Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, et al. Genomic classification and prognosis in acute myeloid leukemia. N Engl J Med. 2016;374:2209–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thol F. What to use to treat AML: the role of emerging therapies. Hematology. 2021;2021:16–23.

Article  PubMed  PubMed Central  Google Scholar 

Döhner H, Wei AH, Löwenberg B. Towards precision medicine for AML. Nat Rev Clin Oncol. 2021;18:577–90.

Article  PubMed  Google Scholar 

Pollyea DA, Bixby D, Perl A, Bhatt VR, Altman JK, Appelbaum FR, et al. NCCN guidelines insights: acute myeloid leukemia, version 2.2021. J Natl Compr Canc Netw. 2021;19:16–27.

Article  PubMed  Google Scholar 

Elagib KE, Goldfarb AN. Oncogenic pathways of AML1-ETO in acute myeloid leukemia: multifaceted manipulation of marrow maturation. Cancer Lett. 2007;251:179–86.

Article  CAS  PubMed  Google Scholar 

Hollein A, Nadarajah N, Meggendorfer M, Jeromin S, Kern W, Haferlach C, et al. Molecular characterization of AML with RUNX1-RUNX1T1 at diagnosis and relapse reveals net loss of co-mutations. Hemasphere. 2019;3:e178.

Article  PubMed  PubMed Central  Google Scholar 

Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. Proc Natl Acad Sci USA. 1998;95:10860–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, et al. ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. Mol Cell Biol. 2001;21:6470–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Trombly DJ, Whitfield TW, Padmanabhan S, Gordon JA, Lian JB, van Wijnen AJ, et al. Genome-wide co-occupancy of AML1-ETO and N-CoR defines the t(8;21) AML signature in leukemic cells. BMC Genomics. 2015;16:309.

Article  PubMed  PubMed Central  Google Scholar 

Wang L, Gural A, Sun XJ, Zhao X, Perna F, Huang G, et al. The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. Science. 2011;333:765–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Wang H, Wang X, Jin W, Tan Y, Fang H, et al. Genome-wide studies identify a novel interplay between AML1 and AML1/ETO in t(8;21) acute myeloid leukemia. Blood. 2016;127:233–42.

Article  CAS  PubMed  Google Scholar 

Ptasinska A, Pickin A, Assi SA, Chin PS, Ames L, Avellino R, et al. RUNX1-ETO depletion in t(8;21) AML leads to C/EBPalpha- and AP-1-mediated alterations in enhancer-promoter interaction. Cell Rep. 2019;28:3022–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun XJ, Wang Z, Wang L, Jiang Y, Kost N, Soong TD, et al. A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis. Nature. 2013;500:93–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duployez N, Marceau-Renaut A, Boissel N, Petit A, Bucci M, Geffroy S, et al. Comprehensive mutational profiling of core binding factor acute myeloid leukemia. Blood. 2016;127:2451–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wichmann C, Quagliano-Lo Coco I, Yildiz O, Chen-Wichmann L, Weber H, Syzonenko T, et al. Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+ hematopoietic progenitors. Leukemia. 2015;29:279–89.

Article  CAS  PubMed  Google Scholar 

Yu X, Ruan X, Zhang J, Zhao Q. Celastrol induces cell apoptosis and inhibits the expression of the AML1-ETO/C-KIT oncoprotein in t(8;21) leukemia. Molecules. 2016;21:574.

Article  PubMed  PubMed Central  Google Scholar 

Hui H, Zhang X, Li H, Liu X, Shen L, Zhu Y, et al. Oroxylin A, a natural anticancer flavonoid compound, induces differentiation of t(8;21)-positive Kasumi-1 and primary acute myeloid leukemia cells. J Cancer Res Clin Oncol. 2016;142:1449–59.

Article  CAS  PubMed  Google Scholar 

Sawney S, Arora R, Aggarwal KK, Saluja D. Esculetin downregulates the expression of AML1-ETO and C-KIT in Kasumi-1 cell line by decreasing half-life of mRNA. J Oncol. 2015;2015:781473.

Article  PubMed  PubMed Central  Google Scholar 

Oo ZM, Illendula A, Grembecka J, Schmidt C, Zhou Y, Esain V, et al. A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFbeta in leukemic cells. Leuk Lymphoma. 2018;59:2188–200.

Article  CAS  PubMed  Google Scholar 

Paschka P, Schlenk RF, Weber D, Benner A, Bullinger L, Heuser M, et al. Adding dasatinib to intensive treatment in core-binding factor acute myeloid leukemia-results of the AMLSG 11-08 trial. Leukemia. 2018;32:1621–30.

Article  CAS  PubMed  Google Scholar 

Zhen T, Wu CF, Liu P, Wu HY, Zhou GB, Lu Y, et al. Targeting of AML1-ETO in t(8;21) leukemia by oridonin generates a tumor suppressor-like protein. Sci Transl Med. 2012;4:127ra38.

Article  PubMed  Google Scholar 

Wang L, Zhao WL, Yan JS, Liu P, Sun HP, Zhou GB, et al. Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kappaB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner. Cell Death Differ. 2007;14:306–17.

Article  PubMed  Google Scholar 

Chen XJ, Zhang WN, Chen B, Xi WD, Lu Y, Huang JY, et al. Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-kappaB repressing factor. Proc Natl Acad Sci USA. 2019;116:2220–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang ZY, Chen Z. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood. 2008;111:2505–15.

Article  CAS  PubMed  Google Scholar 

Wang YY, Zhao LJ, Wu CF, Liu P, Shi L, Liang Y, et al. C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice. Proc Natl Acad Sci USA. 2011;108:2450–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chou TC. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev. 2006;58:621–81.

Article  CAS  PubMed  Google Scholar 

Dhanasekaran DN, Reddy EP. JNK signaling in apoptosis. Oncogene. 2008;27:6245–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Szklarczyk D, Gable AL, Nastou KC, Lyon D, Kirsch R, Pyysalo S, et al. The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets. Nucleic Acids Res. 2021;49:D605–D12.

Article  CAS  PubMed  Google Scholar 

Liu S, Wu LC, Pang J, Santhanam R, Schwind S, Wu YZ, et al. Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia. Cancer Cell. 2010;17:333–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goyama S, Mulloy JC. Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. Int J Hematol. 2011;94:126–33.

Article  CAS  PubMed  Google Scholar 

Ptasinska A, Assi Salam A, Martinez-Soria N, Imperato Maria R, Piper J, Cauchy P, et al. Identification of a dynamic core transcriptional network in t(8;21) AML that regulates differentiation block and self-renewal. Cell Rep. 2014;8:1974–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mangaonkar AA, Patnaik MM. Hereditary predisposition to hematopoietic neoplasms: when bloodline matters for blood cancers. Mayo Clin Proc. 2020;95:1482–98.

Article  CAS  PubMed  Google Scholar 

Kato H, Igarashi K. To be red or white: lineage commitment and maintenance of the hematopoietic system by the “inner myeloid”. Haematologica. 2019;104:1919–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lieu YK, Reddy EP. Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation. Proc Natl Acad Sci USA. 2009;106:21689–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nafria M, Keane P, Ng ES, Stanley EG, Elefanty AG, Bonifer C. Expression of RUNX1-ETO rapidly alters the chromatin landscape and growth of early human myeloid precursor cells. Cell Rep. 2020;31:107691.