An Y, Zhang L, Liu W, Jiang Y, Chen X, Lan X, Li G, Hang Q, Wang J, Gusella JF, Du Y, Shen Y (2020) De novo variants in the Helicase-C domain of CHD8 are associated with severe phenotypes including autism, language disability and overgrowth. Hum Genet 139(4):499–512. https://doi.org/10.1007/s00439-020-02115-9

Article  CAS  PubMed  Google Scholar 

Bakker J, Leinders-Zufall T, Chamero P (2020) The sense of smell: role of the olfactory system in social behavior. In: Neuroscience in the 21st Century: from basic to clinical 1–29. https://doi.org/10.1007/978-1-4614-6434-1_29-4

Barnard RA, Pomaville MB, O’Roak BJ (2015) Mutations and modeling of the chromatin remodeler CHD8 define an emerging autism etiology. Front Neurosci 9:477. https://doi.org/10.3389/fnins.2015.00477

Article  PubMed  PubMed Central  Google Scholar 

Bednarczyk MR, Aumont A, Decary S, Bergeron R, Fernandes KJ (2009) Prolonged voluntary wheel-running stimulates neural precursors in the hippocampus and forebrain of adult CD1 mice. Hippocampus 19(10):913–927. https://doi.org/10.1002/hipo.20621

Article  PubMed  Google Scholar 

Bernier R, Golzio C, Xiong B, Stessman HA, Coe BP, Penn O, Witherspoon K, Gerdts J, Baker C, Vulto-van Silfhout AT, Schuurs-Hoeijmakers JH, Fichera M, Bosco P, Buono S, Alberti A, Failla P, Peeters H, Steyaert J, Vissers L, Francescatto L, Mefford HC, Rosenfeld JA, Bakken T, O’Roak BJ, Pawlus M, Moon R, Shendure J, Amaral DG, Lein E, Rankin J, Romano C, de Vries BBA, Katsanis N, Eichler EE (2014) Disruptive CHD8 mutations define a subtype of autism early in development. Cell 158(2):263–276. https://doi.org/10.1016/j.cell.2014.06.017

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bourgeron T (2015) From the genetic architecture to synaptic plasticity in autism spectrum disorder. Nat Rev Neurosci 16(9):551–563. https://doi.org/10.1038/nrn3992

Article  CAS  PubMed  Google Scholar 

Chan MMY, Han YMY (2020) Differential mirror neuron system (MNS) activation during action observation with and without social-emotional components in autism: a meta-analysis of neuroimaging studies. Mol Autism 11(1):72. https://doi.org/10.1186/s13229-020-00374-x

Article  PubMed  PubMed Central  Google Scholar 

Cotney J, Muhle RA, Sanders SJ, Liu L, Willsey AJ, Niu W, Liu W, Klei L, Lei J, Yin J, Reilly SK, Tebbenkamp AT, Bichsel C, Pletikos M, Sestan N, Roeder K, State MW, Devlin B, Noonan JP (2015) The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment. Nat Commun 6:6404. https://doi.org/10.1038/ncomms7404

Article  CAS  PubMed  Google Scholar 

Cox KH, Rissman EF (2011) Sex differences in juvenile mouse social behavior are influenced by sex chromosomes and social context. Genes Brain Behav 10(4):465–472. https://doi.org/10.1111/j.1601-183X.2011.00688.x

Article  CAS  PubMed  Google Scholar 

Dickter CL, Burk JA, Fleckenstein K, Kozikowski CT (2018) Autistic traits and social anxiety predict differential performance on social cognitive tasks in typically developing young adults. PLoS ONE 13(3):e0195239. https://doi.org/10.1371/journal.pone.0195239

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong C, Zhao C, Chen X, Berry K, Wang J, Zhang F, Liao Y, Han R, Ogurek S, Xu L, Zhang L, Lin Y, Zhou W, Xin M, Lim DA, Campbell K, Nakafuku M, Waclaw RR, Lu QR (2022) Conserved and distinct functions of the autism-related chromatin remodeler CHD8 in embryonic and adult forebrain neurogenesis. J Neurosci 42(44):8373–8392. https://doi.org/10.1523/JNEUROSCI.2400-21.2022

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gage FH (2019) Adult neurogenesis in mammals. Science 364(6443):827–828. https://doi.org/10.1126/science.aav6885

Article  CAS  PubMed  Google Scholar 

Gage FH (2021) Adult neurogenesis in neurological diseases. Science 374(6571):1049–1050. https://doi.org/10.1126/science.abm7468

Article  CAS  PubMed  Google Scholar 

Gompers AL, Su-Feher L, Ellegood J, Copping NA, Riyadh MA, Stradleigh TW, Pride MC, Schaffler MD, Wade AA, Catta-Preta R, Zdilar I, Louis S, Kaushik G, Mannion BJ, Plajzer-Frick I, Afzal V, Visel A, Pennacchio LA, Dickel DE, Lerch JP, Crawley JN, Zarbalis KS, Silverman JL, Nord AS (2017) Germline Chd8 haploinsufficiency alters brain development in mouse. Nat Neurosci 20(8):1062–1073. https://doi.org/10.1038/nn.4592

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hurley S, Mohan C, Suetterlin P, Ellingford R, Riegman KLH, Ellegood J, Caruso A, Michetti C, Brock O, Evans R, Rudari F, Delogu A, Scattoni ML, Lerch JP, Fernandes C, Basson MA (2021) Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development. Mol Autism 12(1):16. https://doi.org/10.1186/s13229-020-00409-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jimenez JA, Ptacek TS, Tuttle AH, Schmid RS, Moy SS, Simon JM, Zylka MJ (2020) Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life. Mol Autism 11(1):74. https://doi.org/10.1186/s13229-020-00369-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jung H, Park H, Choi Y, Kang H, Lee E, Kweon H, Roh JD, Ellegood J, Choi W, Kang J, Rhim I, Choi SY, Bae M, Kim SG, Lee J, Chung C, Yoo T, Park H, Kim Y, Ha S, Um SM, Mo S, Kwon Y, Mah W, Bae YC, Kim H, Lerch JP, Paik SB, Kim E (2018) Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice. Nat Neurosci 21(9):1218–1228. https://doi.org/10.1038/s41593-018-0208-z

Article  CAS  PubMed  Google Scholar 

Katayama Y, Nishiyama M, Shoji H, Ohkawa Y, Kawamura A, Sato T, Suyama M, Takumi T, Miyakawa T, Nakayama KI (2016) CHD8 haploinsufficiency results in autistic-like phenotypes in mice. Nature 537(7622):675–679. https://doi.org/10.1038/nature19357

Article  CAS  PubMed  Google Scholar 

Kawamura A, Nishiyama M (2023) Deletion of the autism-related gene Chd8 alters activity-dependent transcriptional responses in mouse postmitotic neurons. Commun Biol 6(1):593. https://doi.org/10.1038/s42003-023-04968-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kawamura A, Katayama Y, Kakegawa W, Ino D, Nishiyama M, Yuzaki M, Nakayama KI (2021) The autism-associated protein CHD8 is required for cerebellar development and motor function. Cell Rep 35(1):108932. https://doi.org/10.1016/j.celrep.2021.108932

Article  CAS  PubMed  Google Scholar 

Lee SY, Kweon H, Kang H, Kim E (2022) Age-differential sexual dimorphism in CHD8-S62X-mutant mouse behaviors. Front Mol Neurosci 15:1022306. https://doi.org/10.3389/fnmol.2022.1022306

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee SY, Kweon H, Kang H, Kim E (2023) Age-differential sexual dimorphisms in CHD8-S62X-mutant mouse synapses and transcriptomes. Front Mol Neurosci 16:1111388. https://doi.org/10.3389/fnmol.2023.1111388

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lord C, Risi S, DiLavore PS, Shulman C, Thurm A, Pickles A (2006) Autism from 2 to 9 years of age. Arch Gen Psychiatry 63(6):694–701. https://doi.org/10.1001/archpsyc.63.6.694

Article  PubMed  Google Scholar 

Lord C, Elsabbagh M, Baird G, Veenstra-Vanderweele J (2018) Autism spectrum disorder. Lancet 392(10146):508–520. https://doi.org/10.1016/S0140-6736(18)31129-2

Article  PubMed  PubMed Central  Google Scholar 

Marin O, Rubenstein JL (2001) A long, remarkable journey: tangential migration in the telencephalon. Nat Rev Neurosci 2(11):780–790. https://doi.org/10.1038/35097509

Article  CAS  PubMed  Google Scholar 

Nishiyama M, Oshikawa K, Tsukada Y, Nakagawa T, Iemura S, Natsume T, Fan Y, Kikuchi A, Skoultchi AI, Nakayama KI (2009) CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis. Nat Cell Biol 11(2):172–182. https://doi.org/10.1038/ncb1831

Article  CAS  PubMed  PubMed Central  Google Scholar