A Ketogenic Diet Affects Gut Microbiota by Regulating Gut Microbiota and Promoting Hippocampal TRHR Expression to Combat Seizures

Arida RM (2021) Physical exercise and seizure activity. Biochim Biophys Acta Mol Basis Dis 1867(1):165979

Article  CAS  PubMed  Google Scholar 

Beam A, Clinger E, Hao L (2021) Effect of diet and dietary components on the composition of the gut microbiota. Nutrients 13(8):2795

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beydoun A, DuPont S, Zhou D, Matta M, Nagire V, Lagae L (2020) Current role of carbamazepine and oxcarbazepine in the management of epilepsy. Seizure 83:251–263

Article  PubMed  Google Scholar 

Collaborators GUND, Feigin VL, Vos T, Alahdab F, Amit AML, Barnighausen TW, Beghi E, Beheshti M, Chavan PP, Criqui MH, Desai R, Dhamminda Dharmaratne S, Dorsey ER, Wilder Eagan A, Elgendy IY, Filip I, Giampaoli S, Giussani G, Hafezi-Nejad N, Hole MK, Ikeda T, Owens Johnson C, Kalani R, Khatab K, Khubchandani J, Kim D, Koroshetz WJ, Krishnamoorthy V, Krishnamurthi RV, Liu X, Lo WD, Logroscino G, Mensah GA, Miller TR, Mohammed S, Mokdad AH, Moradi-Lakeh M, Morrison SD, Shivamurthy VKN, Naghavi M, Nichols E, Norrving B, Odell CM, Pupillo E, Radfar A, Roth GA, Shafieesabet A, Sheikh A, Sheikhbahaei S, Shin JI, Singh JA, Steiner TJ, Stovner LJ, Wallin MT, Weiss J, Wu C, Zunt JR, Adelson JD, Murray CJL (2021) Burden of neurological disorders across the US from 1990–2017: a global burden of disease study. JAMA Neurol 78(2):165–176

Article  Google Scholar 

Dai Y, Wang M, Zhong D, Xu X (2022) Bacillus subtilis plays a role in the inhibition of transporter ABCB1 in Caco-2 cells. Epilepsy Res 183:106925

Article  CAS  PubMed  Google Scholar 

Daschner PJ, Ross S, Seifried H, Kumar A, Flores R (2023) Nutrition and microbiome interactions in human cancer. J Acad Nutr Diet 123(3):504–514

Article  PubMed  Google Scholar 

de Vos WM, Tilg H, Van Hul M, Cani PD (2022) Gut microbiome and health: mechanistic insights. Gut 71(5):1020–1032

Article  PubMed  Google Scholar 

Dhandapani PK, Lyyski AM, Paulin L, Khan NA, Suomalainen A, Auvinen P, Dufour E, Szibor M, Jacobs HT (2019) Phenotypic effects of dietary stress in combination with a respiratory chain bypass in mice. Physiol Rep 7(13):e14159

Article  PubMed  PubMed Central  Google Scholar 

Ding M, Lang Y, Shu H, Shao J, Cui L (2021) Microbiota-gut-brain axis and epilepsy: a review on mechanisms and potential therapeutics. Front Immunol 12:742449

Douglas GM, Maffei VJ, Zaneveld JR, Yurgel SN, Brown JR, Taylor CM, Huttenhower C, Langille MGI (2020) PICRUSt2 for prediction of metagenome functions. Nat Biotechnol 38(6):685–688

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dowis K, Banga S (2021) The potential health benefits of the ketogenic diet: a narrative review. Nutrients 13(5):1654

Article  CAS  PubMed  PubMed Central  Google Scholar 

Farshbafnadi M, Agah E, Rezaei N (2021) The second brain: the connection between gut microbiota composition and multiple sclerosis. J Neuroimmunol 360:577700

Article  CAS  PubMed  Google Scholar 

Gean PW, Shinnick-Gallagher P (1988) Characterization of the epileptiform activity induced by magnesium-free solution in rat amygdala slices: an intracellular study. Exp Neurol 101(2):248–255

Article  CAS  PubMed  Google Scholar 

Gohel R, Kournoutis A, Petridi S, Nezis IP (2020) Molecular mechanisms of selective autophagy in Drosophila. Int Rev Cell Mol Biol 354:63–105

Article  CAS  PubMed  Google Scholar 

Gomaa EZ (2020) Human gut microbiota/microbiome in health and diseases: a review. Antonie Van Leeuwenhoek 113(12):2019–2040

Article  PubMed  Google Scholar 

Goralczyk-Binkowska A, Szmajda-Krygier D, Kozlowska E (2022) The microbiota-gut-brain axis in psychiatric disorders. Int J Mol Sci 23(19):11245

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guan YF, Huang GB, Xu MD, Gao F, Lin S, Huang J, Wang J, Li YQ, Wu CH, Yao S, Wang Y, Zhang YL, Teoh JP, Xuan A, Sun XD (2020) Anti-depression effects of ketogenic diet are mediated via the restoration of microglial activation and neuronal excitability in the lateral habenula. Brain Behav Immun 88:748–762

Article  CAS  PubMed  Google Scholar 

Gupta A, Osadchiy V, Mayer EA (2020) Brain-gut-microbiome interactions in obesity and food addiction. Nat Rev Gastroenterol Hepatol 17(11):655–672

Article  PubMed  PubMed Central  Google Scholar 

Hanas JS, Hocker JRS, Evangeline B, Prabhakaran V, Oommen A, Rajshekhar V, Drevets DA, Carabin H (2020) Distinguishing patients with idiopathic epilepsy from solitary cysticercus granuloma epilepsy and biochemical phenotype assessment using a serum biomolecule profiling platform. PLoS ONE 15(8):e0237064

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang F, Wu X (2021) Brain neurotransmitter modulation by gut microbiota in anxiety and depression. Front Cell Dev Biol 9:649103

Article  PubMed  PubMed Central  Google Scholar 

Huang S, Wang Y, Xie S, Lai Y, Mo C, Zeng T, Kuang S, Zhou C, Zeng Z, Chen Y, Huang S, Gao L, Lv Z (2022) Isoliquiritigenin alleviates liver fibrosis through caveolin-1-mediated hepatic stellate cells ferroptosis in zebrafish and mice. Phytomedicine 101:154117

Article  CAS  PubMed  Google Scholar 

Kanehisa M, Sato Y, Kawashima M, Furumichi M, Tanabe M (2016) KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res 44(D1):D457-462

Article  CAS  PubMed  Google Scholar 

Ko A, Kwon HE, Kim HD (2022) Updates on the ketogenic diet therapy for pediatric epilepsy. Biomed J 45(1):19–26

Article  CAS  PubMed  Google Scholar 

Koh S, Dupuis N, Auvin S (2020) Ketogenic diet and neuroinflammation. Epilepsy Res 167:106454

Article  CAS  PubMed  Google Scholar 

Kossoff EH, Turner Z, Adams J, Bessone SK, Avallone J, McDonald TJW, Diaz-Arias L, Barron BJ, Vizthum D, Cervenka MC (2020) Ketogenic diet therapy provision in the COVID-19 pandemic: Dual-center experience and recommendations. Epilepsy Behav 111:107181

Article  PubMed  PubMed Central  Google Scholar 

Kwon JT, Ryu C, Lee H, Sheffield A, Fan J, Cho DH, Bigler S, Sullivan HA, Choe HK, Wickersham IR, Heiman M, Choi GB (2021) An amygdala circuit that suppresses social engagement. Nature 593(7857):114–118

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leclercq S, Le Roy T, Furgiuele S, Coste V, Bindels LB, Leyrolle Q, Neyrinck AM, Quoilin C, Amadieu C, Petit G, Dricot L, Tagliatti V, Cani PD, Verbeke K, Colet JM, Starkel P, de Timary P, Delzenne NM (2020) Gut microbiota-induced changes in beta-hydroxybutyrate metabolism are linked to altered sociability and depression in alcohol use disorder. Cell Rep 33(2):108238

Article  CAS  PubMed  Google Scholar 

Lee S, Yang M, Kim J, Son Y, Kim J, Kang S, Ahn W, Kim SH, Kim JC, Shin T, Wang H, Moon C (2016) Involvement of BDNF/ERK signaling in spontaneous recovery from trimethyltin-induced hippocampal neurotoxicity in mice. Brain Res Bull 121:48–58

Article  CAS  PubMed  PubMed Central  Google Scholar 

Levin DN, McClain CD, Stone SSD, Madsen JR, Soriano S (2021) Anesthetic management and outcomes for MRI-guided laser interstitial thermal therapy (LITT) for seizure focus in pediatrics: a single-centre experience with 10 consecutive patients. Paediatr Anaesth 31(2):234–236

Article  PubMed  Google Scholar 

Li Q, Liang J, Fu N, Han Y, Qin J (2021) A ketogenic diet and the treatment of autism spectrum disorder. Front Pediatr 9:650624

Article  PubMed  PubMed Central  Google Scholar 

Liang N, Li Y, Chung HY (2017) Two natural eudesmane-type sesquiterpenes from Laggera alata inhibit angiogenesis and suppress breast cancer cell migration through VEGF- and Angiopoietin 2-mediated signaling pathways. Int J Oncol 51(1):213–222

Article 

Comments (0)

No login
gif