Behera J, Ison J, Voor MJ, Tyagi N (2022) Exercise-linked skeletal irisin ameliorates diabetes-associated osteoporosis by inhibiting the oxidative damage-dependent miR-150-FNDC5/Pyroptosis Axis. Diabetes 71(12):2777–2792. https://doi.org/10.2337/db21-0573

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bouchama A, Aziz MA, Mahri SA, Gabere MN, Dlamy MA, Mohammad S, Abbad MA, Hussein M (2017) A model of exposure to extreme environmental heat uncovers the human transcriptome to heat stress. Sci Rep. https://doi.org/10.1038/s41598-017-09819-5

Article  PubMed  PubMed Central  Google Scholar 

Bruunsgaard H, Pedersen M, Pedersen BK (2001) Aging and proinflammatory cytokines. Curr Opin Hematol 8(3):131–136. https://doi.org/10.1097/00062752-200105000-00001

Article  CAS  PubMed  Google Scholar 

Chapman CL, Johnson BD, Parker MD, Hostler D, Pryor RR, Schlader Z (2021) Kidney physiology and pathophysiology during heat stress and the modification by exercise, dehydration, heat acclimation and aging. Temperature (Austin, Tex) 8(2):108–159. https://doi.org/10.1080/23328940.2020.1826841

Article  PubMed  Google Scholar 

Chaseling G, Batlett A-A, Capon A, Crandall C, Fiatarone Singh M, Bi P, Nigam A, Jay O, Gagnon D (2022) Effects of beta-blockers on thermal and cardiovascular strain of adults with coronary artery disease during extreme heat events. FASEB J. https://doi.org/10.1096/fasebj.2022.36.S1.R3555

Article  Google Scholar 

Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L (2018) Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. https://doi.org/10.18632/oncotarget.23208

Article  PubMed  PubMed Central  Google Scholar 

Devarajan P (2008) Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney disease. Scand J Clin Labor Investigation Supplementum 241:89–94. https://doi.org/10.1080/00365510802150158

Article  CAS  Google Scholar 

Dill DB, Costill DL (1974) Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol 37(2):247–248. https://doi.org/10.1152/jappl.1974.37.2.247

Article  CAS  PubMed  Google Scholar 

DiMagno EP, Corle D, O’Brien JF, Masnyk IJ, Go VL, Aamodt R (1989) Effect of long-term freezer storage, thawing, and refreezing on selected constituents of serum. Mayo Clin Proc 64(10):1226–1234. https://doi.org/10.1016/s0025-6196(12)61285-3

Article  CAS  PubMed  Google Scholar 

Ebi KL, Vanos J, Baldwin JW, Bell JE, Hondula DM, Errett NA, Hayes K, Reid CE, Saha S, Spector J, Berry P (2021) Extreme weather and climate change: population health and health system implications. Annu Rev Public Health 42:293–315. https://doi.org/10.1146/annurev-publhealth-012420-105026

Article  PubMed  PubMed Central  Google Scholar 

Foster J, Mckenna ZJ, Atkins WC, Jarrard CP, Crandall CG (2023) Aging increases enterocyte damage during a 3-hour exposure to very hot and dry heat: a preliminary study. Biology 12(8):1088

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghulam Mohyuddin S, Khan I, Zada A, Qamar A, Arbab AAI, Ma XB, Yu ZC, Liu XX, Yong YH, Ju XH, Zhang-Ping Y, Yong Jiang M (2022) Influence of heat stress on intestinal epithelial barrier function, tight junction protein, and immune and reproductive physiology. Biomed Res Int 2022:8547379. https://doi.org/10.1155/2022/8547379

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hashizaki T, Nishimura Y, Teramura K, Umemoto Y, Shibasaki M, Leicht CA, Kouda K, Tajima F (2018) Differences in serum IL-6 response after 1 °C rise in core body temperature in individuals with spinal cord injury and cervical spinal cord injury during local heat stress. Int J Hyperthermia 35(1):541–547. https://doi.org/10.1080/02656736.2018.1511838

Article  CAS  PubMed  Google Scholar 

Huisse MG, Pease S, Hurtado-Nedelec M, Arnaud B, Malaquin C, Wolff M, Gougerot-Pocidalo MA, Kermarrec N, Bezeaud A, Guillin MC, Paoletti X, Chollet-Martin S (2008) Leukocyte activation: the link between inflammation and coagulation during heatstroke. A study of patients during the 2003 heat wave in Paris. Crit Care Med. https://doi.org/10.1097/CCM.0b013e318180dd43

Article  PubMed  Google Scholar 

Jay O, Capon A, Berry P, Broderick C, de Dear R, Havenith G, Honda Y, Kovats RS, Ma W, Malik A, Morris NB, Nybo L, Seneviratne SI, Vanos J, Ebi KL (2021) Reducing the health effects of hot weather and heat extremes: from personal cooling strategies to green cities. Lancet 398(10301):709–724. https://doi.org/10.1016/S0140-6736(21)01209-5

Article  PubMed  Google Scholar 

Junho CVC, Gonzalez-Lafuente L, Neres-Santos RS, Navarro-Garcia JA, Rodriguez-Sanchez E, Ruiz-Hurtado G, Carneiro-Ramos MS (2022) Klotho relieves inflammation and exerts a cardioprotective effect during renal ischemia/reperfusion-induced cardiorenal syndrome. Biomed Pharmacother 153:113515. https://doi.org/10.1016/j.biopha.2022.113515

Article  CAS  PubMed  Google Scholar 

Kaltsatou A, Notley SR, Kenny GP (2020) Effects of exercise-heat stress on circulating stress hormones and interleukin-6 in young and older men. Temperature 7(4):389–393. https://doi.org/10.1080/23328940.2020.1768032

Article  Google Scholar 

Kenefick RW, Cheuvront SN (2012) Hydration for recreational sport and physical activity. Nutr Rev 70(Suppl 2):S137-142. https://doi.org/10.1111/j.1753-4887.2012.00523.x

Article  PubMed  Google Scholar 

Kenny GP, Sigal RJ, McGinn R (2016) Body temperature regulation in diabetes. Temperature (Austin, Tex) 3(1):119–145. https://doi.org/10.1080/23328940.2015.1131506

Article  PubMed  Google Scholar 

Kenny GP, Notley SR, Gagnon D (2017a) Direct calorimetry: a brief historical review of its use in the study of human metabolism and thermoregulation. Eur J Appl Physiol 117(9):1765–1785. https://doi.org/10.1007/s00421-017-3670-5

Article  PubMed  Google Scholar 

Kenny GP, Poirier MP, Metsios GS, Boulay P, Dervis S, Friesen BJ, Malcolm J, Sigal RJ, Seely AJ, Flouris AD (2017b) Hyperthermia and cardiovascular strain during an extreme heat exposure in young versus older adults. Temperature (Austin) 4(1):79–88. https://doi.org/10.1080/23328940.2016.1230171

Article  PubMed  Google Scholar 

King KE, McCormick JJ, Notley SR, Fujii N, Kenny GP (2022) Serum klotho concentrations in young and older men during prolonged exercise in temperate and hot conditions. Curr Aging Sci 15(2):180–185. https://doi.org/10.2174/1874609815666220304200939

Article  PubMed  Google Scholar 

King KE, McCormick JJ, Notley SR, Boulay P, Fujii N, Amano T, Kenny GP (2023) Serum klotho concentrations in older men with hypertension or type 2 diabetes during prolonged exercise in temperate and hot conditions. Eur J Appl Physiol 123(7):1519–1527. https://doi.org/10.1007/s00421-023-05171-x

Article  CAS  PubMed  Google Scholar 

Kohl HW, Blair SN, Paffenbarger RS Jr, Macera CA, Kronenfeld JJ (1988) A mail survey of physical activity habits as related to measured physical fitness. Am J Epidemiol 127(6):1228–1239. https://doi.org/10.1093/oxfordjournals.aje.a114915

Article  CAS  PubMed  Google Scholar 

Komosinska-Vassev K, Olczyk P, Kuźnik-Trocha K, Jura-Półtorak A, Derkacz A, Purchałka M, Telega A, Olczyk K (2019) Circulating C1q/TNF-related protein 3, omentin-1 and NGAL in obese patients with type 2 diabetes during insulin therapy. J Clin Med. https://doi.org/10.3390/jcm8060805

Article  PubMed  PubMed Central  Google Scholar 

Laws RL, Brooks DR, Amador JJ, Weiner DE, Kaufman JS, Ramírez-Rubio O, Riefkohl A, Scammell MK, López-Pilarte D, Sánchez JM, Parikh CR, McClean MD (2016) Biomarkers of kidney injury among nicaraguan sugarcane workers. Am J Kidney Dis 67(2):209–217. https://doi.org/10.1053/j.ajkd.2015.08.022

Article  CAS  PubMed  Google Scholar 

Lee BJ, Russell SL, Meade RD, McCormick JJ, King KE, Kenny GP (2024) Markers of enterocyte damage, microbial translocation, and systemic inflammation following 9 h of heat exposure in young and older adults. Appl Physiol Nutrit Metabol. https://doi.org/10.1139/apnm-2024-0094

Article  Google Scholar 

Leyk D, Hoitz J, Becker C, Glitz KJ, Nestler K, Piekarski C (2019) Health risks and interventions in exertional heat stress. Deutsches Arzteblatt International 116(31–32):537–544. https://doi.org/10.3238/arztebl.2019.0537

Article  PubMed  PubMed Central