Kathrins M. The varicocele as related to fertility. Fertil Steril. 2017;107(1):72–3.

Article  PubMed  Google Scholar 

Eisenberg ML, et al. Male infertility. Nat Rev Dis Primers. 2023;9(1):49.

Article  PubMed  Google Scholar 

Karna KK et al. Gui-A-Gra attenuates testicular dysfunction in varicocele-induced rats via oxidative stress, ER stress and mitochondrial apoptosis pathway. Int J Mol Sci, 2020. 21(23).

Wang K, et al. Role of oxidative stress in varicocele. Front Genet. 2022;13:850114.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karna KK, et al. The ameliorative effect of monotropein, astragalin, and spiraeoside on oxidative stress, endoplasmic reticulum stress, and mitochondrial signaling pathway in varicocelized rats. BMC Complement Altern Med. 2019;19(1):333.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karna KK, et al. The role of endoplasmic reticulum stress response in Male Reproductive Physiology and Pathology: a review. World J Mens Health. 2020;38(4):484–94.

Article  PubMed  Google Scholar 

Wang K, et al. Is parthanatos involved in varicocele? DNA Cell Biol. 2022;41(10):861–70.

Article  CAS  PubMed  Google Scholar 

Zhang Z, et al. Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress. Redox Biol. 2019;25:101047.

Article  CAS  PubMed  Google Scholar 

Zeeshan HM, et al. Endoplasmic reticulum stress and associated ROS. Int J Mol Sci. 2016;17(3):327.

Article  PubMed  PubMed Central  Google Scholar 

Soni KK, et al. Protective effect of MOTILIPERM in varicocele-induced oxidative injury in rat testis by activating phosphorylated inositol requiring kinase 1α (p-IRE1α) and phosphorylated c-Jun N-terminal kinase (p-JNK) pathways. Pharm Biol. 2018;56(1):94–103.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karna KK et al. The effect of schisandra chinensis baillon on cross-talk between oxidative stress, endoplasmic reticulum stress, and mitochondrial signaling pathway in testes of varicocele-induced SD rat. Int J Mol Sci, 2019. 20(22).

Senft D, Ronai ZA. UPR, autophagy, and mitochondria crosstalk underlies the ER stress response. Trends Biochem Sci. 2015;40(3):141–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Molina AM, et al. Analyses of anaesthesia with ketamine combined with different sedatives in rats. Vet Med. 2016;60:368–75.

Article  Google Scholar 

Ko KW, et al. The effect of the partial obstruction site of the renal vein on testis and kidney in rats: is the traditional animal model suitable for varicocele research? Korean J Urol. 2010;51(8):565–71.

Article  PubMed  PubMed Central  Google Scholar 

Afiyani AA, et al. Evaluation of heat-shock protein A2 (HSPA2) in male rats before and after varicocele induction. Mol Reprod Dev. 2014;81(8):766–76.

Article  CAS  PubMed  Google Scholar 

Chen X, et al. Endoplasmic reticulum stress: molecular mechanism and therapeutic targets. Signal Transduct Target Ther. 2023;8(1):352.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Erfani Majd N, et al. Evaluation of oxidative stress in Testis and sperm of Rat following Induced Varicocele. Urol J. 2019;16(3):300–6.

PubMed  Google Scholar 

Mohammadi P, et al. One-carbon cycle support rescues sperm damage in experimentally induced varicocoele in rats. BJU Int. 2018;122(3):480–9.

Article  CAS  PubMed  Google Scholar 

Ibrahim IM, Abdelmalek DH, Elfiky AA. GRP78: a cell’s response to stress. Life Sci. 2019;226:156–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hosseini M, et al. Endoplasmic reticulum stress (ER stress) and unfolded protein response (UPR) Occur in a Rat Varicocele Testis Model. Oxid Med Cell Longev. 2020;2020:p5909306.

Article  Google Scholar 

Tao T, et al. The PERK/Nrf2 pathway mediates endoplasmic reticulum stress-induced injury by upregulating endoplasmic reticulophagy in H9c2 cardiomyoblasts. Life Sci. 2019;237:116944.

Article  CAS  PubMed  Google Scholar 

Gardner BM, Walter P. Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response. Science. 2011;333(6051):1891–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu H, et al. Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin. Mol Cell Biol. 2000;20(6):2198–208.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nakagawa T, Yuan J. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J Cell Biol. 2000;150(4):887–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morishima N, et al. An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem. 2002;277(37):34287–94.

Article  CAS  PubMed  Google Scholar 

Schröder M. Endoplasmic reticulum stress responses. Cell Mol Life Sci. 2008;65(6):862–94.

Article  PubMed  Google Scholar 

Hetz C, Papa FR. The unfolded protein response and cell fate control. Mol Cell. 2018;69(2):169–81.

Article  CAS  PubMed  Google Scholar 

Rutkowski DT, Kaufman RJ. A trip to the ER: coping with stress. Trends Cell Biol. 2004;14(1):20–8.

Article  CAS  PubMed  Google Scholar 

Guesmi F, et al. Prevention of H2O2 Induced oxidative damages of rat testis by Thymus algeriensis. Biomed Environ Sci. 2016;29(4):275–85.

CAS  PubMed  Google Scholar 

Wu Z, et al. Roles of endoplasmic reticulum stress and autophagy on H2O2–induced oxidative stress injury in HepG2 cells. Mol Med Rep. 2018;18(5):4163–74.

CAS  PubMed  PubMed Central  Google Scholar 

Rahmani M et al. Deferasirox, an iron-chelating agent, improves testicular morphometric and sperm functional parameters in a rat model of varicocele. Oxid Med Cell Longev, 2021. 2021: p. 6698482.

Shaygannia E, et al. Alpha-lipoic acid improves the testicular dysfunction in rats induced by varicocele. Andrologia. 2018;50(9):e13085.

Article  PubMed  Google Scholar 

Hong Y, et al. X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl) phthalate-induced testis toxicity. Genes Dis. 2024;11(2):935–51.

Article  CAS  PubMed  Google Scholar 

Xiong Z, et al. Restoring the epigenetically silenced PCK2 suppresses renal cell carcinoma progression and increases sensitivity to sunitinib by promoting endoplasmic reticulum stress. Theranostics. 2020;10(25):11444–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xin L, et al. 4-phenylbutyric acid attenuates endoplasmic reticulum stress-mediated apoptosis and protects the hepatocytes from intermittent hypoxia-induced injury. Sleep Breath. 2019;23(2):711–7.

Article  PubMed  Google Scholar 

Yao W, et al. IRE1α siRNA relieves endoplasmic reticulum stress-induced apoptosis and alleviates diabetic peripheral neuropathy in vivo