SERCA blockade as a treatment strategy for obesity

Ahmed B, Sultana R, Greene MW (2021) Adipose tissue and insulin resistance in obese. Biomed Pharmacother 137:111315

Article  CAS  PubMed  Google Scholar 

Ahn C, Kang JH, Jeung EB (2017) Calcium homeostasis in diabetes mellitus. J Vet Sci 18(3):261–266

Article  PubMed  PubMed Central  Google Scholar 

Anderson DM et al (2016) Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides. Sci Signal 9(457):ra119

Article  PubMed  PubMed Central  Google Scholar 

Autry JM, Thomas DD, Espinoza-Fonseca LM (2016) Sarcolipin promotes uncoupling of the SERCA Ca(2+) pump by inducing a structural rearrangement in the energy-transduction domain. Biochemistry 55(44):6083–6086

Article  CAS  PubMed  Google Scholar 

Aviv A (1992) The roles of cell Ca2+, protein kinase C and the Na(+)-H+ antiport in the development of hypertension and insulin resistance. J Am Soc Nephrol 3(5):1049–1063

Article  CAS  PubMed  Google Scholar 

Bal NC et al (2021) Is upregulation of sarcolipin beneficial or detrimental to muscle function? Front Physiol 12:633058

Article  PubMed  PubMed Central  Google Scholar 

Bauza-Thorbrugge M et al (2022) Adipocyte-specific ablation of the Ca(2+) pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue. Mol Metab 63:101535

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bednarski TK et al (2024) Pharmacological SERCA activation limits diet-induced steatohepatitis and restores liver metabolic function in mice. J Lipid Res 65(6):100558

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhosale G et al (2015) Calcium signaling as a mediator of cell energy demand and a trigger to cell death. Ann NY Acad Sci 1350(1):107–116

Article  CAS  PubMed  Google Scholar 

Bi J et al (2014) Seipin promotes adipose tissue fat storage through the ER Ca(2)(+)-ATPase SERCA. Cell Metab 19(5):861–871

Article  CAS  PubMed  Google Scholar 

Bidwell PA et al (2022) A large-scale high-throughput screen for modulators of SERCA activity. Biomolecules 12(12)

Bradshaw T, Mairs H (2014) Obesity and serious mental ill health: a critical review of the literature. Healthcare (Basel) 2(2):166–182

Article  PubMed  Google Scholar 

Cai W et al (2024) Tirzepatide as a novel effective and safe strategy for treating obesity: a systematic review and meta-analysis of randomized controlled trials. Front Public Health 12:1277113

Article  PubMed  PubMed Central  Google Scholar 

Camilleri M, Acosta A (2018) Combination therapies for obesity. Metab Syndr Relat Disord 16(8):390–394

Article  PubMed  PubMed Central  Google Scholar 

Chae S et al (2018) A mitochondrial proteome profile indicative of type 2 diabetes mellitus in skeletal muscles. Exp Mol Med 50(9):1–14

Article  CAS  PubMed  Google Scholar 

Chambers PJ et al (2022) Role of SERCA and sarcolipin in adaptive muscle remodeling. Am J Physiol Cell Physiol 322(3):C382–C394

Article  CAS  PubMed  Google Scholar 

Chandrasekaran P, Weiskirchen R (2024) The role of obesity in type 2 diabetes mellitus—an overview. Int J Mol Sci 25(3)

Chen X et al (2023) Endoplasmic reticulum stress: molecular mechanism and therapeutic targets. Signal Transduct Target Ther 8(1):352

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chung N, Park J, Lim K (2017) The effects of exercise and cold exposure on mitochondrial biogenesis in skeletal muscle and white adipose tissue. J Exerc Nutr Biochem 21(2):39–47

Article  Google Scholar 

Conrard L, Tyteca D (2019) Regulation of membrane calcium transport proteins by the surrounding lipid environment. Biomolecules 9(10)

Danpanichkul P et al (2023) Predictors of weight reduction effectiveness of SGLT2 inhibitors in diabetes mellitus type 2 patients. Front Endocrinol (Lausanne) 14:1251798

Article  PubMed  Google Scholar 

Daverkausen-Fischer L, Prols F (2022) Regulation of calcium homeostasis and flux between the endoplasmic reticulum and the cytosol. J Biol Chem 298(7):102061

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dempster AM (2000) Nonclinical safety evaluation of biotechnologically derived pharmaceuticals. Biotechnol Annu Rev 5:221–258

Article  CAS  PubMed  Google Scholar 

Deshpande LS et al (2020) Neuronal-specific inhibition of endoplasmic reticulum Mg(2+)/Ca(2+) ATPase Ca(2+) uptake in a mixed primary hippocampal culture model of status epilepticus. Brain Sci 10(7)

Dobson JR, Jacobson DA (2024) Disrupted endoplasmic reticulum Ca(2+) handling: a harbetainger of beta-cell failure. Biology (Basel) 13(6)

Elaib Z et al (2019) Platelet functions are decreased in obesity and restored after weight loss: evidence for a role of the SERCA3-dependent ADP secretion pathway. Thromb Haemost 119(3):384–396

Article  PubMed  Google Scholar 

Elmaleh-Sachs A et al (2023) Obesity management in adults: a review. JAMA 330(20):2000–2015

Article  CAS  PubMed  PubMed Central  Google Scholar 

Emerenziani S et al (2019) Role of overweight and obesity in gastrointestinal disease. Nutrients 12(1)

Eshima H (2021) Influence of obesity and type 2 diabetes on calcium handling by skeletal muscle: spotlight on the sarcoplasmic reticulum and mitochondria. Front Physiol 12:758316

Article  PubMed  PubMed Central  Google Scholar 

Ezzitouny M et al (2021) Value of SERCA2a as a biomarker for the identification of patients with heart failure requiring circulatory support. J Pers Med 11(11)

Faccioli N et al (2023) Current treatments for patients with genetic obesity. J Clin Res Pediatr Endocrinol 15(2):108–119

Article  PubMed  PubMed Central  Google Scholar 

Fu S et al (2011) Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature 473(7348):528–531

Article  CAS  PubMed  PubMed Central  Google Scholar 

Funai K et al (2013) Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling. J Clin Invest 123(3):1229–1240

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gadde KM, Allison DB (2009) Combination pharmaceutical therapies for obesity. Expert Opin Pharmacother 10(6):921–925

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gamu D et al (2020) The sarcoplasmic reticulum and SERCA: a nexus for muscular adaptive thermogenesis. Appl Physiol Nutr Metab 45(1):1–10

Article  CAS  PubMed  Google Scholar 

Ghemrawi R, Battaglia-Hsu SF, Arnold C (2018) Endoplasmic reticulum stress in metabolic disorders. Cells 7(6)

Gortan Cappellari G et al (2024) Detecting sarcopenia in obesity: emerging new approaches. Curr Opin Clin Nutr Metab Care 27(5):402–409

Article  CAS  PubMed  PubMed Central  Google Scholar 

Greenberg B et al (2016) Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial. Lancet 387(10024):1178–1186

Article  CAS  PubMed  Google Scholar 

Guarnieri AR, Benson TW, Tranter M (2022) Calcium cycling as a mediator of thermogenic metabolism in adipose tissue. Mol Pharmacol 102(1):51–59

Article  CAS 

Comments (0)

No login
gif