Abudayeh ZH, Karpiuk U, Kyslychenko V, Abualassal Q, Hassouneh LK, Qadus S, Talhouni A (2022) Optimizing extractability, phytochemistry, acute toxicity, and hemostatic action of corn silk liquid extract. J Chemy 2022:3059725. https://doi.org/10.1155/2022/3059725

Article  CAS  Google Scholar 

Alam EA (2011) Evaluation of antioxidant and antibacterial activities of Egyptian Maydis stigma (Zea mays hairs) rich in some bioactive constituents. J Am Sci 7:726–729. https://doi.org/10.7537/marsjas070411.101

Article  Google Scholar 

Anvisa (2013) Guia para a condução de estudos não clínicos de toxicologia e segurança farmacológica necessários ao desenvolvimento de medicamentos. https://www.gov.br/anvisa/pt-br/centraisdeconteudo/publicacoes/medicamentos/pesquisa-clinica/manuais-e-guias/guia-para-a-conducao-de-estudos-nao-clinicos-de-toxicologia-e-seguranca-farmacologica-necessarios-ao-desenvolvimento-de-medicamentos-versao-2.pdf/view. Accessed 22 Feb 2025

Anvisa (2014) Resolução da Diretoria Colegiada - RDC n° 26, de 13 de maio de 2014. https://bvsms.saude.gov.br/bvs/saudelegis/anvisa/2014/rdc0026_13_05_2014.pdf. Accessed 22 Feb 2025

Arksey H, O’Malley L (2005) Scoping studies: towards a methodological framework. Int J Soc Res Methodol 8:19–32. https://doi.org/10.1080/1364557032000119616

Article  Google Scholar 

Carvalho ABL, Cruz CA, Freitas CLA, Aguiar JJDS, Nunes PLWS, Lima VMDS, Matias EFF, Muniz DF, Coutinho HDM (2019) Chemical profile, antibacterial activity and antibiotic-modulating effect of the hexanic Zea Mays L. silk extract (Poaceae). Antibiotics 8:22. https://doi.org/10.3390/antibiotics8010022

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cudd TA (2005) Animal model systems for the study of alcohol teratology. Exp Biol Med 230:389–393. https://doi.org/10.1177/15353702-0323006-06

Article  CAS  Google Scholar 

Dorato MA, Engelhardt JA (2005) The no observed adverse effect level in drug safety evaluations: Use, issues, and definition(s). Regul Toxicol Pharmacol 42:265–274. https://doi.org/10.1016/j.yrtph.2005.05.004

Article  CAS  PubMed  Google Scholar 

El-Ghorab A, El-Massry KF, Shibamoto T (2007) Chemical composition of the volatile extract and antioxidant activities of the volatile and nonvolatile extracts of egyptian corn silk (Zea mays L.). J Agric Food Chem 55:9124–9127. https://doi.org/10.1021/jf071646e

Article  CAS  PubMed  Google Scholar 

Emmanuel SA, Olajide O, Abubakar S, Akiode SO, Etuk-Udo G (2016) Chemical evaluation, free radical scavenging activities and antimicrobial evaluation of the methanolic extracts of corn silk (Zea mays). J Adv Med Pharm Sci 9:1–8. https://doi.org/10.9734/JAMPS/2016/28530

Article  Google Scholar 

Ha AW, Kang HJ, Kim SL, Kim MH, Kim WK (2018) Acute and subacute toxicity evaluation of corn silk extract. Prev Nutr Food Sci 23:70–76. https://doi.org/10.3746/pnf.2018.23.1.70

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ikpeazu VO, Ugbogu EA, Emmanuel O, Uche-Ikonne C, Okoro B, Nnaemeka J (2018) Evaluation of the safety of oral intake of aqueous extract of stigma maydis (corn silk) in rats. Acta Sci Pol Technol Aliment 17:387–397. https://doi.org/10.17306/J.AFS.0601

Article  CAS  PubMed  Google Scholar 

Kumar D, Jhariya AN (2013) Nutritional, medicinal and economical importance of corn: a mini Review. Res J Pharm Sci 2:7–8

Google Scholar 

Li Q, Liu B (2017) Genetic regulation of maize flower development and sex determination. Planta 245:1–14. https://doi.org/10.1007/s00425-016-2607-2

Article  CAS  PubMed  Google Scholar 

Li Y, Hu Z, Wang X, Wu M, Zhou H, Zhang Y (2020) Characterization of a polysaccharide with antioxidant and anti-cervical cancer potentials from the corn silk cultivated in Jilin province. Int J Biol Macromolecules 155:1105–1113. https://doi.org/10.1016/j.ijbiomac.2019.11.077

Article  CAS  Google Scholar 

Limmatvapirat C, Nateesathittarn C, Dechasathian K, Moohummad T, Chinajitphan P, Limmatvapirat S (2020) Phytochemical analysis of baby corn silk extracts. J Ayurveda Integr Med 11:344–351. https://doi.org/10.1016/j.jaim.2019.10.005

Article  PubMed  PubMed Central  Google Scholar 

Liu J, Wang C, Wang Z, Zhang C, Lu S, Liu J (2011) The antioxidant and free-radical scavenging activities of extract and fractions from corn silk (Zea mays L.) and related flavone glycosides. Food Chem 126:261–269. https://doi.org/10.1016/j.foodchem.2010.11.014

Article  CAS  Google Scholar 

Ma Y, Yang L, Ma J, Lu L, Wang X, Ren J, Yang J (2017) Rutin attenuates doxorubicin-induced cardiotoxicity via regulating autophagy and apoptosis. Biochim Biophys Acta Mol Basis Dis 1863:81904–81911. https://doi.org/10.1016/j.bbadis.2016.12.021

Article  CAS  Google Scholar 

Maksimovic Z, Malencic D, Kovacevic N (2005) Polyphenol contents and antioxidant activity of Maydis stigma extracts. Bioresour Technol 96:873–877. https://doi.org/10.1016/j.biortech.2004.09.006

Article  CAS  PubMed  Google Scholar 

Marques LC (2005) Preparação de extratos vegetais. J Bras Fitomed 3:74–76

Google Scholar 

Munn Z, Pollock D, Khalil H, Alexander L, Mclnerney P, Godfrey CM, Peters M, Tricco AC (2022) What are scoping reviews? Providing a formal definition of scoping reviews as a type of evidence synthesis. JBI Evid Synth 20:950–952. https://doi.org/10.11124/JBIES-21-00483

Article  PubMed  Google Scholar 

OECD (2001) Guideline for the testing of chemicals, n° 423: acute oral toxicity – acute toxic class method. Paris, France, https://www.oecd-ilibrary.org/environment/test-no-423-acute-oral-toxicity-acute-toxic-class-method_9789264071001-en.

OECD (2016) Guideline for the Testing of Chemicals, n° 421: Reproduction/Developmental Toxicity Screening Test. Paris, France, https://www.oecd.org/en/publications/test-no-421-reproduction-developmental-toxicity-screening-test_9789264264380-en.html.

Ong ES (2004) Extraction methods and chemical standardization of botanicals and herbal preparations. J Chromatogr B Analyt Technol Biomed Life Sci 812:23–33. https://doi.org/10.1016/j.jchromb.2004.07.041

Article  CAS  PubMed  Google Scholar 

Pandey A, Tripathi S (2014) Concept of standardization, extraction and pre phytochemical screening strategies for herbal drug. J Pharmacogn Phytochem 2:115–119

Google Scholar 

Peng KZ, Yang X, Zhou HL, Pan SX (2015) Safety evaluation, in vitro and in vivo antioxidant activity of the flavonoid-rich extract from maydis stigma. Molecules 20:22102–22112. https://doi.org/10.3390/molecules201219835

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng KZ, Zhang SY, Zhou HL (2016) Toxicological evaluation of the flavonoid-rich extract from maydis stigma: subchronic toxicity and genotoxicity studies in mice. J Ethnopharmacol 192:161–169. https://doi.org/10.1016/j.jep.2016.07.012

Article  CAS  PubMed  Google Scholar 

Ren SC, Liu ZL, Ding XL (2009) Isolation and identification of two novel flavone glycosides from corn silk (Stigma maydis). J Med Plants Res 3:1009–1015

CAS  Google Scholar 

Ren SC, Qiao QQ, Ding XL (2013) Antioxidative activity of five flavones glycosides from corn silk (stigma maydis). Czech J Food Sci 31:148–155. https://doi.org/10.17221/194/2012-CJFS

Article  CAS  Google Scholar 

Sabiu S, O’Neill FH, Ashafa AOT (2017) Toxicopathological evaluation of a 28-day repeated dose administration of Zea mays L. (Poaceae), stigma maydis aqueous extract on key metabolic markers of Wistar rats. Trans R Soc South Afr 72:225–233. https://doi.org/10.1080/0035919X.2017.1342713

Article  Google Scholar 

Saheed S, Oladipipo AE, Abdulazeez AA, Olarewaju SA, Ismaila NO, Emmanuel IA, Fatimah QD, Aisha AY (2015) Toxicological evaluations of stigma maydis (corn silk) aqueous extract on hematological and lipid parameters in Wistar rats. Toxicol Rep 2:638–644. https://doi.org/10.1016/j.toxrep.2015.04.001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sahindokuyucu-Kocasari F, Akyol Y, Ozmen O, Erdemli-Kose SB, Garli S (2021) Apigenin alleviates methotrexate-induced liver and kidney injury in mice. Hum Exp Toxicol 40:1721–1731. https://doi.org/10.1177/09603271211009964

Article  CAS  PubMed  Google Scholar 

Sawangwong W, Kiattisin K, Somwongin S, Wongrattanakamon P, Chaiyana W, Poomanee W, Sainakham M (2024) The assessment of composition, biological properties, safety and molecular docking of corn silk (Zea mays L.) extracts from the valorization of agricultural waste products in Thailand. Ind Crops Prod 212:118352. https://doi.org/10.1016/j.indcrop.2024.118352

Article  CAS  Google Scholar 

Tang D, Chen K, Huang L, Li J (2017) Pharmacokinetic properties and drug interactions of apigenin, a natural flavone. Expert Opin Drug Metab Toxicol 13:323–330. https://doi.org/10.1080/17425255.2017.1251903

Article  CAS  PubMed