Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, Boriani G, Castella M, Dan G-A, Dilaveris PE, Fauchier L, Filippatos G, Kalman JM, La Meir M, Lane DA, Lebeau J-P, Lettino M, Lip GYH, Pinto FJ, Thomas GN, Valgimigli M, Van Gelder IC, Van Putte BP, Watkins CL (2021) 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): the task force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J 42(5):373–498

Article  PubMed  Google Scholar 

Reddy YNV, Borlaug BA, Gersh BJ (2022) Management of atrial fibrillation across the spectrum of heart failure with preserved and reduced ejection fraction. Circulation 146(4):339–357

Article  PubMed  Google Scholar 

Farmakis D, Chrysohoou C, Giamouzis G, Giannakoulas G, Hamilos M, Naka K, Tzeis S, Xydonas S, Karavidas A, Parissis J (2021) The management of atrial fibrillation in heart failure: an expert panel consensus. Heart Fail Rev 26(6):1345–1358

Article  PubMed  Google Scholar 

Temporelli PL, Arbelo E, Laroche C, Blomström-Lundqvist C, Kirchhof P, Lip GYH, Boriani G, Nakou E, Maggioni AP, Tavazzi L (2022) Atrial fibrillation ablation in heart failure: findings from the ESC-EHRA EORP Atrial Fibrillation Ablation long-term (AFA LT) registry. Int J Cardiol 346:19–26

Article  PubMed  Google Scholar 

Redfield MM, Borlaug BA (2023) Heart failure with preserved ejection fraction: a review. JAMA 329(10):827–838

Article  PubMed  Google Scholar 

Santhanakrishnan R, Wang N, Larson MG, Magnani JW, McManus DD, Lubitz SA, Ellinor PT, Cheng S, Vasan RS, Lee DS, Wang TJ, Levy D, Benjamin EJ, Ho JE (2016) Atrial fibrillation begets heart failure and vice versa: temporal associations and differences in preserved versus reduced ejection fraction. Circulation 133(5):484–492

Article  PubMed  PubMed Central  Google Scholar 

Vermond RA, Geelhoed B, Verweij N, Tieleman RG, Van der Harst P, Hillege HL, Van Gilst WH, Van Gelder IC, Rienstra M (2015) Incidence of atrial fibrillation and relationship with cardiovascular events, heart failure, and mortality: a community-based study from the Netherlands. J Am Coll Cardiol 66(9):1000–1007

Article  PubMed  Google Scholar 

Campbell RT, McMurray JJV (2014) Comorbidities and differential diagnosis in heart failure with preserved ejection fraction. Heart Fail Clin 10(3):481–501

Article  PubMed  Google Scholar 

Bishu K, Deswal A, Chen HH, LeWinter MM, Lewis GD, Semigran MJ, Borlaug BA, McNulty S, Hernandez AF, Braunwald E, Redfield MM (2012) Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction. Am Heart J 164(5)

Ariyaratnam JP, Lau DH, Sanders P, Kalman JM (2021) Atrial fibrillation and heart failure: epidemiology, pathophysiology, prognosis, and management. Card Electrophysiol Clin 13(1):47–62

Article  PubMed  Google Scholar 

Mentz RJ, Kelly JP, von Lueder TG, Voors AA, Lam CSP, Cowie MR, Kjeldsen K, Jankowska EA, Atar D, Butler J, Fiuzat M, Zannad F, Pitt B, O’Connor CM (2014) Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction. J Am Coll Cardiol 64(21):2281–2293

Article  PubMed  PubMed Central  Google Scholar 

Hanna A, Frangogiannis NG (2020) Inflammatory cytokines and chemokines as therapeutic targets in heart failure. Cardiovasc Drugs Ther 34(6):849–863

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paulus WJ, Tschöpe C (2013) A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol 62(4):263–271

Article  PubMed  Google Scholar 

Knackstedt C, Gramley F, Schimpf T, Mischke K, Zarse M, Plisiene J, Schmid M, Lorenzen J, Frechen D, Neef P, Hanrath P, Kelm M, Schauerte P (2008) Association of echocardiographic atrial size and atrial fibrosis in a sequential model of congestive heart failure and atrial fibrillation. Cardiovasc Pathol 17(5):318–324

Article  PubMed  Google Scholar 

Sanders P, Morton JB, Davidson NC, Spence SJ, Vohra JK, Sparks PB, Kalman JM (2003) Electrical remodeling of the atria in congestive heart failure: electrophysiological and electroanatomic mapping in humans. Circulation 108(12):1461–1468

Article  PubMed  Google Scholar 

Kitzman DW, Little WC, Brubaker PH, Anderson RT, Hundley WG, Marburger CT, Brosnihan B, Morgan TM, Stewart KP (2002) Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure. JAMA 288(17):2144–2150

Article  PubMed  Google Scholar 

Harada D, Asanoi H, Noto T, Takagawa J (2020) Different pathophysiology and outcomes of heart failure with preserved ejection fraction stratified by k-means clustering. Front Cardiovasc Med 7:607760

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vaduganathan M, Piccini JP, Camm AJ, Crijns HJGM, Anker SD, Butler J, Stewart J, Braceras R, Albuquerque APA, Wieloch M, Hohnloser SH (2022) Dronedarone for the treatment of atrial fibrillation with concomitant heart failure with preserved and mildly reduced ejection fraction: a post-hoc analysis of the ATHENA trial. Eur J Heart Fail 24(6):1094–1101

Article  CAS  PubMed  Google Scholar 

Rahbar Kouibaran F, Sabatino M, Barozzi C, Diemberger I (2023) Atrial natriuretic peptides as a bridge between atrial fibrillation, heart failure, and amyloidosis of the atria. Int J Mol Sci 24(7)

Shantsila E, Shantsila A, Blann AD, Lip GYH (2013) Left ventricular fibrosis in atrial fibrillation. Am J Cardiol 111(7)

McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, Burri H, Butler J, Čelutkienė J, Chioncel O, Cleland JGF, Coats AJS, Crespo-Leiro MG, Farmakis D, Gilard M, Heymans S, Hoes AW, Jaarsma T, Jankowska EA, Lainscak M, Lam CSP, Lyon AR, McMurray JJV, Mebazaa A, Mindham R, Muneretto C, Francesco Piepoli M, Price S, Rosano GMC, Ruschitzka F, Kathrine Skibelund A (2021) 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 42(36):3599–3726

Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Nnacheta LC, Sandhu AT, Stevenson LW, Vardeny O, Vest AR, Yancy CW (2022) 2022 AHA/ACC/HFSA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 145(18):e876–e894

PubMed  Google Scholar 

Marrouche NF, Brachmann J, Andresen D, Siebels J, Boersma L, Jordaens L, Merkely B, Pokushalov E, Sanders P, Proff J, Schunkert H, Christ H, Vogt J, Bänsch D (2018) Catheter ablation for atrial fibrillation with heart failure. N Engl J Med 378(5):417–427

Article  PubMed  Google Scholar 

Packer DL, Mark DB, Robb RA, Monahan KH, Bahnson TD, Poole JE, Noseworthy PA, Rosenberg YD, Jeffries N, Mitchell LB, Flaker GC, Pokushalov E, Romanov A, Bunch TJ, Noelker G, Ardashev A, Revishvili A, Wilber DJ, Cappato R, Kuck K-H, Hindricks G, Davies DW, Kowey PR, Naccarelli GV, Reiffel JA, Piccini JP, Silverstein AP, Al-Khalidi HR, Lee KL (2019) Effect of catheter ablation vs antiarrhythmic drug therapy on mortality, stroke, bleeding, and cardiac arrest among patients with atrial fibrillation: the CABANA randomized clinical trial. JAMA 321(13):1261–1274

Article  CAS  PubMed  PubMed Central  Google Scholar 

Di Biase L, Mohanty P, Mohanty S, Santangeli P, Trivedi C, Lakkireddy D, Reddy M, Jais P, Themistoclakis S, Dello Russo A, Casella M, Pelargonio G, Narducci ML, Schweikert R, Neuzil P, Sanchez J, Horton R, Beheiry S, Hongo R, Hao S, Rossillo A, Forleo G, Tondo C, Burkhardt JD, Haissaguerre M, Natale A (2016) Ablation versus amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device: results from the AATAC multicenter randomized trial. Circulation 133(17):1637–1644

Article  PubMed  Google Scholar 

Nassif ME, Windsor SL, Borlaug BA, Kitzman DW, Shah SJ, Tang F, Khariton Y, Malik AO, Khumri T, Umpierrez G, Lamba S, Sharma K, Khan SS, Chandra L, Gordon RA, Ryan JJ, Chaudhry S-P, Joseph SM, Chow CH, Kanwar MK, Pursley M, Siraj ES, Lewis GD, Clemson BS, Fong M, Kosiborod MN (2021) The SGLT2 inhibitor dapagliflozin in heart failure with preserved ejection fraction: a multicenter randomized trial. Nat Med 27(11):1954–1960

Article  PubMed  PubMed Central  Google Scholar 

Butler J, Filippatos G, Jamal Siddiqi T, Brueckmann M, Böhm M, Chopra VK, Pedro Ferreira J, Januzzi JL, Kaul S, Piña IL, Ponikowski P, Shah SJ, Senni M, Vedin O, Verma S, Peil B, Pocock SJ, Zannad F, Packer M, Anker SD (2022) Empagliflozin, Health status, and quality of life in patients with heart failure and preserved ejection fraction: the EMPEROR-preserved trial. Circulation 145(3):184–193

Solomon SD, McMurray JJV, Anand IS, Ge J, Lam CSP, Maggioni AP, Martinez F, Packer M, Pfeffer MA, Pieske B, Redfield MM, Rouleau JL, van Veldhuisen DJ, Zannad F, Zile MR, Desai AS, Claggett B, Jhund PS, Boytsov SA, Comin-Colet J, Cleland J, Düngen HD, Goncalvesova E, Katova T, Kerr Saraiva JF, Lelonek M, Merkely B, Senni M, Shah SJ, Zhou J, Rizkala AR, Gong  J, Shi VP, Lefkowitz MP (2019) Angiotensin-neprilysin inhibition in heart failure with preserved ejection fraction. N Engl J Med 381(17):1609–1620

Jia R, Zhang X, Xu Y, Zheng Z, Jiang L, Zhang X, Sun C, Wu X, Li S, Raj A, Sun D (2022) Effect of Sacubitril/Valsartan on renal function in patients with chronic kidney disease and heart failure with preserved ejection fraction: a real-world 12-week study. Eur J Pharmacol 928:175053

Article  CAS  PubMed  Google Scholar 

Silverman DN, Plante TB, Infeld M, Callas PW, Juraschek SP, Dougherty GB, Meyer M (2019) Association of β-blocker use with heart failure hospitalizations and cardiovascular disease mortality among patients with heart failure with a preserved ejection fraction: a secondary analysis of the TOPCAT trial. JAMA Netw Open 2(12):e1916598

Article  PubMed  PubMed Central  Google Scholar 

Pfeffer MA, Claggett B, Assmann SF, Boineau R, Anand IS, Clausell N, Desai AS, Diaz R, Fleg JL, Gordeev I, Heitner JF, Lewis EF, O’Meara E, Rouleau J-L, Probstfield JL, Shaburishvili T, Shah SJ, Solomon SD, Sweitzer NK, McKinlay SM, Pitt B (2015) Regional variation in patients and outcomes in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) trial. Circulation 131(1):34–42

Article  CAS  PubMed  Google Scholar 

Kosiborod MN, Abildstrøm SZ, Borlaug BA, Butler J, Rasmussen S, Davies M, Hovingh GK, Kitzman DW, Lindegaard ML, Møller DV, Shah SJ, Treppendahl MB, Verma S, Abhayaratna W, Ahmed FZ, Chopra V, Ezekowitz J, Fu M, Ito H, Lelonek M, Melenovsky V, Merkely B, Núñez J, Perna E, Schou M, Senni M, Sharma K, Van der Meer P, von Lewinski D, Wolf D, Petrie MC (2023) Semaglutide in patients with heart failure with preserved ejection fraction and obesity. N Engl J Med 389(12):1069–1084

Article  CAS  PubMed  Google Scholar 

Oikonomou E, Zografos T, Papamikroulis G-A, Siasos G, Vogiatzi G, Theofilis P, Briasoulis A, Papaioannou S, Vavuranakis M, Gennimata V, Tousoulis D (2019) Biomarkers in atrial fibrillation and heart failure. Curr Med Chem 26(5):873–887

Article  CAS  PubMed  Google Scholar 

Sepehrvand N, Alemayehu W, Dyck GJB, Dyck JRB, Anderson T, Howlett J, Paterson I, McAlister FA, Ezekowitz JA (2019) External validation of the H2F-PEF model in diagnosing patients with heart failure and preserved ejection fraction. Circulation 139(20):2377–2379

Article  PubMed  Google Scholar 

Sun Y, Si J, Li J, Dai M, King E, Zhang X, Zhang Y, Xia Y, Tse G, Liu Y (2021) Predictive value of HFA-PEFF score in patients with heart failure with preserved ejection fraction. Front Cardiovasc Med 8:656536

Article  PubMed  PubMed Central  Google Scholar 

Reddy YNV, Kaye DM, Handoko ML, van de Bovenkamp AA, Tedford RJ, Keck C, Andersen MJ, Sharma K, Trivedi RK, Carter RE, Obokata M, Verbrugge FH, Redfield MM, Borlaug BA (2022) Diagnosis of heart failure with preserved ejection fraction among patients with unexplained dyspnea. JAMA Cardiol 7(9):891–899

Article  PubMed  PubMed Central