alterations: does phosphodiesterase 5 inhibition help to drug vulnerability? Psychopharmacology 229(1):41–50. https://doi.org/10.1007/s00213-013-3084-y
Article CAS PubMed Google Scholar
Gao M, Rejaei D, Liu H (2016) Ketamine use in current clinical practice. Acta Pharmacol Sin 37(7):865–872. https://doi.org/10.1038/aps.2016.5
Article CAS PubMed PubMed Central Google Scholar
Ghanbari R, Sumner S (2018) Using metabolomics to investigate biomarkers of drug addiction. Trends Mol Med 24(2):197–205. https://doi.org/10.1016/j.molmed.2017.12.005
Article CAS PubMed Google Scholar
Hilmas C, Pereira EF, Alkondon M, Rassoulpour A, Schwarcz R, Albuquerque EX (2001) The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 21(19):7463–7473. https://doi.org/10.1523/jneurosci.21-19-07463.2001
Article CAS PubMed Google Scholar
Hyman SE, Malenka RC, Nestler EJ (2006) Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci 29:565–598. https://doi.org/10.1146/annurev.neuro.29.051605.113009
Article CAS PubMed Google Scholar
Ingrosso G, Cleare AJ, Juruena MF (2025) Is there a risk of addiction to ketamine during the treatment of depression? A systematic review of available literature. Journal of Psychopharmacology (Oxford, England) 39(1):49–65. https://doi.org/10.1177/02698811241303597
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