Spirulina and Thymoquinone Protect Against Methotrexate-Induced Hepatic Injury in Rats

Abd El-Ghafar OA, Hassanein EH, Ali FE, Omar ZM, Rashwan EK, Mohammedsaleh ZM, Sayed AM (2022) Hepatoprotective effect of acetovanillone against methotrexate hepatotoxicity: role of Keap-1/Nrf2/ARE, IL6/STAT-3, and NF-κB/AP-1 signaling pathways. Phytother Res 36:488–505. https://doi.org/10.1002/ptr.7355

Article  CAS  PubMed  Google Scholar 

Abdelaziz RM, Abdelazem AZ, Hashem KS, Attia YA (2020) Protective effects of hesperidin against MTX-induced hepatotoxicity in male albino rats. Naunyn-Schmiedeberg’s Arch Pharmacol 393:1405–1417. https://doi.org/10.1007/s00210-020-01843-z

Article  CAS  Google Scholar 

Abdel-Daim MM, Abuzead SM, Halawa SM (2013) Protective role of Spirulina platensis against acute deltamethrin-induced toxicity in rats. PLoS ONE 8:e72991. https://doi.org/10.1371/journal.pone.0072991

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abdel-Daim MM, Abushouk AI, Alkhalf MI, Toraih EA, Fawzy MS, Ijaz H, Aleya L, Bungau SG (2018) Antagonistic effects of Spirulina platensis on diazinon-induced hemato-biochemical alterations and oxidative stress in rats. Environ Sci Pollut Res 25:27463–27470. https://doi.org/10.1007/s11356-018-2761-0

Article  CAS  Google Scholar 

Abdel-Daim MM, Ahmed A, Ijaz H, Abushouk AI, Ahmed H, Negida A, Aleya L, Bungau SG (2019) Influence of Spirulina platensis and ascorbic acid on amikacin-induced nephrotoxicity in rabbits. Environ Sci Pollut Res 26:8080–8086. https://doi.org/10.1007/s11356-019-04249-4

Article  CAS  Google Scholar 

Abdel-Daim MM, Abo El-Ela FI, Alshahrani FK, Bin-Jumah M, Al-Zharani M, Almutairi B, Alyousif MS, Bungau S, Aleya L, Alkahtani S (2020a) Protective effects of thymoquinone against acrylamide-induced liver, kidney and brain oxidative damage in rats. Environ Sci Pollut Res 27:37709–37717. https://doi.org/10.1007/s11356-020-09516-3

Article  CAS  Google Scholar 

Abdel-Daim MM, Abushouk AI, Bungău SG, Bin-Jumah M, El-Kott AF, Shati AA, Aleya L, Alkahtani S (2020b) Protective effects of thymoquinone and diallyl sulphide against malathion-induced toxicity in rats. Environ Sci Pollut Res 27:10228–10235. https://doi.org/10.1007/s11356-019-07580-y

Article  CAS  Google Scholar 

AbdelKader G, Abdelaziz EZ, Hassan R, Greish SM, Abogresha NM, Sultan BO, Yousef EM, Morsi S, Abdelaziz E, Greish S (2023) Protective Effects of Crocin Against Methotrexate-Induced Hepatotoxicity in Adult Male Albino Rats: Histological, Immunohistochemical, and Biochemical Study. Cureus 15:e34468. https://doi.org/10.7759/cureus.34468

Article  PubMed  PubMed Central  Google Scholar 

Abdelkhalek NK, Ghazy EW, Abdel-Daim MM (2015) Pharmacodynamic interaction of Spirulina platensis and deltamethrin in freshwater fish Nile tilapia, Oreochromis niloticus: impact on lipid peroxidation and oxidative stress. Environ Sci Pollut Res 22:3023–3031. https://doi.org/10.1007/s11356-014-3578-0

Article  CAS  Google Scholar 

Abdel-Raheem IT, Khedr NF (2014) Renoprotective effects of montelukast, a cysteinyl leukotriene receptor antagonist, against methotrexate-induced kidney damage in rats. Naunyn-Schmiedebergs Arch Pharmacol 387:341–353. https://doi.org/10.1007/s00210-013-0949-x

Article  CAS  PubMed  Google Scholar 

Abdo W, Elmadawy MA, Abdelhiee EY, Abdel-Kareem MA, Farag A, Aboubakr M, Ghazy E, Fadl SE (2021) Protective effect of thymoquinone against lung intoxication induced by malathion inhalation. Sci Rep 11:2498. https://doi.org/10.1038/s41598-021-82083-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aboubakr M, Elshafae SM, Abdelhiee EY, Fadl SE, Soliman A, Abdelkader A, Abdel-Daim MM, Bayoumi KA, Baty RS, Elgendy E, Elalfy A, Baioumy B, Ibrahim SF, Abdeen A (2021) Antioxidant and Anti-Inflammatory Potential of Thymoquinone and Lycopene Mitigate the Chlorpyrifos-Induced Toxic Neuropathy. Pharmaceuticals 14:940. https://doi.org/10.3390/ph14090940

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aboubakr M, Elbadawy M, Ibrahim SS, Khalil E, Darweish M, Farag A, Elfadadny A, Alkafafy M, Soliman A, Elsayed A (2023) Allicin and lycopene possesses a protective effect against methotrexate induced testicular toxicity in rats. Pak Vet J 43:559–566. https://doi.org/10.29261/pakvetj/2023.057

Article  CAS  Google Scholar 

Aboubakr M, Farag A, Elfadadny A, Alkafafy M, Soliman A, Elbadawy M (2023b) Antioxidant and anti-apoptotic potency of allicin and lycopene against methotrexate-induced cardiac injury in rats. Environ Sci Pollut Res 30:88724–88733. https://doi.org/10.1007/s11356-023-28686-4

Article  CAS  Google Scholar 

Aktaş İ, Mehmet Gür F (2022) Hepato-protective effects of thymoquinone and beta-aminoisobutyric acid in streptozocin induced diabetic rats. Biotech Histochem 97:67–76. https://doi.org/10.1080/10520295.2021.1949041

Article  CAS  PubMed  Google Scholar 

Al Aboud D, Baty RS, Alsharif KF, Hassan KE, Zhery AS, Habotta OA, Elmahallawy EK, Amin HK, Abdel Moneim AE, Kassab RB (2021) Protective efficacy of thymoquinone or ebselen separately against arsenic-induced hepatotoxicity in rat. Environ Sci Pollut Res 28:6195–6206. https://doi.org/10.1007/s11356-020-10955-1

Article  CAS  Google Scholar 

Alam T, Shahid F, Abidi S, Parwez I, Khan F (2022) Thymoquinone supplementation mitigates arsenic-induced cytotoxic and genotoxic alterations in rat liver. J Trace Elem Med Biol 74:127067. https://doi.org/10.1016/j.jtemb.2022.127067

Article  CAS  PubMed  Google Scholar 

Alanazi S, Alsaqer R, Alsaeed F, Almakhaytah R, Buwashl N, Mohamed M, Younis N (2023) Studying the actions of sage and thymoquinone combination on metabolic syndrome induced by high-fat diet in rats. Eur Rev Med Pharmacol Sci 27:2404–2418. https://doi.org/10.26355/eurrev_202303_31775

Article  CAS  PubMed  Google Scholar 

Al-Brakati A, Kassab R, Lokman M, Elmahallawy E, Amin H, Abdel Moneim A (2019) Role of thymoquinone and ebselen in the prevention of sodium arsenite–induced nephrotoxicity in female rats. Hum Exp Toxicol 38:482–493. https://doi.org/10.1177/0960327118818246

Article  CAS  PubMed  Google Scholar 

Al-Dhabi NA (2013) Heavy metal analysis in commercial Spirulina products for human consumption. Saudi J Biol Sci 20:383–388. https://doi.org/10.1016/j.sjbs.2013.04.006

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alfwuaires MA (2022) Galangin mitigates oxidative stress, inflammation, and apoptosis in a rat model of methotrexate hepatotoxicity. Environ Sci Pollut Res 29:20279–20288. https://doi.org/10.1007/s11356-021-16804-z

Article  CAS  Google Scholar 

Al-Malki AL, Sayed AA (2014) Thymoquinone attenuates cisplatin-induced hepatotoxicity via nuclear factor kappa-β. BMC Complement Altern Med 14:282. https://doi.org/10.1186/1472-6882-14-282

Article  CAS  PubMed  PubMed Central  Google Scholar 

Atawodi SE, Yakubu OE, Liman ML, Iliemene DU (2014) Effect of methanolic extract of Tetrapleura tetraptera (Schum and Thonn) Taub leaves on hyperglycemia and indices of diabetic complications in alloxan–induced diabetic rats. Asian Pac J Trop Biomed 4:272–278. https://doi.org/10.12980/APJTB.4.2014C73

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baratta F, Cocomello N, Coronati M, Ferro D, Pastori D, Angelico F, Ben MD (2023) Cholesterol Remnants, Triglyceride-Rich Lipoproteins and Cardiovascular Risk. Int J Mol Sci 24:4268. https://doi.org/10.3390/ijms24054268

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bath RK, Brar NK, Forouhar FA, Wu GY (2014) A review of methotrexate-associated hepatotoxicity. J Dig Dis 15:517–524. https://doi.org/10.1111/1751-2980.12184

Article  CAS  PubMed  Google Scholar 

Behairy A, Elkomy A, Elsayed F, Gaballa MMS, Soliman A, Aboubakr M (2023) Antioxidant and anti-inflammatory potential of spirulina and thymoquinone mitigate the methotrexate-induced neurotoxicity. Naunyn Schmiedebergs Arch Pharmacol. https://doi.org/10.1007/s00210-023-02739-4

Article  PubMed  Google Scholar 

Belfield A, Goldberg D (1971) Colorimetric determination of alkaline phosphatase activity. Enzyme 12:561–568

Article  CAS  PubMed  Google Scholar 

Beutler E, Duron O, Kelly BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882–888

CAS  PubMed  Google Scholar 

Bin-Jumah MN, Al-Huqail AA, Abdelnaeim N, Kamel M, Fouda MM, Abulmeaty MM, Saadeldin IM, Abdel-Daim MM (2021) Potential protective effects of Spirulina platensis on liver, kidney, and brain acrylamide toxicity in rats. Environ Sci Pollut Res 28:26653–26663. https://doi.org/10.1007/s11356-021-12422-x

Article  CAS  Google Scholar 

Bortolini DG, Maciel GM, Fernandes IAA, Pedro AC, Rubio FTV, Branco IG, Haminiuk CWI (2022) Functional properties of bioactive compounds from Spirulina spp.: current status and future trends. Food Chem 5:100134. https://doi.org/10.1016/j.fochms.2022.100134

Article  CAS  Google Scholar 

Burstein M, Scholnick H, Morfin R (1970) Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res 11:583–595

Article  CAS  PubMed  Google Scholar 

Cao Y, Shi H, Sun Z, Wu J, Xia Y, Wang Y, Wu Y, Li X, Chen W, Wang A (2019) Protective effects of magnesium glycyrrhizinate on methotrexate-induced hepatotoxicity and intestinal toxicity may be by reducing COX-2. Front Pharmacol 10:119. https://doi.org/10.3389/fphar.2019.00119

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang CJ, Lin JF, Chang HH, Lee GA, Hung CF (2013) Lutein protects against methotrexate-induced and reactive oxygen species-mediated apoptotic cell injury of IEC-6 cells. PLoS ONE 8:e72553. https://doi.org/10.1371/journal.pone.0072553

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