Jia D, Sun F, Han S, Lu L, Sun Y, Song Q. Adverse outcomes in subsequent pregnancies in women with history of recurrent spontaneous abortion: a meta-analysis. J Obstet Gynaecol Res. 2024;50(3):281–97.

Article  PubMed  Google Scholar 

La X, Wang W, Zhang M, Liang L. Definition and multiple factors of recurrent spontaneous abortion. Adv Exp Med Biol. 2021;1300:231–57.

Article  CAS  PubMed  Google Scholar 

Quenby S, Gallos ID, Dhillon-Smith RK, Podesek M, Stephenson MD, Fisher J, et al. Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss. Lancet. 2021;397(10285):1658–67.

Article  CAS  PubMed  Google Scholar 

Fee N, McEvoy A, Cullen S, Doyle S, Crosby D, Allen C. Pregnancy outcomes following recurrent miscarriage. Ir J Med Sci. 2023;192(5):2255–8.

PubMed  Google Scholar 

Goncalves C, Feitosa BM, Cavalcante BV, Lima A, de Souza CM, Joventino LB, et al. Obesity and recurrent miscarriage: the interconnections between adipose tissue and the immune system. Am J Reprod Immunol. 2023;90(3):e13757.

Article  CAS  PubMed  Google Scholar 

John DG, Carlin WV. An unusual case of surgical emphysema. J Laryngol Otol. 1986;100(10):1209–11.

Article  CAS  PubMed  Google Scholar 

Bilardi JE, Temple-Smith M. We know all too well the significant psychological impact of miscarriage and recurrent miscarriage: so where is the support? Fertil Steril. 2023;120(5):937–9.

Article  PubMed  Google Scholar 

He Y, Su X, Li H, Tang R, Ju Y, Chen S, et al. Subcutaneous injection granulocyte colony-stimulating factor (G-CSF) is superior to intrauterine infusion on patients with recurrent implantation failure: a systematic review and network meta-analysis. J Reprod Immunol. 2024;163:104250.

Article  CAS  PubMed  Google Scholar 

Cavalcante MB, Costa Fda S, Barini R, Araujo Junior E. Granulocyte colony-stimulating factor and reproductive medicine: a review. Iran J Reprod Med. 2015;13(4):195–202.

PubMed  PubMed Central  Google Scholar 

Cuadrado-Torroglosa I, Garcia-Velasco JA, Alecsandru D. Maternal-fetal compatibility in recurrent pregnancy loss. J Clin Med. 2024;13(8).

Li N, Guan Y, Liu J, Ren B, Du Y, Wang K, et al. History of recurrent implantation failure is Associated with the incidence of adverse perinatal outcomes in Singleton Live births following frozen-thawed embryo transfer cycles. Front Endocrinol (Lausanne). 2021;12:774646.

Article  PubMed  Google Scholar 

Gan C, Chen W, Liu Q. Progress in research on production-related mechanisms between granulocyte-macrophage colony stimulating factor and regulatory interactions to improve unexplained recurrent flow T cells. Chin J Frontier Med. 2023;15(4):60–5.

Google Scholar 

Han X, Zhao X, Feng X. The regulatory mechanism of granulocyte colony stimulating factor in pregnancy and its research progress in the treatment of unexplained recurrent abortion Chinese. J Reprod Contracept. 2021;41(3):6–9.

Google Scholar 

Fu J, Zhu X, Sun H. Granulocyte colony stimulating factor in the treatment of unexplained recurrent abortion: a randomized controlled trial. Chin J New Drugs Clin. 2015;34(8):602–6.

CAS  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.

Article  PubMed  PubMed Central  Google Scholar 

Sterne JAC, Savovic J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.

Article  PubMed  Google Scholar 

Eapen A, Joing M, Kwon P, Tong J, Maneta E, De Santo C, et al. Recombinant human granulocyte- colony stimulating factor in women with unexplained recurrent pregnancy losses: a randomized clinical trial. Hum Reprod. 2019;34(3):424–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo X. Clinical application of recombinant human granulocyte stimulating factor in the treatment of recurrent abortion. Jiangxi Med. 2022;57(10):1550–4.

Google Scholar 

Jin S, Fang J, Li S. The effect of intrauterine instillation of recombinant human granulocyte colony-stimulating factor on endometrial receptivity and pregnancy outcomes in patients with recurrent miscarriage. Shaanxi Med J. 2020;49(8):592–4.

Google Scholar 

Li L, Zhao C, Feng F. Clinical study on the use of granulocyte colony-stimulating factor (G-CSF) perfusion in the treatment of recurrent abortion. Reprod Contracept. 2015;35(11):791–4.

Google Scholar 

Ni S, Liu J, Li L. Clinical study of granulocyte colony stimulating factor in the treatment of recurrent abortion. Hebei Med. 2021;43(24):3766–8.

Google Scholar 

Wu X, Weng A, Song Z. Effect of rhG-CSF subcutaneous injection combined with conventional treatment on pregnancy outcome in patients with recurrent abortion. Chin Foreign Med Res. 2023;21(23):126–9.

CAS  Google Scholar 

Zafardoust S, Akhondi MM, Sadeghi MR, Mohammadzadeh A, Karimi A, Jouhari S, et al. Efficacy of Intrauterine Injection of Granulocyte Colony stimulating factor (G-CSF) on treatment of unexplained recurrent miscarriage: a pilot RCT study. J Reprod Infertil. 2017;18(4):379–85.

PubMed  PubMed Central  Google Scholar 

Ali A, Elfituri A, Doumouchtsis SK, Zini ME, Jan H, Ganapathy R, et al. Managing couples with recurrent miscarriage: a narrative review and practice recommendations. Int J Gynaecol Obstet. 2024;164(2):499–503.

Article  PubMed  Google Scholar 

Chen J, Yue J, Lu Y, Li T, Li X, Zhang JY. Recurrent miscarriage and low-titer antiphospholipid antibodies. Clin Rheumatol. 2024;43(4):1327–34.

Article  PubMed  PubMed Central  Google Scholar 

Hou Z, Jiang F, Yang J, Liu Y, Zha H, Yang X, et al. What is the impact of granulocyte colony-stimulating factor (G-CSF) in subcutaneous injection or intrauterine infusion and during both the fresh and frozen embryo transfer cycles on recurrent implantation failure: a systematic review and meta-analysis? Reprod Biol Endocrinol. 2021;19(1):125.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arefi S, Fazeli E, Esfahani M, Borhani N, Yamini N, Hosseini A, et al. Granulocyte-colony stimulating factor may improve pregnancy outcome in patients with history of unexplained recurrent implantation failure: an RCT. Int J Reprod Biomed. 2018;16(5):299–304.

CAS  PubMed  PubMed Central  Google Scholar 

Yang X, Tian Y, Zheng L, Luu T, Kwak-Kim J. The Update Immune-Regulatory Role of Pro- and anti-inflammatory cytokines in recurrent pregnancy losses. Int J Mol Sci. 2022;24(1).

Kunicki M, Lukaszuk K, Liss J, Skowronska P, Szczyptanska J. Granulocyte colony stimulating factor treatment of resistant thin endometrium in women with frozen-thawed blastocyst transfer. Syst Biol Reprod Med. 2017;63(1):49–57.

Article  CAS  PubMed  Google Scholar 

Baybordi E, Mohseni J, Mosapour P. The effect of platelet-rich plasma on the improvement of pregnancy results in repeated implantation failure: a randomized controlled trial. Int J Reprod Biomed. 2022;20(9):753–60.

CAS  PubMed  PubMed Central  Google Scholar 

Kashani L, Moini A, Esfidani T, Yamini N, Mohiti S. Effect of intrauterine granulocyte-colony stimulating factor administration on in vitro fertilization outcome in women with moderate-to-severe endometriosis: an RCT. Int J Reprod Biomed. 2021;19(8):733–40.

CAS  PubMed  PubMed Central  Google Scholar 

Torky H, El-Desouky ES, El-Baz A, Aly R, El-Taher O, Shata A, et al. Effect of Intra Uterine Granulocyte Colony stimulating factor vs. human chorionic gonadotropin at Ovum pick up day on pregnancy rate in IVF/ICSI cases with recurrent implantation failure. JBRA Assist Reprod. 2022;26(2):274–9.

PubMed  PubMed Central  Google Scholar 

Kamath MS, Kirubakaran R, Sunkara SK. Granulocyte-colony stimulating factor administration for subfertile women undergoing assisted reproduction. Cochrane Database Syst Rev. 2020;1(1):CD013226.

PubMed  Google Scholar 

Isik G, Oktem M, Guler I, Oktem E, Ozogul C, Saribas S, et al. The impact of granulocyte colony-stimulating factor (G-CSF) on thin endometrium of an animal model with rats. Gynecol Endocrinol. 2021;37(5):438–45.

Article  CAS  PubMed  Google Scholar 

Dakre SM, More A, Dutta S, Ulhe SM, Choudhary N. Combination therapy with platelet-rich plasma (PRP) and granulocyte colony-stimulating factor (G-CSF) for thin endometrium: a Case Report. Cureus. 2024;16(2):e54378.

PubMed  PubMed Central  Google Scholar 

Ding J, Wang J, Cai X, Yin T, Zhang Y, Yang C, et al. Granulocyte colony-stimulating factor in reproductive-related disease: function, regulation and therapeutic effect. Biomed Pharmacother. 2022;150:112903.

Article  CAS  PubMed  Google Scholar 

Yang Y, Ru H, Zhang S, Wu C, Dong J, Wang X et al. The Effect of Granulocyte colony-stimulating factor on endometrial receptivity of implantation failure mouse. Reprod Sci. 2024.

Su Q, Pan Z, Yin R, Li X. The value of G-CSF in women experienced at least one implantation failure: a systematic review and meta-analysis. Front Endocrinol (Lausanne). 2024;15:1370114.

Article  PubMed