Apers S, Vlietinck A, Pieters L (2003) Lignans and neolignans as lead compounds. Phytochem Rev 2:201–217. https://doi.org/10.1023/B:PHYT.0000045497.90158.d2

Article  CAS  Google Scholar 

Ara I, Siddiqui BS, Faizi S, Siddiqui S (1988) Terpenoids from the stem bark of Azadirachta indica. Phytochemistry 27:1801–1804. https://doi.org/10.1016/0031-9422(88)80447-3

Article  CAS  Google Scholar 

Cai R, Zhu L, Shen W, Zhao Y (2019) Synthesis, cytotoxicity and anti-invasion activity of three natural diphyllin L-arabinopyranosides. Fitoterapia 137:104198. https://doi.org/10.1016/j.fitote.2019.104198

Article  CAS  PubMed  Google Scholar 

Chang C-W, Lin M-T, Lee S-S, Liu KCSC, Hsu F-L, Lin J-Y (1995) Differential inhibition of reverse transcriptase and cellular DNA polymerase-α activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix. Antiviral Res 27:367–374. https://doi.org/10.1016/0166-3542(95)00020-M

Article  CAS  PubMed  Google Scholar 

Da Silva R, Ruas MM, Donate PM (2007) Complete assignments of1 H and 13C NMR spectral data for arylnaphthalene lignan lactones. Magn Reson Chem 45:902–904. https://doi.org/10.1002/mrc.2065

Article  CAS  PubMed  Google Scholar 

de Oliveira-Júnior RG, Alves Ferraz CA, Pontes MC, Cavalcante NB, da Cruz Araújo EC, de Oliveira AP, Picot L, Rolim LA, da Silva Almeida JRG (2018) Antibacterial activity of terpenoids isolated from Cnidoscolus quercifolius Pohl (Euphorbiaceae), a Brazilian medicinal plant from Caatinga biome. Eur J Integr Med 24:30–34. https://doi.org/10.1016/j.eujim.2018.10.011

Article  Google Scholar 

Dimitrov MD, Pesheva MG, Venkov PV (2013) New cell-based assay indicates dependence of antioxidant biological activity on the origin of reactive oxygen species. J Agric Food Chem 61(18):4344–4351

Article  CAS  PubMed  Google Scholar 

Dougué Kentsop RA, Consonni R, Alfieri M, Laura M, Ottolina G, Mascheretti I, Mattana M (2022) Linum lewisii adventitious and hairy-roots cultures as lignan plant factories. Antioxidants 11:1526. https://doi.org/10.3390/antiox11081526

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gertsch J, Tobler RT, Brun R, Sticher O, Heilmann J (2003) Antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum. Planta Med 69:420–424. https://doi.org/10.1055/s-2003-39706

Article  CAS  PubMed  Google Scholar 

Hasegawa S, Hirose Y, Yatagai M, Takahashi T (1984) On the structures of pisiferin and isopisiferin. Chem Lett 13:1837–1838. https://doi.org/10.1246/cl.1984.1837

Article  Google Scholar 

Hasegawa S, Kojima T, Hirose Y (1985) Terpenoids from the seed of Chamaecyparis pisifera: the structures of six diterpenoids. Phytochemistry 24:1545–1551. https://doi.org/10.1016/S0031-9422(00)81063-8

Article  CAS  Google Scholar 

Hemmati S, Seradj H (2016) Justicidin B: a promising bioactive lignan. Molecules 21:820. https://doi.org/10.3390/molecules21070820

Article  CAS  PubMed  PubMed Central  Google Scholar 

Innocenti G, Puricelli L, Piacente S, Caniato R, Filippini R, Cappelletti EM (2002) Patavine, a new arylnaphthalene lignan glycoside from shoot cultures of Haplophyllum patavinum. Chem Pharm Bull 50:844–846. https://doi.org/10.1248/cpb.50.844

Article  CAS  Google Scholar 

Ionkova I, Sasheva P, Ionkov T, Momekov G (2013) Linum narbonense: a new valuable tool for biotechnological production of a potent anticancer lignan justicidine B. Phcog Mag 9:39. https://doi.org/10.4103/0973-1296.108138

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ishii T, Yanagisawa M (1998) Synthesis, separation and NMR spectral analysis of methyl apiofuranosides. Carbohyd Res 313:189–192. https://doi.org/10.1016/S0008-6215(98)00262-6

Article  CAS  Google Scholar 

Jamieson DJ (1998) Oxidative stress responses of the yeast Saccharomyces cerevisiae. Yeast 14:1511–1527. https://doi.org/10.1002/(SICI)1097-0061(199812)14:16%3c1511::AID-YEA356%3e3.0.CO;2-S

Article  CAS  PubMed  Google Scholar 

Jullian-Pawlicki N, Lequart-Pillon M, Huynh-Cong L, Lesur D, Cailleu D, Mesnard F, Laberche JC, Gontier E, Boitel-Conti M (2015) Arylnaphthalene and aryltetralin-type lignans in hairy root cultures of Linum perenne, and the stereochemistry of 6-methoxypodophyllotoxin and one diastereoisomer by HPLC-MS and NMR spectroscopy. Phytochem Anal 26:310–319. https://doi.org/10.1002/pca.2565

Article  CAS  PubMed  Google Scholar 

Konuklugil B, Ionkova I, Vasilev N, Schmidt TJ, Windhövel J, Fuss E, Alfermann AW (2007) Lignans from Linum species of sections Syllinum and Linum. Nat Prod Res 21:1–6. https://doi.org/10.1080/14786410600798385

Article  CAS  PubMed  Google Scholar 

Lemos TLGD, Silveira ER, Oliveira MF, Braz Filho R, Hufford CD (1991) Terpenoids from Cnidoscolus phyllacanthus Pax et Hoff. J Braz Chem Soc 2:105–110. https://doi.org/10.5935/0103-5053.19910023

Article  Google Scholar 

Li C, Wang M (2021) Application of hairy root culture for bioactive compounds production in medicinal plants. Curr Pharm Biotechnol 22:592–608. https://doi.org/10.2174/1389201021666200516155146

Article  CAS  PubMed  Google Scholar 

Liu Y, Zhang T, Zhou J, Wang Q (2008) Three new arylnaphthalide lignans from the aerial parts of Bupleurum marginatum Wall. ex DC. Helv Chim Acta 91:2316–2320. https://doi.org/10.1002/hlca.200890252

Article  CAS  Google Scholar 

Ma J-X, Lan M-S, Qu S-J, Tan J-J, Luo H-F, Tan C-H, Zhu D-Y (2012) Arylnaphthalene lignan glycosides and other constituents from Phyllanthus reticulatus. J Asian Nat Prod Res 14:1073–1077. https://doi.org/10.1080/10286020.2012.712040

Article  CAS  PubMed  Google Scholar 

Marinovska PG, Todorova TI, Boyadzhiev KP, Pisareva EI, Tomova AA, Parvanova PN, Dimitrova M, Chankova SG, Petrova VY (2022) Cellular susceptibility and oxidative stress response to menadione of logarithmic, quiescent, and nonquiescent Saccharomyces cerevisiae cell populations. BioRisk 17:127–138. https://doi.org/10.3897/biorisk.17.77320

Article  Google Scholar 

Mascheretti I, Alfieri M, Lauria M, Locatelli F, Consonni R, Cusano E, Dougué Kentsop RA, Laura M, Ottolina G, Faoro F, Mattana M (2021) New insight into justicidin B pathway and production in Linum austriacum. Int J Mol Sci 22:2507. https://doi.org/10.3390/ijms22052507

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mohagheghzadeh A, Schmidt TJ, Alfermann AW (2002) Arylnaphthalene lignans from in vitro cultures of Linum austriacum. J Nat Prod 65:69–71. https://doi.org/10.1021/np0102814

Article  CAS  PubMed  Google Scholar 

Mohagheghzadeh A, Dehshahri S, Hemmati S (2009) Accumulation of lignans by in vitro cultures of three Linum species. Z Naturforsch C 64:73–76. https://doi.org/10.1515/znc-2009-1-213

Article  CAS  PubMed  Google Scholar 

Momekov G, Konstantinov S, Dineva I, Ionkova I (2011) Effect of justicidin B – a potent cytotoxic and pro-apoptotic arylnaphtalene lignan on human breast cancer-derived cell lines. Neoplasma 58:320–325. https://doi.org/10.4149/neo_2011_04_320

Article  CAS  PubMed  Google Scholar 

Nedelcheva R, Zarev Y, Mihaylova R, Kozuharova E, Momekov G, Ionkova I (2024a) Arylnaphthalene lignans with a focus Linum species: a review on phytochemical, biotechnological and pharmacological potential. PHAR 71:1–10. https://doi.org/10.3897/pharmacia.71.e117690

Article  CAS  Google Scholar 

Nedelcheva R, Zarev Y, Ionkova I (2024b) Comparative quantitative profiling of rare justicidin B in in vitro cultivated Linum species. Pharmacia 71:1–5. https://doi.org/10.3897/pharmacia.71.e131544

Article  CAS  Google Scholar