Dose Optimization of Vancomycin in Pediatric Post-Cardiac Surgery Patients: A Population Pharmacokinetic Modeling Study

Chung E, Sen J, Patel P, Seto W. Population pharmacokinetic models of vancomycin in paediatric patients: a systematic review. Clin Pharmacokinet. 2021;60(8):985–1001.

Article  CAS  PubMed  Google Scholar 

Batchelor HK, Marriott JF. Paediatric pharmacokinetics: key considerations. Br J Clin Pharmacol. 2015;79(3):395–404.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsutsuura M, Moriyama H, Kojima N, Mizukami Y, Tashiro S, Osa S, et al. The monitoring of vancomycin: a systematic review and meta-analyses of area under the concentration-time curve-guided dosing and trough-guided dosing. BMC Infect Dis. 2021;21(1):153.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moffett BS, Morris J, Galati M, Munoz F, Arikan AA. Population pharmacokinetics of vancomycin in pediatric extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2018;19(10):973–80.

Article  PubMed  Google Scholar 

Rybak MJ, Le J, Lodise TP, Levine DP, Bradley JS, Liu C, et al. Therapeutic monitoring of vancomycin for serious methicillin-resistant Staphylococcus aureus infections: a revised consensus guideline and review by the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists. Am J Health Syst Pharm. 2020;77(11):835–64.

Article  PubMed  Google Scholar 

Stewart JJ, Jorgensen SC, Dresser L, Lau TT, Gin A, Thirion DJ, et al. A Canadian perspective on the revised 2020 ASHP-IDSA-PIDS-SIDP guidelines for vancomycin AUC-based therapeutic drug monitoring for serious MRSA infections. J Assoc Med Microbiol Infect Dis Can. 2021;6(1):3–9.

PubMed  PubMed Central  Google Scholar 

Le J, Bradley JS, Murray W, Romanowski GL, Tran TT, Nguyen N, et al. Improved vancomycin dosing in children using area under the curve exposure. Pediatr Infect Dis J. 2013;32(4):e155–63.

Article  PubMed  PubMed Central  Google Scholar 

Beken S, Akbulut BB, Albayrak E, Guner B, Unlu Y, Temur B, et al. Evaluation of neonatal acute kidney injury after critical congenital heart disease surgery. Pediatr Nephrol. 2021;36(7):1923–9.

Article  PubMed  Google Scholar 

Khuong JN, Wilson TG, Iyengar AJ, d’Udekem Y. Acute and chronic kidney disease following congenital heart surgery: a review. Ann Thorac Surg. 2021;112(5):1698–706.

Article  PubMed  Google Scholar 

Madsen NL, Goldstein SL, Froslev T, Christiansen CF, Olsen M. Cardiac surgery in patients with congenital heart disease is associated with acute kidney injury and the risk of chronic kidney disease. Kidney Int. 2017;92(3):751–6.

Article  PubMed  Google Scholar 

Moffett BS, Resendiz K, Morris J, Akcan-Arikan A, Checchia PA. Population pharmacokinetics of vancomycin in the pediatric cardiac surgical population. J Pediatr Pharmacol Ther. 2019;24(2):107–16.

PubMed  PubMed Central  Google Scholar 

Aurobindo Pharma. Summary of Product Characteristics, Vancomycin Powder for concentrate for solution for infusion. 2022.

Moffett BS, Humlicek TJ, Akcan-Arikan A, Anders M, Tume S. Population pharmacokinetics of vancomycin in the pediatric ventricular assist device population. Pediatr Crit Care Med. 2020;21(8):e566–71.

Article  PubMed  Google Scholar 

Shimamoto Y, Fukushima K, Mizuno T, Ichikawa H, Kurosaki K, Maeda S, et al. Model-informed vancomycin dosing optimization to address delayed renal maturation in infants and young children with critical congenital heart disease. Clin Pharmacol Ther. 2023;115(2):239–47.

Article  PubMed  Google Scholar 

Nederlands Kinderformularium. 2023 June, 2020; Available from: https://www.kinderformularium.nl/geneesmiddel/337/vancomycine

Darwich AS, Polasek TM, Aronson JK, Ogungbenro K, Wright DFB, Achour B, et al. Model-informed precision dosing: background, requirements, validation, implementation, and forward trajectory of individualizing drug therapy. Annu Rev Pharmacol Toxicol. 2021;6(61):225–45.

Article  Google Scholar 

Jager AAN, van Hest R, van Schip A. TDM Monograph Vancomycin. 2021. Available from: https://tdm-monografie.org/vancomycine/

Anderson BJ, Holford NH. Mechanism-based concepts of size and maturity in pharmacokinetics. Annu Rev Pharmacol Toxicol. 2008;48:303–32.

Article  CAS  PubMed  Google Scholar 

Schwartz GJ, Munoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, et al. New equations to estimate GFR in children with CKD. J Am Soc Nephrol. 2009;20(3):629–37.

Article  PubMed  PubMed Central  Google Scholar 

Dolan E, Hellinga R, London M, Ryan K, Dehority W. Effect of vancomycin loading doses on the attainment of target trough concentrations in hospitalized children. J Pediatr Pharmacol Ther. 2020;25(5):423–30.

PubMed  PubMed Central  Google Scholar 

Wang W, Hallow KM, James DA. A tutorial on RxODE: simulating differential equation pharmacometric models in R. CPT Pharmacometrics Syst Pharmacol. 2016;5(1):3–10.

Article  CAS  PubMed  Google Scholar 

Zylbersztajn BL, Izquierdo G, Santana RC, Fajardo C, Torres JP, Cordero J, et al. Therapeutic drug monitoring of vancomycin in pediatric patients with extracorporeal membrane oxygenation support. J Pediatr Pharmacol Ther. 2018;23(4):305–10.

PubMed  PubMed Central  Google Scholar 

Zylbersztajn B, Parker S, Navea D, Izquierdo G, Ortiz P, Torres JP, et al. Population pharmacokinetics of vancomycin and meropenem in pediatric extracorporeal membrane oxygenation support. Front Pharmacol. 2021;12: 709332.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng V, Abdul-Aziz MH, Burrows F, Buscher H, Cho YJ, Corley A, et al. Population pharmacokinetics of vancomycin in critically ill adult patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study). Antimicrob Agents Chemother. 2022;66(1): e0137721.

Article  PubMed  Google Scholar 

Shekar K, Roberts JA, McDonald CI, Ghassabian S, Anstey C, Wallis SC, et al. Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: results from an ex vivo study. Crit Care. 2015;19(1):164.

Article  PubMed  PubMed Central  Google Scholar 

Shekar K, Roberts JA, Barnett AG, Diab S, Wallis SC, Fung YL, et al. Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models. Crit Care. 2015;15(19):437.

Article  Google Scholar 

Sridharan K, Abbasi MY, Mulubwa M. Population pharmacokinetics and dose optimization of vancomycin in critically ill children. Eur J Drug Metab Pharmacokinet. 2021;46(4):539–46.

Article  CAS  PubMed  Google Scholar 

He CY, Ye PP, Liu B, Song L, van den Anker J, Zhao W. Population pharmacokinetics and dosing optimization of vancomycin in infants, children, and adolescents with augmented renal clearance. Antimicrob Agents Chemother. 2021;65(10): e0089721.

Article  PubMed  Google Scholar 

Jancic SG, Mocnik M, Marcun Varda N. Glomerular filtration rate assessment in children. Children (Basel). 2022;9(12):1995.

PubMed  PubMed Central  Google Scholar 

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