Rousseau A, Mokhtari K, Duyckaerts C. The 2007 WHO classification of tumors of the central nervous system - what has changed? Curr Opin Neurol. 2008;21(6):720–7.

Article  PubMed  Google Scholar 

Poon CC, Sarkar S, Yong VW, Kelly JJP. Glioblastoma-associated microglia and macrophages: targets for therapies to improve prognosis. Brain. 2017;140(6):1548–60.

Article  PubMed  Google Scholar 

Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, Hau P, Brandes AA, Gijtenbeek J, Marosi C, Vecht CJ, Mokhtari K, Wesseling P, Villa S, Eisenhauer E, Gorlia T, Weller M, Lacombe D, Cairncross JG, Mirimanoff RO, European Organisation for R, Treatment of Cancer Brain T, Radiation Oncology G, National Cancer Institute of Canada Clinical Trials G. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 2009;10(5):459–66.

Stupp R, Taillibert S, Kanner A, Read W, Steinberg D, Lhermitte B, Toms S, Idbaih A, Ahluwalia MS, Fink K, Di Meco F, Lieberman F, Zhu J-J, Stragliotto G, Tran D, Brem S, Hottinger A, Kirson ED, Lavy-Shahaf G, Weinberg U, Kim C-Y, Paek S-H, Nicholas G, Bruna J, Hirte H, Weller M, Palti Y, Hegi ME, Ram Z. Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma: a randomized clinical trial. JAMA. 2017;318(23):2306–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stowell SR, Ju T, Cummings RD. Protein glycosylation in cancer. Annu Rev Pathol. 2015;10:473–510.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peixoto A, Relvas-Santos M, Azevedo R, Santos LL, Ferreira JA. Protein glycosylation and tumor microenvironment alterations driving cancer hallmarks. Front Oncol. 2019;9:380.

Article  PubMed  PubMed Central  Google Scholar 

Fabris D, Rožman M, Sajko T, Vukelić Ž. Aberrant ganglioside composition in glioblastoma multiforme and peritumoral tissue: A mass spectrometry characterization. Biochimie. 2017;137:56–68.

Article  CAS  PubMed  Google Scholar 

Sethi MK, Downs M, Shao C, Hackett WE, Phillips JJ, Zaia J. In-depth matrisome and glycoproteomic analysis of human brain glioblastoma versus control tissue. Mol Cell Proteomics. 2022;21(4): 100216.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yamamoto H, Swoger J, Greene S, Saito T, Hurh J, Sweeley C, Leestma J, Mkrdichian E, Cerullo L, Nishikawa A, Ihara Y, Taniguchi N, Moskal JR. Beta 1,6-N-acetylglucosamine-bearing N-glycans in human gliomas: implications for a role in regulating invasivity. Cancer Res. 2000;60(1):134–42.

CAS  PubMed  Google Scholar 

Yamamoto H, Oviedo A, Sweeley C, Saito T, Moskal JR. Alpha 2,6-sialylation of cell-surface N-glycans inhibits glioma formation in vivo. Can Res. 2001;61(18):6822–9.

CAS  Google Scholar 

Büll C, Stoel MA, den Brok MH, Adema GJ. Sialic acids sweeten a tumor’s life. Can Res. 2014;74(12):3199–204.

Article  Google Scholar 

Büll C, Boltje TJ, Balneger N, Weischer SM, Wassink M, van Gemst JJ, Bloemendal VR, Boon L, van der Vlag J, Heise T, den Brok MH, Adema GJ. Sialic acid blockade suppresses tumor growth by enhancing T-cell-mediated tumor immunity. Can Res. 2018;78(13):3574–88.

Article  Google Scholar 

Yue J, Huang R, Lan Z, Xiao B, Luo Z. Abnormal glycosylation in glioma: related changes in biology, biomarkers and targeted therapy. Biomarker Res. 2023;11(1):54.

Article  Google Scholar 

Jin X, Chen Z, Zhao H. Deciphering glycosylation-driven prognostic insights and therapeutic prospects in glioblastoma through a comprehensive regulatory model. Front Oncol. 2014;14: 1288820.

Article  Google Scholar 

Cuello HA, Ferreira GM, Gulino CA, Toledo AG, Segatori VI, Gabri MR. Terminally sialylated and fucosylated complex N-glycans are involved in the malignant behavior of high-grade glioma. Oncotarget. 2020;11:4822.

Article  PubMed  PubMed Central  Google Scholar 

Kaiyue X, Kaiqian Z, Jiying M, Qianqian Y, Ge Y, Tingting Z, Guowei W, Bo Y, Jule S, Chao C, Liang W, Huijuan W. CKAP4-mediated activation of FOXM1 via phosphorylation pathways regulates malignant behavior of glioblastoma cells. Transl Oncol. 2023;29: 101628.

Article  Google Scholar 

Reis CA, Osorio H, Silva L, Gomes C, David L. Alterations in glycosylation as biomarkers for cancer detection. J Clin Pathol. 2010;63(4):322–9.

Article  CAS  PubMed  Google Scholar 

Veillon L, Fakih C, Abou-El-Hassan H, Kobeissy F, Mechref Y. Glycosylation changes in brain cancer. ACS Chem Neurosci. 2018;9(1):51–72.

Article  CAS  PubMed  Google Scholar 

Munkley J, Vodak D, Livermore KE, James K, Wilson BT, Knight B, McCullagh P, McGrath J, Crundwell M, Harries LW, Leung HY, Robson CN, Mills IG, Rajan P, Elliott DJ. Glycosylation is an androgen-regulated process essential for prostate cancer cell viability. EBioMedicine. 2016;8:103–16.

Article  PubMed  PubMed Central  Google Scholar 

Dimitroff CJ. I-branched carbohydrates as emerging effectors of malignant progression. Proc Natl Acad Sci USA. 2019;116(28):13729–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Munkley J. Glycosylation is a global target for androgen control in prostate cancer cells. Endocr Relat Cancer. 2017;24(3):R49–64.

Article  CAS  PubMed  Google Scholar 

Shah P, Wang X, Yang W, Toghi Eshghi S, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A, Zhang H. Integrated proteomic and glycoproteomic analyses of prostate cancer cells reveal glycoprotein alteration in protein abundance and glycosylation. Mol Cell Proteomics. 2015;14(10):2753–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kolarich D, Jensen PH, Altmann F, Packer NH. Determination of site-specific glycan heterogeneity on glycoproteins. Nat Protoc. 2012;7(7):1285–98.

Article  CAS  PubMed  Google Scholar 

Brennan CW, Verhaak RGW, McKenna A, Campos B, Noushmehr H, Salama SR, Zheng S, Chakravarty D, Sanborn JZ, Berman SH, Beroukhim R, Bernard B, Wu C-J, Genovese G, Shmulevich I, Barnholtz-Sloan J, Zou L, Vegesna R, Shukla SA, Ciriello G, Yung WK, Zhang W, Sougnez C, Mikkelsen T, Aldape K, Bigner DD, Van Meir EG, Prados M, Sloan A, Black KL, Eschbacher J, Finocchiaro G, Friedman W, Andrews DW, Guha A, Iacocca M, O’Neill BP, Foltz G, Myers J, Weisenberger DJ, Penny R, Kucherlapati R, Perou CM, Hayes DN, Gibbs R, Marra M, Mills GB, Lander E, Spellman P, Wilson R, Sander C, Weinstein J, Meyerson M, Gabriel S, Laird PW, Haussler D, Getz G, Chin L, Network TR. The somatic genomic landscape of glioblastoma. Cell. 2013;155(2):462–77.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bruford EA, Braschi B, Denny P, Jones TEM, Seal RL, Tweedie S. Guidelines for human gene nomenclature. Nat Genet. 2020;52(8):754–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eskilsson E, Rosland GV, Talasila KM, Knappskog S, Keunen O, Sottoriva A, Foerster S, Solecki G, Taxt T, Jirik R, Fritah S, Harter PN, Välk K, Al Hossain J, Joseph JV, Jahedi R, Saed HS, Piccirillo SG, Spiteri I, Leiss L, Euskirchen P, Graziani G, Daubon T, Lund-Johansen M, Enger PØ, Winkler F, Ritter CA, Niclou SP, Watts C, Bjerkvig R, Miletic H. EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation. Neuro Oncol. 2016;18(12):1644–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tilak M, Holborn J, New LA, Lalonde J, Jones N. Receptor tyrosine kinase signaling and targeting in glioblastoma multiforme. Int J Mol Sci. 2021;22(4):1831.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iwadate Y. Epithelial-mesenchymal transition in glioblastoma progression. Oncol Lett. 2016;11(3):1615–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mecca C, Giambanco I, Donato R, Arcuri C. Targeting mTOR in glioblastoma: rationale and preclinical/clinical evidence. Dis Markers. 2018;2018:9230479.

Article  PubMed  PubMed Central  Google Scholar 

Finch A, Solomou G, Wykes V, Pohl U, Bardella C, Watts C. Advances in research of adult gliomas. Int J Mol Sci. 2021;22(2):924.

Article  CAS  PubMed  PubMed Central