Turner KJ, Vasu V, Griffin DK. Telomere biology and human phenotype. Cells. 2019. https://doi.org/10.3390/cells8010073.
Article PubMed PubMed Central Google Scholar
de Lange T. Shelterin-mediated telomere protection. Annu Rev Genet. 2018;52:223–47. https://doi.org/10.1146/annurev-genet-032918-021921.
Article PubMed CAS Google Scholar
Lim CJ, Cech TR. Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization. Nat Rev Mol Cell Biol. 2021;22:283–98. https://doi.org/10.1038/s41580-021-00328-y.
Article PubMed PubMed Central CAS Google Scholar
Blasco MA. Telomere length, stem cells and aging. Nat Chem Biol. 2007;3:640–9. https://doi.org/10.1038/nchembio.2007.38.
Article PubMed CAS Google Scholar
Lin J, Epel E. Stress and telomere shortening: insights from cellular mechanisms. Ageing Res Rev. 2022;73: 101507. https://doi.org/10.1016/j.arr.2021.101507.
Article PubMed CAS Google Scholar
van Steensel B, Smogorzewska A, de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell. 1998;92:401–13. https://doi.org/10.1016/s0092-8674(00)80932-0.
Herrmann M, Pusceddu I, Marz W, Herrmann W. Telomere biology and age-related diseases. Clin Chem Lab Med. 2018;56:1210–22. https://doi.org/10.1515/cclm-2017-0870.
Article PubMed CAS Google Scholar
Chan SR, Blackburn EH. Telomeres and telomerase. Philos Trans R Soc Lond B Biol Sci. 2004;359:109–21. https://doi.org/10.1098/rstb.2003.1370.
Article PubMed PubMed Central CAS Google Scholar
Hemann MT, Strong MA, Hao LY, Greider CW. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell. 2001;107:67–77. https://doi.org/10.1016/s0092-8674(01)00504-9.
Article PubMed CAS Google Scholar
Shay JW, Wright WE. Telomeres and telomerase: three decades of progress. Nat Rev Genet. 2019;20:299–309. https://doi.org/10.1038/s41576-019-0099-1.
Article PubMed CAS Google Scholar
De Meyer T, Nawrot T, Bekaert S, De Buyzere ML, Rietzschel ER, Andres V. Telomere length as cardiovascular aging biomarker: JACC review topic of the week. J Am Coll Cardiol. 2018;72:805–13. https://doi.org/10.1016/j.jacc.2018.06.014.
Article PubMed CAS Google Scholar
Schneider CV, Schneider KM, Teumer A, Rudolph KL, Hartmann D, Rader DJ, Strnad P. Association of telomere length with risk of disease and mortality. JAMA Intern Med. 2022;182:291–300. https://doi.org/10.1001/jamainternmed.2021.7804.
Article PubMed PubMed Central CAS Google Scholar
Blackburn EH, Greider CW, Szostak JW. Telomeres and telomerase: the path from maize, tetrahymena and yeast to human cancer and aging. Nat Med. 2006;12:1133–8. https://doi.org/10.1038/nm1006-1133.
Article PubMed CAS Google Scholar
Wang Y, Susac L, Feigon J. Structural biology of telomerase. Cold Spring Harb Perspect Biol. 2019. https://doi.org/10.1101/cshperspect.a032383.
Article PubMed PubMed Central Google Scholar
Bernardes de Jesus B, Blasco MA. Telomerase at the intersection of cancer and aging. Trends Genet. 2013;29:513–20. https://doi.org/10.1016/j.tig.2013.06.007.
Article PubMed CAS Google Scholar
Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153:1194–217. https://doi.org/10.1016/j.cell.2013.05.039.
Article PubMed PubMed Central CAS Google Scholar
Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: an expanding universe. Cell. 2023;186:243–78. https://doi.org/10.1016/j.cell.2022.11.001.
Article PubMed CAS Google Scholar
Tomas-Loba A, Flores I, Fernandez-Marcos PJ, Cayuela ML, Maraver A, Tejera A, Borras C, Matheu A, Klatt P, Flores JM, et al. Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell. 2008;135:609–22. https://doi.org/10.1016/j.cell.2008.09.034.
Article PubMed CAS Google Scholar
Watson JD. Origin of concatemeric T7 DNA. Nat New Biol. 1972;239:197–201. https://doi.org/10.1038/newbio239197a0.
Article PubMed CAS Google Scholar
Di Micco R, Krizhanovsky V, Baker D, d’Adda di Fagagna F. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat Rev Mol Cell Biol. 2021;22:75–95. https://doi.org/10.1038/s41580-020-00314-w.
Article PubMed CAS Google Scholar
Cesare AJ, Karlseder J. A three-state model of telomere control over human proliferative boundaries. Curr Opin Cell Biol. 2012;24:731–8. https://doi.org/10.1016/j.ceb.2012.08.007.
Article PubMed PubMed Central CAS Google Scholar
Hewitt G, Jurk D, Marques FD, Correia-Melo C, Hardy T, Gackowska A, Anderson R, Taschuk M, Mann J, Passos JF. Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Nat Commun. 2012;3:708. https://doi.org/10.1038/ncomms1708.
Article PubMed CAS Google Scholar
Rossiello F, Jurk D, Passos JF, d’Adda di Fagagna F. Telomere dysfunction in ageing and age-related diseases. Nat Cell Biol. 2022;24:135–47. https://doi.org/10.1038/s41556-022-00842-x.
Article PubMed PubMed Central CAS Google Scholar
Papathanassoglou ED, Moynihan JA, Ackerman MH. Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? a review and a theoretical framework. Crit Care Med. 2000;28:537–49. https://doi.org/10.1097/00003246-200002000-00042.
Article PubMed CAS Google Scholar
Hinz B, Lagares D. Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases. Nat Rev Rheumatol. 2020;16:11–31. https://doi.org/10.1038/s41584-019-0324-5.
Article PubMed CAS Google Scholar
Su L, Dong Y, Wang Y, Wang Y, Guan B, Lu Y, Wu J, Wang X, Li D, Meng A, et al. Potential role of senescent macrophages in radiation-induced pulmonary fibrosis. Cell Death Dis. 2021;12:527. https://doi.org/10.1038/s41419-021-03811-8.
Article PubMed PubMed Central CAS Google Scholar
Fumagalli M, Rossiello F, Clerici M, Barozzi S, Cittaro D, Kaplunov JM, Bucci G, Dobreva M, Matti V, Beausejour CM, et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat Cell Biol. 2012;14:355–65. https://doi.org/10.1038/ncb2466.
Article PubMed PubMed Central CAS Google Scholar
Victorelli S, Passos JF. Telomeres and cell senescence - size matters not. EBioMedicine. 2017;21:14–20. https://doi.org/10.1016/j.ebiom.2017.03.027.
Comments (0)