Effects of combined protein and exercise interventions on bone health in middle-aged and older adults — A systematic literature review and meta-analysis of randomized controlled trials

Demontiero O, Vidal C, Duque G (2012) Aging and bone loss: new insights for the clinician. Ther Adv Musculoskelet Dis 4(2):61–76

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salari N, Darvishi N, Bartina Y et al (2021) Global prevalence of osteoporosis among the world older adults: a comprehensive systematic review and meta-analysis. J Orthop Surg Res 16(1):669

Article  PubMed  PubMed Central  Google Scholar 

Borgström F, Karlsson L, Ortsäter G et al (2020) Fragility fractures in Europe: burden, management and opportunities. Arch Osteoporos 15(1):59

Article  PubMed  PubMed Central  Google Scholar 

Ong T, Kantachuvesiri P, Sahota O, Gladman JRF (2018) Characteristics and outcomes of hospitalised patients with vertebral fragility fractures: a systematic review. Age Ageing 47(1):17–25

Article  PubMed  Google Scholar 

Al-Sari U, Tobias J, Clark E (2016) Health-related quality of life in older people with osteoporotic vertebral fractures: a systematic review and meta-analysis. Osteoporos Int 27(10):2891–2900

Article  CAS  PubMed  Google Scholar 

Oden A, McCloskey EV, Kanis JA et al (2015) Burden of high fracture probability worldwide: secular increases 2010–2040. Osteoporos Int 26(9):2243–2248

Article  CAS  PubMed  Google Scholar 

Kanis JA, Norton N, Harvey NC et al (2021) SCOPE 2021: a new scorecard for osteoporosis in Europe. Arch Osteoporos 16(1):82

Article  PubMed  PubMed Central  Google Scholar 

Aspray TJ, Hill TR (2019) Osteoporosis and the ageing skeleton. Subcell Biochem 91:453–476

Article  CAS  PubMed  Google Scholar 

Johnston CB, Dagar M (2020) Osteoporosis in older adults. Med Clin North Am 104(5):873–884

Article  PubMed  Google Scholar 

Peeters G, van Schoor NM, Cooper R et al (2018) Should prevention of falls start earlier? Co-ordinated analyses of harmonised data on falls in middle-aged adults across four population-based cohort studies. PLoS One 13(8):e0201989

Article  PubMed  PubMed Central  Google Scholar 

Tarantino U, Iolascon G, Cianferotti L et al (2017) Clinical guidelines for the prevention and treatment of osteoporosis: summary statements and recommendations from the Italian Society for Orthopaedics and Traumatology. J Orthop Traumatol 18(Suppl 1):3–36

Article  PubMed  PubMed Central  Google Scholar 

Beck B, Daly R, Singh M, Taaffe D (2017) Exercise and sports science Australia (ESSA) position statement on exercise prescription for the prevention and management of osteoporosis. J Sci Med Sport 20(5):438–445

Article  PubMed  Google Scholar 

Gader AGMA (2018) The effect of exercise and nutrition on bone health. J Musculoskelet Surg Res 2:142

Article  Google Scholar 

Shojaa M, Von Stengel S, Schoene D et al (2020) Effect of exercise training on bone mineral density in post-menopausal women: a systematic review and meta-analysis of intervention studies. Front Physiol 11:652

Article  PubMed  PubMed Central  Google Scholar 

Hejazi K, Askari R, Hofmeister M (2022) Effects of physical exercise on bone mineral density in older postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. Arch Osteoporos 17(1):102

Article  PubMed  Google Scholar 

Mages M, Shojaa M, Kohl M et al (2021) Exercise effects on bone mineral density in men. Nutrients 13(12):4244

Article  PubMed  PubMed Central  Google Scholar 

Schinzel E, Kast S, Kohl M et al (2023) The effect of aquatic exercise on bone mineral density in older adults. A systematic review and meta-analysis. Front Physiol 14:1135663

Article  PubMed  PubMed Central  Google Scholar 

Heaney RP (2007) Effects of protein on the calcium economy. Int Congr Ser 1297(6):191–197

Article  CAS  Google Scholar 

Daly RM, Duckham RL, Gianoudis J (2014) Evidence for an interaction between exercise and nutrition for improving bone and muscle health. Curr Osteoporos Rep 12(2):219–226

Article  PubMed  Google Scholar 

Zittermann A, Schmidt A, Haardt J et al (2023) Protein intake and bone health: an umbrella review of systematic reviews for the evidence-based guideline of the German Nutrition Society. Osteoporos Int 34(8):1335–1353

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wallace T, Frankenfeld CL (2017) Dietary protein intake above the current RDA and bone health: a systematic review and meta-analysis. J Am Coll Nutr 36(6):481–96

Article  CAS  PubMed  Google Scholar 

Shams-White MM, Chung M, Du M et al (2017) Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation. Am J Clin Nutr 105(6):1528–1543

Article  CAS  PubMed  Google Scholar 

Bauer J, Morley J, Schols A et al (2019) Sarcopenia: a time for action. An SCWD position paper. J Cachexia Sarcopenia Muscle 10(5):956–61

Article  PubMed  PubMed Central  Google Scholar 

Jager R, Kerksick CM, Campbell BI et al (2017) International Society of Sports Nutrition position stand: protein and exercise. J Int Soc Sports Nutr 14:20

Article  PubMed  PubMed Central  Google Scholar 

Roschel H, Hayashi AP, Fernandes AL et al (2021) Supplement-based nutritional strategies to tackle frailty: a multifactorial, double-blind, randomized placebo-controlled trial. Clin Nutr 40(8):4849–4858

Article  CAS  PubMed  Google Scholar 

Zdzieblik D, Oesser S, Baumstark M et al (2015) Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. Br J Nutr 114(8):1237–1245

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holm L, Olesen JL, Matsumoto K et al (2008) Protein-containing nutrient supplementation following strength training enhances the effect on muscle mass, strength, and bone formation in postmenopausal women. J Appl Physiol 105(1):274–281

Article  CAS  PubMed  Google Scholar 

Wright C, McMorrow A, Weinheimer-Haus E, Campbell W (2017) Whey protein supplementation and higher total protein intake do not influence bone quantity in overweight and obese adults following a 36-week exercise and diet intervention. J Nutr 147(2):179–186

Article  CAS  PubMed  Google Scholar 

Shenoy S, Bedi R, Sandhu JS (2013) Effect of soy isolate protein and resistance exercises on muscle performance and bone health of osteopenic/osteoporotic post-menopausal women. J Women Aging 25(2):183–198

Article  PubMed  Google Scholar 

Kemmler W, Kohl M, Jakob F et al (2020) Effects of high intensity dynamic resistance exercise and whey protein supplements on osteosarcopenia in older men with low bone and muscle mass. Final results of the randomized controlled FrOST study. Nutrients 12(8):2341

Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71

Article  PubMed  PubMed Central  Google Scholar 

Rethlefsen ML, Kirtley S, Waffenschmidt S et al (2021) PRISMA-S: an extension to the PRISMA statement for reporting literature searches in systematic reviews. Syst Rev 10(1):39

Article  PubMed  PubMed Central  Google Scholar 

American College of Sports Medicine, Chodzko-Zajko WJ, Proctor DN, Fiatarone Singh MA, Minson CT, Nigg CR, Salem GJ, Skinner JS (2009) American college of sports medicine position stand exercise and physical activity for older adults. Med Sci Sports Exerc 41(7):1510–30

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