Giglio P, Gilbert MR (2003) Cerebral radiation necrosis. Neurologist 9(4):180–188. https://doi.org/10.1097/01.nrl.0000080951.78533.c4

Article  PubMed  Google Scholar 

Vellayappan BA, McGranahan T, Graber J, Taylor L, Venur V, Ellenbogen R, Sloan AE, Redmond KJ, Foote M, Chao ST, Suh JH, Chang EL, Sahgal A, Lo SS (2021) Radiation necrosis from stereotactic Radiosurgery-How do we mitigate?? Curr Treat Options Oncol 22(7):57. https://doi.org/10.1007/s11864-021-00854-z

Article  PubMed  Google Scholar 

Ryan R, Booth S, Price S (2012) Corticosteroid-use in primary and secondary brain tumour patients: a review. J Neurooncol 106(3):449–459. https://doi.org/10.1007/s11060-011-0713-3

Article  CAS  PubMed  Google Scholar 

Hempen C, Weiss E, Hess CF (2002) Dexamethasone treatment in patients with brain metastases and primary brain tumors: do the benefits outweigh the side-effects? Support Care Cancer 10(4):322–328. https://doi.org/10.1007/s00520-001-0333-0

Article  PubMed  Google Scholar 

Jessurun CAC, Hulsbergen AFC, de Wit AE, Tewarie IA, Snijders TJ, Verhoeff JJC, Phillips JG, Reardon DA, Mekary RA, Broekman MLD (2021) The combined use of steroids and immune checkpoint inhibitors in brain metastasis patients: a systematic review and meta-analysis. Neuro Oncol 23(8):1261–1272. https://doi.org/10.1093/neuonc/noab046

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li YQ, Ballinger JR, Nordal RA, Su ZF, Wong CS (2001) Hypoxia in radiation-induced blood-spinal cord barrier breakdown. Cancer Res 61(8):3348–3354

CAS  PubMed  Google Scholar 

Gonzalez J, Kumar AJ, Conrad CA, Levin VA (2007) Effect of bevacizumab on radiation necrosis of the brain. Int J Radiat Oncol Biol Phys 67(2):323–326. https://doi.org/10.1016/j.ijrobp.2006.10.010

Article  CAS  PubMed  Google Scholar 

Zhuang H, Shi S, Yuan Z, Chang JY (2019) Bevacizumab treatment for radiation brain necrosis: mechanism, efficacy and issues. Mol Cancer 18(1):21. https://doi.org/10.1186/s12943-019-0950-1

Article  PubMed  PubMed Central  Google Scholar 

Liao G, Khan M, Zhao Z, Arooj S, Yan M, Li X (2021) Bevacizumab treatment of Radiation-Induced brain necrosis: A systematic review. Front Oncol 11:593449. https://doi.org/10.3389/fonc.2021.593449

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee SH, Choi JW, Kong DS, Seol HJ, Nam DH, Lee JI (2023) Effect of bevacizumab treatment in cerebral radiation necrosis: investigation of response predictors in a Single-Center experience. J Korean Neurosurg Soc 66(5):562–572. https://doi.org/10.3340/jkns.2022.0229

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lasocki A, Sia J, Stuckey SL (2025) Differentiation between radiation necrosis and true tumour progression after radiotherapy to intracranial metastases. J Med Imaging Radiat Oncol 69(3):414–424. https://doi.org/10.1111/1754-9485.13847

Article  PubMed  PubMed Central  Google Scholar 

Zhuang H, Zhuang H, Shi S, Wang Y (2019) Ultra-Low-Dose bevacizumab for cerebral radiation necrosis: A prospective phase II clinical study. Onco Targets Ther 12:8447–8453. https://doi.org/10.2147/ott.S223258

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khan M, Zhao Z, Arooj S, Liao G (2021) Bevacizumab for radiation necrosis following radiotherapy of brain metastatic disease: a systematic review & meta-analysis. BMC Cancer 21(1):167. https://doi.org/10.1186/s12885-021-07889-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meixner E, Hörner-Rieber J, Lischalk JW, Eichkorn T, Krämer A, Sandrini E, Paul A, Hoegen P, Deng M, Welzel T, Erdem S, Debus J, König L (2023) Management of initial and recurrent radiation-induced contrast enhancements following radiotherapy for brain metastases: clinical and radiological impact of bevacizumab and corticosteroids. Clin Transl Radiat Oncol 39:100600. https://doi.org/10.1016/j.ctro.2023.100600

Article  PubMed  PubMed Central  Google Scholar 

Zhuang H, Yuan X, Chang JY, Song Y, Wang J, Yuan Z, Wang X, Wang P (2016) Exploration of the recurrence in radiation brain necrosis after bevacizumab discontinuation. Oncotarget 7(30):48842–48849. https://doi.org/10.18632/oncotarget.7768

Article  PubMed  PubMed Central  Google Scholar 

Dashti SR, Kadner RJ, Folley BS, Sheehan JP, Han DY, Kryscio RJ, Carter MB, Shields LBE, Plato BM, Rocca L, Spalding RV, Yao AC, T. L., Fraser JF (2022) Single low-dose targeted bevacizumab infusion in adult patients with steroid-refractory radiation necrosis of the brain: a phase II open-label prospective clinical trial. J Neurosurg 137(6):1676–1686. https://doi.org/10.3171/2022.2.Jns212006

Article  CAS  PubMed  Google Scholar 

Vellayappan B, Lim-Fat MJ, Kotecha R, De Salles A, Fariselli L, Levivier M, Ma L, Paddick I, Pollock BE, Regis J, Sheehan JP, Suh JH, Yomo S, Sahgal A (2024) A systematic review informing the management of symptomatic brain radiation necrosis after stereotactic radiosurgery and international stereotactic radiosurgery society recommendations. Int J Radiat Oncol Biol Phys 118(1):14–28. https://doi.org/10.1016/j.ijrobp.2023.07.015

Article  PubMed  Google Scholar 

Li J, He J, Cai L, Lai M, Hu Q, Ren C, Wen L, Wang J, Zhou J, Zhou Z, Li S, Ye M, Shan C, Chen L, Zhou C (2021) Bevacizumab as a treatment for radiation necrosis following stereotactic radiosurgery for brain metastases: clinical and radiation dosimetric impacts. Ann Palliat Med 10(2):2018–2026. https://doi.org/10.21037/apm-20-2417

Article  PubMed  Google Scholar 

Moore A, Yust-Katz S, Icht O, Eliyahou R, Gordon N, Cohen AY, Goldstein IM, Peled N, Seigal T, Amiel A, Dudnik E (2021) Bevacizumab for stereotactic radiosurgery-induced radiation necrosis in patients with non-small cell lung cancer treated with immune check-point inhibitors. J Neurol Sci 427:117556. https://doi.org/10.1016/j.jns.2021.117556

Article  CAS  PubMed  Google Scholar 

Zoto Mustafayev T, Turna M, Bolukbasi Y, Tezcanli E, Guney Y, Dincbas FO, Atasoy BM, Ugurluer G, Caglar HB, Atalar B, Ozyar E (2024) Clinical and radiological effects of bevacizumab for the treatment of radionecrosis after stereotactic brain radiotherapy. BMC Cancer 24(1):918. https://doi.org/10.1186/s12885-024-12643-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weng Y, Shen J, Zhang L, Fang Z, Xiao F, Zhang C, Fan Z, Huang K, Wang L, Huang B, Wu F, Zhang T, Xu Q (2021) Low-Dosage bevacizumab treatment: effect on radiation necrosis after gamma knife radiosurgery for brain metastases. Front Surg 8:720506. https://doi.org/10.3389/fsurg.2021.720506

Article  PubMed  PubMed Central  Google Scholar 

Gao M, Wang X, Wang X, Niu G, Liu X, Zhao S, Wang Y, Yu H, Huo S, Su H, Song Y, Wang X, Zhuang HQ, Yuan ZY (2024) Can low-dose intravenous bevacizumab be as effective as high-dose bevacizumab for cerebral radiation necrosis? Cancer Sci 115(2):589–599. https://doi.org/10.1111/cas.16053

Article  CAS  PubMed  Google Scholar 

Shibahara D, Tanaka K, Togao O, Shiraishi Y, Yoneshima Y, Iwama E, Yoshitake T, Ishigami K, Okamoto I (2024) Bevacizumab for brain radiation necrosis in patients with nonsquamous nonsmall cell lung Cancer. Clin Lung Cancer 25(6):581–586e583. https://doi.org/10.1016/j.cllc.2024.06.010

Article  CAS  PubMed  Google Scholar 

Tanigawa K, Mizuno K, Kamenohara Y, Unoki T, Misono S, Inoue H (2019) Effect of bevacizumab on brain radiation necrosis in anaplastic lymphoma kinase-positive lung cancer. Respirol Case Rep 7(7):e00454. https://doi.org/10.1002/rcr2.454

Article  PubMed  PubMed Central  Google Scholar 

Glitza IC, Guha-Thakurta N, D’Souza NM, Amaria RN, McGovern SL, Rao G, Li J (2017) Bevacizumab as an effective treatment for radiation necrosis after radiotherapy for melanoma brain metastases. Melanoma Res 27(6):580–584. https://doi.org/10.1097/cmr.0000000000000389

Article  CAS  PubMed  Google Scholar 

Alessandretti M, Buzaid AC, Brandão R, Brandão EP (2013) Low-dose bevacizumab is effective in radiation-induced necrosis. Case Rep Oncol 6(3):598–601. https://doi.org/10.1159/000357401

Article  PubMed  PubMed Central  Google Scholar